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Volumn 9, Issue 6, 2014, Pages 585-590

Adjunctive and long-acting nanoformulated antiretroviral therapies for HIV-associated neurocognitive disorders

Author keywords

HIV associated neurocognitive disorders; Mixed lineage kinase; Nanoformulated antiretroviral therapy; Neuroinflammation

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CEP 1347; LONG ACTING DRUG; MIXED LINEAGE KINASE; ANTIRETROVIRUS AGENT;

EID: 84924257481     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0000000000000111     Document Type: Review
Times cited : (14)

References (59)
  • 1
    • 77957076581 scopus 로고    scopus 로고
    • Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: A therapeutic strategy based on modulation of mixed lineage kinase
    • Gelbard HA, Dewhurst S, Maggirwar SB, et al. Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase. Neurotherapeutics 2010; 7:392-398.
    • (2010) Neurotherapeutics , vol.7 , pp. 392-398
    • Gelbard, H.A.1    Dewhurst, S.2    Maggirwar, S.B.3
  • 2
    • 84855170693 scopus 로고    scopus 로고
    • Diagnosing symptomatic HIVassociated neurocognitive disorders: Self-report versus performance-based assessment of everyday functioning
    • CNS HIV Antiretroviral Therapy Effects Research (CHARTER) Group
    • Blackstone K, Moore DJ, Heaton RK, et al. CNS HIV Antiretroviral Therapy Effects Research (CHARTER) Group. Diagnosing symptomatic HIVassociated neurocognitive disorders: self-report versus performance-based assessment of everyday functioning. J Int Neuropsychol Soc 2012; 18:79-88.
    • (2012) J Int Neuropsychol Soc , vol.18 , pp. 79-88
    • Blackstone, K.1    Moore, D.J.2    Heaton, R.K.3
  • 3
    • 84881313545 scopus 로고    scopus 로고
    • Limitations to the identification of HIV-associated neurocognitive disorders in clinical practice
    • Morley D, McNamara P, Kennelly S, et al. Limitations to the identification of HIV-associated neurocognitive disorders in clinical practice. HIV Med 2013; 14:497-502.
    • (2013) HIV Med , vol.14 , pp. 497-502
    • Morley, D.1    McNamara, P.2    Kennelly, S.3
  • 4
    • 78650834306 scopus 로고    scopus 로고
    • HIVassociated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
    • CHARTER Group
    • Heaton RK, Clifford DB, Franklin DR Jr, et al. CHARTER Group. HIVassociated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology 2010; 75:2087-2096.
    • (2010) Neurology , vol.75 , pp. 2087-2096
    • Heaton, R.K.1    Clifford, D.B.2    Franklin, D.R.3
  • 5
    • 84985909417 scopus 로고    scopus 로고
    • Randomized trial of central nervous systemtargeted antiretrovirals for HIV-associated neurocognitive disorder
    • Ellis RJ, Letendre S, Vaida F, et al. Randomized trial of central nervous systemtargeted antiretrovirals for HIV-associated neurocognitive disorder. Clinical Infect Dis 2014; 58:1015-1022.
    • (2014) Clinical Infect Dis , vol.58 , pp. 1015-1022
    • Ellis, R.J.1    Letendre, S.2    Vaida, F.3
  • 6
    • 84904022110 scopus 로고    scopus 로고
    • Antiretroviral penetration into the CNS and incidence of AIDS-defining neurologic conditions
    • Caniglia EC, Cain LE, Justice A, et al. Antiretroviral penetration into the CNS and incidence of AIDS-defining neurologic conditions. Neurology 2014; 83:134-141.
    • (2014) Neurology , vol.83 , pp. 134-141
    • Caniglia, E.C.1    Cain, L.E.2    Justice, A.3
  • 7
    • 84927667639 scopus 로고    scopus 로고
    • NanoART facilitated HIV-1 clearance by a mixed-lineage kinase 3 inhibitor
    • 3-6 March, 2013; Boston, Massachusetts, USA
    • Zhang G, Dash PK, Guo D et al. NanoART facilitated HIV-1 clearance by a mixed-lineage kinase 3 inhibitor. Conference on retroviruses and opportunistic infections; 3-6 March 2013; Boston, Massachusetts, USA; 2014.
