메뉴 건너뛰기




Volumn 1, Issue 2, 2012, Pages 100-108

Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase

Author keywords

Cancer; DNA double strand break; IKK ; Ionizing radiation; NF B

Indexed keywords

ANTINEOPLASTIC AGENT; I KAPPA B KINASE BETA; I KAPPA B KINASE INHIBITOR;

EID: 84962646360     PISSN: 2218676X     EISSN: 22196803     Source Type: Journal    
DOI: 10.3978/j.issn.2218-676X.2012.05.04     Document Type: Review
Times cited : (15)

References (62)
  • 1
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-kappaB and IKK function
    • Perkins ND. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 2007;8:49-62.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 49-62
    • Perkins, N.D.1
  • 2
    • 33645999706 scopus 로고    scopus 로고
    • NF-kappaB and IKK as therapeutic targets in cancer
    • Kim HJ, Hawke N, Baldwin AS. NF-kappaB and IKK as therapeutic targets in cancer. Cell Death Differ 2006;13:738-47.
    • (2006) Cell Death Differ , vol.13 , pp. 738-747
    • Kim, H.J.1    Hawke, N.2    Baldwin, A.S.3
  • 3
    • 26444605834 scopus 로고    scopus 로고
    • IKK/NF-kappaB signaling: balancing life and death-a new approach to cancer therapy
    • Luo JL, Kamata H, Karin M. IKK/NF-kappaB signaling: balancing life and death-a new approach to cancer therapy. J Clin Invest 2005;115:2625-32.
    • (2005) J Clin Invest , vol.115 , pp. 2625-2632
    • Luo, J.L.1    Kamata, H.2    Karin, M.3
  • 4
    • 16844366650 scopus 로고    scopus 로고
    • Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
    • Nakanishi C, Toi M. Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat Rev Cancer 2005;5:297-309.
    • (2005) Nat Rev Cancer , vol.5 , pp. 297-309
    • Nakanishi, C.1    Toi, M.2
  • 5
    • 33947202249 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in development, prevention, and therapy of cancer
    • Van Waes C. Nuclear factor-kappaB in development, prevention, and therapy of cancer. Clin Cancer Res 2007;13:1076-82.
    • (2007) Clin Cancer Res , vol.13 , pp. 1076-1082
    • Van Waes, C.1
  • 6
    • 58149202128 scopus 로고    scopus 로고
    • Is NF-kappaB a good target for cancer therapy?. Hopes and pitfalls
    • Baud V, Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 2009;8:33-40.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 7
    • 77649341172 scopus 로고    scopus 로고
    • Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy
    • Li F, Sethi G. Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy. Biochim Biophys Acta 2010;1805:167-80.
    • (2010) Biochim Biophys Acta , vol.1805 , pp. 167-180
    • Li, F.1    Sethi, G.2
  • 8
    • 33644538632 scopus 로고    scopus 로고
    • Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
    • Wu ZH, Shi Y, Tibbetts RS, et al. Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science 2006;311:1141-6.
    • (2006) Science , vol.311 , pp. 1141-1146
    • Wu, Z.H.1    Shi, Y.2    Tibbetts, R.S.3
  • 9
    • 35448960010 scopus 로고    scopus 로고
    • Many faces of NF-kappaB signaling induced by genotoxic stress
    • Wu ZH, Miyamoto S. Many faces of NF-kappaB signaling induced by genotoxic stress. J Mol Med 2007;85:1187-202.
    • (2007) J Mol Med , vol.85 , pp. 1187-1202
    • Wu, Z.H.1    Miyamoto, S.2
  • 10
    • 77957570183 scopus 로고    scopus 로고
    • Inhibiting NFkappaB activation by small molecules as a therapeutic strategy
    • Gupta SC, Sundaram C, Reuter S, et al. Inhibiting NFkappaB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta 2010;1799:775-87.
    • (2010) Biochim Biophys Acta , vol.1799 , pp. 775-787
    • Gupta, S.C.1    Sundaram, C.2    Reuter, S.3
  • 11
    • 77957333810 scopus 로고    scopus 로고
    • A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-kappaB activation
    • Hinz M, Stilmann M, Arslan SC, et al. A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-kappaB activation. Mol Cell 2010;40:63-74.
    • (2010) Mol Cell , vol.40 , pp. 63-74
    • Hinz, M.1    Stilmann, M.2    Arslan, S.C.3
  • 12
    • 77957374335 scopus 로고    scopus 로고
    • ATM-and NEMOdependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress
