Why does the hemolytic activity of silica predict its pro-inflammatory activity?

Particle and Fibre Toxicology

Volumn 11, Issue 1, 2014, Pages

  Pavan, Cristina ^a   Rabolli, Virginie ^b   Tomatis, Maura ^a   Fubini, Bice ^a   Lison, Dominique ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Alveolar macrophages; Hemolysis; IL 1 ; Inflammasome; Lysosomal damage; Membrane interaction; Phagolysosome; Quartz; Red blood cells; Silica

Indexed keywords

APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN; CATHEPSIN B; CELL PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; SILICON DIOXIDE; UNCLASSIFIED DRUG; AIR POLLUTANT; APOPTOSIS REGULATORY PROTEIN; HEMOLYTIC AGENT; IL1B PROTEIN, MOUSE; PYCARD PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELL PHAGOCYTOSIS; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOKINE RELEASE; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMOLYSIS; HUMAN; HUMAN CELL; INFLAMMATION; LYSOSOME; MALE; MEMBRANE DAMAGE; MOUSE; MURINAE; NONHUMAN; NORMAL HUMAN; PERITONEUM MACROPHAGE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SURFACE PROPERTY; WESTERN BLOTTING; WILD TYPE; AIR POLLUTANT; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE ACTIVATION; METABOLISM; PARTICLE SIZE; SECRETION (PROCESS); TOXICITY;

MURINAE;

AIR POLLUTANTS; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CELL SURVIVAL; CELLS, CULTURED; HEMOLYTIC AGENTS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PARTICLE SIZE; PHYSICOCHEMICAL PHENOMENA; QUARTZ; SILICON DIOXIDE; SURFACE PROPERTIES;

EID: 84924274409     PISSN: 17438977     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/s12989-014-0076-y     Document Type: Article

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