-
1
-
-
0035066383
-
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
-
Kyriakis, J. M., and J. Avruch. 2001. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81: 807-869.
-
(2001)
Physiol. Rev.
, vol.81
, pp. 807-869
-
-
Kyriakis, J.M.1
Avruch, J.2
-
2
-
-
0036731701
-
Mixed-lineage kinase control of JNK and p38 MAPK pathways
-
Gallo, K. A., and G. L. Johnson. 2002. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat. Rev. Mol. Cell. Biol. 3: 663-672.
-
(2002)
Nat. Rev. Mol. Cell. Biol.
, vol.3
, pp. 663-672
-
-
Gallo, K.A.1
Johnson, G.L.2
-
3
-
-
22844445441
-
Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: A new therapeutic target in Parkinson's disease
-
Silva, R. M., C. Y. Kuan, P. Rakic, and R. E. Burke. 2005. Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease. Mov. Disord. 20: 653-664.
-
(2005)
Mov. Disord.
, vol.20
, pp. 653-664
-
-
Silva, R.M.1
Kuan, C.Y.2
Rakic, P.3
Burke, R.E.4
-
5
-
-
1542319928
-
Dysregulation of mitogen-activated protein kinase signaling pathways in simian immunodeficiency virus encephalitis
-
Barber, S, A., J. L. Uhrlaub, J. B. DeWitt, P. M. Tarwater, and M. C. Zink. 2004. Dysregulation of mitogen-activated protein kinase signaling pathways in simian immunodeficiency virus encephalitis. Am. J. Pathol 164: 355-362.
-
(2004)
Am. J. Pathol
, vol.164
, pp. 355-362
-
-
Barber, S.A.1
Uhrlaub, J.L.2
DeWitt, J.B.3
Tarwater, P.M.4
Zink, M.C.5
-
6
-
-
0141449089
-
The p38 MAP kinase signaling pathway in Alzheimer's disease
-
Johnson, G. V., and C. D. Bailey. 2003. The p38 MAP kinase signaling pathway in Alzheimer's disease. Exp. Neurol. 183: 263-268.
-
(2003)
Exp. Neurol.
, vol.183
, pp. 263-268
-
-
Johnson, G.V.1
Bailey, C.D.2
-
7
-
-
0037399165
-
MAPKs: New targets for neurodegeneration
-
Harper, S. J., and N. Wilkie. 2003. MAPKs: new targets for neurodegeneration. Expert Opin. Ther. Targets 7: 187-200.
-
(2003)
Expert Opin. Ther. Targets
, vol.7
, pp. 187-200
-
-
Harper, S.J.1
Wilkie, N.2
-
8
-
-
0033810404
-
Therapeutic potential of antiinflammatory drugs in focal stroke
-
Barone, F. C., and A. A. Parsons. 2000. Therapeutic potential of antiinflammatory drugs in focal stroke. Expert Opin. Invest. Drugs 9: 2281-2306.
-
(2000)
Expert Opin. Invest. Drugs
, vol.9
, pp. 2281-2306
-
-
Barone, F.C.1
Parsons, A.A.2
-
9
-
-
20844450752
-
Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy
-
Kuan, C. Y., and R. E. Burke. 2005. Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy. Curr. Drug Targets CNS Neurol. Disord. 4: 63-67.
-
(2005)
Curr. Drug Targets CNS Neurol. Disord.
, vol.4
, pp. 63-67
-
-
Kuan, C.Y.1
Burke, R.E.2
-
11
-
-
0035879151
-
Evidence for a role of mixed lineage kinases in neuronal apoptosis
-
Mota, M., M. Reeder, J. Chernoff, and C. E. Bazenet. 2001. Evidence for a role of mixed lineage kinases in neuronal apoptosis. J. Neurosci. 21: 4949-4957.
-
(2001)
J. Neurosci.
, vol.21
, pp. 4949-4957
-
-
Mota, M.1
Reeder, M.2
Chernoff, J.3
Bazenet, C.E.4
-
12
-
-
0037423289
-
Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival
-
Barthwal, M. K., P. Sathyanarayana, C. N. Kundu, B. Rana, A. Pradeep, C. Sharma, J. R. Woodgett, and A. Rana. 2003. Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J. Biol. Chem. 278: 3897-3902.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 3897-3902
-
-
Barthwal, M.K.1
Sathyanarayana, P.2
Kundu, C.N.3
Rana, B.4
Pradeep, A.5
Sharma, C.6
Woodgett, J.R.7
Rana, A.8
-
13
-
-
18844452864
-
Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation
-
Yin, X. H., Q. G. Zhang, B. Miao, and G. Y. Zhang. 2005. Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation. J. Neurochem. 93: 1021-1029.
