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Volumn 7, Issue 4, 2010, Pages 392-398

Rebuilding Synaptic Architecture in HIV-1 Associated Neurocognitive Disease: A Therapeutic Strategy Based on Modulation of Mixed Lineage Kinase

Author keywords

HIV 1; HIV 1 associated neurocognitive disease (HAND); Microglia; Mixed lineage kinase type 3; Neuroinflammation; Neurotrophins; Synapse; Tat

Indexed keywords

CEP 1347; MEMANTINE; MIXED LINEAGE KINASE 3;

EID: 77957076581     PISSN: 19337213     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nurt.2010.08.001     Document Type: Article
Times cited : (11)

References (86)
  • 1
    • 85205871254 scopus 로고    scopus 로고
    • HIV-associated neurocognitive impairment remains prevalent in the era of combination ART: The CHARTER Study. Paper presented at: 16th Conference on Retroviruses and Opportunistic Infections; February Montreal, CA.
    • Heaton R, Clifford D, Woods S, et al. HIV-associated neurocognitive impairment remains prevalent in the era of combination ART: The CHARTER Study. Paper presented at: 16th Conference on Retroviruses and Opportunistic Infections; February 2009; Montreal, CA.
    • (2009)
    • Heaton, R.1    Clifford, D.2    Woods, S.3
  • 2
    • 0036800561 scopus 로고    scopus 로고
    • HIV-related neuropathology, 1985 to 1999: rising prevalence of HIV encephalopathy in the era of highly active antiretroviral therapy
    • Neuenburg J.K., Brodt H.R., Herndier B.G., et al. HIV-related neuropathology, 1985 to 1999: rising prevalence of HIV encephalopathy in the era of highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2002, 31:171-177.
    • (2002) J Acquir Immune Defic Syndr , vol.31 , pp. 171-177
    • Neuenburg, J.K.1    Brodt, H.R.2    Herndier, B.G.3
  • 3
    • 68449083930 scopus 로고    scopus 로고
    • Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance
    • Marra C.M., Zhao Y., Clifford D.B., et al. Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance. Aids 2009, 23:1359-1366.
    • (2009) Aids , vol.23 , pp. 1359-1366
    • Marra, C.M.1    Zhao, Y.2    Clifford, D.B.3
  • 4
    • 69249214157 scopus 로고    scopus 로고
    • Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy
    • Brennan T.P., Woods J.O., Sedaghat A.R., Siliciano J.D., Siliciano R.F., Wilke C.O. Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy. J Virol 2009, 83:8470-8481.
    • (2009) J Virol , vol.83 , pp. 8470-8481
    • Brennan, T.P.1    Woods, J.O.2    Sedaghat, A.R.3    Siliciano, J.D.4    Siliciano, R.F.5    Wilke, C.O.6
  • 5
    • 69449083091 scopus 로고    scopus 로고
    • A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy
    • Dinoso J.B., Rabi S.A., Blankson J.N., et al. A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy. J Virol 2009, 83:9247-9257.
    • (2009) J Virol , vol.83 , pp. 9247-9257
    • Dinoso, J.B.1    Rabi, S.A.2    Blankson, J.N.3
  • 6
    • 70449377960 scopus 로고    scopus 로고
    • Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation
    • Yang H.C., Xing S., Shan L., et al. Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation. J Clin Invest 2009, 119:3473-3486.
    • (2009) J Clin Invest , vol.119 , pp. 3473-3486
    • Yang, H.C.1    Xing, S.2    Shan, L.3
  • 8
    • 12244255096 scopus 로고    scopus 로고
    • Persistent brain abnormalities in antiretroviral-naive HIV patients 3 months after HAART
    • Chang L., Ernst T., Witt M.D., et al. Persistent brain abnormalities in antiretroviral-naive HIV patients 3 months after HAART. Antivir Ther 2003, 8:17-26.
    • (2003) Antivir Ther , vol.8 , pp. 17-26
    • Chang, L.1    Ernst, T.2    Witt, M.D.3
  • 9
    • 0037069298 scopus 로고    scopus 로고
    • Abnormal brain activation on functional MRI in cognitively asymptomatic HIV patients
    • Ernst T., Chang L., Jovicich J., Ames N., Arnold S. Abnormal brain activation on functional MRI in cognitively asymptomatic HIV patients. Neurology 2002, 59:1343-1349.
