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Volumn 2014, Issue APR, 2014, Pages

Cancer stem cells: Progress and challenges in lung cancer

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EID: 84924218745     PISSN: None     EISSN: 23069759     Source Type: Journal    
DOI: 10.3978/j.issn.2306-9759.2014.03.06     Document Type: Review
Times cited : (32)

References (176)
  • 1
    • 16844378799 scopus 로고    scopus 로고
    • Leukaemia stem cells and the evolution of cancer-stem-cell research
    • Huntly BJ, Gilliland DG. Leukaemia stem cells and the evolution of cancer-stem-cell research. Nat Rev Cancer 2005;5:311-21.
    • (2005) Nat Rev Cancer , vol.5 , pp. 311-321
    • Huntly, B.J.1    Gilliland, D.G.2
  • 2
    • 0002740313 scopus 로고
    • A Quantitative Assay for the Number of Murine Lymphoma Cells Capable of Proliferation in Vivo
    • Bruce WR, Van Der Gaag H. A Quantitative Assay for the Number of Murine Lymphoma Cells Capable of Proliferation in Vivo. Nature 1963;199:79-80.
    • (1963) Nature , vol.199 , pp. 79-80
    • Bruce, W.R.1    Van Der Gaag, H.2
  • 3
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-7.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 4
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003;63:5821-8.
    • (2003) Cancer Res , vol.63 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3
  • 5
    • 33846512398 scopus 로고    scopus 로고
    • Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
    • Prince ME, Sivanandan R, Kaczorowski A, et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A 2007;104:973-8.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 973-978
    • Prince, M.E.1    Sivanandan, R.2    Kaczorowski, A.3
  • 7
    • 39449088496 scopus 로고    scopus 로고
    • Identification and expansion of the tumorigenic lung cancer stem cell population
    • Eramo A, Lotti F, Sette G, et al. Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ 2008;15:504-14.
    • (2008) Cell Death Differ , vol.15 , pp. 504-514
    • Eramo, A.1    Lotti, F.2    Sette, G.3
  • 8
    • 38549139140 scopus 로고    scopus 로고
    • Significance of CD90+ cancer stem cells in human liver cancer
    • Yang ZF, Ho DW, Ng MN, et al. Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell 2008;13:153-66.
    • (2008) Cancer Cell , vol.13 , pp. 153-166
    • Yang, Z.F.1    Ho, D.W.2    Ng, M.N.3
  • 9
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O'Brien CA, Pollett A, Gallinger S, et al. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007;445:106-10.
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3
  • 10
    • 70449719361 scopus 로고    scopus 로고
    • Identification of human pancreatic cancer stem cells
    • Li C, Lee CJ, Simeone DM. Identification of human pancreatic cancer stem cells. Methods Mol Biol 2009;568:161-73.
    • (2009) Methods Mol Biol , vol.568 , pp. 161-173
    • Li, C.1    Lee, C.J.2    Simeone, D.M.3
  • 11
    • 49249091523 scopus 로고    scopus 로고
    • Identification and characterization of ovarian cancer-initiating cells from primary human tumors
    • Zhang S, Balch C, Chan MW, et al. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res 2008;68:4311-20.
    • (2008) Cancer Res , vol.68 , pp. 4311-4320
    • Zhang, S.1    Balch, C.2    Chan, M.W.3
  • 12
    • 28244472369 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic prostate cancer stem cells
    • Collins AT, Berry PA, Hyde C, et al. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 2005;65:10946-51.
    • (2005) Cancer Res , vol.65 , pp. 10946-10951
    • Collins, A.T.1    Berry, P.A.2    Hyde, C.3
  • 13
    • 34547113747 scopus 로고    scopus 로고
    • Tumor growth need not be driven by rare cancer stem cells
    • Kelly PN, Dakic A, Adams JM, et al. Tumor growth need not be driven by rare cancer stem cells. Science 2007;317:337.
    • (2007) Science , vol.317 , pp. 337
    • Kelly, P.N.1    Dakic, A.2    Adams, J.M.3
  • 14
    • 77953722864 scopus 로고    scopus 로고
    • The difficulty of targeting cancer stem cell niches
    • LaBarge MA. The difficulty of targeting cancer stem cell niches. Clin Cancer Res 2010;16:3121-9.
    • (2010) Clin Cancer Res , vol.16 , pp. 3121-3129
    • LaBarge, M.A.1
  • 15
    • 33646428091 scopus 로고    scopus 로고
    • Normal stem cells and cancer stem cells: The niche matters
    • Li L, Neaves WB. Normal stem cells and cancer stem cells: the niche matters. Cancer Res 2006;66:4553-7.
    • (2006) Cancer Res , vol.66 , pp. 4553-4557
    • Li, L.1    Neaves, W.B.2
  • 16
    • 28444486367 scopus 로고    scopus 로고
    • Stem cell niche: Structure and function
    • Li L, Xie T. Stem cell niche: structure and function. Annu Rev Cell Dev Biol 2005;21:605-31.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 605-631
    • Li, L.1    Xie, T.2
  • 17
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nature Reviews Cancer 2009;9:239-52.
    • (2009) Nature Reviews Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 18
    • 79551519982 scopus 로고    scopus 로고
    • Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice
    • Elkabets M, Gifford AM, Scheel C, et al. Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J Clin Invest 2011;121:784-99.
    • (2011) J Clin Invest , vol.121 , pp. 784-799
    • Elkabets, M.1    Gifford, A.M.2    Scheel, C.3
  • 20
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NFkappaB- Dependent Manner
    • Erez N, Truitt M, Olson P, et al. Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NFkappaB- Dependent Manner. Cancer Cell 2010;17:135-47.
    • (2010) Cancer Cell , vol.17 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3
  • 21
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/ CXCL12 secretion
    • Orimo A, Gupta PB, Sgroi DC, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/ CXCL12 secretion. Cell 2005;121:335-48.
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3
  • 22
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelialmesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelialmesenchymal transition. J Clin Invest 2009;119:1420-8.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 24
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • Tlsty TD, Coussens LM. Tumor stroma and regulation of cancer development. Annu Rev Pathol 2006;1:119-50.
    • (2006) Annu Rev Pathol , vol.1 , pp. 119-150
    • Tlsty, T.D.1    Coussens, L.M.2
  • 25
    • 84879463046 scopus 로고    scopus 로고
    • The Potential for Resident Lung Mesenchymal Stem Cells to Promote Functional Tissue Regeneration: Understanding Microenvironmental Cues
    • Foronjy RF, Majka SM. The Potential for Resident Lung Mesenchymal Stem Cells to Promote Functional Tissue Regeneration: Understanding Microenvironmental Cues. Cells 2012;1:874.
    • (2012) Cells , vol.1 , pp. 874
    • Foronjy, R.F.1    Majka, S.M.2
  • 27
    • 0036328019 scopus 로고    scopus 로고
    • Organ- and tissue-specific stem cells and carcinogenesis
    • Pathak S. Organ- and tissue-specific stem cells and carcinogenesis. Anticancer Res 2002;22:1353-6.
    • (2002) Anticancer Res , vol.22 , pp. 1353-1356
    • Pathak, S.1
  • 28
    • 0034948357 scopus 로고    scopus 로고
    • Cellular and molecular characteristics of basal cells in airway epithelium
    • Evans MJ, Van Winkle LS, Fanucchi MV, et al. Cellular and molecular characteristics of basal cells in airway epithelium. Exp Lung Res 2001;27:401-15.
    • (2001) Exp Lung Res , vol.27 , pp. 401-415
    • Evans, M.J.1    Van Winkle, L.S.2    Fanucchi, M.V.3
  • 29
    • 69149106207 scopus 로고    scopus 로고
    • Basal cells as stem cells of the mouse trachea and human airway epithelium
    • Rock JR, Onaitis MW, Rawlins EL, et al. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci U S A 2009;106:12771-5.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12771-12775
    • Rock, J.R.1    Onaitis, M.W.2    Rawlins, E.L.3
  • 30
    • 0032440058 scopus 로고    scopus 로고
    • Immunohistochemical and ultrastructural studies of basal cells, Clara cells and bronchiolar cuboidal cells in normal human airways
    • Nakajima M, Kawanami O, Jin E, et al. Immunohistochemical and ultrastructural studies of basal cells, Clara cells and bronchiolar cuboidal cells in normal human airways. Pathol Int 1998;48:944-53.