-
(2005)
J. Neurochem.
, vol.93
, pp. 1021-1029
-
-
Yin, X.H.1
Zhang, Q.G.2
Miao, B.3
Zhang, G.Y.4
-
14
-
-
0035816685
-
Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family
-
Maroney, A. C., J. P. Finn, T. J. Connors, J. T. Durkin, T. Angeles, G. Gessner, Z. Xu, S. L. Meyer, M. J. Savage, L. A. Greene, et al. 2001. Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J. Biol. Chem. 276: 25302-25308.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 25302-25308
-
-
Maroney, A.C.1
Finn, J.P.2
Connors, T.J.3
Durkin, J.T.4
Angeles, T.5
Gessner, G.6
Xu, Z.7
Meyer, S.L.8
Savage, M.J.9
Greene, L.A.10
-
15
-
-
0037147130
-
K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK
-
Roux, P. P., G. Dorval, M. Boudreau, A. Angers-Loustau, S. J. Morris, J. Makkerh, and P. A. Barker. 2002. K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. J. Biol. Chem. 277: 49473-49480.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49473-49480
-
-
Roux, P.P.1
Dorval, G.2
Boudreau, M.3
Angers-Loustau, A.4
Morris, S.J.5
Makkerh, J.6
Barker, P.A.7
-
16
-
-
21844442345
-
Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway
-
Lotharius, J., J. Falsig, J. van Beek, S. Payne, R. Dringen, P. Brundin, and M. Leist. 2005. Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. J. Neurosci. 25: 6329-6342.
-
(2005)
J. Neurosci.
, vol.25
, pp. 6329-6342
-
-
Lotharius, J.1
Falsig, J.2
Van Beek, J.3
Payne, S.4
Dringen, R.5
Brundin, P.6
Leist, M.7
-
17
-
-
12144290127
-
+-induced neurotoxicity in SH-SY5Y cells
-
+-induced neurotoxicity in SH-SY5Y cells. Brain Res. 1003: 86-97.
-
(2004)
Brain Res.
, vol.1003
, pp. 86-97
-
-
Mathiasen, J.R.1
McKenna, B.A.2
Saporito, M.S.3
Ghadge, G.D.4
Roos, R.P.5
Holskin, B.P.6
Wu, Z.L.7
Trusko, S.P.8
Connors, T.C.9
Maroney, A.C.10
-
18
-
-
0033029823
-
CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo
-
Saporito, M. S., E. M. Brown, M. S. Miller, and S. Carswell. 1999. CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo. J. Pharmacol. Exp. Ther. 288: 421-427.
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.288
, pp. 421-427
-
-
Saporito, M.S.1
Brown, E.M.2
Miller, M.S.3
Carswell, S.4
-
19
-
-
0036988312
-
Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases
-
Saporito, M. S., R. L. Hudkins, and A. C. Maroney. 2002. Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases. Prog. Med. Chem. 40: 23-62.
-
(2002)
Prog. Med. Chem.
, vol.40
, pp. 23-62
-
-
Saporito, M.S.1
Hudkins, R.L.2
Maroney, A.C.3
-
20
-
-
0842324952
-
The safety and tolerability of a mixed lineage kinase inhibitor (CEP-1347) in PD
-
Group, P. S. 2004. The safety and tolerability of a mixed lineage kinase inhibitor (CEP-1347) in PD. Neurology 62: 330-332.
-
(2004)
Neurology
, vol.62
, pp. 330-332
-
-
Group, P.S.1
-
21
-
-
24944582908
-
Treatment of Parkinson's disease: What's on the horizon?
-
Wu, S. S., and S. J. Frucht. 2005. Treatment of Parkinson's disease: what's on the horizon? CNS Drugs 19: 723-743.
-
(2005)
CNS Drugs
, vol.19
, pp. 723-743
-
-
Wu, S.S.1
Frucht, S.J.2
-
22
-
-
0035019371
-
CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with αβ-induced cortical neuron apoptosis
-
Bozyczko-Coyne, D., T. M. O'Kane, Z. L. Wu, P. Dobrzanski, S. Murthy, J. L. Vaught, and R. W. Scott. 2001. CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with αβ-induced cortical neuron apoptosis. J. Neurochem. 77: 849-863.
-
(2001)
J. Neurochem.
, vol.77
, pp. 849-863
-
-
Bozyczko-Coyne, D.1
O'Kane, T.M.2
Wu, Z.L.3
Dobrzanski, P.4
Murthy, S.5
Vaught, J.L.6
Scott, R.W.7
-
23
-
-
0028808135
-
Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementia
-
Glass, J. D., H. Fedor, S. L. Wesselingh, and J. C. McArthur. 1995. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann. Neural 38: 755-762.
-
(1995)
Ann. Neural
, vol.38
, pp. 755-762
-
-
Glass, J.D.1
Fedor, H.2
Wesselingh, S.L.3
McArthur, J.C.4
-
24
-
-
15844371968
-
Neuroprotective strategies for HIV-1 associated dementia
-
Dou, H., J. D. Kingsley, R. L. Mosley, H. A. Gelbard, and H. E. Gendelman. 2004. Neuroprotective strategies for HIV-1 associated dementia. Neurotox. Res. 6: 503-521.
-
(2004)
Neurotox. Res.
