In search of the chemical basis of the hemolytic potential of silicas

Chemical Research in Toxicology

Volumn 26, Issue 8, 2013, Pages 1188-1198

  Pavan, Cristina ^a   Tomatis, Maura ^a   Ghiazza, Mara ^a   Rabolli, Virginie ^b   Bolis, Vera ^a   Lison, Dominique ^b   Fubini, Bice ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM; EPITOPE; FREE RADICAL; PYROGEN; SILANOL; SILICON DIOXIDE; SILOXANE;

AQUEOUS SOLUTION; ARTICLE; CELL MEMBRANE; CHEMICAL COMPOSITION; CONTROLLED STUDY; CRYSTALLIZATION; ELECTRICITY; ERYTHROCYTE; FENTON REACTION; HEMOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROPHILICITY; HYDROPHOBICITY; NORMAL HUMAN; PARTICLE SIZE; PATHOGENICITY; PHYSICAL CHEMISTRY; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; ZETA POTENTIAL;

ALUMINUM; CRYSTALLIZATION; ERYTHROCYTES; FREE RADICALS; HEMOLYSIS; HOT TEMPERATURE; HUMANS; IONS; PARTICLE SIZE; SILICON DIOXIDE; SURFACE PROPERTIES;

EID: 84882668549     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx400105f     Document Type: Article

References (65)

