Sequence composition of disordered regions fine-tunes protein half-life

Nature Structural and Molecular Biology

Volumn 22, Issue 3, 2015, Pages 214-221

  Fishbain, Susan ^a,b   Inobe, Tomonao ^b,c   Israeli, Eitan ^b   Chavali, Sreenivas ^d   Yu, Houqing ^a,b   Kago, Grace ^a   Babu, M Madan ^d   Matouschek, Andreas ^a,b  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF TOYAMA   (Japan)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; FUNGAL PROTEIN; GLUTAMINE; HEMAGGLUTININ; INTRINSICALLY DISORDERED PROTEIN; LACTATE DEHYDROGENASE (CYTOCHROME); PROLINE; PROTEASOME; RAD23 PROTEIN; TRANSCRIPTION FACTOR; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME E2; UNCLASSIFIED DRUG; CDC34 PROTEIN, S CEREVISIAE; DNA BINDING PROTEIN; RAD23 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; UBIQUITIN CONJUGATING ENZYME;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; EUKARYOTIC CELL; HALF LIFE TIME; HIRSCHSPRUNG DISEASE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; SACCHAROMYCES CEREVISIAE; STEADY STATE; UBIQUITINATION; WESTERN BLOTTING; YEAST; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PHYSIOLOGY; PROTEIN FOLDING; SEQUENCE ANALYSIS;

EUKARYOTA;

AMINO ACID SEQUENCE; BINDING SITES; DNA-BINDING PROTEINS; HALF-LIFE; MODELS, MOLECULAR; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; PROTEOLYSIS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ANALYSIS, PROTEIN; UBIQUITIN-CONJUGATING ENZYMES;

EID: 84924125611     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2958     Document Type: Article

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