, vol.6
, pp. 503-521
-
-
Dou, H.1
Kingsley, J.D.2
Mosley, R.L.3
Gelbard, H.A.4
Gendelman, H.E.5
-
25
-
-
0347320928
-
Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection
-
Persidsky, Y., and H. E. Gendelman. 2003. Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection. J. Leukocyte Biol. 74: 691-701.
-
(2003)
J. Leukocyte Biol.
, vol.74
, pp. 691-701
-
-
Persidsky, Y.1
Gendelman, H.E.2
-
26
-
-
0032504151
-
HIV-1 Tat induces neuronal death via tumor necrosis factor-α and activation of non-N-methyl-D-aspartate receptors by a NFκB-independent mechanism
-
New, D. R., S. B. Maggirwar, L. G. Epstein, S. Dewhurst, and H. A. Gelbard. 1998. HIV-1 Tat induces neuronal death via tumor necrosis factor-α and activation of non-N-methyl-D-aspartate receptors by a NFκB-independent mechanism. J. Biol. Chem. 273: 17852-17858.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 17852-17858
-
-
New, D.R.1
Maggirwar, S.B.2
Epstein, L.G.3
Dewhurst, S.4
Gelbard, H.A.5
-
27
-
-
8844245664
-
Antioxidants are required during the early critical period, but not later, for neuronal survival
-
Perry, S. W., J. P. Norman, A. Litzburg, and H. A. Gelbard. 2004. Antioxidants are required during the early critical period, but not later, for neuronal survival. J. Neurosci. Res. 78: 485-492.
-
(2004)
J. Neurosci. Res.
, vol.78
, pp. 485-492
-
-
Perry, S.W.1
Norman, J.P.2
Litzburg, A.3
Gelbard, H.A.4
-
28
-
-
0027226219
-
Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination
-
Brewer, G. J., J. R. Torricelli, E. K. Evege, and P. J. Price. 1993. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35: 567-576.
-
(1993)
J. Neurosci. Res.
, vol.35
, pp. 567-576
-
-
Brewer, G.J.1
Torricelli, J.R.2
Evege, E.K.3
Price, P.J.4
-
29
-
-
14544280192
-
Valproic acid enhances gene expression from viral gene transfer vectors
-
Fan, S., C. A. Maguire, S. H. Ramirez, B. Bradel-Tretheway, R. Sapinoro, Z. Sui, S. Chakraborty-Sett, and S. Dewhurst. 2005. Valproic acid enhances gene expression from viral gene transfer vectors. J. Virol. Methods 125: 23-33.
-
(2005)
J. Virol. Methods
, vol.125
, pp. 23-33
-
-
Fan, S.1
Maguire, C.A.2
Ramirez, S.H.3
Bradel-Tretheway, B.4
Sapinoro, R.5
Sui, Z.6
Chakraborty-Sett, S.7
Dewhurst, S.8
-
30
-
-
0034883795
-
Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-κB (NF-κB)-dependent mechanism
-
Ramirez, S. H., J. F. Sanchez, C. A. Dimitri, H. A. Gelbard, S. Dewhurst, and S. B. Maggirwar. 2001. Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-κB (NF-κB)-dependent mechanism. J. Neurochem. 78: 874-889.
-
(2001)
J. Neurochem.
, vol.78
, pp. 874-889
-
-
Ramirez, S.H.1
Sanchez, J.F.2
Dimitri, C.A.3
Gelbard, H.A.4
Dewhurst, S.5
Maggirwar, S.B.6
-
31
-
-
0035910529
-
The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation
-
Leung, I. W., and N. Lassam. 2001. The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation. J. Biol. Chem. 276: 1961-1967.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 1961-1967
-
-
Leung, I.W.1
Lassam, N.2
-
32
-
-
30044441291
-
Cdc42 induces activation loop phosphorylation and membrane targeting of MLK3
-
Du, Y., B. C. Bock, K. A. Schachter, M. Chao, and K. A. Gallo. 2005. Cdc42 induces activation loop phosphorylation and membrane targeting of MLK3. J. Biol. Chem. 280: 42984-42993.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 42984-42993
-
-
Du, Y.1
Bock, B.C.2
Schachter, K.A.3
Chao, M.4
Gallo, K.A.5
-
33
-
-
4444231185
-
Treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor in vitro enhances expression of other neurotrophic factors as well as cytokines and chemokines
-
Yabe, T., J. T. Herbert, A. Takanohashi, and J. P. Schwartz. 2004. Treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor in vitro enhances expression of other neurotrophic factors as well as cytokines and chemokines. J. Neurosci. Res. 77: 642-652.