1. International Agency for Research on Cancer (IARC) (1987) Silica and Some Silicates, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 42, IARC, Lyon, France.
2. International Agency for Research on Cancer (IARC) (1997) Silica, Some Silicates, Coal Dust and Para-Aramid Fibrils, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 68, IARC, Lyon, France.
3. International Agency for Research on Cancer (IARC) (2012) A Review of Human Carcinogens: Arsenic, Metals, Fibres, and Dusts, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 100C, IARC, Lyon, France.
4. Donaldson, K. and Borm, P. J. (1998) The quartz hazard: a variable entity Ann. Occup. Hyg. 42, 287-294
5. Donaldson, K. and Seaton, A. (2012) A short history of the toxicology of inhaled particles Part. Fibre Toxicol. 9, 13
6. Fubini, B. (1998) Surface chemistry and quartz hazard Ann. Occup. Hyg. 42, 521-530
7. Napierska, D., Thomassen, L. C., Lison, D., Martens, J. A., and Hoet, P. H. (2010) The nanosilica hazard: another variable entity Part. Fibre Toxicol. 7, 39
8. Rimola, A., Costa, D., Sodupe, M., Lambert, J. F., and Ugliengo, P. (2013) Silica surface features and their role in the adsorption of biomolecules: computational modeling and experiments Chem. Rev. 113, 4216-4313
9. Harley, J. D. and Margolis, J. (1961) Haemolytic activity of colloidal silica Nature 189, 1010-1011
10. Nolan, R. P., Langer, A. M., Harrington, J. S., Oster, G., and Selikoff, I. J. (1981) Quartz hemolysis as related to its surface functionalities Environ. Res. 26, 503-520
11. Zhao, Y., Sun, X., Zhang, G., Trewyn, B. G., Slowing, I. I., and Lin, V. S. (2011) Interaction of mesoporous silica nanoparticles with human red blood cell membranes: size and surface effects ACS Nano 5, 1366-1375
12. Warheit, D. B., Webb, T. R., Colvin, V. L., Reed, K. L., and Sayes, C. R. (2007) Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: Toxicity is not dependent upon particle size but on surface characteristics Toxicol. Sci. 95, 270-280
13. Clouter, A., Brown, D., Hohr, D., Borm, P., and Donaldson, K. (2001) Inflammatory effects of respirable quartz collected in workplaces versus standard DQ12 quartz: Particle surface correlates Toxicol. Sci. 63, 90-98
14. Hemenway, D. R., Absher, M. P., Fubini, B., and Bolis, V. (1993) What is the relationship between hemolytic potential and fibrogenicity of mineral dusts? Arch. Environ. Health 48, 343-347
15. Lu, S., Duffin, R., Poland, C., Daly, P., Murphy, F., Drost, E., MacNee, W., Stone, V., and Donaldson, K. (2009) Efficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammation Environ. Health Perspect. 117, 241-247
16. Duffin, R., Gilmour, P. S., Schins, R. P. F., Clouter, A., Guy, K., Brown, D. M., MacNee, W., Borm, P. J., Donaldson, K., and Stone, V. (2001) Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression, and nuclear factor-kappa B activation Toxicol. Appl. Pharmacol. 176, 10-17
17. Razzaboni, B. L. and Bolsaitis, P. (1990) Evidence of an oxidative mechanism for the hemolytic activity of silica particles Environ. Health Perspect. 87, 337-341
18. Zhang, H., Dunphy, D. R., Jiang, X., Meng, H., Sun, B., Tarn, D., Xue, M., Wang, X., Lin, S., Ji, Z., Li, R., Garcia, F. L., Yang, J., Kirk, M. L., Xia, T., Zink, J. I., Nel, A., and Brinker, C. J. (2012) Processing pathway dependence of amorphous silica nanoparticle toxicity: colloidal vs pyrolytic J. Am. Chem. Soc. 134, 15790-15804
19. Dalal, N. S., Shi, X. L., and Vallyathan, V. (1990) Role of free radicals in the mechanisms of hemolysis and lipid peroxidation by silica: comparative ESR and cytotoxicity studies J. Toxicol. Environ. Health 29, 307-316
20. Vallyathan, V. (1994) Generation of oxygen radicals by minerals and its correlation to cytotoxicity Environ. Health Perspect. 102 (Suppl. 10) 111-115
21. Hemenway, D., Absher, A., Fubini, B., Trombley, L., Vacek, P. M., Volante, M., and Cavenago, A. (1994) Surface functionalities are related to biological response and transport of crystalline silica Ann. Occup. Hyg. 38 (Suppl. 1) 447-454
22. Fubini, B., Zanetti, G., Altilia, S., Tiozzo, R., Lison, D., and Saffiotti, U. (1999) Relationship between surface properties and cellular responses to crystalline silica: studies with heat-treated cristobalite Chem. Res. Toxicol. 12, 737-745
23. Fubini, B., Bolis, V., Cavenago, A., and Volante, M. (1995) Physicochemical properties of crystalline silica dusts and their possible implication in various biological responses Scand. J. Work Environ. Health 21 (Suppl. 2) 9-14