    • (2002) Neurology , vol.59 , pp. 1343-1349
    • Ernst, T.1    Chang, L.2    Jovicich, J.3    Ames, N.4    Arnold, S.5
  • 10
    • 65249116373 scopus 로고    scopus 로고
    • Declined neural efficiency in cognitively stable human immunodeficiency virus patients
    • Ernst T., Yakupov R., Nakama H., et al. Declined neural efficiency in cognitively stable human immunodeficiency virus patients. Ann Neurol 2009, 65:316-325.
    • (2009) Ann Neurol , vol.65 , pp. 316-325
    • Ernst, T.1    Yakupov, R.2    Nakama, H.3
  • 11
    • 4143125610 scopus 로고    scopus 로고
    • Memantine protects hippocampal neuronal function in murine human immunodeficiency virus type 1 encephalitis
    • Anderson E.R., Gendelman H.E., Xiong H. Memantine protects hippocampal neuronal function in murine human immunodeficiency virus type 1 encephalitis. J Neurosci 2004, 24:7194-7198.
    • (2004) J Neurosci , vol.24 , pp. 7194-7198
    • Anderson, E.R.1    Gendelman, H.E.2    Xiong, H.3
  • 12
    • 34249786117 scopus 로고    scopus 로고
    • Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study
    • Schifitto G., Navia B.A., Yiannoutsos C.T., et al. Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study. Aids 2007, 21:1877-1886.
    • (2007) Aids , vol.21 , pp. 1877-1886
    • Schifitto, G.1    Navia, B.A.2    Yiannoutsos, C.T.3
  • 13
    • 33747476112 scopus 로고    scopus 로고
    • Protecting the synapse: evidence for a rational strategy to treat HIV-1 associated neurologic disease
    • Bellizzi M.J., Lu S.M., Gelbard H.A. Protecting the synapse: evidence for a rational strategy to treat HIV-1 associated neurologic disease. J Neuroimmune Pharmacol 2006, 1:20-31.
    • (2006) J Neuroimmune Pharmacol , vol.1 , pp. 20-31
    • Bellizzi, M.J.1    Lu, S.M.2    Gelbard, H.A.3
  • 14
    • 27644590902 scopus 로고    scopus 로고
    • Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor
    • Bellizzi M.J., Lu S.M., Masliah E., Gelbard H.A. Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor. J Clin Invest 2005, 115:3185-3192.
    • (2005) J Clin Invest , vol.115 , pp. 3185-3192
    • Bellizzi, M.J.1    Lu, S.M.2    Masliah, E.3    Gelbard, H.A.4
  • 15
    • 33845775666 scopus 로고    scopus 로고
    • HIV and antiretroviral therapy in the brain: neuronal injury and repair
    • Ellis R., Langford D., Masliah E. HIV and antiretroviral therapy in the brain: neuronal injury and repair. Nat Rev Neurosci 2007, 8:33-44.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 33-44
    • Ellis, R.1    Langford, D.2    Masliah, E.3
  • 16
    • 0036731701 scopus 로고    scopus 로고
    • Mixed-lineage kinase control of JNK and p38 MAPK pathways
    • Gallo K.A., Johnson G.L. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol 2002, 3:663-672.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 663-672
    • Gallo, K.A.1    Johnson, G.L.2
  • 17
    • 22844445441 scopus 로고    scopus 로고
    • Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease
    • Silva R.M., Kuan C.Y., Rakic P., Burke R.E. Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease. Mov Disord 2005, 20:653-664.
    • (2005) Mov Disord , vol.20 , pp. 653-664
    • Silva, R.M.1    Kuan, C.Y.2    Rakic, P.3    Burke, R.E.4
  • 18
    • 1342344813 scopus 로고    scopus 로고
    • Mixed-lineage kinases: a target for the prevention of neurodegeneration
    • Wang L.H., Besirli C.G., Johnson E.M. Mixed-lineage kinases: a target for the prevention of neurodegeneration. Annu Rev Pharmacol Toxicol 2004, 44:451-474.
    • (2004) Annu Rev Pharmacol Toxicol , vol.44 , pp. 451-474
    • Wang, L.H.1    Besirli, C.G.2    Johnson, E.M.3
  • 19
    • 0035816685 scopus 로고    scopus 로고
    • Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family
    • Maroney A.C., Finn J.P., Connors T.J., et al. Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem 2001, 276:25302-25308.