-
(2004)
J. Neurosci. Res.
, vol.77
, pp. 642-652
-
-
Yabe, T.1
Herbert, J.T.2
Takanohashi, A.3
Schwartz, J.P.4
-
34
-
-
0034954603
-
The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis
-
Xu, Z., A. C. Maroney, P. Dobrzanski, N. V. Kukekov, and L. A. Greene. 2001. The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol. Cell. Biol. 21: 4713-4724.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 4713-4724
-
-
Xu, Z.1
Maroney, A.C.2
Dobrzanski, P.3
Kukekov, N.V.4
Greene, L.A.5
-
35
-
-
18244364894
-
+ peripheral blood-derived monocytes in HIV dementia: Perivascular accumulation and reservoir of HIV infection
-
+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection. J. Neurovirol. 7: 528-541.
-
(2001)
J. Neurovirol.
, vol.7
, pp. 528-541
-
-
Fischer-Smith, T.1
Croul, S.2
Sverstiuk, A.E.3
Capini, C.4
L'Heureux, D.5
Regulier, E.G.6
Richardson, M.W.7
Amini, S.8
Morgello, S.9
Khalili, K.10
Rappaport, J.11
-
36
-
-
0141726832
-
HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain
-
Pu, H., J. Tian, G. Flora, Y. W. Lee, A. Nath, B. Hennig, and M. Toborek. 2003. HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain. Mol. Cell. Neurosci. 24: 224-237.
-
(2003)
Mol. Cell. Neurosci.
, vol.24
, pp. 224-237
-
-
Pu, H.1
Tian, J.2
Flora, G.3
Lee, Y.W.4
Nath, A.5
Hennig, B.6
Toborek, M.7
-
37
-
-
0023277604
-
Severe parkinsonism in two AIDS patients taking prochlorperazine
-
Edelstein, H., and R. T. Knight. 1987. Severe parkinsonism in two AIDS patients taking prochlorperazine. Lancet 2: 341-342.
-
(1987)
Lancet
, vol.2
, pp. 341-342
-
-
Edelstein, H.1
Knight, R.T.2
-
38
-
-
0033728966
-
HIV dementia: The role of the basal ganglia and dopaminergic systems
-
Berger, J. R., and G. Arendt. 2000. HIV dementia: the role of the basal ganglia and dopaminergic systems. J. Psychopharmacol. 14: 214-221.
-
(2000)
J. Psychopharmacol.
, vol.14
, pp. 214-221
-
-
Berger, J.R.1
Arendt, G.2
-
39
-
-
0036322227
-
Parkinsonism in HIV dementia
-
Koutsilieri, E., S. Sopper, C. Scheller, V. ter Meulen, and P. Riederer. 2002. Parkinsonism in HIV dementia. J. Neurol Transm. 109: 767-775.
-
(2002)
J. Neurol Transm.
, vol.109
, pp. 767-775
-
-
Koutsilieri, E.1
Sopper, S.2
Scheller, C.3
Ter Meulen, V.4
Riederer, P.5
-
40
-
-
3242709616
-
Movement disorders and AIDS: A review
-
Tse, W., M. G. Cersosimo, J. M. Gracies, S. Morgello, C. W. Olanow, and W. Koller. 2004. Movement disorders and AIDS: a review. Parkinsonism Relat. Disord. 10: 323-334.
-
(2004)
Parkinsonism Relat. Disord.
, vol.10
, pp. 323-334
-
-
Tse, W.1
Cersosimo, M.G.2
Gracies, J.M.3
Morgello, S.4
Olanow, C.W.5
Koller, W.6
-
41
-
-
0035936629
-
Parkinsonism as the presenting manifestation of HIV infection: Improvement on HAART
-
Hersh, B. P., P. R. Rajendran, and D. Battinelli. 2001. Parkinsonism as the presenting manifestation of HIV infection: improvement on HAART. Neurology 56: 278-279.
-
(2001)
Neurology
, vol.56
, pp. 278-279
-
-
Hersh, B.P.1
Rajendran, P.R.2
Battinelli, D.3
-
42
-
-
0036730466
-
Movement disorders in 28 HIV-infected patients
-
Mattos, J. P., A. L. Rosso, R. B. Correa, and S. A. Novis. 2002. Movement disorders in 28 HIV-infected patients. Ar. Qneuropsiquiatr. 60: 525-530.
-
(2002)
Ar. Qneuropsiquiatr.
, vol.60
, pp. 525-530
-
-
Mattos, J.P.1
Rosso, A.L.2
Correa, R.B.3
Novis, S.A.4
-
43
-
-
0029891452
-
Dopamine deficits in the brain: The neurochemical basis of parkinsonian symptoms in AIDS
-
Sardar, A. M., C. Czudek, and G. P. Reynolds. 1996. Dopamine deficits in the brain: the neurochemical basis of parkinsonian symptoms in AIDS. Neuroreport 7: 910-912.
-
(1996)
Neuroreport
, vol.7
, pp. 910-912
-
-
Sardar, A.M.1
Czudek, C.2
Reynolds, G.P.3
-
44
-
-
3042840152
-
IIIB- and nucleoside analogue-induced sensory neuron toxicity
-
IIIB- and nucleoside analogue-induced sensory neuron toxicity. Exp. Neurol. 188: 246-253.
