Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

Particle and Fibre Toxicology

Volumn 11, Issue 1, 2014, Pages

  Peeters, Paul M ^a,b   Eurlings, Irene M J ^a   Perkins, Timothy N ^a   Wouters, Emiel F ^a   Schins, Roel P F ^b   Borm, Paul J A ^c   Drommer, Wolfgang ^d   Reynaert, Niki L ^a   Albrecht, Catrin ^b  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b IUF LEIBNIZ RESEARCH INSTITUTE FOR ENVIRONMENTAL MEDICINE   (Germany)

^c ZUYD UNIVERSITY OF APPLIED SCIENCES   (Netherlands)

^d Histo Path GmbH   (Germany)

Author keywords

BFGF; Caspase 1; Crystalline silica; HMGB1; IL 1 ; NLRP3 inflammasome; PVNO; TRX

Indexed keywords

CRYOPYRIN; FIBROBLAST GROWTH FACTOR 2; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; SILICON DIOXIDE; THIOREDOXIN; AIR POLLUTANT; BIOLOGICAL MARKER; CARRIER PROTEIN; INFLAMMASOME; NLRP3 PROTEIN, HUMAN; NOD-LIKE RECEPTOR 3, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; FEMALE; GENE ACTIVATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; LUNG LAVAGE; LYMPHOCYTE; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; SILICOSIS; STAINING; WESTERN BLOTTING; ADVERSE EFFECTS; AGONISTS; AIR POLLUTANT; ANIMAL; BRONCHUS; CELL LINE; CELL SURVIVAL; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; EXPOSURE; IMMUNOLOGY; LUNG; METABOLISM; PARTICLE SIZE; PATHOLOGY; RESPIRATORY TRACT MUCOSA; SURFACE PROPERTY; TOXICITY; TOXICITY TESTING; WISTAR RAT;

AIR POLLUTANTS; ANIMALS; BIOMARKERS; BRONCHI; CARRIER PROTEINS; CELL LINE; CELL SURVIVAL; FEMALE; HUMANS; INFLAMMASOMES; INHALATION EXPOSURE; LUNG; MACROPHAGES; PARTICLE SIZE; RATS; RATS, WISTAR; RESPIRATORY MUCOSA; SILICON DIOXIDE; SILICOSIS; SURFACE PROPERTIES; TOXICITY TESTS, ACUTE; TOXICITY TESTS, CHRONIC;

EID: 84964696384     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/s12989-014-0058-0     Document Type: Article

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