Evolutionary conserved Tyr169 stabilizes the β2-α2 loop of the prion protein

Journal of the American Chemical Society

Volumn 137, Issue 8, 2015, Pages 2948-2957

  Huang, Danzhi ^a   Caflisch, Amedeo ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; HYDROGEN BONDS; MAMMALS; MOBILE SECURITY; MOLECULAR DYNAMICS; PROTEINS;

EXPERIMENTAL EVIDENCE; FREE ENERGY SURFACE; MAMMALIAN PRION PROTEINS; MOLECULAR DYNAMICS SIMULATIONS; MULTIPLE CONFORMATIONS; PRIMARY STRUCTURES; SOLVENT EXPOSURE; SPONTANEOUS TRANSITION;

FREE ENERGY;

PRION PROTEIN; PEPTIDE FRAGMENT; PRION; SOLVENT; TYROSINE;

ARTICLE; CONFORMATION; ENERGY; EVOLUTION; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR STABILITY; PROTEIN STRUCTURE; SAMPLING; SIMULATION; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; HUMAN; KINETICS; MOLECULAR EVOLUTION; MOUSE; NUCLEOTIDE SEQUENCE; PRION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY;

AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; HUMANS; KINETICS; MICE; MOLECULAR DYNAMICS SIMULATION; PEPTIDE FRAGMENTS; PRIONS; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; SOLVENTS; TYROSINE;

EID: 84924301761     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja511568m     Document Type: Article

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