-
(2004)
Exp. Neurol.
, vol.188
, pp. 246-253
-
-
Bodner, A.1
Toth, P.T.2
Miller, R.J.3
-
45
-
-
0037770027
-
Human immunodeficiency virus type 1 Tat protein directly activates neuronal N-methyl-D-aspartate receptors at an allosteric zinc-sensitive site
-
Song, L., A. Nath, J. D. Geiger, A. Moore, and S. Hochman. 2003. Human immunodeficiency virus type 1 Tat protein directly activates neuronal N-methyl-D-aspartate receptors at an allosteric zinc-sensitive site. J. Neurovirol. 9: 399-403.
-
(2003)
J. Neurovirol.
, vol.9
, pp. 399-403
-
-
Song, L.1
Nath, A.2
Geiger, J.D.3
Moore, A.4
Hochman, S.5
-
46
-
-
0038579653
-
MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis
-
Eugenin, E. A., T. G. D'Aversa, L. Lopez, T. M. Calderon, and J. W. Berman. 2003. MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. J. Neurochem. 85: 1299-1311.
-
(2003)
J. Neurochem.
, vol.85
, pp. 1299-1311
-
-
Eugenin, E.A.1
D'Aversa, T.G.2
Lopez, L.3
Calderon, T.M.4
Berman, J.W.5
-
48
-
-
0027450488
-
Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: A study with rat cerebellar granule cell cultures
-
Savio, T., and G. Levi. 1993. Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: a study with rat cerebellar granule cell cultures. J. Neurosci. Res. 34: 265-272.
-
(1993)
J. Neurosci. Res.
, vol.34
, pp. 265-272
-
-
Savio, T.1
Levi, G.2
-
49
-
-
0036800480
-
Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120
-
Haughey, N. J., and M. P. Mattson. 2002. Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120. J. Acquir. Immune Defic. Syndr. 31(Suppl. 2):S55-S61.
-
(2002)
J. Acquir. Immune Defic. Syndr.
, vol.31
, Issue.SUPPL. 2
-
-
Haughey, N.J.1
Mattson, M.P.2
-
50
-
-
26844507074
-
Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition
-
Harris-White, M. E., and S. A. Frautschy. 2005. Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition. Curr. Drug Targets CNS Neurol. Dlsord. 4: 469-480.
-
(2005)
Curr. Drug Targets CNS Neurol. Dlsord.
, vol.4
, pp. 469-480
-
-
Harris-White, M.E.1
Frautschy, S.A.2
-
51
-
-
0034529953
-
Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands
-
Liu, Y., M. Jones, C. M. Hingtgen, G. Bu, N. Laribee, R. E. Tanzi, R. D. Moir, A. Nath, and J. J. He. 2000. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat. Med. 6: 1380-1387.
-
(2000)
Nat. Med.
, vol.6
, pp. 1380-1387
-
-
Liu, Y.1
Jones, M.2
Hingtgen, C.M.3
Bu, G.4
Laribee, N.5
Tanzi, R.E.6
Moir, R.D.7
Nath, A.8
He, J.J.9
-
52
-
-
3442882468
-
Effects of apolipoprotein e on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes
-
Pocernich, C. B., R. Sultana, E. Hone, J. Turchan, R. N. Martins, V. Calabrese, A. Nath, and D. A. Butterfield. 2004. Effects of apolipoprotein E on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes. J. Neurosci. Res. 77: 532-539.
-
(2004)
J. Neurosci. Res.
, vol.77
, pp. 532-539
-
-
Pocernich, C.B.1
Sultana, R.2
Hone, E.3
Turchan, J.4
Martins, R.N.5
Calabrese, V.6
Nath, A.7
Butterfield, D.A.8
-
53
-
-
0042380209
-
N-Methyl-D-aspartate-triggered neuronal death in organotypic hippocampal cultures is endocytic, autophagic and mediated by the c-Jun N-terminal kinase pathway
-
Borsello, T., K. Croquelois, J. P. Hornung, and P. G. Clarke. 2003. N-Methyl-D-aspartate-triggered neuronal death in organotypic hippocampal cultures is endocytic, autophagic and mediated by the c-Jun N-terminal kinase pathway. Eur J. Neurosci. 18: 473-485.
-
(2003)
Eur J. Neurosci.
, vol.18
, pp. 473-485
-
-
Borsello, T.1
Croquelois, K.2
Hornung, J.P.3
Clarke, P.G.4
-
55
-
-
0030741894
-
Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells
-
Kawasaki, H., T. Morooka, S. Shimohama, J. Kimura, T. Hirano, Y. Gotoh, and E. Nishida. 1997. Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J. Biol. Chem. 272: 18518-18521.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 18518-18521
-
-
Kawasaki, H.1
Morooka, T.2
Shimohama, S.3
Kimura, J.4
Hirano, T.5
Gotoh, Y.6
Nishida, E.7
-
56
-
-
33644839923
-
The shifting patterns of HIV encephalitis neuropathology
-
Everall, I. P., L. A. Hansen, and E. Masliah. 2005. The shifting patterns of HIV encephalitis neuropathology. Neurotox. Res. 8: 51-62.