24. Fubini, B. (1997) Surface reactivity in the pathogenic response to particulates Environ. Health Perspect. 105 (Suppl. 5) 1013-1020
25. Iler, R. K. (1979) The Surface Chemistry of Silica, in The Chemistry of Silica: Solubility, Polymerization, Colloid and Surface Properties, and Biochemistry, pp 622-729, Wiley, New York.
26. Pandurangi, R. S., Seehra, M. S., Razzaboni, B. L., and Bolsaitis, P. (1990) Surface and bulk infrared modes of crystalline and amorphous silica particles: a study of the relation of surface structure to cytotoxicity of respirable silica Environ. Health Perspect. 86, 327-336
27. Fuji, M., Machida, K., Takei, T., Watanabe, T., and Chikazawa, M. (1998) Effect of surface geometric structure on the adhesion force between silica particles J. Phys. Chem. B 102, 8782-8787
28. Murashov, V., Harper, M., and Demchuk, E. (2006) Impact of silanol surface density on the toxicity of silica aerosols measured by erythrocyte haemolysis J. Occup. Environ. Hyg. 3, 718-723
29. Singh, S. V., Viswanathan, P. N., and Rahman, Q. (1983) Interaction between erythrocyte plasma membrane and silicate dusts Environ. Health Perspect. 51, 55-60
30. Hadnagy, W., Marsetz, B., and Idel, H. (2003) Hemolytic activity of crystalline silica-Separated erythrocytes versus whole blood Int. J. Hyg. Environ. Health 206, 103-107
31. Shi, J., Hedberg, Y., Lundin, M., Odnevall, W., I, Karlsson, H. L., and Moller, L. (2012) Hemolytic properties of synthetic nano-and porous silica particles: the effect of surface properties and the protection by the plasma corona Acta Biomater. 8, 3478-3490
32. Depasse, J. (1978) Interaction between silica and hydrophobic cations Br. J. Ind. Med. 35, 32-34
33. Rabolli, V., Thomassen, L. C., Princen, C., Napierska, D., Gonzalez, L., Kirsch-Volders, M., Hoet, P. H., Huaux, F., Kirschhock, C. E., Martens, J. A., and Lison, D. (2010) Influence of size, surface area and microporosity on the in vitro cytotoxic activity of amorphous silica nanoparticles in different cell types Nanotoxicology 4, 307-318
34. Depasse, J. (1978) Influence of the sialic acid content of membranes on their sensitivity to silica and aluminate-modified silica Environ. Res. 16, 88-91
35. Gun'ko, V. M., Galagan, N. P., Grytsenko, I. V., Zarko, V. I., Oranska, O. I., Osaulenko, V. L., Bogatyrev, V. M., and Turov, V. V. (2007) Interaction of unmodified and partially silylated nanosilica with red blood cells Cent. Eur. J. Chem. 5, 951-969
36. Nolan, R. P., Langer, A. M., and Fourcy, A. (1985) Particle Size and Chemically-Induced Variability in the Membranolytic Activity of Quartz: Preliminary Observation, in In Vitro Effects of Mineral Dusts (Beck, E. G. and Bignon, J., Ed.) pp 39-50, Springer-Verlag, Berlin, Germany.
37. Daniel, L. N., Mao, Y., Wang, T. C., Markey, C. J., Markey, S. P., Shi, X., and Saffiotti, U. (1995) DNA strand breakage, thymine glycol production, and hydroxyl radical generation induced by different samples of crystalline silica in vitro Environ. Res. 71, 60-73
38. Slowing, I. I., Wu, C. W., Vivero-Escoto, J. L., and Lin, V. S. Y. (2009) Mesoporous silica nanoparticles for reducing hemolytic activity towards mammalian Red Blood Cells Small 5, 57-62
39. Lin, Y. S. and Haynes, C. L. (2010) Impacts of mesoporous silica nanoparticle size, pore ordering, and pore integrity on hemolytic activity J. Am. Chem. Soc. 132, 4834-4842
40. Yu, T., Malugin, A., and Ghandehari, H. (2011) Impact of silica nanoparticle design on cellular toxicity and hemolytic activity ACS Nano 5, 5717-5728
41. Wiessner, J. H., Mandel, N. S., Sohnle, P. G., and Mandel, G. S. (1989) Effect of particle size on quartz-induced hemolysis and on lung inflammation and fibrosis Exp. Lung Res. 15, 801-812
42. Razzaboni, B. L., Bolsaitis, P., Wallace, W. E., and Keane, M. J. (1990) Effect of Thermal Treatment on the Surface Characteristics and Hemolytic Activity of Respirable Size Silica Particles, in Proceedings of the VIIth International Pneumoconiosis Conference (Baker, E. L., Ed.) pp 215-230, U.S. Department of Health and Human Services, Pittsburgh, PA.
43. Thomassen, L. C., Rabolli, V., Masschaele, K., Alberto, G., Tomatis, M., Ghiazza, M., Turci, F., Breynaert, E., Martra, G., Kirschhock, C. E., Martens, J. A., Lison, D., and Fubini, B. (2011) Model system to study the influence of aggregation on the hemolytic potential of silica nanoparticles Chem. Res. Toxicol. 24, 1869-1875