    • (1998) Pathol Int , vol.48 , pp. 944-953
    • Nakajima, M.1    Kawanami, O.2    Jin, E.3
  • 32
    • 0031862237 scopus 로고    scopus 로고
    • Number and proliferation of basal and parabasal cells in normal human airway epithelium
    • Boers JE, Ambergen AW, Thunnissen FB. Number and proliferation of basal and parabasal cells in normal human airway epithelium. Am J Respir Crit Care Med 1998;157:2000-6.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 2000-2006
    • Boers, J.E.1    Ambergen, A.W.2    Thunnissen, F.B.3
  • 34
    • 0030909517 scopus 로고    scopus 로고
    • Cell proliferation contributes to PNEC hyperplasia after acute airway injury
    • Stevens TP, McBride JT, Peake JL, et al. Cell proliferation contributes to PNEC hyperplasia after acute airway injury. Am J Physiol 1997;272:L486-93.
    • (1997) Am J Physiol , vol.272 , pp. L486-L493
    • Stevens, T.P.1    McBride, J.T.2    Peake, J.L.3
  • 35
    • 1642269178 scopus 로고    scopus 로고
    • In vivo differentiation potential of tracheal basal cells: Evidence for multipotent and unipotent subpopulations
    • Hong KU, Reynolds SD, Watkins S, et al. In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations. Am J Physiol Lung Cell Mol Physiol 2004;286:L643-9.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286 , pp. L643-L649
    • Hong, K.U.1    Reynolds, S.D.2    Watkins, S.3
  • 36
    • 20444397431 scopus 로고    scopus 로고
    • Identification of bronchioalveolar stem cells in normal lung and lung cancer
    • Kim CF, Jackson EL, Woolfenden AE, et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 2005;121:823-35.
    • (2005) Cell , vol.121 , pp. 823-835
    • Kim, C.F.1    Jackson, E.L.2    Woolfenden, A.E.3
  • 37
    • 0029584831 scopus 로고
    • Plasticity of airway cell proliferation and gene expression after acute naphthalene injury
    • Stripp BR, Maxson K, Mera R, et al. Plasticity of airway cell proliferation and gene expression after acute naphthalene injury. Am J Physiol 1995;269:L791-9.
    • (1995) Am J Physiol , vol.269 , pp. L791-L799
    • Stripp, B.R.1    Maxson, K.2    Mera, R.3
  • 38
    • 77349109478 scopus 로고    scopus 로고
    • Evidence for selfrenewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy
    • Sullivan JP, Minna JD, Shay JW. Evidence for selfrenewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Rev 2010;29:61-72.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 61-72
    • Sullivan, J.P.1    Minna, J.D.2    Shay, J.W.3
  • 39
    • 0019231212 scopus 로고
    • Cell proliferation in the mammalian lung
    • Kauffman SL. Cell proliferation in the mammalian lung. Int Rev Exp Pathol 1980;22:131-91.
    • (1980) Int Rev Exp Pathol , vol.22 , pp. 131-191
    • Kauffman, S.L.1
  • 40
    • 33846275259 scopus 로고    scopus 로고
    • Lung development and repair: Contribution of the ciliated lineage
    • Rawlins EL, Ostrowski LE, Randell SH, et al. Lung development and repair: contribution of the ciliated lineage. Proc Natl Acad Sci U S A 2007;104:410-7.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 410-417
    • Rawlins, E.L.1    Ostrowski, L.E.2    Randell, S.H.3
  • 41
    • 1642382947 scopus 로고    scopus 로고
    • A subset of mouse tracheal epithelial basal cells generates large colonies in vitro
    • Schoch KG, Lori A, Burns KA, et al. A subset of mouse tracheal epithelial basal cells generates large colonies in vitro. Am J Physiol Lung Cell Mol Physiol 2004;286:L631-42.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286 , pp. L631-L642
    • Schoch, K.G.1    Lori, A.2    Burns, K.A.3
  • 42
    • 0026180660 scopus 로고
    • Properties of rat tracheal epithelial cells separated based on expression of cell surface alpha-galactosyl end groups
    • Randell SH, Comment CE, Ramaekers FC, et al. Properties of rat tracheal epithelial cells separated based on expression of cell surface alpha-galactosyl end groups. Am J Respir Cell Mol Biol 1991;4:544-54.
    • (1991) Am J Respir Cell Mol Biol , vol.4 , pp. 544-554
    • Randell, S.H.1    Comment, C.E.2    Ramaekers, F.C.3
  • 43
    • 33846016908 scopus 로고    scopus 로고
    • Basal cells of the human adult airway surface epithelium retain transitamplifying cell properties
    • Hajj R, Baranek T, Le Naour R, et al. Basal cells of the human adult airway surface epithelium retain transitamplifying cell properties. Stem Cells 2007;25:139-48.
    • (2007) Stem Cells , vol.25 , pp. 139-148
    • Hajj, R.1    Baranek, T.2    Le Naour, R.3
  • 44
    • 23844477177 scopus 로고    scopus 로고
    • Aquaporin-3 expression in human fetal airway epithelial progenitor cells
    • Avril-Delplanque A, Casal I, Castillon N, et al. Aquaporin-3 expression in human fetal airway epithelial progenitor cells. Stem Cells 2005;23:992-1001.
    • (2005) Stem Cells , vol.23 , pp. 992-1001
    • Avril-Delplanque, A.1    Casal, I.2    Castillon, N.3
  • 45
    • 34447530782 scopus 로고    scopus 로고
    • Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm
    • Que J, Okubo T, Goldenring JR, et al. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development 2007;134:2521-31.
    • (2007) Development , vol.134 , pp. 2521-2531
    • Que, J.1    Okubo, T.2    Goldenring, J.R.3
  • 46
    • 69549090537 scopus 로고    scopus 로고
    • Multiple roles for Sox2 in the developing and adult mouse trachea
    • Que J, Luo X, Schwartz RJ, Hogan BL. Multiple roles for Sox2 in the developing and adult mouse trachea. Development 2009;136:1899-907.
    • (2009) Development , vol.136 , pp. 1899-1907
    • Que, J.1    Luo, X.2    Schwartz, R.J.3    Hogan, B.L.4
  • 47
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 48
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-20.
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3
  • 49
    • 34249908901 scopus 로고    scopus 로고
    • In vitro reprogramming of fibroblasts into a pluripotent ES-celllike state
    • Wernig M, Meissner A, Foreman R, et al. In vitro reprogramming of fibroblasts into a pluripotent ES-celllike state. Nature 2007;448:318-24.
    • (2007) Nature , vol.448 , pp. 318-324
    • Wernig, M.1    Meissner, A.2    Foreman, R.3
  • 50
    • 0017201538 scopus 로고
    • Renewal of the terminal bronchiolar epithelium in the rat following exposure to NO2 or O3
    • Evans MJ, Johnson LV, Stephens RJ, et al. Renewal of the terminal bronchiolar epithelium in the rat following exposure to NO2 or O3. Lab Invest 1976;35:246-57.
    • (1976) Lab Invest , vol.35 , pp. 246-257
    • Evans, M.J.1    Johnson, L.V.2    Stephens, R.J.3
  • 51
    • 84865084976 scopus 로고    scopus 로고
    • Novel method for isolation of murine clara cell secretory proteinexpressing cells with traces of stemness
    • Wang XY, Keefe KM, Jensen-Taubman SM, et al. Novel method for isolation of murine clara cell secretory proteinexpressing cells with traces of stemness. PLoS One 2012;7:e43008.