    • (2014) Conference on Retroviruses and Opportunistic Infections
    • Zhang, G.1    Dash, P.K.2    Guo, D.3
  • 8
    • 84856452536 scopus 로고    scopus 로고
    • HIV-associated neurological disorders: A guide to pharmacotherapy
    • Tan IL, McArthur JC. HIV-associated neurological disorders: a guide to pharmacotherapy. CNS Drugs 2012; 26:123-134.
    • (2012) CNS Drugs , vol.26 , pp. 123-134
    • Tan, I.L.1    McArthur, J.C.2
  • 9
    • 0036731701 scopus 로고    scopus 로고
    • Mixed-lineage kinase control of JNK and p38 MAPK pathways
    • Gallo KA, Johnson GL. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol 2002; 3:663-672.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 663-672
    • Gallo, K.A.1    Johnson, G.L.2
  • 10
    • 22844445441 scopus 로고    scopus 로고
    • Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: A new therapeutic target in Parkinson's disease
    • Silva RM, Kuan CY, Rakic P, Burke RE. Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease. Mov Disord 2005; 20:653-664.
    • (2005) Mov Disord , vol.20 , pp. 653-664
    • Silva, R.M.1    Kuan, C.Y.2    Rakic, P.3    Burke, R.E.4
  • 11
    • 1342344813 scopus 로고    scopus 로고
    • Mixed-lineage kinases: A target for the prevention of neurodegeneration
    • Wang LH, Besirli CG, Johnson EM Jr. Mixed-lineage kinases: a target for the prevention of neurodegeneration. Annu Rev Pharmacol Toxicol 2004; 44:451-474.
    • (2004) Annu Rev Pharmacol Toxicol , vol.44 , pp. 451-474
    • Wang, L.H.1    Besirli, C.G.2    Johnson, E.M.3
  • 12
    • 0035816685 scopus 로고    scopus 로고
    • Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family
    • Maroney AC, Finn JP, Connors TJ, et al. Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem 2001; 276:25302-25308.
    • (2001) J Biol Chem , vol.276 , pp. 25302-25308
    • Maroney, A.C.1    Finn, J.P.2    Connors, T.J.3
  • 13
    • 34548598359 scopus 로고    scopus 로고
    • Expression and function of mixed lineage kinases in dendritic cells
    • Handley ME, Rasaiyaah J, Barnett J, et al. Expression and function of mixed lineage kinases in dendritic cells. Int Immunol 2007; 19:923-933.
    • (2007) Int Immunol , vol.19 , pp. 923-933
    • Handley, M.E.1    Rasaiyaah, J.2    Barnett, J.3
  • 14
    • 34147162898 scopus 로고    scopus 로고
    • Mixed lineage kinases (MLKs): A role in dendritic cells, inflammation and immunity?
    • Handley ME, Rasaiyaah J, Chain BM, Katz DR. Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity? Int J Exp Pathol 2007; 88:111-126.
    • (2007) Int J Exp Pathol , vol.88 , pp. 111-126
    • Handley, M.E.1    Rasaiyaah, J.2    Chain, B.M.3    Katz, D.R.4
  • 15
    • 34547219895 scopus 로고    scopus 로고
    • Metabolic stress signaling mediated by mixed-lineage kinases
    • Jaeschke A, Davis RJ. Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell 2007; 27:498-508.
    • (2007) Mol Cell , vol.27 , pp. 498-508
    • Jaeschke, A.1    Davis, R.J.2
  • 16
    • 0036924048 scopus 로고    scopus 로고
    • Activation of the drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3
    • Sathyanarayana P, Barthwal MK, Kundu CN, et al. Activation of the drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3. Mol Cell 2002; 10:1527-1533.
    • (2002) Mol Cell , vol.10 , pp. 1527-1533
    • Sathyanarayana, P.1    Barthwal, M.K.2    Kundu, C.N.3
  • 17
    • 0032484215 scopus 로고    scopus 로고
    • Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3
    • Leung IW, Lassam N. Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3. J Biol Chem 1998; 273:32408-32415.
    • (1998) J Biol Chem , vol.273 , pp. 32408-32415
    • Leung, I.W.1    Lassam, N.2
  • 18
    • 0035910529 scopus 로고    scopus 로고
    • The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation
    • Leung IW, Lassam N. The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation. J Biol Chem 2001; 276:1961-1967.