-
(2005)
Neurotox. Res.
, vol.8
, pp. 51-62
-
-
Everall, I.P.1
Hansen, L.A.2
Masliah, E.3
-
57
-
-
0034076898
-
Neuronal damage: Recent issues and implications for therapy
-
Everall, I. P. 2000. Neuronal damage: recent issues and implications for therapy. J. Neurovirol. 6(Suppl. 1): S103-S105.
-
(2000)
J. Neurovirol.
, vol.6
, Issue.SUPPL. 1
-
-
Everall, I.P.1
-
58
-
-
0025272486
-
Loss of neurons in the frontal cortex in AIDS brains
-
Ketzler, S., S. Weis, H. Haug, and H. Budka. 1990. Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol. 80: 92-94.
-
(1990)
Acta Neuropathol.
, vol.80
, pp. 92-94
-
-
Ketzler, S.1
Weis, S.2
Haug, H.3
Budka, H.4
-
59
-
-
0034087078
-
Neuronal apoptosis in human immunodeficiency virus infection
-
Gray, F., H. Adle-Biassette, F. Brion, T. Ereau, I. le Maner, V. Levy, and G. Corcket. 2000. Neuronal apoptosis in human immunodeficiency virus infection. J. Neurovirol. 6(Suppl. 1): S38-S43.
-
(2000)
J. Neurovirol.
, vol.6
, Issue.SUPPL. 1
-
-
Gray, F.1
Adle-Biassette, H.2
Brion, F.3
Ereau, T.4
Le Maner, I.5
Levy, V.6
Corcket, G.7
-
60
-
-
0029069563
-
Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy
-
Gelbard, H. A., H. J. James, L. R. Sharer, S. W. Perry, Y. Saito, A. M. Kazee, B. M. Blumberg, and L. G. Epstein. 1995. Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol. Appl. Neurobiot. 21: 208-217.
-
(1995)
Neuropathol. Appl. Neurobiot.
, vol.21
, pp. 208-217
-
-
Gelbard, H.A.1
James, H.J.2
Sharer, L.R.3
Perry, S.W.4
Saito, Y.5
Kazee, A.M.6
Blumberg, B.M.7
Epstein, L.G.8
-
62
-
-
26044450555
-
Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neunte degeneration in striatal neurons
-
Singh, I. N., N. El-Hage, M. E. Campbell, S. E. Lutz, P. E. Knapp, A. Nath, and K. F. Hauser. 2005. Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neunte degeneration in striatal neurons. Neuroscience 135: 781-790.
-
(2005)
Neuroscience
, vol.135
, pp. 781-790
-
-
Singh, I.N.1
El-Hage, N.2
Campbell, M.E.3
Lutz, S.E.4
Knapp, P.E.5
Nath, A.6
Hauser, K.F.7
-
63
-
-
0033839573
-
Activation of human microglial cells by HIV-1 gp41 and Tat proteins
-
Sheng, W. S., S. Hu, C. C. Hegg, S. A. Thayer, and P. K. Peterson. 2000. Activation of human microglial cells by HIV-1 gp41 and Tat proteins. Clin. Immunol. 96: 243-251.
-
(2000)
Clin. Immunol.
, vol.96
, pp. 243-251
-
-
Sheng, W.S.1
Hu, S.2
Hegg, C.C.3
Thayer, S.A.4
Peterson, P.K.5
-
64
-
-
25444487187
-
NeuroAIDS: Contributions of the human immunodeficiency virus-1 proteins Tat and gp120 as well as CD40 to microglial activation
-
D'Aversa, T. G., E. A. Eugenin, and J. W. Berman. 2005. NeuroAIDS: contributions of the human immunodeficiency virus-1 proteins Tat and gp120 as well as CD40 to microglial activation. J. Neurosci. Res. 81: 436-446.
-
(2005)
J. Neurosci. Res.
, vol.81
, pp. 436-446
-
-
D'Aversa, T.G.1
Eugenin, E.A.2
Berman, J.W.3
-
65
-
-
20144367957
-
Inhibition of microglial inflammation by the MLK inhibitor CEP-1347
-
Lund, S., P. Porzgen, A. L. Mortensen, H. Hasseldam, D. Bozyczko-Coyne, S. Morath, T. Hartung, M. Bianchi, P. Ghezzi, M. Bsibsi, et al. 2005. Inhibition of microglial inflammation by the MLK inhibitor CEP-1347. J. Neurochem. 92: 1439-1451.