    • (2012) PLoS One , vol.7
    • Wang, X.Y.1    Keefe, K.M.2    Jensen-Taubman, S.M.3
  • 52
    • 0034974148 scopus 로고    scopus 로고
    • Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion
    • Hong KU, Reynolds SD, Giangreco A, et al. Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. Am J Respir Cell Mol Biol 2001;24:671-81.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 671-681
    • Hong, K.U.1    Reynolds, S.D.2    Giangreco, A.3
  • 53
    • 33745459322 scopus 로고    scopus 로고
    • Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro
    • Ling TY, Kuo MD, Li CL, et al. Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro. Proc Natl Acad Sci U S A 2006;103:9530-5.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 9530-9535
    • Ling, T.Y.1    Kuo, M.D.2    Li, C.L.3
  • 54
    • 0033875885 scopus 로고    scopus 로고
    • Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration
    • Reynolds SD, Giangreco A, Power JH, et al. Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration. Am J Pathol 2000;156:269-78.
    • (2000) Am J Pathol , vol.156 , pp. 269-278
    • Reynolds, S.D.1    Giangreco, A.2    Power, J.H.3
  • 55
    • 0033932143 scopus 로고    scopus 로고
    • Conditional clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells
    • Reynolds SD, Hong KU, Giangreco A, et al. Conditional clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells. Am J Physiol Lung Cell Mol Physiol 2000;278:L1256-63.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.278 , pp. L1256-L1263
    • Reynolds, S.D.1    Hong, K.U.2    Giangreco, A.3
  • 56
    • 0036314791 scopus 로고    scopus 로고
    • Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction
    • Giangreco A, Reynolds SD, Stripp BR. Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. Am J Pathol 2002;161:173-82.
    • (2002) Am J Pathol , vol.161 , pp. 173-182
    • Giangreco, A.1    Reynolds, S.D.2    Stripp, B.R.3
  • 57
    • 66049083441 scopus 로고    scopus 로고
    • The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium
    • Rawlins EL, Okubo T, Xue Y, et al. The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell 2009;4:525-34.
    • (2009) Cell Stem Cell , vol.4 , pp. 525-534
    • Rawlins, E.L.1    Okubo, T.2    Xue, Y.3
  • 58
    • 80155148257 scopus 로고    scopus 로고
    • Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection
    • Kumar PA, Hu Y, Yamamoto Y, et al. Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell 2011;147:525-38.
    • (2011) Cell , vol.147 , pp. 525-538
    • Kumar, P.A.1    Hu, Y.2    Yamamoto, Y.3
  • 59
    • 0035893252 scopus 로고    scopus 로고
    • Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
    • Jackson EL, Willis N, Mercer K, et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 2001;15:3243-8.
    • (2001) Genes Dev , vol.15 , pp. 3243-3248
    • Jackson, E.L.1    Willis, N.2    Mercer, K.3
  • 60
    • 79951993290 scopus 로고    scopus 로고
    • Lung adenocarcinoma stem cell phenotypes and their correlation with patient prognosis
    • Zhang XY, Zheng BQ, Han BH, et al. Lung adenocarcinoma stem cell phenotypes and their correlation with patient prognosis. Zhonghua Zhong Liu Za Zhi 2009;31:836-40.
    • (2009) Zhonghua Zhong Liu Za Zhi , vol.31 , pp. 836-840
    • Zhang, X.Y.1    Zheng, B.Q.2    Han, B.H.3
  • 61
    • 79955924124 scopus 로고    scopus 로고
    • Evidence for human lung stem cells
    • Kajstura J, Rota M, Hall SR, et al. Evidence for human lung stem cells. N Engl J Med 2011;364:1795-806.
    • (2011) N Engl J Med , vol.364 , pp. 1795-1806
    • Kajstura, J.1    Rota, M.2    Hall, S.R.3
  • 62
    • 21844432133 scopus 로고    scopus 로고
    • Dedifferentiation of adult human myoblasts induced by ciliary neurotrophic factor in vitro
    • Chen X, Mao Z, Liu S, et al. Dedifferentiation of adult human myoblasts induced by ciliary neurotrophic factor in vitro. Mol Biol Cell 2005;16:3140-51.
    • (2005) Mol Biol Cell , vol.16 , pp. 3140-3151
    • Chen, X.1    Mao, Z.2    Liu, S.3
  • 63
    • 34547872767 scopus 로고    scopus 로고
    • New sources of pancreatic beta cells
    • Porat S, Dor Y. New sources of pancreatic beta cells. Current Diabetes Reports 2007;7:304-8.
    • (2007) Current Diabetes Reports , vol.7 , pp. 304-308
    • Porat, S.1    Dor, Y.2
  • 64
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    • Zhou Q, Brown J, Kanarek A, et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008;455:627-32.
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3
  • 65
    • 55849117368 scopus 로고    scopus 로고
    • Generation of mouse induced pluripotent stem cells without viral vectors
    • Okita K, Nakagawa M, Hyenjong H, et al. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008;322:949-53.
    • (2008) Science , vol.322 , pp. 949-953
    • Okita, K.1    Nakagawa, M.2    Hyenjong, H.3
  • 66
    • 79955106228 scopus 로고    scopus 로고
    • Prognostic value of CD133 expression in stage i lung adenocarcinomas
    • Woo T, Okudela K, Mitsui H, et al. Prognostic value of CD133 expression in stage I lung adenocarcinomas. Int J Clin Exp Pathol 2010;4:32-42.
    • (2010) Int J Clin Exp Pathol , vol.4 , pp. 32-42
    • Woo, T.1    Okudela, K.2    Mitsui, H.3
  • 67
    • 68349083134 scopus 로고    scopus 로고
    • Association of CD133 and endothelin-converting enzyme expressions with prognosis of non-small cell lung carcinoma
    • Zhang HZ, Wei YP, Wang M, et al. Association of CD133 and endothelin-converting enzyme expressions with prognosis of non-small cell lung carcinoma. Nan Fang Yi Ke Da Xue Xue Bao 2007;27:696-9.
    • (2007) Nan Fang Yi Ke da Xue Xue Bao , vol.27 , pp. 696-699
    • Zhang, H.Z.1    Wei, Y.P.2    Wang, M.3
  • 68
    • 49949111381 scopus 로고    scopus 로고
    • Oct-4 expression maintained cancer stem-like properties in lung cancerderived CD133-positive cells
    • Chen YC, Hsu HS, Chen YW, et al. Oct-4 expression maintained cancer stem-like properties in lung cancerderived CD133-positive cells. PLoS One 2008;3:e2637.
    • (2008) PLoS One , vol.3
    • Chen, Y.C.1    Hsu, H.S.2    Chen, Y.W.3
  • 69
    • 4444251520 scopus 로고    scopus 로고
    • CD133 positive endothelial progenitor cells contribute to the tumour vasculature in non-small cell lung cancer
    • Hilbe W, Dirnhofer S, Oberwasserlechner F, et al. CD133 positive endothelial progenitor cells contribute to the tumour vasculature in non-small cell lung cancer. J Clin Pathol 2004;57:965-9.
    • (2004) J Clin Pathol , vol.57 , pp. 965-969
    • Hilbe, W.1    Dirnhofer, S.2    Oberwasserlechner, F.3
  • 70
    • 79960348627 scopus 로고    scopus 로고
    • Selection of radioresistant tumor cells and presence of ALDH1 activity in vitro
    • Mihatsch J, Toulany M, Bareiss PM, et al. Selection of radioresistant tumor cells and presence of ALDH1 activity in vitro. Radiother Oncol 2011;99:300-6.
    • (2011) Radiother Oncol , vol.99 , pp. 300-306
    • Mihatsch, J.1    Toulany, M.2    Bareiss, P.M.3
  • 71
    • 84655175065 scopus 로고    scopus 로고
    • The combination of stem cell markers CD133 and ABCG2 predicts relapse in stage i nonsmall cell lung carcinomas
    • Li F, Zeng H, Ying K. The combination of stem cell markers CD133 and ABCG2 predicts relapse in stage I nonsmall cell lung carcinomas. Med Oncol 2011;28:1458-62.
    • (2011) Med Oncol , vol.28 , pp. 1458-1462
    • Li, F.1    Zeng, H.2    Ying, K.3
  • 72
    • 84899967059 scopus 로고    scopus 로고
    • CD133 expression: A potential prognostic marker for non-small cell lung cancers
    • Mizugaki H, Sakakibara-Konishi J, Kikuchi J, et al. CD133 expression: a potential prognostic marker for non-small cell lung cancers. Int J Clin Oncol 2014;19:254-9.
