K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK

Journal of Biological Chemistry

Volumn 277, Issue 51, 2002, Pages 49473-49480

  Roux, Philippe P ^a   Dorval, Geneviève ^a   Boudreau, Mathieu ^a   Angers Loustau, Alexandre ^a   Morris, Stephen J ^b   Makkerh, Joe ^a   Barker, Philip A ^a  

^a MCGILL UNIVERSITY   (Canada)

^b Aegera Therapeutics   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELLS; ENZYMES;

NEUROPROTECTIVE PROPERTIES;

ENZYME INHIBITION;

CEP 1347; K 252A; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MIXED LINEAGE KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STRAIN; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; NERVE CELL; NERVE CELL GROWTH; NEUROPROTECTION; NEUROTROPISM; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOVIRIDAE; ANIMALS; CARBAZOLES; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; INDOLES; INHIBITORY CONCENTRATION 50; MAP KINASE KINASE KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, CHEMICAL; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS;

ANIMALIA;

EID: 0037147130     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M203428200     Document Type: Article

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