    • (2001) J Biol Chem , vol.276 , pp. 1961-1967
    • Leung, I.W.1    Lassam, N.2
  • 19
    • 33745317973 scopus 로고    scopus 로고
    • Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation
    • Sui Z, Fan S, Sniderhan L, et al. Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation. J Immunol 2006; 177:702-711.
    • (2006) J Immunol , vol.177 , pp. 702-711
    • Sui, Z.1    Fan, S.2    Sniderhan, L.3
  • 20
    • 0032504151 scopus 로고    scopus 로고
    • HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism
    • New DR, Maggirwar SB, Epstein LG, et al. HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism. J Biol Chem 1998; 273:17852-17858.
    • (1998) J Biol Chem , vol.273 , pp. 17852-17858
    • New, D.R.1    Maggirwar, S.B.2    Epstein, L.G.3
  • 21
    • 33846822053 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS
    • Dewhurst S, Maggirwar SB, Schifitto G, et al. Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS. J Neuroimmune Pharmacol 2007; 2:93-96.
    • (2007) J Neuroimmune Pharmacol , vol.2 , pp. 93-96
    • Dewhurst, S.1    Maggirwar, S.B.2    Schifitto, G.3
  • 22
    • 35648972690 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3
    • Mishra R, Barthwal MK, Sondarva G, et al. Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3. J Biol Chem 2007; 282:30393-30405.
    • (2007) J Biol Chem , vol.282 , pp. 30393-30405
    • Mishra, R.1    Barthwal, M.K.2    Sondarva, G.3
  • 23
    • 18844452864 scopus 로고    scopus 로고
    • Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation
    • Yin XH, Zhang QG, Miao B, Zhang GY. Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation. J Neurochem 2005; 93:1021-1029.
    • (2005) J Neurochem , vol.93 , pp. 1021-1029
    • Yin, X.H.1    Zhang, Q.G.2    Miao, B.3    Zhang, G.Y.4
  • 24
    • 0037423289 scopus 로고    scopus 로고
    • Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival
    • Barthwal MK, Sathyanarayana P, Kundu CN, et al. Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J Biol Chem 2003; 278:3897-3902.
    • (2003) J Biol Chem , vol.278 , pp. 3897-3902
    • Barthwal, M.K.1    Sathyanarayana, P.2    Kundu, C.N.3
  • 25
    • 33645229806 scopus 로고    scopus 로고
    • Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein
    • Chadee DN, Xu D, Hung G, et al. Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Proc Natl Acad Sci U S A 2006; 103:4463-4468.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 4463-4468
    • Chadee, D.N.1    Xu, D.2    Hung, G.3
  • 26
    • 0035879151 scopus 로고    scopus 로고
    • Evidence for a role of mixed lineage kinases in neuronal apoptosis
    • Mota M, Reeder M, Chernoff J, Bazenet CE. Evidence for a role of mixed lineage kinases in neuronal apoptosis. J Neurosci 2001; 21:4949-4957.
    • (2001) J Neurosci , vol.21 , pp. 4949-4957
    • Mota, M.1    Reeder, M.2    Chernoff, J.3    Bazenet, C.E.4
  • 27
    • 0035815679 scopus 로고    scopus 로고
    • Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via postsynaptic density protein
    • Savinainen A, Garcia EP, Dorow D, et al. Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via postsynaptic density protein. J Biol Chem 2001; 276:11382-11386.
    • (2001) J Biol Chem , vol.276 , pp. 11382-11386
    • Savinainen, A.1    Garcia, E.P.2    Dorow, D.3
  • 28
    • 0033029823 scopus 로고    scopus 로고
    • CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo
    • Saporito MS, Brown EM, Miller MS, Carswell S. CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo. J Pharmacol Exp Ther 1999; 288:421-427.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 421-427
    • Saporito, M.S.1    Brown, E.M.2    Miller, M.S.3    Carswell, S.4
  • 29
    • 0036988312 scopus 로고    scopus 로고
    • Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases
    • Saporito MS, Hudkins RL, Maroney AC. Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases. Prog Med Chem 2002; 40:23-62.
    • (2002) Prog Med Chem , vol.40 , pp. 23-62
    • Saporito, M.S.1    Hudkins, R.L.2    Maroney, A.C.3
  • 30
    • 12144290127 scopus 로고    scopus 로고
    • Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells
    • Mathiasen JR, McKenna BA, Saporito MS, et al. Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells. Brain Res 2004; 1003:86-97.