    • (2014) Int J Clin Oncol , vol.19 , pp. 254-259
    • Mizugaki, H.1    Sakakibara-Konishi, J.2    Kikuchi, J.3
  • 73
    • 84871392441 scopus 로고    scopus 로고
    • Expression of the potential cancer stem cell markers, CD133, CD44, ALDH1, and beta-catenin, in primary lung adenocarcinoma-their prognostic significance
    • Okudela K, Woo T, Mitsui H, et al. Expression of the potential cancer stem cell markers, CD133, CD44, ALDH1, and beta-catenin, in primary lung adenocarcinoma--their prognostic significance. Pathol Int 2012;62:792-801.
    • (2012) Pathol Int , vol.62 , pp. 792-801
    • Okudela, K.1    Woo, T.2    Mitsui, H.3
  • 74
    • 74049105514 scopus 로고    scopus 로고
    • CD133 is indicative for a resistance phenotype but does not represent a prognostic marker for survival of non-small cell lung cancer patients
    • Salnikov AV, Gladkich J, Moldenhauer G, et al. CD133 is indicative for a resistance phenotype but does not represent a prognostic marker for survival of non-small cell lung cancer patients. Int J Cancer 2010;126:950-8.
    • (2010) Int J Cancer , vol.126 , pp. 950-958
    • Salnikov, A.V.1    Gladkich, J.2    Moldenhauer, G.3
  • 75
    • 84872275911 scopus 로고    scopus 로고
    • Subpopulation of smallcell lung cancer cells expressing CD133 and CD87 show resistance to chemotherapy
    • Kubo T, Takigawa N, Osawa M, et al. Subpopulation of smallcell lung cancer cells expressing CD133 and CD87 show resistance to chemotherapy. Cancer Sci 2013;104:78-84.
    • (2013) Cancer Sci , vol.104 , pp. 78-84
    • Kubo, T.1    Takigawa, N.2    Osawa, M.3
  • 76
    • 67649890779 scopus 로고    scopus 로고
    • Both CD133+ and CD133- subpopulations of A549 and H446 cells contain cancerinitiating cells
    • Meng X, Li M, Wang X, et al. Both CD133+ and CD133- subpopulations of A549 and H446 cells contain cancerinitiating cells. Cancer Sci 2009;100:1040-6.
    • (2009) Cancer Sci , vol.100 , pp. 1040-1046
    • Meng, X.1    Li, M.2    Wang, X.3
  • 77
    • 79551605961 scopus 로고    scopus 로고
    • CD133 is a temporary marker of cancer stem cells in small cell lung cancer, but not in nonsmall cell lung cancer
    • Cui F, Wang J, Chen D, et al. CD133 is a temporary marker of cancer stem cells in small cell lung cancer, but not in nonsmall cell lung cancer. Oncol Rep 2011;25:701-8.
    • (2011) Oncol Rep , vol.25 , pp. 701-708
    • Cui, F.1    Wang, J.2    Chen, D.3
  • 78
    • 49749144107 scopus 로고    scopus 로고
    • The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells
    • Bidlingmaier S, Zhu X, Liu B. The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells. J Mol Med (Berl) 2008;86:1025-32.
    • (2008) J Mol Med (Berl) , vol.86 , pp. 1025-1032
    • Bidlingmaier, S.1    Zhu, X.2    Liu, B.3
  • 79
    • 0028242956 scopus 로고
    • CD44 in differentiated embryonic stem cells: Surface expression and transcripts encoding multiple variants
    • Haegel H, Dierich A, Ceredig R. CD44 in differentiated embryonic stem cells: surface expression and transcripts encoding multiple variants. Dev Immunol 1994;3:239-46.
    • (1994) Dev Immunol , vol.3 , pp. 239-246
    • Haegel, H.1    Dierich, A.2    Ceredig, R.3
  • 80
    • 84866856496 scopus 로고    scopus 로고
    • Multiple myeloma-related deregulation of bone marrow-derived CD34(+) hematopoietic stem and progenitor cells
    • Bruns I, Cadeddu RP, Brueckmann I, et al. Multiple myeloma-related deregulation of bone marrow-derived CD34(+) hematopoietic stem and progenitor cells. Blood 2012;120:2620-30.
    • (2012) Blood , vol.120 , pp. 2620-2630
    • Bruns, I.1    Cadeddu, R.P.2    Brueckmann, I.3
  • 81
    • 0035889146 scopus 로고    scopus 로고
    • Identification of mesenchymal stem/progenitor cells in human firsttrimester fetal blood, liver, and bone marrow
    • Campagnoli C, Roberts IA, Kumar S, et al. Identification of mesenchymal stem/progenitor cells in human firsttrimester fetal blood, liver, and bone marrow. Blood 2001;98:2396-402.
    • (2001) Blood , vol.98 , pp. 2396-2402
    • Campagnoli, C.1    Roberts, I.A.2    Kumar, S.3
  • 82
    • 58149269566 scopus 로고    scopus 로고
    • CD44 is of functional importance for colorectal cancer stem cells
    • Du L, Wang H, He L, et al. CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res 2008;14:6751-60.
    • (2008) Clin Cancer Res , vol.14 , pp. 6751-6760
    • Du, L.1    Wang, H.2    He, L.3
  • 83
    • 34547193404 scopus 로고    scopus 로고
    • Phenotypic characterization of human colorectal cancer stem cells
    • Dalerba P, Dylla SJ, Park IK, et al. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A 2007;104:10158-63.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10158-10163
    • Dalerba, P.1    Dylla, S.J.2    Park, I.K.3
  • 84
    • 21344454219 scopus 로고    scopus 로고
    • Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/ progenitor cell properties
    • Ponti D, Costa A, Zaffaroni N, et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/ progenitor cell properties. Cancer Res 2005;65:5506-11.
    • (2005) Cancer Res , vol.65 , pp. 5506-5511
    • Ponti, D.1    Costa, A.2    Zaffaroni, N.3
  • 85
    • 33645026803 scopus 로고    scopus 로고
    • Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells
    • Patrawala L, Calhoun T, Schneider-Broussard R, et al. Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene 2006;25:1696-708.
    • (2006) Oncogene , vol.25 , pp. 1696-1708
    • Patrawala, L.1    Calhoun, T.2    Schneider-Broussard, R.3
  • 86
    • 79955660106 scopus 로고    scopus 로고
    • Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells
    • Rybak AP1, He L, Kapoor A, et al. Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells. Biochim Biophys Acta 2011;1813:683-94.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 683-694
    • Ap, R.1    He, L.2    Kapoor, A.3
  • 87
    • 84863388257 scopus 로고    scopus 로고
    • Hyaluronan regulates cell behavior: A potential niche matrix for stem cells
    • Solis MA, Chen YH, Wong TY, et al. Hyaluronan regulates cell behavior: a potential niche matrix for stem cells. Biochem Res Int 2012;2012:346972.
    • (2012) Biochem Res Int , vol.2012 , pp. 346972
    • Solis, M.A.1    Chen, Y.H.2    Wong, T.Y.3
  • 88
    • 0028271337 scopus 로고
    • Expression of CD44 in human lung tumors
    • Penno MB, August JT, Baylin SB, et al. Expression of CD44 in human lung tumors. Cancer Res 1994;54:1381-7.
    • (1994) Cancer Res , vol.54 , pp. 1381-1387
    • Penno, M.B.1    August, J.T.2    Baylin, S.B.3
  • 89
    • 78649522166 scopus 로고    scopus 로고
    • Non-small cell lung cancer cells expressing CD44 are enriched for stem celllike properties
    • Leung EL, Fiscus RR, Tung JW, et al. Non-small cell lung cancer cells expressing CD44 are enriched for stem celllike properties. PLoS One 2010;5:e14062.
    • (2010) PLoS One , vol.5
    • Leung, E.L.1    Fiscus, R.R.2    Tung, J.W.3
  • 90
    • 0023952342 scopus 로고
    • Characterization of cytosolic aldehyde dehydrogenase from cyclophosphamide resistant L1210 cells
    • Russo JE, Hilton J. Characterization of cytosolic aldehyde dehydrogenase from cyclophosphamide resistant L1210 cells. Cancer Res 1988;48:2963-8.