    • (2001) J Biol Chem , vol.276 , pp. 25302-25308
    • Maroney, A.C.1    Finn, J.P.2    Connors, T.J.3
  • 20
    • 34548598359 scopus 로고    scopus 로고
    • Expression and function of mixed lineage kinases in dendritic cells
    • Handley M.E., Rasaiyaah J., Barnett J., et al. Expression and function of mixed lineage kinases in dendritic cells. Int Immunol 2007, 19:923-933.
    • (2007) Int Immunol , vol.19 , pp. 923-933
    • Handley, M.E.1    Rasaiyaah, J.2    Barnett, J.3
  • 21
    • 34147162898 scopus 로고    scopus 로고
    • Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?
    • Handley M.E., Rasaiyaah J., Chain B.M., Katz D.R. Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?. Int J Exp Pathol 2007, 88:111-126.
    • (2007) Int J Exp Pathol , vol.88 , pp. 111-126
    • Handley, M.E.1    Rasaiyaah, J.2    Chain, B.M.3    Katz, D.R.4
  • 22
    • 34547219895 scopus 로고    scopus 로고
    • Metabolic stress signaling mediated by mixed-lineage kinases
    • Jaeschke A., Davis R.J. Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell 2007, 27:498-508.
    • (2007) Mol Cell , vol.27 , pp. 498-508
    • Jaeschke, A.1    Davis, R.J.2
  • 23
    • 0036924048 scopus 로고    scopus 로고
    • Activation of the drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3
    • Sathyanarayana P., Barthwal M.K., Kundu C.N., et al. Activation of the drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3. Mol Cell 2002, 10:1527-1533.
    • (2002) Mol Cell , vol.10 , pp. 1527-1533
    • Sathyanarayana, P.1    Barthwal, M.K.2    Kundu, C.N.3
  • 24
    • 0032484215 scopus 로고    scopus 로고
    • Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3
    • Leung I.W., Lassam N. Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3. J Biol Chem 1998, 273:32408-32415.
    • (1998) J Biol Chem , vol.273 , pp. 32408-32415
    • Leung, I.W.1    Lassam, N.2
  • 25
    • 0035910529 scopus 로고    scopus 로고
    • The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation
    • Leung I.W., Lassam N. The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation. J Biol Chem 2001, 276:1961-1967.
    • (2001) J Biol Chem , vol.276 , pp. 1961-1967
    • Leung, I.W.1    Lassam, N.2
  • 26
    • 33745317973 scopus 로고    scopus 로고
    • Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation
    • Sui Z., Fan S., Sniderhan L., et al. Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation. J Immunol 2006, 177:702-711.
    • (2006) J Immunol , vol.177 , pp. 702-711
    • Sui, Z.1    Fan, S.2    Sniderhan, L.3
  • 27
    • 35648972690 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3
    • Mishra R., Barthwal M.K., Sondarva G., et al. Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3. J Biol Chem 2007, 282:30393-30405.
    • (2007) J Biol Chem , vol.282 , pp. 30393-30405
    • Mishra, R.1    Barthwal, M.K.2    Sondarva, G.3
  • 28
    • 0035879151 scopus 로고    scopus 로고
    • Evidence for a role of mixed lineage kinases in neuronal apoptosis
    • Mota M., Reeder M., Chernoff J., Bazenet C.E. Evidence for a role of mixed lineage kinases in neuronal apoptosis. J Neurosci 2001, 21:4949-4957.
    • (2001) J Neurosci , vol.21 , pp. 4949-4957
    • Mota, M.1    Reeder, M.2    Chernoff, J.3    Bazenet, C.E.4
  • 29
    • 0035815679 scopus 로고    scopus 로고
    • Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95
    • Savinainen A., Garcia E.P., Dorow D., Marshall J., Liu Y.F. Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95. J Biol Chem 2001, 276:11382-11386.
    • (2001) J Biol Chem , vol.276 , pp. 11382-11386
    • Savinainen, A.1    Garcia, E.P.2    Dorow, D.3    Marshall, J.4    Liu, Y.F.5
  • 30
    • 21844442345 scopus 로고    scopus 로고
    • Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway
    • Lotharius J., Falsig J., van Beek J., et al. Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. J Neurosci 2005, 25:6329-6342.
