Pathophysiological hypoxia affects the redox state and IL-2 signalling of human CD4+ T cells and concomitantly impairs survival and proliferation

European Journal of Immunology

Volumn 43, Issue 6, 2013, Pages 1588-1597

  Gaber, Timo ^a,b,c   Tran, Cam Loan ^a,b   Schellmann, Saskia ^a,b   Hahne, Martin ^a,b,d   Strehl, Cindy ^a,b   Hoff, Paula ^a,b   Radbruch, Andreas ^b   Burmester, Gerd Rüdiger ^a   Buttgereit, Frank ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^c Berlin Brandenburg Center for Regenerative Therapies   (Germany)

^d Berlin Brandenburg School of Regenerative Therapies (BSRT)   (Germany)

Author keywords

Bioenergetics; CD4+ T cells; Hypoxia; ROS

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA INTERFERON; CASPASE 3; CASPASE 4; CASPASE 5; CASPASE 6; CASPASE 7; CD4 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 9; PLATELET DERIVED GROWTH FACTOR BB; REACTIVE OXYGEN METABOLITE; STAT5A PROTEIN;

APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELL ENERGY; CELL GROWTH; CELL ISOLATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; HUMAN; HUMAN CELL; HYPOXIA; INTRACELLULAR SIGNALING; LYMPHOCYTE PROLIFERATION; MITOGENICITY; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STEADY STATE; T LYMPHOCYTE ACTIVATION;

CD4-POSITIVE T-LYMPHOCYTES; CELL HYPOXIA; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; HUMANS; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR;

EID: 84879477859     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242754     Document Type: Article

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