    • (1988) Cancer Res , vol.48 , pp. 2963-2968
    • Russo, J.E.1    Hilton, J.2
  • 91
    • 40249108437 scopus 로고    scopus 로고
    • ALDH1A1 and ALDH3A1 expression in lung cancers: Correlation with histologic type and potential precursors
    • Patel M, Lu L, Zander DS, et al. ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors. Lung Cancer 2008;59:340-9.
    • (2008) Lung Cancer , vol.59 , pp. 340-349
    • Patel, M.1    Lu, L.2    Zander, D.S.3
  • 92
    • 78649960144 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling
    • Sullivan JP, Spinola M, Dodge M, et al. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res 2010;70:9937-48.
    • (2010) Cancer Res , vol.70 , pp. 9937-9948
    • Sullivan, J.P.1    Spinola, M.2    Dodge, M.3
  • 93
    • 84864865194 scopus 로고    scopus 로고
    • Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity
    • Akunuru S, James Zhai Q, Zheng Y. Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity. Cell Death Dis 2012;3:e352.
    • (2012) Cell Death Dis , vol.3 , pp. e352
    • Akunuru, S.1    James Zhai, Q.2    Zheng, Y.3
  • 94
    • 84868496506 scopus 로고    scopus 로고
    • ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors
    • Huang CP, Tsai MF, Chang TH, et al. ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Cancer Lett 2013;328:144-51.
    • (2013) Cancer Lett , vol.328 , pp. 144-151
    • Huang, C.P.1    Tsai, M.F.2    Chang, T.H.3
  • 95
    • 58049221188 scopus 로고    scopus 로고
    • ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells
    • Moreb JS, Baker HV, Chang LJ, et al. ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells. Mol Cancer 2008;7:87.
    • (2008) Mol Cancer , vol.7 , pp. 87
    • Moreb, J.S.1    Baker, H.V.2    Chang, L.J.3
  • 96
    • 34250877411 scopus 로고    scopus 로고
    • Heterogeneity of aldehyde dehydrogenase expression in lung cancer cell lines is revealed by Aldefluor flow cytometry-based assay
    • Moreb JS, Zucali JR, Ostmark B, et al. Heterogeneity of aldehyde dehydrogenase expression in lung cancer cell lines is revealed by Aldefluor flow cytometry-based assay. Cytometry B Clin Cytom 2007;72:281-9.
    • (2007) Cytometry B Clin Cytom , vol.72 , pp. 281-289
    • Moreb, J.S.1    Zucali, J.R.2    Ostmark, B.3
  • 97
    • 67349191354 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase as a marker for stem cells
    • Moreb JS. Aldehyde dehydrogenase as a marker for stem cells. Curr Stem Cell Res Ther 2008;3:237-46.
    • (2008) Curr Stem Cell Res Ther , vol.3 , pp. 237-246
    • Moreb, J.S.1
  • 98
    • 59049095990 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase activity as a functional marker for lung cancer
    • Ucar D, Cogle CR, Zucali JR, et al. Aldehyde dehydrogenase activity as a functional marker for lung cancer. Chem Biol Interact 2009;178:48-55.
    • (2009) Chem Biol Interact , vol.178 , pp. 48-55
    • Ucar, D.1    Cogle, C.R.2    Zucali, J.R.3
  • 99
    • 85043560114 scopus 로고    scopus 로고
    • Cancer Stem Cells in Lung Cancer: Distinct Differences between Small Cell and Non-Small Cell Lung Carcinomas
    • Shostak S. ed., InTech;
    • Okudela K, Nagahara N, Katayama A, et al. Cancer Stem Cells in Lung Cancer: Distinct Differences between Small Cell and Non-Small Cell Lung Carcinomas. In: Shostak S. ed. Cancer Stem Cells Theories and Practice. InTech; 2011.
    • (2011) Cancer Stem Cells Theories and Practice
    • Okudela, K.1    Nagahara, N.2    Katayama, A.3
  • 100
    • 0032903793 scopus 로고    scopus 로고
    • HCA, an immunoglobulin-like adhesion molecule present on the earliest human hematopoietic precursor cells, is also expressed by stromal cells in blood-forming tissues
    • Cortés F, Deschaseaux F, Uchida N, et al. HCA, an immunoglobulin-like adhesion molecule present on the earliest human hematopoietic precursor cells, is also expressed by stromal cells in blood-forming tissues. Blood 1999;93:826-37.
    • (1999) Blood , vol.93 , pp. 826-837
    • Cortés, F.1    Deschaseaux, F.2    Uchida, N.3
  • 101
    • 78649689208 scopus 로고    scopus 로고
    • Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract
    • Levin TG, Powell AE, Davies PS, et al. Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract. Gastroenterology 2010;139:2072-82.e5.
    • (2010) Gastroenterology , vol.139 , pp. 2072
    • Levin, T.G.1    Powell, A.E.2    Davies, P.S.3
  • 102
    • 84864571560 scopus 로고    scopus 로고
    • Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells
    • Jiao J, Hindoyan A, Wang S, et al. Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. PLoS One 2012;7:e42564.
    • (2012) PLoS One , vol.7
    • Jiao, J.1    Hindoyan, A.2    Wang, S.3
  • 103
    • 0037218432 scopus 로고    scopus 로고
    • ALCAM/CD166 is up-regulated in low-grade prostate cancer and progressively lost in high-grade lesions
    • Kristiansen G, Pilarsky C, Wissmann C, et al. ALCAM/CD166 is up-regulated in low-grade prostate cancer and progressively lost in high-grade lesions. Prostate 2003;54:34-43.
    • (2003) Prostate , vol.54 , pp. 34-43
    • Kristiansen, G.1    Pilarsky, C.2    Wissmann, C.3
  • 104
    • 84866946180 scopus 로고    scopus 로고
    • CD166/activated leukocyte cell adhesion molecule is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion
    • Kijima N, Hosen N, Kagawa N, et al. CD166/activated leukocyte cell adhesion molecule is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion. Neuro Oncol 2012;14:1254-64.
    • (2012) Neuro Oncol , vol.14 , pp. 1254-1264
    • Kijima, N.1    Hosen, N.2    Kagawa, N.3
  • 105
    • 84856087055 scopus 로고    scopus 로고
    • Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis
    • Zhang WC, Shyh-Chang N, Yang H, et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 2012;148:259-72.
    • (2012) Cell , vol.148 , pp. 259-272
    • Zhang, W.C.1    Shyh-Chang, N.2    Yang, H.3
  • 106
    • 84870585138 scopus 로고    scopus 로고
    • CD166(pos) subpopulation from differentiated human ES and iPS cells support repair of acute lung injury
    • Soh BS, Zheng D, Li Yeo JS, et al. CD166(pos) subpopulation from differentiated human ES and iPS cells support repair of acute lung injury. Mol Ther 2012;20:2335-46.
    • (2012) Mol Ther , vol.20 , pp. 2335-2346
    • Soh, B.S.1    Zheng, D.2    Li Yeo, J.S.3
  • 107
    • 0035877978 scopus 로고    scopus 로고
    • Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma
    • van Kemenade FJ, Raaphorst FM, Blokzijl T, et al. Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma. Blood 2001;97:3896-901.
    • (2001) Blood , vol.97 , pp. 3896-3901
    • Van Kemenade, F.J.1    Raaphorst, F.M.2    Blokzijl, T.3
  • 108
    • 80052289137 scopus 로고    scopus 로고
    • Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci
    • Zacharek SJ, Fillmore CM, Lau AN, et al. Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci. Cell Stem Cell 2011;9:272-81.
    • (2011) Cell Stem Cell , vol.9 , pp. 272-281
    • Zacharek, S.J.1    Fillmore, C.M.2    Lau, A.N.3
  • 109
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003;423:255-60.
