Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 2, 2013, Pages 648-653

  Bock, Fabian ^a,b   Shahzad, Khurrum ^a,c   Wang, Hongjie ^a,d   Stoyanov, Stoyan ^e   Wolter, Juliane ^a   Dong, Wei ^a   Pelicci, Pier Giuseppe ^f   Kashif, Muhammed ^b   Ranjan, Satish ^a   Schmidt, Simone ^b   Ritzel, Robert ^b,g   Schwenger, Vedat ^b   Reymann, Klaus G ^e   Esmon, Charles T ^h   Madhusudhan, Thati ^a   Nawroth, Peter P ^b   Isermann, Berend ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF THE PUNJAB   (Pakistan)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^e GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^f EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^g Klinikum Schwabing   (Germany)

^h OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; BUTYRIC ACID; MESSENGER RNA; PROTEIN P66; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENDOTHELIUM CELL; EPIGENETICS; GENE TRANSLOCATION; HISTONE ACETYLATION; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANALYSIS OF VARIANCE; ANIMALS; BUTYRATES; CHROMATIN IMMUNOPRECIPITATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DNA METHYLATION; DNA PRIMERS; EPIGENETIC REPRESSION; GENE KNOCKDOWN TECHNIQUES; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; PODOCYTES; PROTEIN C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SHC SIGNALING ADAPTOR PROTEINS; STATISTICS, NONPARAMETRIC; SUBCELLULAR FRACTIONS;

EID: 84872193981     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218667110     Document Type: Article

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