    • (2005) J Neurosci , vol.25 , pp. 6329-6342
    • Lotharius, J.1    Falsig, J.2    van Beek, J.3
  • 31
    • 12144290127 scopus 로고    scopus 로고
    • Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells
    • Mathiasen J.R., McKenna B.A., Saporito M.S., et al. Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells. Brain Res 2004, 1003:86-97.
    • (2004) Brain Res , vol.1003 , pp. 86-97
    • Mathiasen, J.R.1    McKenna, B.A.2    Saporito, M.S.3
  • 32
    • 0033029823 scopus 로고    scopus 로고
    • CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo
    • Saporito M.S., Brown E.M., Miller M.S., Carswell S. CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo. J Pharmacol Exp Ther 1999, 288:421-427.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 421-427
    • Saporito, M.S.1    Brown, E.M.2    Miller, M.S.3    Carswell, S.4
  • 33
    • 0036988312 scopus 로고    scopus 로고
    • Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases
    • Saporito M.S., Hudkins R.L., Maroney A.C. Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases. Prog Med Chem 2002, 40:23-62.
    • (2002) Prog Med Chem , vol.40 , pp. 23-62
    • Saporito, M.S.1    Hudkins, R.L.2    Maroney, A.C.3
  • 35
    • 3042840152 scopus 로고    scopus 로고
    • Activation of c-Jun N-terminal kinase mediates gp120IIIB- and nucleoside analogue-induced sensory neuron toxicity
    • Bodner A., Toth P.T., Miller R.J. Activation of c-Jun N-terminal kinase mediates gp120IIIB- and nucleoside analogue-induced sensory neuron toxicity. Exp Neurol 2004, 188:246-253.
    • (2004) Exp Neurol , vol.188 , pp. 246-253
    • Bodner, A.1    Toth, P.T.2    Miller, R.J.3
  • 36
    • 35148882113 scopus 로고    scopus 로고
    • Parkinson Study Group PRECEPT Investigators. Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease
    • Parkinson Study Group PRECEPT Investigators. Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease. Neurology 2007, 69:1480-1490.
    • (2007) Neurology , vol.69 , pp. 1480-1490
  • 38
    • 0033840581 scopus 로고    scopus 로고
    • MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo
    • Saporito M.S., Thomas B.A., Scott R.W. MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo. J Neurochem 2000, 75:1200-1208.
    • (2000) J Neurochem , vol.75 , pp. 1200-1208
    • Saporito, M.S.1    Thomas, B.A.2    Scott, R.W.3
  • 39
    • 49049083497 scopus 로고    scopus 로고
    • Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease
    • Wang L.H., Johnson E.M. Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease. Neurology 2008, 71:462-463.
    • (2008) Neurology , vol.71 , pp. 462-463
    • Wang, L.H.1    Johnson, E.M.2
  • 40
    • 76249099852 scopus 로고    scopus 로고
    • Neuroprotective activities of CEP-1347 in models of neuroAIDS
    • Eggert D., Dash P.K., Gorantla S., et al. Neuroprotective activities of CEP-1347 in models of neuroAIDS. J Immunol 2010, 184:746-756.
    • (2010) J Immunol , vol.184 , pp. 746-756
    • Eggert, D.1    Dash, P.K.2    Gorantla, S.3
  • 41
    • 0028808135 scopus 로고
    • Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia
    • Glass J.D., Fedor H., Wesselingh S.L., McArthur J.C. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol 1995, 38:755-762.
    • (1995) Ann Neurol , vol.38 , pp. 755-762
    • Glass, J.D.1    Fedor, H.2    Wesselingh, S.L.3    McArthur, J.C.4
  • 42
    • 40449102954 scopus 로고    scopus 로고
    • CD163, a marker of perivascular macrophages, is up-regulated by microglia in simian immunodeficiency virus encephalitis after haptoglobin-hemoglobin complex stimulation and is suggestive of breakdown of the blood-brain barrier
    • Borda J.T., Alvarez X., Mohan M., et al. CD163, a marker of perivascular macrophages, is up-regulated by microglia in simian immunodeficiency virus encephalitis after haptoglobin-hemoglobin complex stimulation and is suggestive of breakdown of the blood-brain barrier. Am J Pathol 2008, 172:725-737.