    • (2003) Nature , vol.423 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 110
    • 70349479538 scopus 로고    scopus 로고
    • Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
    • Bertolini G, Roz L, Perego P, et al. Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment. Proc Natl Acad Sci U S A 2009;106:16281-6.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 16281-16286
    • Bertolini, G.1    Roz, L.2    Perego, P.3
  • 111
    • 49649083394 scopus 로고    scopus 로고
    • Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: A tissue microarray study
    • Vrzalikova K, Skarda J, Ehrmann J, et al. Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: a tissue microarray study. J Cancer Res Clin Oncol 2008;134:1037-42.
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 1037-1042
    • Vrzalikova, K.1    Skarda, J.2    Ehrmann, J.3
  • 112
    • 72849130207 scopus 로고    scopus 로고
    • The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
    • Song LB, Li J, Liao WT, et al. The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest 2009;119:3626-36.
    • (2009) J Clin Invest , vol.119 , pp. 3626-3636
    • Song, L.B.1    Li, J.2    Liao, W.T.3
  • 113
    • 84862822127 scopus 로고    scopus 로고
    • ShRNA-mediated knockdown of Bmi-1 inhibit lung adenocarcinoma cell migration and metastasis
    • Meng X, Wang Y, Zheng X, et al. shRNA-mediated knockdown of Bmi-1 inhibit lung adenocarcinoma cell migration and metastasis. Lung Cancer 2012;77:24-30.
    • (2012) Lung Cancer , vol.77 , pp. 24-30
    • Meng, X.1    Wang, Y.2    Zheng, X.3
  • 114
    • 33846230130 scopus 로고    scopus 로고
    • Podocalyxin-like protein 1 expression is useful to differentiate pancreatic ductal adenocarcinomas from adenocarcinomas of the biliary and gastrointestinal tracts
    • Ney JT, Zhou H, Sipos B, et al. Podocalyxin-like protein 1 expression is useful to differentiate pancreatic ductal adenocarcinomas from adenocarcinomas of the biliary and gastrointestinal tracts. Hum Pathol 2007;38:359-64.
    • (2007) Hum Pathol , vol.38 , pp. 359-364
    • Ney, J.T.1    Zhou, H.2    Sipos, B.3
  • 115
    • 3442882797 scopus 로고    scopus 로고
    • Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression
    • Somasiri A, Nielsen JS, Makretsov N, et al. Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression. Cancer Res 2004;64:5068-73.
    • (2004) Cancer Res , vol.64 , pp. 5068-5073
    • Somasiri, A.1    Nielsen, J.S.2    Makretsov, N.3
  • 116
    • 21744441931 scopus 로고    scopus 로고
    • Podocalyxin: A marker of blasts in acute leukemia
    • Kelley TW, Huntsman D, McNagny KM, et al. Podocalyxin: a marker of blasts in acute leukemia. Am J Clin Pathol 2005;124:134-42.
    • (2005) Am J Clin Pathol , vol.124 , pp. 134-142
    • Kelley, T.W.1    Huntsman, D.2    McNagny, K.M.3
  • 117
    • 53849121588 scopus 로고    scopus 로고
    • Stem cell marker expression in small cell lung carcinoma and developing lung tissue
    • Koch LK, Zhou H, Ellinger J, et al. Stem cell marker expression in small cell lung carcinoma and developing lung tissue. Hum Pathol 2008;39:1597-605.
    • (2008) Hum Pathol , vol.39 , pp. 1597-1605
    • Koch, L.K.1    Zhou, H.2    Ellinger, J.3
  • 118
    • 13844256438 scopus 로고    scopus 로고
    • The urokinase plasminogen activator and its receptor: Role in cell growth and apoptosis
    • Alfano D, Franco P, Vocca I, et al. The urokinase plasminogen activator and its receptor: role in cell growth and apoptosis. Thromb Haemost 2005;93:205-11.
    • (2005) Thromb Haemost , vol.93 , pp. 205-211
    • Alfano, D.1    Franco, P.2    Vocca, I.3
  • 119
    • 55349148006 scopus 로고    scopus 로고
    • Identification of uPAR-positive chemoresistant cells in small cell lung cancer
    • Gutova M, Najbauer J, Gevorgyan A, et al. Identification of uPAR-positive chemoresistant cells in small cell lung cancer. PLoS One 2007;2:e243.
    • (2007) PLoS One , vol.2 , pp. e243
    • Gutova, M.1    Najbauer, J.2    Gevorgyan, A.3
  • 120
    • 84863100269 scopus 로고    scopus 로고
    • Characterization of sphere forming cells with stem-like properties from the small cell lung cancer cell line H446
    • Qiu X, Wang Z, Li Y, et al. Characterization of sphere forming cells with stem-like properties from the small cell lung cancer cell line H446. Cancer Lett 2012;323:161-70.
    • (2012) Cancer Lett , vol.323 , pp. 161-170
    • Qiu, X.1    Wang, Z.2    Li, Y.3
  • 121
    • 84862517728 scopus 로고    scopus 로고
    • Cancer stem cells: Current status and evolving complexities
    • Visvader JE, Lindeman GJ. Cancer stem cells: current status and evolving complexities. Cell Stem Cell 2012;10:717-28.
    • (2012) Cell Stem Cell , vol.10 , pp. 717-728
    • Visvader, J.E.1    Lindeman, G.J.2
  • 122
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-11.
    • (2001) Nature , vol.414 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3
  • 123
    • 0345059767 scopus 로고    scopus 로고
    • Applying the principles of stem-cell biology to cancer
    • Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 2003;3:895-902.
    • (2003) Nat Rev Cancer , vol.3 , pp. 895-902
    • Pardal, R.1    Clarke, M.F.2    Morrison, S.J.3
  • 124
    • 18644376279 scopus 로고    scopus 로고
    • Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB
    • Batlle E, Henderson JT, Beghtel H, et al. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 2002;111:251-63.
    • (2002) Cell , vol.111 , pp. 251-263
    • Batlle, E.1    Henderson, J.T.2    Beghtel, H.3
  • 125
    • 0031848068 scopus 로고    scopus 로고
    • Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    • Korinek V, Barker N, Moerer P, et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 1998;19:379-83.
    • (1998) Nat Genet , vol.19 , pp. 379-383
    • Korinek, V.1    Barker, N.2    Moerer, P.3
  • 126
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005;434:843-50.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 127
    • 18644373146 scopus 로고    scopus 로고
    • The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • van de Wetering M, Sancho E, Verweij C, et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002;111:241-50.
    • (2002) Cell , vol.111 , pp. 241-250
    • Van De Wetering, M.1    Sancho, E.2    Verweij, C.3
  • 128
    • 23844481478 scopus 로고    scopus 로고
    • Wnt signaling in stem cells and non-small-cell lung cancer
    • He B, Barg RN, You L, et al. Wnt signaling in stem cells and non-small-cell lung cancer. Clin Lung Cancer 2005;7:54-60.
    • (2005) Clin Lung Cancer , vol.7 , pp. 54-60
    • He, B.1    Barg, R.N.2    You, L.3
  • 129
    • 0035146996 scopus 로고    scopus 로고
    • Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma
    • Sunaga N, Kohno T, Kolligs FT, et al. Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma. Genes Chromosomes Cancer 2001;30:316-21.
    • (2001) Genes Chromosomes Cancer , vol.30 , pp. 316-321
    • Sunaga, N.1    Kohno, T.2    Kolligs, F.T.3
  • 130
    • 17944377840 scopus 로고    scopus 로고
    • Genetic alteration of the beta-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion
    • Shigemitsu K, Sekido Y, Usami N, et al. Genetic alteration of the beta-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion. Oncogene 2001;20:4249-57.
    • (2001) Oncogene , vol.20 , pp. 4249-4257
    • Shigemitsu, K.1    Sekido, Y.2    Usami, N.3
  • 131
    • 0035816261 scopus 로고    scopus 로고
    • Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas
    • Ueda M, Gemmill RM, West J, et al. Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas. Br J Cancer 2001;85:64-8.
    • (2001) Br J Cancer , vol.85 , pp. 64-68
    • Ueda, M.1    Gemmill, R.M.2    West, J.3
  • 132
    • 1642341682 scopus 로고    scopus 로고
    • A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells
    • He B, You L, Uematsu K, et al. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia 2004;6:7-14.
