Disruption of the X-loop turn of the prion protein linked to scrapie resistance

Protein Engineering, Design and Selection

Volumn 25, Issue 5, 2012, Pages 243-249

  Scouras, Alexander D ^a,b   Daggett, Valerie ^a,b,c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c University of Washington   (United States)

Author keywords

prion disease; resistance to disease; species barrier; X loop

Indexed keywords

ATOMISTIC MOLECULAR DYNAMICS SIMULATIONS; CONTROL CONSTRUCTS; DISEASE SUSCEPTIBILITY; MISFOLDING; NEUTRAL PH; PH CONDITION; PRION DISEASE; PRION PROTEIN; RANDOM MUTAGENESIS; RESISTANT MUTANTS; SECOND GROUP; SELECTIVE BREEDING; SIMULATION TIME; SPECIES BARRIER; SPIRAL MODELS; STRUCTURAL BASIS; WILD TYPES; X-LOOP;

CELL CULTURE; DIAGNOSIS; MOLECULAR DYNAMICS; OLIGOMERS; PROTEINS;

NEURODEGENERATIVE DISEASES;

PRION PROTEIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREEDING; CONTROLLED STUDY; GENE MUTATION; MOLECULAR DYNAMICS; MOUSE; MUTAGENESIS; MUTANT; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN STRUCTURE; SCRAPIE; SCREENING TEST; SHEEP; WILD TYPE;

ANIMALS; HYDROGEN-ION CONCENTRATION; MICE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PRPSC PROTEINS; SCRAPIE; SHEEP;

MUS; OVIS ARIES;

EID: 84860469091     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzs009     Document Type: Article

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