    • (2008) Am J Pathol , vol.172 , pp. 725-737
    • Borda, J.T.1    Alvarez, X.2    Mohan, M.3
  • 43
    • 22644433445 scopus 로고    scopus 로고
    • CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation
    • Fabriek B.O., Van Haastert E.S., Galea I., et al. CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation. Glia 2005, 51:297-305.
    • (2005) Glia , vol.51 , pp. 297-305
    • Fabriek, B.O.1    Van Haastert, E.S.2    Galea, I.3
  • 44
    • 33644657843 scopus 로고    scopus 로고
    • CD163 identifies perivascular macrophages in normal and viral encephalitic brains and potential precursors to perivascular macrophages in blood
    • Kim W.K., Alvarez X., Fisher J., et al. CD163 identifies perivascular macrophages in normal and viral encephalitic brains and potential precursors to perivascular macrophages in blood. Am J Pathol 2006, 168:822-834.
    • (2006) Am J Pathol , vol.168 , pp. 822-834
    • Kim, W.K.1    Alvarez, X.2    Fisher, J.3
  • 45
    • 43949110573 scopus 로고    scopus 로고
    • Increased expression of monocyte CD44v6 correlates with the deveopment of encephalitis in rhesus macaques infected with simian immunodeficiency virus
    • Marcondes M.C., Lanigan C.M., Burdo T.H., Watry D.D., Fox H.S. Increased expression of monocyte CD44v6 correlates with the deveopment of encephalitis in rhesus macaques infected with simian immunodeficiency virus. J Infect Dis 2008, 197:1567-1576.
    • (2008) J Infect Dis , vol.197 , pp. 1567-1576
    • Marcondes, M.C.1    Lanigan, C.M.2    Burdo, T.H.3    Watry, D.D.4    Fox, H.S.5
  • 47
    • 10044292902 scopus 로고    scopus 로고
    • CD163 identifies a unique population of ramified microglia in HIV encephalitis (HIVE)
    • Roberts E.S., Masliah E., Fox H.S. CD163 identifies a unique population of ramified microglia in HIV encephalitis (HIVE). J Neuropathol Exp Neurol 2004, 63:1255-1264.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 1255-1264
    • Roberts, E.S.1    Masliah, E.2    Fox, H.S.3
  • 48
    • 0037568318 scopus 로고    scopus 로고
    • Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS
    • Roberts E.S., Zandonatti M.A., Watry D.D., et al. Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS. Am J Pathol 2003, 162:2041-2057.
    • (2003) Am J Pathol , vol.162 , pp. 2041-2057
    • Roberts, E.S.1    Zandonatti, M.A.2    Watry, D.D.3
  • 51
    • 33644839923 scopus 로고    scopus 로고
    • The shifting patterns of HIV encephalitis neuropathology
    • Everall I.P., Hansen L.A., Masliah E. The shifting patterns of HIV encephalitis neuropathology. Neurotox Res 2005, 8:51-61.
    • (2005) Neurotox Res , vol.8 , pp. 51-61
    • Everall, I.P.1    Hansen, L.A.2    Masliah, E.3
  • 53
    • 0037565256 scopus 로고    scopus 로고
    • Regulation of MCP-1 gene transcription by Smads and HIV-1 Tat in human glial cells
    • Abraham S., Sawaya B.E., Safak M., Batuman O., Khalili K., Amini S. Regulation of MCP-1 gene transcription by Smads and HIV-1 Tat in human glial cells. Virology 2003, 309:196-202.
    • (2003) Virology , vol.309 , pp. 196-202
    • Abraham, S.1    Sawaya, B.E.2    Safak, M.3    Batuman, O.4    Khalili, K.5    Amini, S.6
  • 54
    • 0032539828 scopus 로고    scopus 로고
    • Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia
    • Conant K., Garzino-Demo A., Nath A., et al. Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc Natl Acad Sci U S A 1998, 95:3117-3121.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 3117-3121
    • Conant, K.1    Garzino-Demo, A.2    Nath, A.3
  • 55
    • 1942486751 scopus 로고    scopus 로고
    • Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat
    • D'Aversa T.G., Yu K.O., Berman J.W. Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat. J Neurovirol 2004, 10:86-97.
    • (2004) J Neurovirol , vol.10 , pp. 86-97
    • D'Aversa, T.G.1    Yu, K.O.2    Berman, J.W.3
  • 56
  • 57
    • 33644796067 scopus 로고    scopus 로고
    • HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines
    • El-Hage N., Wu G., Wang J., et al. HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines. Glia 2006, 53:132-146.