    • (2004) Neoplasia , vol.6 , pp. 7-14
    • He, B.1    You, L.2    Uematsu, K.3
  • 133
    • 4344570800 scopus 로고    scopus 로고
    • Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells
    • You L, He B, Xu Z, et al. Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells. Oncogene 2004;23:6170-4.
    • (2004) Oncogene , vol.23 , pp. 6170-6174
    • You, L.1    He, B.2    Xu, Z.3
  • 134
    • 0242551656 scopus 로고    scopus 로고
    • Activation of the Wnt pathway in non small cell lung cancer: Evidence of dishevelled overexpression
    • Uematsu K, He B, You L, et al. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene 2003;22:7218-21.
    • (2003) Oncogene , vol.22 , pp. 7218-7221
    • Uematsu, K.1    He, B.2    You, L.3
  • 135
    • 76349104842 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells
    • Teng Y, Wang X, Wang Y, et al. Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells. Biochem Biophys Res Commun 2010;392:373-9.
    • (2010) Biochem Biophys Res Commun , vol.392 , pp. 373-379
    • Teng, Y.1    Wang, X.2    Wang, Y.3
  • 136
    • 77953700950 scopus 로고    scopus 로고
    • Targeting Notch to target cancer stem cells
    • Pannuti A, Foreman K, Rizzo P, et al. Targeting Notch to target cancer stem cells. Clin Cancer Res 2010;16:3141-52.
    • (2010) Clin Cancer Res , vol.16 , pp. 3141-3152
    • Pannuti, A.1    Foreman, K.2    Rizzo, P.3
  • 137
    • 0031899677 scopus 로고    scopus 로고
    • Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines
    • Bigas A, Martin DI, Milner LA. Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines. Mol Cell Biol 1998;18:2324-33.
    • (1998) Mol Cell Biol , vol.18 , pp. 2324-2333
    • Bigas, A.1    Martin, D.I.2    Milner, L.A.3
  • 138
    • 7444224783 scopus 로고    scopus 로고
    • Notch1 and notch2 have opposite effects on embryonal brain tumor growth
    • Fan X, Mikolaenko I, Elhassan I, et al. Notch1 and notch2 have opposite effects on embryonal brain tumor growth. Cancer Res 2004;64:7787-93.
    • (2004) Cancer Res , vol.64 , pp. 7787-7793
    • Fan, X.1    Mikolaenko, I.2    Elhassan, I.3
  • 139
    • 0036296480 scopus 로고    scopus 로고
    • Functional diversity among Notch1, Notch2, and Notch3 receptors
    • Shimizu K, Chiba S, Saito T. Functional diversity among Notch1, Notch2, and Notch3 receptors. Biochem Biophys Res Commun 2002;291:775-9.
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 775-779
    • Shimizu, K.1    Chiba, S.2    Saito, T.3
  • 141
    • 0034674896 scopus 로고    scopus 로고
    • Chromosome 19 translocation, overexpression of Notch3, and human lung cancer
    • Dang TP, Gazdar AF, Virmani AK, et al. Chromosome 19 translocation, overexpression of Notch3, and human lung cancer. J Natl Cancer Inst 2000;92:1355-7.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1355-1357
    • Dang, T.P.1    Gazdar, A.F.2    Virmani, A.K.3
  • 142
    • 18144426777 scopus 로고    scopus 로고
    • Dominant-negative Notch3 receptor inhibits mitogenactivated protein kinase pathway and the growth of human lung cancers
    • Haruki N, Kawaguchi KS, Eichenberger S, et al. Dominant-negative Notch3 receptor inhibits mitogenactivated protein kinase pathway and the growth of human lung cancers. Cancer Res 2005;65:3555-61.
    • (2005) Cancer Res , vol.65 , pp. 3555-3561
    • Haruki, N.1    Kawaguchi, K.S.2    Eichenberger, S.3
  • 143
    • 75749138443 scopus 로고    scopus 로고
    • Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim
    • Konishi J, Yi F, Chen X, et al. Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim. Oncogene 2010;29:589-96.
    • (2010) Oncogene , vol.29 , pp. 589-596
    • Konishi, J.1    Yi, F.2    Chen, X.3
  • 144
    • 78751503434 scopus 로고    scopus 로고
    • Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells
    • Chen Y, Li D, Liu H, et al. Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells. Cancer Biol Ther 2011;11:14-21.
    • (2011) Cancer Biol Ther , vol.11 , pp. 14-21
    • Chen, Y.1    Li, D.2    Liu, H.3
  • 145
    • 0035300448 scopus 로고    scopus 로고
    • Notch signaling induces cell cycle arrest in small cell lung cancer cells
    • Sriuranpong V, Borges MW, Ravi RK, et al. Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res 2001;61:3200-5.
    • (2001) Cancer Res , vol.61 , pp. 3200-3205
    • Sriuranpong, V.1    Borges, M.W.2    Ravi, R.K.3
  • 146
    • 0036232405 scopus 로고    scopus 로고
    • Notch signaling induces rapid degradation of achaete-scute homolog 1
    • Sriuranpong V, Borges MW, Strock CL, et al. Notch signaling induces rapid degradation of achaete-scute homolog 1. Mol Cell Biol 2002;22:3129-39.
    • (2002) Mol Cell Biol , vol.22 , pp. 3129-3139
    • Sriuranpong, V.1    Borges, M.W.2    Strock, C.L.3
  • 147
    • 0842287503 scopus 로고    scopus 로고
    • Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer
    • Ball DW. Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer. Cancer Lett 2004;204:159-69.
    • (2004) Cancer Lett , vol.204 , pp. 159-169
    • Ball, D.W.1
  • 148
    • 27644561755 scopus 로고    scopus 로고
    • Hypoxia requires notch signaling to maintain the undifferentiated cell state
    • Gustafsson MV, Zheng X, Pereira T, et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell 2005;9:617-28.
    • (2005) Dev Cell , vol.9 , pp. 617-628
    • Gustafsson, M.V.1    Zheng, X.2    Pereira, T.3
  • 149
    • 34548599785 scopus 로고    scopus 로고
    • Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung
    • Chen Y, De Marco MA, Graziani I, et al. Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung. Cancer Res 2007;67:7954-9.
    • (2007) Cancer Res , vol.67 , pp. 7954-7959
    • Chen, Y.1    De Marco, M.A.2    Graziani, I.3
  • 150
    • 77951880179 scopus 로고    scopus 로고
    • Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway
    • Eliasz S, Liang S, Chen Y, et al. Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. Oncogene 2010;29:2488-98.
    • (2010) Oncogene , vol.29 , pp. 2488-2498
    • Eliasz, S.1    Liang, S.2    Chen, Y.3
  • 151
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature 2001;411:349-54.
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 152
    • 33847022189 scopus 로고    scopus 로고
    • Frequent requirement of hedgehog signaling in non-small cell lung carcinoma
    • Yuan Z, Goetz JA, Singh S, et al. Frequent requirement of hedgehog signaling in non-small cell lung carcinoma. Oncogene 2007;26:1046-55.
    • (2007) Oncogene , vol.26 , pp. 1046-1055
    • Yuan, Z.1    Goetz, J.A.2    Singh, S.3
  • 153
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    • Watkins DN, Berman DM, Burkholder SG, et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003;422:313-7.
    • (2003) Nature , vol.422 , pp. 313-317
    • Watkins, D.N.1    Berman, D.M.2    Burkholder, S.G.3
  • 154
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    • Liu S, Dontu G, Mantle ID, et al. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 2006;66:6063-71.
    • (2006) Cancer Res , vol.66 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3
  • 155
    • 0033579163 scopus 로고    scopus 로고
    • Mutational spectra of PTEN/MMAC1 gene: A tumor suppressor with lipid phosphatase activity
    • Ali IU, Schriml LM, Dean M. Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst 1999;91:1922-32.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1922-1932
    • Ali, I.U.1    Schriml, L.M.2    Dean, M.3
  • 156
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 1999;96:4240-5.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 157
    • 70349861927 scopus 로고    scopus 로고
    • Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury
    • Tiozzo C, De Langhe S, Yu M, et al. Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury. Am J Respir Crit Care Med 2009;180:701-12.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 701-712
    • Tiozzo, C.1    De Langhe, S.2    Yu, M.3
  • 158
    • 34948850396 scopus 로고    scopus 로고
    • Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
    • Yanagi S, Kishimoto H, Kawahara K, et al. Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest 2007;117:2929-40.
