LIM mineralization protein-1 suppresses TNF-α induced intervertebral disc degeneration by maintaining nucleus pulposus extracellular matrix production and inhibiting matrix metalloproteinases expression

Journal of Orthopaedic Research

Volumn 33, Issue 3, 2015, Pages 294-303

  Liu, Hui ^a   Pan, Hehai ^a   Yang, Hao ^a   Wang, Jianru ^a   Zhang, Kuibo ^a   Li, Xiang ^a   Wang, Hua ^a   Ding, Wenbin ^a   Li, Bingxue ^a   Zheng, Zhaomin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Extracellular matrix; Intervertebral disc degeneration; LIM Mineralization Protein 1; Matrix metalloproteinase; NF B

Indexed keywords

AGGRECAN; COLLAGEN TYPE 2; COLLAGENASE 3; GLYCOSAMINOGLYCAN POLYSULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LENTIVIRUS VECTOR; LIM MINERALIZATION PROTEIN 1; LIM PROTEIN; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RENILLA LUCIFERIN 2 MONOOXYGENASE; STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VERSICAN; CYTOSKELETON PROTEIN; GLYCOSAMINOGLYCAN; MATRIX METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PDLIM7 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; IN VITRO STUDY; INTERVERTEBRAL DISK DEGENERATION; LUCIFERASE ASSAY; NONHUMAN; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; GENETICS; HUMAN; INTERVERTEBRAL DISC DEGENERATION; INTERVERTEBRAL DISK; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELLS, CULTURED; CYTOSKELETAL PROTEINS; EXTRACELLULAR MATRIX; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLYCOSAMINOGLYCANS; HUMANS; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; LIM DOMAIN PROTEINS; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE INHIBITORS; NF-KAPPA B; PROMOTER REGIONS, GENETIC; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84923804470     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22732     Document Type: Article

References (45)