    • (2006) Glia , vol.53 , pp. 132-146
    • El-Hage, N.1    Wu, G.2    Wang, J.3
  • 58
    • 0038579653 scopus 로고    scopus 로고
    • MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis
    • Eugenin E.A., D'Aversa T.G., Lopez L., Calderon T.M., Berman J.W. MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. J Neurochem 2003, 85:1299-1311.
    • (2003) J Neurochem , vol.85 , pp. 1299-1311
    • Eugenin, E.A.1    D'Aversa, T.G.2    Lopez, L.3    Calderon, T.M.4    Berman, J.W.5
  • 59
    • 14844358547 scopus 로고    scopus 로고
    • HIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism: possible role in NeuroAIDS
    • Eugenin E.A., Dyer G., Calderon T.M., Berman J.W. HIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism: possible role in NeuroAIDS. Glia 2005, 49:501-510.
    • (2005) Glia , vol.49 , pp. 501-510
    • Eugenin, E.A.1    Dyer, G.2    Calderon, T.M.3    Berman, J.W.4
  • 60
    • 0042112656 scopus 로고    scopus 로고
    • The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites
    • Lim S.P., Garzino-Demo A. The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites. J Virol 2000, 74:1632-1640.
    • (2000) J Virol , vol.74 , pp. 1632-1640
    • Lim, S.P.1    Garzino-Demo, A.2
  • 61
    • 0033843359 scopus 로고    scopus 로고
    • Chemokine and chemokine-receptor expression in human glial elements: induction by the HIV protein, Tat, and chemokine autoregulation
    • McManus C.M., Weidenheim K., Woodman S.E., et al. Chemokine and chemokine-receptor expression in human glial elements: induction by the HIV protein, Tat, and chemokine autoregulation. Am J Pathol 2000, 156:1441-1453.
    • (2000) Am J Pathol , vol.156 , pp. 1441-1453
    • McManus, C.M.1    Weidenheim, K.2    Woodman, S.E.3
  • 62
    • 0036016547 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1-induced activation of p42/44 MAPK and c-Jun in murine peritoneal macrophages: a potential pathway for macrophage activation
    • Sodhi A., Biswas S.K. Monocyte chemoattractant protein-1-induced activation of p42/44 MAPK and c-Jun in murine peritoneal macrophages: a potential pathway for macrophage activation. J Interferon Cytokine Res 2002, 22:517-526.
    • (2002) J Interferon Cytokine Res , vol.22 , pp. 517-526
    • Sodhi, A.1    Biswas, S.K.2
  • 63
    • 0037262112 scopus 로고    scopus 로고
    • HIV-Tat protein induces oxidative and inflammatory pathways in brain endothelium
    • Toborek M., Lee Y.W., Pu H., et al. HIV-Tat protein induces oxidative and inflammatory pathways in brain endothelium. J Neurochem 2003, 84:169-179.
    • (2003) J Neurochem , vol.84 , pp. 169-179
    • Toborek, M.1    Lee, Y.W.2    Pu, H.3
  • 64
    • 0033198104 scopus 로고    scopus 로고
    • HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and up-regulates CCR5 expression on human monocytes
    • Weiss J.M., Nath A., Major E.O., Berman J.W. HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and up-regulates CCR5 expression on human monocytes. J Immunol 1999, 163:2953-2959.
    • (1999) J Immunol , vol.163 , pp. 2953-2959
    • Weiss, J.M.1    Nath, A.2    Major, E.O.3    Berman, J.W.4
  • 65
    • 49849084594 scopus 로고    scopus 로고
    • HIV-1-infected and/or immune-activated macrophages regulate astrocyte CXCL8 production through IL-1beta and TNF-alpha: involvement of mitogen-activated protein kinases and protein kinase R
    • Zheng J.C., Huang Y., Tang K., et al. HIV-1-infected and/or immune-activated macrophages regulate astrocyte CXCL8 production through IL-1beta and TNF-alpha: involvement of mitogen-activated protein kinases and protein kinase R. J Neuroimmunol 2008, 200:100-110.