    • (2007) J Clin Invest , vol.117 , pp. 2929-2940
    • Yanagi, S.1    Kishimoto, H.2    Kawahara, K.3
  • 159
    • 51849097348 scopus 로고    scopus 로고
    • The role of PTEN signaling perturbations in cancer and in targeted therapy
    • Keniry M, Parsons R. The role of PTEN signaling perturbations in cancer and in targeted therapy. Oncogene 2008;27:5477-85.
    • (2008) Oncogene , vol.27 , pp. 5477-5485
    • Keniry, M.1    Parsons, R.2
  • 160
    • 0036094196 scopus 로고    scopus 로고
    • Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation
    • Soria JC, Lee HY, Lee JI, et al. Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. Clin Cancer Res 2002;8:1178-84.
    • (2002) Clin Cancer Res , vol.8 , pp. 1178-1184
    • Soria, J.C.1    Lee, H.Y.2    Lee, J.I.3
  • 161
    • 23444461754 scopus 로고    scopus 로고
    • PTEN expression in non-small-cell lung cancer: Evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration
    • Marsit CJ, Zheng S, Aldape K, et al. PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration. Hum Pathol 2005;36:768-76.
    • (2005) Hum Pathol , vol.36 , pp. 768-776
    • Marsit, C.J.1    Zheng, S.2    Aldape, K.3
  • 162
    • 66449115036 scopus 로고    scopus 로고
    • PTEN, stem cells, and cancer stem cells
    • Hill R, Wu H. PTEN, stem cells, and cancer stem cells. J Biol Chem 2009;284:11755-9.
    • (2009) J Biol Chem , vol.284 , pp. 11755-11759
    • Hill, R.1    Wu, H.2
  • 163
    • 62549129875 scopus 로고    scopus 로고
    • Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies
    • Diaz Miqueli A, Rolff J, Lemm M, et al. Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies. Br J Cancer 2009;100:950-8.
    • (2009) Br J Cancer , vol.100 , pp. 950-958
    • Diaz Miqueli, A.1    Rolff, J.2    Lemm, M.3
  • 164
    • 2442704412 scopus 로고    scopus 로고
    • Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients
    • Crombet T, Osorio M, Cruz T, et al. Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients. J Clin Oncol 2004;22:1646-54.
    • (2004) J Clin Oncol , vol.22 , pp. 1646-1654
    • Crombet, T.1    Osorio, M.2    Cruz, T.3
  • 165
    • 33646434844 scopus 로고    scopus 로고
    • Treatment of highgrade glioma patients with the humanized anti-epidermal growth factor receptor (EGFR) antibody h-R3: Report from a phase I/II trial
    • Ramos TC, Figueredo J, Catala M, et al. Treatment of highgrade glioma patients with the humanized anti-epidermal growth factor receptor (EGFR) antibody h-R3: report from a phase I/II trial. Cancer Biol Ther 2006;5:375-9.
    • (2006) Cancer Biol Ther , vol.5 , pp. 375-379
    • Ramos, T.C.1    Figueredo, J.2    Catala, M.3
  • 166
    • 77953664765 scopus 로고    scopus 로고
    • Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin
    • Ramakrishnan MS, Eswaraiah A, Crombet T, et al. Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin. MAbs 2009;1:41-8.
    • (2009) MAbs , vol.1 , pp. 41-48
    • Ramakrishnan, M.S.1    Eswaraiah, A.2    Crombet, T.3
  • 167
    • 70349238733 scopus 로고    scopus 로고
    • Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
    • Von Hoff DD, LoRusso PM, Rudin CM, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009;361:1164-72.
    • (2009) N Engl J Med , vol.361 , pp. 1164-1172
    • Von Hoff, D.D.1    LoRusso, P.M.2    Rudin, C.M.3
  • 168
    • 80053206941 scopus 로고    scopus 로고
    • Therapeutic Approaches to Target Cancer Stem Cells
    • Diaz A, Leon K. Therapeutic Approaches to Target Cancer Stem Cells. Cancers (Basel) 2011;3:3331-52.
    • (2011) Cancers (Basel) , vol.3 , pp. 3331-3352
    • Diaz, A.1    Leon, K.2
  • 169
    • 0141461414 scopus 로고    scopus 로고
    • Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia
    • Matsunaga T, Takemoto N, Sato T, et al. Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Nat Med 2003;9:1158-65.
    • (2003) Nat Med , vol.9 , pp. 1158-1165
    • Matsunaga, T.1    Takemoto, N.2    Sato, T.3
  • 170
    • 34250829120 scopus 로고    scopus 로고
    • Epigenetic reversion of breast carcinoma phenotype is accompanied by changes in DNA sequestration as measured by AluI restriction enzyme
    • Sandal T, Valyi-Nagy K, Spencer VA, et al. Epigenetic reversion of breast carcinoma phenotype is accompanied by changes in DNA sequestration as measured by AluI restriction enzyme. Am J Pathol 2007;170:1739-49.
    • (2007) Am J Pathol , vol.170 , pp. 1739-1749
    • Sandal, T.1    Valyi-Nagy, K.2    Spencer, V.A.3
  • 171
    • 84870421832 scopus 로고    scopus 로고
    • Trifluoperazine, an antipsychotic agent, inhibits cancer stem cell growth and overcomes drug resistance of lung cancer
    • Yeh CT, Wu AT, Chang PM, et al. Trifluoperazine, an antipsychotic agent, inhibits cancer stem cell growth and overcomes drug resistance of lung cancer. Am J Respir Crit Care Med 2012;186:1180-8.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 1180-1188
    • Yeh, C.T.1    Wu, A.T.2    Chang, P.M.3
  • 172
    • 34548572895 scopus 로고    scopus 로고
    • Gammasecretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers
    • Konishi J, Kawaguchi KS, Vo H, et al. Gammasecretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res 2007;67:8051-7.
    • (2007) Cancer Res , vol.67 , pp. 8051-8057
    • Konishi, J.1    Kawaguchi, K.S.2    Vo, H.3
  • 173
    • 84858157329 scopus 로고    scopus 로고
    • Effects of the Hedgehog pathway inhibitor GDC-0449 on lung cancer cell lines are mediated by side populations
    • Tian F, Mysliwietz J, Ellwart J, et al. Effects of the Hedgehog pathway inhibitor GDC-0449 on lung cancer cell lines are mediated by side populations. Clin Exp Med 2012;12:25-30.
    • (2012) Clin Exp Med , vol.12 , pp. 25-30
    • Tian, F.1    Mysliwietz, J.2    Ellwart, J.3
  • 174
    • 75149117750 scopus 로고    scopus 로고
    • Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loop
    • Levina V, Marrangoni A, Wang T, et al. Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loop. Cancer Res 2010;70:338-46.
    • (2010) Cancer Res , vol.70 , pp. 338-346
    • Levina, V.1    Marrangoni, A.2    Wang, T.3
  • 175
    • 84867385274 scopus 로고    scopus 로고
    • Are we missing the target? Cancer stem cells and drug resistance in non-small cell lung cancer
    • Gottschling S, Schnabel PA, Herth FJ, et al. Are we missing the target? Cancer stem cells and drug resistance in non-small cell lung cancer. Cancer Genomics Proteomics 2012;9:275-86.
    • (2012) Cancer Genomics Proteomics , vol.9 , pp. 275-286
    • Gottschling, S.1    Schnabel, P.A.2    Herth, F.J.3
  • 176
    • 39749163359 scopus 로고    scopus 로고
    • Telomerase and cancer therapeutics
    • Harley CB. Telomerase and cancer therapeutics. Nat Rev Cancer 2008;8:167-79.
    • (2008) Nat Rev Cancer , vol.8 , pp. 167-179
    • Harley, C.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.