    • (2004) Brain Res , vol.1003 , pp. 86-97
    • Mathiasen, J.R.1    McKenna, B.A.2    Saporito, M.S.3
  • 31
    • 21844442345 scopus 로고    scopus 로고
    • Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway
    • Lotharius J, Falsig J, van Beek J, et al. Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. J Neurosci 2005; 25:6329-6342.
    • (2005) J Neurosci , vol.25 , pp. 6329-6342
    • Lotharius, J.1    Falsig, J.2    Van Beek, J.3
  • 32
    • 1542319928 scopus 로고    scopus 로고
    • Dysregulation of mitogen-activated protein kinase signaling pathways in simian immunodeficiency virus encephalitis
    • Barber SA, Uhrlaub JL, DeWitt JB, et al. Dysregulation of mitogen-activated protein kinase signaling pathways in simian immunodeficiency virus encephalitis. Am J Pathol 2004; 164:355-362.
    • (2004) Am J Pathol , vol.164 , pp. 355-362
    • Barber, S.A.1    Uhrlaub, J.L.2    Dewitt, J.B.3
  • 33
    • 0141449089 scopus 로고    scopus 로고
    • The p38 MAP kinase signaling pathway in Alzheimer's disease
    • Johnson GV, Bailey CD. The p38 MAP kinase signaling pathway in Alzheimer's disease. Exp Neurol 2003; 183:263-268.
    • (2003) Exp Neurol , vol.183 , pp. 263-268
    • Johnson, G.V.1    Bailey, C.D.2
  • 34
    • 0035076483 scopus 로고    scopus 로고
    • Beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation
    • Troy CM, Rabacchi SA, Xu Z, et al. beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. J Neurochem 2001; 77:157-164.
    • (2001) J Neurochem , vol.77 , pp. 157-164
    • Troy, C.M.1    Rabacchi, S.A.2    Xu, Z.3
  • 35
    • 0033810404 scopus 로고    scopus 로고
    • Therapeutic potential of anti-inflammatory drugs in focal stroke
    • Barone FC, Parsons AA. Therapeutic potential of anti-inflammatory drugs in focal stroke. Expert Opin Investig Drugs 2000; 9:2281-2306.
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 2281-2306
    • Barone, F.C.1    Parsons, A.A.2
  • 36
    • 42149166874 scopus 로고    scopus 로고
    • Neuroprotection of hypothermia against neuronal death in rat hippocampus through inhibiting the increased assembly of GluR6-PSD95-MLK3 signaling module induced by cerebral ischemia/reperfusion
    • Hu WW, Du Y, Li C, et al. Neuroprotection of hypothermia against neuronal death in rat hippocampus through inhibiting the increased assembly of GluR6-PSD95-MLK3 signaling module induced by cerebral ischemia/reperfusion. Hippocampus 2008; 18:386-397.
    • (2008) Hippocampus , vol.18 , pp. 386-397
    • Hu, W.W.1    Du, Y.2    Li, C.3
  • 37
    • 27444434211 scopus 로고    scopus 로고
    • Activation of c-Jun NH2-terminal kinase 3 is mediated by the GluR6.PSD-95.MLK3 signaling module following cerebral ischemia in rat hippocampus
    • Tian H, Zhang QG, Zhu GX, et al. Activation of c-Jun NH2-terminal kinase 3 is mediated by the GluR6.PSD-95.MLK3 signaling module following cerebral ischemia in rat hippocampus. Brain Res 2005; 1061:57-66.
    • (2005) Brain Res , vol.1061 , pp. 57-66
    • Tian, H.1    Zhang, Q.G.2    Zhu, G.X.3
  • 38
    • 27644433927 scopus 로고    scopus 로고
    • Knock-down of POSH expression is neuroprotective through down-regulating activation of the MLK3-MKK4-JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield
    • Zhang QG, Wang RM, Yin XH, et al. Knock-down of POSH expression is neuroprotective through down-regulating activation of the MLK3-MKK4-JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield. J Neurochem 2005; 95:784-795.