    • (2008) J Neuroimmunol , vol.200 , pp. 100-110
    • Zheng, J.C.1    Huang, Y.2    Tang, K.3
  • 66
    • 47949092541 scopus 로고    scopus 로고
    • Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events
    • Gouwy M., Struyf S., Noppen S., et al. Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events. Mol Pharmacol 2008, 74:485-495.
    • (2008) Mol Pharmacol , vol.74 , pp. 485-495
    • Gouwy, M.1    Struyf, S.2    Noppen, S.3
  • 67
    • 70149090632 scopus 로고    scopus 로고
    • CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8
    • Gouwy M., Struyf S., Verbeke H., et al. CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8. J Leukoc Biol 2009, 86:671-680.
    • (2009) J Leukoc Biol , vol.86 , pp. 671-680
    • Gouwy, M.1    Struyf, S.2    Verbeke, H.3
  • 68
    • 67349260434 scopus 로고    scopus 로고
    • C-Jun N-terminal kinases inhibitor suppresses the TNF-alpha induced MCP-1 expression in human umbilical vein endothelial cells
    • Ahmed R.A., Murao K., Imachi H., et al. c-Jun N-terminal kinases inhibitor suppresses the TNF-alpha induced MCP-1 expression in human umbilical vein endothelial cells. Endocrine 2009, 35:184-188.
    • (2009) Endocrine , vol.35 , pp. 184-188
    • Ahmed, R.A.1    Murao, K.2    Imachi, H.3
  • 69
    • 1642483742 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways
    • Arndt P.G., Suzuki N., Avdi N.J., Malcolm K.C., Worthen G.S. Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways. J Biol Chem 2004, 279:10883-10891.
    • (2004) J Biol Chem , vol.279 , pp. 10883-10891
    • Arndt, P.G.1    Suzuki, N.2    Avdi, N.J.3    Malcolm, K.C.4    Worthen, G.S.5
  • 70
    • 65249114367 scopus 로고    scopus 로고
    • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    • Gao Y.J., Zhang L., Samad O.A., et al. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J Neurosci 2009, 29:4096-4108.
    • (2009) J Neurosci , vol.29 , pp. 4096-4108
    • Gao, Y.J.1    Zhang, L.2    Samad, O.A.3
  • 71
    • 46149104370 scopus 로고    scopus 로고
    • C-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene
    • Wolter S., Doerrie A., Weber A., et al. c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene. Mol Cell Biol 2008, 28:4407-4423.
    • (2008) Mol Cell Biol , vol.28 , pp. 4407-4423
    • Wolter, S.1    Doerrie, A.2    Weber, A.3
  • 72
    • 70449511174 scopus 로고    scopus 로고
    • C-Jun NH2-terminal kinase regulates lipopolysaccharide-induced pulmonary mononuclear cell recruitment via CCL2
    • Young S.K., Arndt P.G. c-Jun NH2-terminal kinase regulates lipopolysaccharide-induced pulmonary mononuclear cell recruitment via CCL2. Exp Lung Res 2009, 35:682-700.
    • (2009) Exp Lung Res , vol.35 , pp. 682-700
    • Young, S.K.1    Arndt, P.G.2
  • 73
    • 0035863864 scopus 로고    scopus 로고
    • Signal transduction involved in MCP-1-mediated monocytic transendothelial migration
    • Cambien B., Pomeranz M., Millet M.A., Rossi B., Schmid-Alliana A. Signal transduction involved in MCP-1-mediated monocytic transendothelial migration. Blood 2001, 97:359-366.
    • (2001) Blood , vol.97 , pp. 359-366
    • Cambien, B.1    Pomeranz, M.2    Millet, M.A.3    Rossi, B.4    Schmid-Alliana, A.5
  • 74
    • 0036838917 scopus 로고    scopus 로고
    • MCP-1 induces activation of MAP-kinases ERK, JNK and p38 MAPK in human endothelial cells
    • Werle M., Schmal U., Hanna K., Kreuzer J. MCP-1 induces activation of MAP-kinases ERK, JNK and p38 MAPK in human endothelial cells. Cardiovasc Res 2002, 56:284-292.
    • (2002) Cardiovasc Res , vol.56 , pp. 284-292
    • Werle, M.1    Schmal, U.2    Hanna, K.3    Kreuzer, J.4
  • 75
    • 33744515765 scopus 로고    scopus 로고
    • Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts
    • Sui Z., Kovacs A.D., Maggirwar S.B. Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts. Biochem Biophys Res Commun 2006, 345:1643-1648.