1. Balague F, Mannion AF, Pellise F, et al. 2012. Non-specific low back pain. Lancet 379:482-491.
2. Katz JN. 2006. Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. J Bone Joint Surg Am 88:21-24.
3. Feng H, Danfelter M, Stromqvist B, et al. 2006. Extracellular matrix in disc degeneration. J Bone Joint Surg Am 88:25-29.
4. Mern DS, Fontana J, Beierfuss A, et al. 2013. A combinatorial relative mass value evaluation of endogenous bioactive proteins in three-dimensional cultured nucleus pulposus cells of herniated intervertebral discs: identification of potential target proteins for gene therapeutic approaches. PLoS One 8:e81467.
5. Weiler C, Nerlich AG, Zipperer J, et al. 2002. 2002 SSE Award Competition in Basic Science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption. Eur Spine J 11:308-320.
6. Luo Y, Zhang L, Wang WY, et al. 2013. Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats. Bone 55:439-448.
7. Roberts S, Caterson B, Menage J, et al. 2000. Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc. Spine (Phila Pa 1976) 25:3005-3013.
8. Fosang AJ, Last K, Knauper V, et al. 1996. Degradation of cartilage aggrecan by collagenase-3 (MMP-13). FEBS Lett 380:17-20.
9. Fosang AJ, Last K, Maciewicz RA. 1996. Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent. J Clin Invest 98:2292-2299.
10. Nagase H, Kashiwagi M. 2003. Aggrecanases and cartilage matrix degradation. Arthritis Res Ther 5:94-103.
11. Le Maitre CL, Hoyland JA, Freemont AJ. 2007. Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. Arthritis Res Ther 9:R77.
12. Le Maitre CL, Freemont AJ, Hoyland JA. 2005. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 7:R732-R745.
13. Risbud MV, Shapiro IM. 2014. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol 10:44-56.
14. Adams MA, Roughley PJ. 2006. What is intervertebral disc degeneration, and what causes it? Spine (Phila Pa 1976) 31:2151-2161.
15. Vo NV, Hartman RA, Yurube T, et al. 2013. Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration. Spine J 13:331-341.
16. Masuda K, An HS. 2004. Growth factors and the intervertebral disc. Spine J 4:330S-340S.
17. Woods BI, Vo N, Sowa G, et al. 2011. Gene therapy for intervertebral disk degeneration. Orthop Clin North Am 42:563-574.
18. Boden SD, Liu Y, Hair GA, et al. 1998. LMP-1, a LIMdomain protein, mediates BMP-6 effects on bone formation. Endocrinology 139:5125-5134.
19. Okada M, Sangadala S, Liu Y, et al. 2009. Development and optimization of a cell-based assay for the selection of synthetic compounds that potentiate bone morphogenetic protein-2 activity. Cell Biochem Funct 27:526-534.
20. Sangadala S, Boden SD, Viggeswarapu M, et al. 2006. LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads. J Biol Chem 281:17212-17219.
21. Sangadala S, Yoshioka K, Enyo Y, et al. 2014. Characterization of a unique motif in LIM mineralization protein-1 that interacts with jun activation-domain-binding protein 1. Mol Cell Biochem 385:145-157.
22. Yoon ST, Park JS, Kim KS, et al. 2004. ISSLS prize winner: LMP-1 upregulates intervertebral disc cell production of proteoglycans and BMPs in vitro and in vivo. Spine (Phila Pa 1976) 29:2603-2611.
23. Liu H, Bargouti M, Zughaier S, et al. 2010. Osteoinductive LIM mineralization protein-1 suppresses activation of NFkappaB and selectively regulates MAPK pathways in preosteoclasts. Bone 46:1328-1335.
24. Zhou L, Li F, Xu HB, et al. 2010. Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med 16:1439-1443.
25. Setton LA, Chen J. 2006. Mechanobiology of the intervertebral disc and relevance to disc degeneration. J Bone Joint Surg Am 88:52-57.
26. Smith LJ, Nerurkar NL, Choi KS, et al. 2011. Degeneration and regeneration of the intervertebral disc: lessons from development. Dis Model Mech 4:31-41.
27. Hoyland JA, Le Maitre C, Freemont AJ. 2008. Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc. Rheumatology (Oxford) 47:809-814.
28. Seguin CA, Pilliar RM, Roughley PJ, et al. 2005. Tumor necrosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissue. Spine (Phila Pa 1976) 30:1940-1948.
29. Shinmei M, Kikuchi T, Yamagishi M, et al. 1988. The role of interleukin-1 on proteoglycan metabolism of rabbit annulus fibrosus cells cultured in vitro. Spine (Phila Pa 1976) 13:1284-1290.
30. Wang SL, Yu YL, Tang CL, et al. 2013. Effects of TGF-beta1 and IL-1beta on expression of ADAMTS enzymes and TIMP- 3 in human intervertebral disc degeneration. Exp Ther Med 6:1522-1526.
31. Hiyama A, Gogate SS, Gajghate S, et al. 2010. BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. J Bone Miner Res 25:1179-1190.
32. Kim JS, Ellman MB, An HS, et al. 2010. Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7- mediated anabolism in bovine intervertebral disc cells. Arthritis Rheum 62:3706-3715.
33. Wang Z, Hutton WC, Yoon ST. 2014. Bone morphogenetic protein-7 antagonizes tumor necrosis factor-alpha-induced activation of nuclear factor kappaB and up-regulation of the ADAMTS, leading to decreased degradation of disc matrix macromolecules aggrecan and collagen II. Spine J 14:505-512.
34. Weiler C, Nerlich AG, Bachmeier BE, et al. 2005. Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Spine (Phila Pa 1976) 30:44-53 54.
35. Seguin CA, Bojarski M, Pilliar RM, et al. 2006. Differential regulation of matrix degrading enzymes in a TNFalphainduced model of nucleus pulposus tissue degeneration. Matrix Biol 25:409-418.
36. Studer RK, Gilbertson LG, Georgescu H, et al. 2008. p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1. J Orthop Res 26:991-998.
37. Kim JS, Ellman MB, An HS, et al. 2012. Lactoferricin mediates anabolic and anti-catabolic effects in the intervertebral disc. J Cell Physiol 227:1512-1520.
38. Xia M, Zhu Y. 2011. Fibronectin fragment activation of ERK increasing integrin alpha(5) and beta(1) subunit expression to degenerate nucleus pulposus cells. J Orthop Res 29:556-561.
39. Risbud MV, Guttapalli A, Albert TJ, et al. 2005. Hypoxia activates MAPK activity in rat nucleus pulposus cells: regulation of integrin expression and cell survival. Spine (Phila Pa 1976) 30:2503-2509.
40. Pratsinis H, Kletsas D. 2007. PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways. Eur Spine J 16:1858-1866.
41. Risbud MV, Di Martino A, Guttapalli A, et al. 2006. Toward an optimum system for intervertebral disc organ culture: TGFbeta 3 enhances nucleus pulposus and anulus fibrosus survival and function through modulation of TGF-beta-R expression and ERK signaling. Spine (Phila Pa 1976) 31:884-890.
42. Basilio J, Hoeth M, Holper-Schichl YM, et al. 2013. TNFalpha- induced down-regulation of Sox18 in endothelial cells is dependent on NF-kappaB. Biochem Biophys Res Commun 442:221-226.
43. Pugazhenthi S, Zhang Y, Bouchard R, et al. 2013. Induction of an inflammatory loop by interleukin-1βeta and tumor necrosis factor-alpha involves NF-κB and STAT-1 in differentiated human neuroprogenitor cells. PLoS One 8:e69585.
44. Shao L, Wu L, Zhou D. 2012. Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor kappaB kinase. Transl Cancer Res 1:100-108.
45. Frank S, Peters MA, Wehmeyer C, et al. 2013. Regulation of matrixmetalloproteinase-3 and matrixmetalloproteinase-13 by SUMO-2/3 through the transcription factor NF-kappaB. Ann Rheum Dis 72:1874-1881.