-
(2005)
J. Neurochem.
, vol.92
, pp. 1439-1451
-
-
Lund, S.1
Porzgen, P.2
Mortensen, A.L.3
Hasseldam, H.4
Bozyczko-Coyne, D.5
Morath, S.6
Hartung, T.7
Bianchi, M.8
Ghezzi, P.9
Bsibsi, M.10
-
66
-
-
20344365580
-
CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-α release from lipopolysaccharide-treated cells and mice
-
Ciallella, J. R., M. Saporito, S. Lund, M. Leist, H. Hasseldam, N. McGann, C. S. Smith, D. Bozyczko-Coyne, and D. G. Flood. 2005. CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-α release from lipopolysaccharide-treated cells and mice. Eur. J. Pharmacol. 515: 179-187.
-
(2005)
Eur. J. Pharmacol.
, vol.515
, pp. 179-187
-
-
Ciallella, J.R.1
Saporito, M.2
Lund, S.3
Leist, M.4
Hasseldam, H.5
McGann, N.6
Smith, C.S.7
Bozyczko-Coyne, D.8
Flood, D.G.9
-
67
-
-
0035887671
-
Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis
-
Zink, M. C., G. D. Coleman, J. L. Mankowski, R. J. Adams, P. M. Tarwater, K. Fox, and J. E. Clements. 2001. Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis. J. Infect. Dis. 184: 1015-1021.
-
(2001)
J. Infect. Dis.
, vol.184
, pp. 1015-1021
-
-
Zink, M.C.1
Coleman, G.D.2
Mankowski, J.L.3
Adams, R.J.4
Tarwater, P.M.5
Fox, K.6
Clements, J.E.7
-
68
-
-
10444241256
-
Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia
-
Sevigny, J. J., S. M. Albert, M. P. McDermott, J. C. McArthur, N. Sacktor, K. Conant, G. Schifitto, O. A. Seines, Y. Stern, D. R. McClernon, et al. 2004. Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia. Neurology 63: 2084-2090.
-
(2004)
Neurology
, vol.63
, pp. 2084-2090
-
-
Sevigny, J.J.1
Albert, S.M.2
McDermott, M.P.3
McArthur, J.C.4
Sacktor, N.5
Conant, K.6
Schifitto, G.7
Seines, O.A.8
Stern, Y.9
McClernon, D.R.10
-
69
-
-
9644283129
-
Cerebrospinal fluid markers that predict SIV CNS disease
-
Mankowski, J. L., S. E. Queen, J. E. Clements, and M. C. Zink. 2004. Cerebrospinal fluid markers that predict SIV CNS disease. J. Neuroimmunol. 157: 66-70.
-
(2004)
J. Neuroimmunol.
, vol.157
, pp. 66-70
-
-
Mankowski, J.L.1
Queen, S.E.2
Clements, J.E.3
Zink, M.C.4
-
70
-
-
0031737417
-
β-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia
-
Kelder, W., J. C. McArthur, T. Nance-Sproson, D. McClernon, and D. E. Griffin. 1998. β-Chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia. Ann. Neurol. 44: 831-835.
-
(1998)
Ann. Neurol.
, vol.44
, pp. 831-835
-
-
Kelder, W.1
McArthur, J.C.2
Nance-Sproson, T.3
McClernon, D.4
Griffin, D.E.5
-
71
-
-
0037108817
-
HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels
-
Gonzalez, E., B. H. Rovin, L. Sen, G. Cooke, R. Dhanda, S. Mummidi, H. Kulkarni, M. J. Bamshad, V. Telles, S. A. Anderson, et al. 2002. HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels. Proc. Natl. Acad. Sci. USA 99: 13795-13800.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13795-13800
-
-
Gonzalez, E.1
Rovin, B.H.2
Sen, L.3
Cooke, G.4
Dhanda, R.5
Mummidi, S.6
Kulkarni, H.7
Bamshad, M.J.8
Telles, V.9
Anderson, S.A.10
-
72
-
-
0027436791
-
Clinical-neuropathologic correlation in HIV-associated dementia
-
Glass, J. D., S. L. Wesselingh, O. A. Seines, and J. C. McArthur. 1993. Clinical-neuropathologic correlation in HIV-associated dementia. Neurology 43: 2230-2237.
-
(1993)
Neurology
, vol.43
, pp. 2230-2237
-
-
Glass, J.D.1
Wesselingh, S.L.2
Seines, O.A.3
McArthur, J.C.4
-
73
-
-
0032539828
-
Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia
-
Conant, K., A. Garzino-Demo, A. Nath, J. C. McArthur, W. Halliday, C. Power, R. C. Gallo, and E. O. Major. 1998. Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc. Natl. Acad. Sci. USA 95: 3117-3121.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3117-3121
-
-
Conant, K.1
Garzino-Demo, A.2
Nath, A.3
McArthur, J.C.4
Halliday, W.5
Power, C.6
Gallo, R.C.7
Major, E.O.8
-
74
-
-
0031572515
-
Activation of monocytes by HIV-Tat treatment is mediated by cytokine expression
-
Lafrenie, R. M., L. M. Wahl, J. S. Epstein, K. M. Yamada, and S. Dhawan. 1997. Activation of monocytes by HIV-Tat treatment is mediated by cytokine expression. J. Immunol. 159: 4077-4083.