    • (2005) J Neurochem , vol.95 , pp. 784-795
    • Zhang, Q.G.1    Wang, R.M.2    Yin, X.H.3
  • 39
    • 33748030120 scopus 로고    scopus 로고
    • Akt inhibits MLK3/JNK3 signaling by inactivating Rac1: A protective mechanism against ischemic brain injury
    • Zhang QG, Wang XT, Han D, et al. Akt inhibits MLK3/JNK3 signaling by inactivating Rac1: a protective mechanism against ischemic brain injury. J Neurochem 2006; 98:1886-1898.
    • (2006) J Neurochem , vol.98 , pp. 1886-1898
    • Zhang, Q.G.1    Wang, X.T.2    Han, D.3
  • 40
    • 34047215495 scopus 로고    scopus 로고
    • Crosstalk between PSD-95 and JIP1-mediated signaling modules: The mechanism of MLK3 activation in cerebral ischemia
    • Zhang QX, Pei DS, Guan QH, et al. Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia. Biochemistry 2007; 46:4006-4016.
    • (2007) Biochemistry , vol.46 , pp. 4006-4016
    • Zhang, Q.X.1    Pei, D.S.2    Guan, Q.H.3
  • 41
    • 33845657462 scopus 로고    scopus 로고
    • The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: The role of JNK signaling
    • Liao S, Porter D, Scott A, et al. The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: the role of JNK signaling. J Mol Cell Cardiol 2007; 42:106-120.
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 106-120
    • Liao, S.1    Porter, D.2    Scott, A.3
  • 42
    • 0036733148 scopus 로고    scopus 로고
    • Mixed lineage kinase 3 mediates gp120IIIB-induced neurotoxicity
    • Bodner A, Maroney AC, Finn JP, et al. Mixed lineage kinase 3 mediates gp120IIIB-induced neurotoxicity. J Neurochem 2002; 82:1424-1434.
    • (2002) J Neurochem , vol.82 , pp. 1424-1434
    • Bodner, A.1    Maroney, A.C.2    Finn, J.P.3
  • 43
    • 3042840152 scopus 로고    scopus 로고
    • Activation of c-Jun N-terminal kinase mediates gp120IIIB-and nucleoside analogue-induced sensory neuron toxicity
    • Bodner A, Toth PT, Miller RJ. Activation of c-Jun N-terminal kinase mediates gp120IIIB-and nucleoside analogue-induced sensory neuron toxicity. Exp Neurol 2004; 188:246-253.
    • (2004) Exp Neurol , vol.188 , pp. 246-253
    • Bodner, A.1    Toth, P.T.2    Miller, R.J.3
  • 44
    • 0033994234 scopus 로고    scopus 로고
    • Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation
    • Pirvola U, Xing-Qun L, Virkkala J, et al. Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci 2000; 20:43-50.
    • (2000) J Neurosci , vol.20 , pp. 43-50
    • Pirvola, U.1    Xing-Qun, L.2    Virkkala, J.3
  • 45
    • 33749243905 scopus 로고    scopus 로고
    • JNK signaling in neomycin-induced vestibular hair cell death
    • Sugahara K, Rubel EW, Cunningham LL. JNK signaling in neomycin-induced vestibular hair cell death. Hear Res 2006; 221:128-135.
    • (2006) Hear Res , vol.221 , pp. 128-135
    • Sugahara, K.1    Rubel, E.W.2    Cunningham, L.L.3
  • 46
    • 0035985743 scopus 로고    scopus 로고
    • Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death
    • Ylikoski J, Xing-Qun L, Virkkala J, Pirvola U. Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death. Hear Res 2002; 166:33-43.
    • (2002) Hear Res , vol.166 , pp. 33-43
    • Ylikoski, J.1    Xing-Qun, L.2    Virkkala, J.3    Pirvola, U.4
  • 47
    • 4043136542 scopus 로고    scopus 로고
    • Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347
    • Falsig J, Porzgen P, Lotharius J, Leist M. Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347. J Immunol 2004; 173:2762-2770.
    • (2004) J Immunol , vol.173 , pp. 2762-2770
    • Falsig, J.1    Porzgen, P.2    Lotharius, J.3    Leist, M.4
  • 48
    • 20144367957 scopus 로고    scopus 로고
    • Inhibition of microglial inflammation by the MLK inhibitor CEP-1347
    • Lund S, Porzgen P, Mortensen AL, et al. Inhibition of microglial inflammation by the MLK inhibitor CEP-1347. J Neurochem 2005; 92:1439-1451.
