Ser170 controls the conformational multiplicity of the loop 166-175 in prion proteins: Implication for conversion and species barrier

FASEB Journal

Volumn 21, Issue 12, 2007, Pages 3279-3287

  Gorfe, Alemayehu A ^a,b   Caflisch, Amedeo ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Allosteric control; Elk; Flexibility; Molecular dynamics; Mouse

Indexed keywords

ASPARTIC ACID; HYBRID PROTEIN; PRION PROTEIN; SERINE; TRANSCRIPTION FACTOR ELK 1; SOLVENT;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA SHEET; CONTROLLED STUDY; CORRELATION ANALYSIS; EXPERIMENTAL ANIMAL; GENE DISRUPTION; MOLECULAR DYNAMICS; NONHUMAN; PRION; PRION DISEASE; PRIORITY JOURNAL; PROTEIN CONFORMATION; SEQUENCE ANALYSIS; SIMULATION; VIRUS TRANSMISSION; AMINO ACID SEQUENCE; ANIMAL; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; DEER; GENETICS; HUMAN; HYDROGEN BOND; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEAR MAGNETIC RESONANCE; PATHOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SPECIES DIFFERENCE;

ANIMALIA; BOVINAE; CERVIDAE; MUS;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; DEER; HUMANS; HYDROGEN BONDING; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PRION DISEASES; PRIONS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SERINE; SOLVENTS; SPECIES SPECIFICITY;

EID: 35248848952     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.07-8292com     Document Type: Article

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