A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the α2- β2 loop of PrPC

Journal of Biological Chemistry

Volumn 289, Issue 15, 2014, Pages 10660-10667

  Kurt, Timothy D ^a   Jiang, Lin ^b   Bett, Cyrus ^a   Eisenberg, David ^b   Sigurdson, Christina J ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; MAMMALS; PLANTS (BOTANY);

AROMATIC RESIDUES; CROSS-SPECIES; INFECTIOUS PRIONS; MODEL-BASED OPC; PRIMARY STRUCTURES; STRUCTURAL REQUIREMENTS; TRANSGENIC MICE; TYROSINE RESIDUES;

AMINO ACIDS;

GLUTAMINE; GLYCINE; LEUCINE; PHENYLALANINE; PRION PROTEIN; TRYPTOPHAN; TYROSINE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; BETA SHEET; CONTROLLED STUDY; MAMMAL; PRIORITY JOURNAL; TRANSGENIC MOUSE;

AMYLOID; INFECTIOUS DISEASES; NEURODEGENERATIVE DISEASES; PRIONS; PROTEIN AGGREGATION; STERIC ZIPPER; TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY; TSE; Β2-Α2 LOOP;

AMYLOID; ANIMALS; CELL-FREE SYSTEM; MICE; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEURODEGENERATIVE DISEASES; PRION DISEASES; PRIONS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PRPC PROTEINS; TYROSINE;

EID: 84898651807     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.549030     Document Type: Article

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