-
(1997)
J. Immunol.
, vol.159
, pp. 4077-4083
-
-
Lafrenie, R.M.1
Wahl, L.M.2
Epstein, J.S.3
Yamada, K.M.4
Dhawan, S.5
-
75
-
-
0033546424
-
Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes: A hit and run phenomenon
-
Nath, A., K. Conant, P. Chen, C. Scott, and E. O. Major. 1999. Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes: a hit and run phenomenon. J. Biol. Chem. 274: 17098-17102.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17098-17102
-
-
Nath, A.1
Conant, K.2
Chen, P.3
Scott, C.4
Major, E.O.5
-
76
-
-
4444252806
-
Adenosine receptors control HIV-1 Tat-induced inflammatory responses through protein phosphatase
-
Fotheringham, J., M. Mayne, C. Holden, A. Nath, and J. D. Geiger. 2004. Adenosine receptors control HIV-1 Tat-induced inflammatory responses through protein phosphatase. Virology 327: 186-195.
-
(2004)
Virology
, vol.327
, pp. 186-195
-
-
Fotheringham, J.1
Mayne, M.2
Holden, C.3
Nath, A.4
Geiger, J.D.5
-
77
-
-
0034659771
-
Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-α production in human macrophages
-
Mayne, M., C. P. Holden, A. Nath, and J. D. Geiger. 2000. Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-α production in human macrophages. J. Immunol. 164: 6538-6542.
-
(2000)
J. Immunol.
, vol.164
, pp. 6538-6542
-
-
Mayne, M.1
Holden, C.P.2
Nath, A.3
Geiger, J.D.4
-
78
-
-
13144251117
-
HIV-1 Tat protein mimicry of chemokines
-
Albini, A., S. Ferrini, R. Benelli, S. Sforzini, D. Giunciuglio, M. G. Aluigi, A. E. Proudfoot, S. Alouani, T. N. Wells, G. Mariani, et al. 1998. HIV-1 Tat protein mimicry of chemokines. Proc. Natl. Acad. Sci. USA 95: 13153-13158.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13153-13158
-
-
Albini, A.1
Ferrini, S.2
Benelli, R.3
Sforzini, S.4
Giunciuglio, D.5
Aluigi, M.G.6
Proudfoot, A.E.7
Alouani, S.8
Wells, T.N.9
Mariani, G.10
-
79
-
-
12344307860
-
Human immunodeficiency virus type 1 Tat protein induces an intracellular calcium increase in human monocytes that requires DHP receptors: Involvement in TNF-α production
-
Contreras, X., Y. Bennasser, N. Chazal, M. Moreau, C. Leclerc, J. Tkaczuk, and E. Bahraoui. 2005. Human immunodeficiency virus type 1 Tat protein induces an intracellular calcium increase in human monocytes that requires DHP receptors: involvement in TNF-α production. Virology 332: 316-328.
-
(2005)
Virology
, vol.332
, pp. 316-328
-
-
Contreras, X.1
Bennasser, Y.2
Chazal, N.3
Moreau, M.4
Leclerc, C.5
Tkaczuk, J.6
Bahraoui, E.7
-
80
-
-
1542345590
-
Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: Implications for neuropathogenesis
-
Yi, Y., C. Lee, Q. H. Liu, B. D. Freedman, and R. G. Collman. 2004. Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: implications for neuropathogenesis. J. Neurovirol. 10(Suppl. 1): 91-96.
-
(2004)
J. Neurovirol.
, vol.10
, Issue.SUPPL. 1
, pp. 91-96
-
-
Yi, Y.1
Lee, C.2
Liu, Q.H.3
Freedman, B.D.4
Collman, R.G.5
-
81
-
-
0035892099
-
HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling
-
Del Corno, M., Q. H. Liu, D. Schols, E. de Clercq, S. Gessani, B. D. Freedman, and R. G. Collman. 2001. HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling. Blood 98: 2909-2916.
-
(2001)
Blood
, vol.98
, pp. 2909-2916
-
-
Del Corno, M.1
Liu, Q.H.2
Schols, D.3
De Clercq, E.4
Gessani, S.5
Freedman, B.D.6
Collman, R.G.7
-
82
-
-
1942486751
-
Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat
-
D'Aversa, T. G., K. O. Yu, and J. W. Berman. 2004. Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat. J. Neurovirol. 10: 86-97.
-
(2004)
J. Neurovirol.
, vol.10
, pp. 86-97
-
-
D'Aversa, T.G.1
Yu, K.O.2
Berman, J.W.3
-
83
-
-
17644373073
-
Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades
-
Brancho, D., J. J. Ventura, A. Jaeschke, B. Doran, R. A. Flavell, and R. J. Davis. 2005. Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Mol Cell Biol. 25: 3670-3681.
-
(2005)
Mol Cell Biol.
, vol.25
, pp. 3670-3681
-
-
Brancho, D.1
Ventura, J.J.2
Jaeschke, A.3
Doran, B.4
Flavell, R.A.5
Davis, R.J.6
|