    • (2006) Biochem Biophys Res Commun , vol.345 , pp. 1643-1648
    • Sui, Z.1    Kovacs, A.D.2    Maggirwar, S.B.3
  • 76
    • 0032504151 scopus 로고    scopus 로고
    • HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism
    • New D.R., Maggirwar S.B., Epstein L.G., Dewhurst S., Gelbard H.A. HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism. J Biol Chem 1998, 273:17852-17858.
    • (1998) J Biol Chem , vol.273 , pp. 17852-17858
    • New, D.R.1    Maggirwar, S.B.2    Epstein, L.G.3    Dewhurst, S.4    Gelbard, H.A.5
  • 78
    • 0033104019 scopus 로고    scopus 로고
    • Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor
    • Batchelor P.E., Liberatore G.T., Wong J.Y., et al. Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. J Neurosci 1999, 19:1708-1716.
    • (1999) J Neurosci , vol.19 , pp. 1708-1716
    • Batchelor, P.E.1    Liberatore, G.T.2    Wong, J.Y.3
  • 79
    • 38349086976 scopus 로고    scopus 로고
    • Differential regulation of trophic and proinflammatory microglial effectors is dependent on severity of neuronal injury
    • Lai A.Y., Todd K.G. Differential regulation of trophic and proinflammatory microglial effectors is dependent on severity of neuronal injury. Glia 2008, 56:259-270.
    • (2008) Glia , vol.56 , pp. 259-270
    • Lai, A.Y.1    Todd, K.G.2
  • 81
    • 76249126511 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia
    • Mizoguchi Y., Monji A., Kato T., et al. Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia. J Immunol 2009, 183:7778-7786.
    • (2009) J Immunol , vol.183 , pp. 7778-7786
    • Mizoguchi, Y.1    Monji, A.2    Kato, T.3
  • 82
    • 0032211015 scopus 로고    scopus 로고
    • Neurotrophins regulate the function of cultured microglia
    • Nakajima K., Kikuchi Y., Ikoma E., et al. Neurotrophins regulate the function of cultured microglia. Glia 1998, 24:272-289.
    • (1998) Glia , vol.24 , pp. 272-289
    • Nakajima, K.1    Kikuchi, Y.2    Ikoma, E.3
  • 83
    • 70450255073 scopus 로고    scopus 로고
    • Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways
    • Pedraza N., Rafel M., Navarro I., Encinas M., Aldea M., Gallego C. Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways. J Biol Chem 2009, 284:32980-32988.
    • (2009) J Biol Chem , vol.284 , pp. 32980-32988
    • Pedraza, N.1    Rafel, M.2    Navarro, I.3    Encinas, M.4    Aldea, M.5    Gallego, C.6
  • 84
    • 14344262713 scopus 로고    scopus 로고
    • Mixed-lineage kinase inhibitors require the activation of Trk receptors to maintain long-term neuronal trophism and survival
    • Wang L.H., Paden A.J., Johnson E.M. Mixed-lineage kinase inhibitors require the activation of Trk receptors to maintain long-term neuronal trophism and survival. J Pharmacol Exp Ther 2005, 312:1007-1019.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 1007-1019
    • Wang, L.H.1    Paden, A.J.2    Johnson, E.M.3
  • 85
    • 34247254468 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor prevents the nigrostriatal degeneration induced by human immunodeficiency virus-1 glycoprotein 120 in vivo
    • Nosheny R.L., Ahmed F., Yakovlev A., et al. Brain-derived neurotrophic factor prevents the nigrostriatal degeneration induced by human immunodeficiency virus-1 glycoprotein 120 in vivo. Eur J Neurosci 2007, 25:2275-2284.
    • (2007) Eur J Neurosci , vol.25 , pp. 2275-2284
    • Nosheny, R.L.1    Ahmed, F.2    Yakovlev, A.3
  • 86
    • 9744260297 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor activation of TrkB protects neurons from HIV-1/gp120-induced cell death
    • Mocchetti I., Bachis A. Brain-derived neurotrophic factor activation of TrkB protects neurons from HIV-1/gp120-induced cell death. Crit Rev Neurobiol 2004, 16:51-57.
    • (2004) Crit Rev Neurobiol , vol.16 , pp. 51-57
    • Mocchetti, I.1    Bachis, A.2


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