    • (2005) J Neurochem , vol.92 , pp. 1439-1451
    • Lund, S.1    Porzgen, P.2    Mortensen, A.L.3
  • 49
    • 0034073381 scopus 로고    scopus 로고
    • Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex
    • Hehner SP, Hofmann TG, Ushmorov A, et al. Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex. Mol Cell Biol 2000; 20:2556-2568.
    • (2000) Mol Cell Biol , vol.20 , pp. 2556-2568
    • Hehner, S.P.1    Hofmann, T.G.2    Ushmorov, A.3
  • 50
    • 0842324952 scopus 로고    scopus 로고
    • The safety and tolerability of a mixed lineage kinase inhibitor (CEP-1347) in PD
    • Parkinson Study Group
    • Parkinson Study Group. The safety and tolerability of a mixed lineage kinase inhibitor (CEP-1347) in PD. Neurology 2004; 62:330-332.
    • (2004) Neurology , vol.62 , pp. 330-332
  • 51
    • 24944582908 scopus 로고    scopus 로고
    • Treatment of Parkinson's disease: What's on the horizon?
    • Wu SS, Frucht SJ. Treatment of Parkinson's disease: what's on the horizon? CNS Drugs 2005; 19:723-743.
    • (2005) CNS Drugs , vol.19 , pp. 723-743
    • Wu, S.S.1    Frucht, S.J.2
  • 52
    • 35148882113 scopus 로고    scopus 로고
    • Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease
    • Parkinson Study Group PRECEPT Investigators
    • Parkinson Study Group PRECEPT Investigators. Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease. Neurology 2007; 69:1480-1490.
    • (2007) Neurology , vol.69 , pp. 1480-1490
  • 53
    • 24944473825 scopus 로고    scopus 로고
    • Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis
    • Dou H, Ellison B, Bradley J, et al. Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. J Neurosci 2005; 25:8375-8385.
    • (2005) J Neurosci , vol.25 , pp. 8375-8385
    • Dou, H.1    Ellison, B.2    Bradley, J.3
  • 54
    • 76249099852 scopus 로고    scopus 로고
    • Neuroprotective activities of CEP-1347 in models of neuroAIDS
    • Eggert D, Dash PK, Gorantla S, et al. Neuroprotective activities of CEP-1347 in models of neuroAIDS. J Immunol 2010; 184:746-756.
    • (2010) J Immunol , vol.184 , pp. 746-756
    • Eggert, D.1    Dash, P.K.2    Gorantla, S.3
  • 55
    • 17644373073 scopus 로고    scopus 로고
    • Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades
    • Brancho D, Ventura JJ, Jaeschke A, et al. Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Mol Cell Biol 2005; 25:3670-3681.
    • (2005) Mol Cell Biol , vol.25 , pp. 3670-3681
    • Brancho, D.1    Ventura, J.J.2    Jaeschke, A.3
  • 56
    • 19744365702 scopus 로고    scopus 로고
    • A small molecule-kinase interaction map for clinical kinase inhibitors
    • Fabian MA, Biggs WH 3rd, Treiber DK, et al. A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol 2005; 23:329-336.
    • (2005) Nat Biotechnol , vol.23 , pp. 329-336
    • Fabian, M.A.1    Biggs, W.H.2    Treiber, D.K.3
  • 57
    • 0037147130 scopus 로고    scopus 로고
    • K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK
    • Roux PP, Dorval G, Boudreau M, et al. K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. J Biol Chem 2002; 277:49473-49480.
    • (2002) J Biol Chem , vol.277 , pp. 49473-49480
    • Roux, P.P.1    Dorval, G.2    Boudreau, M.3
  • 58
    • 84886452695 scopus 로고    scopus 로고
    • Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3
    • Goodfellow VS, Loweth CJ, Ravula SB, et al. Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem 2013; 56:8032-8048.
    • (2013) J Med Chem , vol.56 , pp. 8032-8048
    • Goodfellow, V.S.1    Loweth, C.J.2    Ravula, S.B.3
  • 59
    • 84878869102 scopus 로고    scopus 로고
    • The new small-molecule mixedlineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders
    • Marker DF, Tremblay ME, Puccini JM, et al. The new small-molecule mixedlineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders. J Neurosci 2013; 33:9998-10010.
    • (2013) J Neurosci , vol.33 , pp. 9998-10010
    • Marker, D.F.1    Tremblay, M.E.2    Puccini, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.