    • Wu ZH, Wong ET, Shi Y, et al. ATM-and NEMOdependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. Mol Cell 2010;40:75-86.
    • (2010) Mol Cell , vol.40 , pp. 75-86
    • Wu, Z.H.1    Wong, E.T.2    Shi, Y.3
  • 13
    • 77957252647 scopus 로고    scopus 로고
    • The IKK complex, a central regulator of NFkappaB activation
    • Israël A. The IKK complex, a central regulator of NFkappaB activation. Cold Spring Harb Perspect Biol 2010;2:a000158.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Israël, A.1
  • 14
    • 68749103771 scopus 로고    scopus 로고
    • The NF-kappaB-independent functions of IKK subunits in immunity and cancer
    • Chariot A. The NF-kappaB-independent functions of IKK subunits in immunity and cancer. Trends Cell Biol 2009;19:404-13.
    • (2009) Trends Cell Biol , vol.19 , pp. 404-413
    • Chariot, A.1
  • 15
    • 80051987703 scopus 로고    scopus 로고
    • Crosstalk in NFkappaB signaling pathways
    • Oeckinghaus A, Hayden MS, Ghosh S. Crosstalk in NFkappaB signaling pathways. Nat Immunol 2011;12:695-708.
    • (2011) Nat Immunol , vol.12 , pp. 695-708
    • Oeckinghaus, A.1    Hayden, M.S.2    Ghosh, S.3
  • 16
    • 0022930702 scopus 로고
    • Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism
    • Sen R, Baltimore D. Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell 1986;47:921-8.
    • (1986) Cell , vol.47 , pp. 921-928
    • Sen, R.1    Baltimore, D.2
  • 17
    • 0033596120 scopus 로고    scopus 로고
    • Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views
    • Chen FE, Ghosh G. Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views. Oncogene 1999;18:6845-52.
    • (1999) Oncogene , vol.18 , pp. 6845-6852
    • Chen, F.E.1    Ghosh, G.2
  • 18
    • 0029858387 scopus 로고    scopus 로고
    • TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB
    • Wang CY, Mayo MW, Baldwin AS Jr. TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 1996;274:784-7.
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.Y.1    Mayo, M.W.2    Baldwin, A.S.3
  • 19
    • 0042663849 scopus 로고    scopus 로고
    • Inhibition of inducible NF-kappaB activity reduces chemoresistance to 5-fluorouracil in human stomach cancer cell line
    • Uetsuka H, Haisa M, Kimura M, et al. Inhibition of inducible NF-kappaB activity reduces chemoresistance to 5-fluorouracil in human stomach cancer cell line. Exp Cell Res 2003;289:27-35.
    • (2003) Exp Cell Res , vol.289 , pp. 27-35
    • Uetsuka, H.1    Haisa, M.2    Kimura, M.3
  • 20
    • 0034710539 scopus 로고    scopus 로고
    • Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide
    • Patel NM, Nozaki S, Shortle NH, et al. Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide. Oncogene 2000;19:4159-69.
    • (2000) Oncogene , vol.19 , pp. 4159-4169
    • Patel, N.M.1    Nozaki, S.2    Shortle, N.H.3
  • 21
    • 0035864344 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin
    • Arlt A, Vorndamm J, Breitenbroich M, et al. Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin. Oncogene 2001;20:859-68.
    • (2001) Oncogene , vol.20 , pp. 859-868
    • Arlt, A.1    Vorndamm, J.2    Breitenbroich, M.3
  • 22
    • 2542449068 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to irinotecan by RNA interferencemediated down-regulation of the nuclear factor-kappaB p65 subunit
    • Guo J, Verma UN, Gaynor RB, et al. Enhanced chemosensitivity to irinotecan by RNA interferencemediated down-regulation of the nuclear factor-kappaB p65 subunit. Clin Cancer Res 2004;10:3333-41.
    • (2004) Clin Cancer Res , vol.10 , pp. 3333-3341
    • Guo, J.1    Verma, U.N.2    Gaynor, R.B.3
  • 23
    • 2542495145 scopus 로고    scopus 로고
    • Inhibition of NFkappaB increases the efficacy of cisplatin in in vitro and in vivo ovarian cancer models
    • Mabuchi S, Ohmichi M, Nishio Y, et al. Inhibition of NFkappaB increases the efficacy of cisplatin in in vitro and in vivo ovarian cancer models. J Biol Chem 2004;279:23477-85.
    • (2004) J Biol Chem , vol.279 , pp. 23477-23485
    • Mabuchi, S.1    Ohmichi, M.2    Nishio, Y.3