44. Bolis, V., Fubini, B., Marchese, L., Martra, G., and Costa, D. (1991) Hydrophilic and hydrophobic sites on dehydrated crystalline and amorphous J. Chem. Soc., Faraday Trans. 87, 497-505
45. Fenoglio, I., Martra, G., Prandi, L., Tomatis, M., and Fubini, B. (2001) The role of mechanochemistry in the pulmonary toxicity caused by particulate minerals J. Mater. Synth. Process. 8, 145-154
46. Fubini, B. (1988) Adsorption calorimetry in surface chemistry Thermochim. Acta 135, 19-29
47. Bolis, V., Busco, C., and Ugliengo, P. (2006) Thermodynamic study of water adsorption in high-silica zeolites J. Phys. Chem. B 110, 14849-14859
48. Ghiazza, M., Tomatis, M., Doublier, S., Grendene, F., Gazzano, E., Ghigo, D., and Fubini, B. (2013) Carbon in intimate contact with quartz reduces the biological activity of crystalline silica dusts Chem. Res. Toxicol. 26, 46-54
49. Ghiazza, M., Scherbart, A. M., Fenoglio, I., Grendene, F., Turci, F., Martra, G., Albrecht, C., Schins, R. P., and Fubini, B. (2011) Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages Chem. Res. Toxicol. 24, 99-110
50. Ghiazza, M., Polimeni, M., Fenoglio, I., Gazzano, E., Ghigo, D., and Fubini, B. (2010) Does vitreous silica contradict the toxicity of the crystalline silica paradigm? Chem. Res. Toxicol. 23, 620-629
51. Gazzano, E., Ghiazza, M., Polimeni, M., Bolis, V., Fenoglio, I., Attanasio, A., Mazzucco, G., Fubini, B., and Ghigo, D. (2012) Physicochemical determinants in the cellular responses to nanostructured amorphous silicas Toxicol. Sci. 128, 158-170
52. Morrow, B. A. and Gay, I. D. (2000) Infrared and NMR characterization of the silica surface Surf. Sci. Ser. 9-34
53. Denny, J. J., Robson, W. D., and Irwin, D. A. (1937) The prevention of silicosis by metallic aluminium: first paper Can. Med. Assoc. J. 37, 1-8
54. Le Bouffant, L., Daniel, H., and Martin, J. C. (1977) The therapeutic action of aluminium compounds on the development of experimental lesions produced by pure quartz or mixed dust Inhaled Part. 4, 389-400
55. Begin, R., Masse, S., Rola-Pleszczynski, M., Martel, M., Desmarais, Y., Geoffroy, M., LeBouffant, L., Daniel, H., and Martin, J. (1986) Aluminum lactate treatment alters the lung biological activity of quartz Exp. Lung Res. 10, 385-399
56. Begin, R., Masse, S., Sebastien, P., Martel, M., Bosse, J., Dubois, F., Geoffroy, M., and Labbe, J. (1987) Sustained efficacy of aluminum to reduce quartz toxicity in the lung Exp. Lung Res. 13, 205-222
57. Knaapen, A. M., Albrecht, C., Becker, A., Hohr, D., Winzer, A., Haenen, G. R., Borm, P. J. A., and Schins, R. P. F. (2002) DNA damage in lung epithelial cells isolated from rats exposed to quartz: role of surface reactivity and neutrophilic inflammation Carcinogenesis 23, 1111-1120
58. Schins, R. P. F., Duffin, R., Hohr, D., Knaapen, A. M., Shi, T. M., Weishaupt, C., Stone, V., Donaldson, K., and Borm, P. J. A. (2002) Surface modification of quartz inhibits toxicity, particle uptake, and oxidative DNA damage in human lung epithelial cells Chem. Res. Toxicol. 15, 1166-1173
59. Rabolli, V., Thomassen, L. C., Uwambayinema, F., Martens, J. A., and Lison, D. (2011) The cytotoxic activity of amorphous silica nanoparticles is mainly influenced by surface area and not by aggregation Toxicol. Lett. 206, 197-203
60. Nash, T., Allison, A. C., and Harington, J. S. (1966) Physico-chemical properties of silica in relation to its toxicity Nature 210, 259-261
61. Summerton, J. and Hoenig, S. (1977) The mechanism of hemolysis by silica and its bearing on silicosis Exp. Mol. Pathol. 26, 113-128
62. Iler, R. (1981) The Surface Chemistry of Amorphous Synthetic Silica: Interaction with Organic Molecules in an Aqueous Medium, in Health Effects of Synthetic Silica Particulates (Dunnom, D., Ed.) pp 3-21, American Society for Testing and Materials, Philadelphia, PA.
63. Begin, R., Masse, S., Sebastien, P., Martel, M., Geoffroy, M., and Labbe, J. (1987) Late aluminum therapy reduces the cellular activities of simple silicosis in the sheep model J. Leukocyte Biol. 41, 400-406
64. Prugger, F., Mallner, B., and Schlipköter, H. W. (1984) Polyvinylpyridine N-oxide (Bay 3504, P-204, PVNO) in the treatment of human silicosis Wien. Klin. Wochenschr. 96, 848-853
65. Stalder, K. and Stöber, W. (1965) Haemolytic activity of suspensions of different silica modifications and inert dusts Nature 207, 874-875