  • 24
    • 34248573808 scopus 로고    scopus 로고
    • Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products
    • Kunnumakkara AB, Guha S, Krishnan S, et al. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res 2007;67:3853-61.
    • (2007) Cancer Res , vol.67 , pp. 3853-3861
    • Kunnumakkara, A.B.1    Guha, S.2    Krishnan, S.3
  • 25
    • 37549033098 scopus 로고    scopus 로고
    • RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin
    • Mi J, Zhang X, Rabbani ZN, et al. RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin. Mol Ther 2008;16:66-73.
    • (2008) Mol Ther , vol.16 , pp. 66-73
    • Mi, J.1    Zhang, X.2    Rabbani, Z.N.3
  • 26
    • 0030810968 scopus 로고    scopus 로고
    • Enhanced radiosensitivity by inhibition of nuclear factor kappa B activation in human malignant glioma cells
    • Yamagishi N, Miyakoshi J, Takebe H. Enhanced radiosensitivity by inhibition of nuclear factor kappa B activation in human malignant glioma cells. Int J Radiat Biol 1997;72:157-62.
    • (1997) Int J Radiat Biol , vol.72 , pp. 157-162
    • Yamagishi, N.1    Miyakoshi, J.2    Takebe, H.3
  • 27
    • 0035887492 scopus 로고    scopus 로고
    • Indomethacininduced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase
    • Bradbury CM, Markovina S, Wei SJ, et al. Indomethacininduced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase. Cancer Res 2001;61:7689-96.
    • (2001) Cancer Res , vol.61 , pp. 7689-7696
    • Bradbury, C.M.1    Markovina, S.2    Wei, S.J.3
  • 28
    • 0035341494 scopus 로고    scopus 로고
    • Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB
    • Russo SM, Tepper JE, Baldwin AS Jr, et al. Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB. Int J Radiat Oncol Biol Phys 2001;50:183-93.
    • (2001) Int J Radiat Oncol Biol Phys , vol.50 , pp. 183-193
    • Russo, S.M.1    Tepper, J.E.2    Baldwin, A.S.3
  • 29
    • 4444328524 scopus 로고    scopus 로고
    • The p65 subunit of nuclear factor-kappaB is a molecular target for radiation sensitization of human squamous carcinoma cells
    • Kim KM, Zhang Y, Kim BY, et al. The p65 subunit of nuclear factor-kappaB is a molecular target for radiation sensitization of human squamous carcinoma cells. Mol Cancer Ther 2004;3:693-8.
    • (2004) Mol Cancer Ther , vol.3 , pp. 693-698
    • Kim, K.M.1    Zhang, Y.2    Kim, B.Y.3
  • 30
    • 42249102138 scopus 로고    scopus 로고
    • Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products
    • Kunnumakkara AB, Diagaradjane P, Guha S, et al. Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. Clin Cancer Res 2008;14:2128-36.
    • (2008) Clin Cancer Res , vol.14 , pp. 2128-2136
    • Kunnumakkara, A.B.1    Diagaradjane, P.2    Guha, S.3
  • 32
    • 0035736138 scopus 로고    scopus 로고
    • If not apoptosis, then what?. Treatment-induced senescence and mitotic catastrophe in tumor cells
    • Roninson IB, Broude EV, Chang BD. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat 2001;4:303-13.
    • (2001) Drug Resist Updat , vol.4 , pp. 303-313
    • Roninson, I.B.1    Broude, E.V.2    Chang, B.D.3
  • 33
    • 22244477083 scopus 로고    scopus 로고
    • Activation of nuclear factorkappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells
    • Jin F, Liu X, Zhou Z, et al. Activation of nuclear factorkappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res 2005;65:6354-63.
    • (2005) Cancer Res , vol.65 , pp. 6354-6363
    • Jin, F.1    Liu, X.2    Zhou, Z.3
  • 34
    • 1842526076 scopus 로고    scopus 로고
    • Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B
    • Campbell KJ, Rocha S, Perkins ND. Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol Cell 2004;13:853-65.
    • (2004) Mol Cell , vol.13 , pp. 853-865
    • Campbell, K.J.1    Rocha, S.2    Perkins, N.D.3
  • 35
    • 0033384179 scopus 로고    scopus 로고
    • NF-kappa B-dependent Fas ligand expression
    • Hsu SC, Gavrilin MA, Lee HH, et al. NF-kappa B-dependent Fas ligand expression. Eur J Immunol 1999;29:2948-56.
    • (1999) Eur J Immunol , vol.29 , pp. 2948-2956
    • Hsu, S.C.1    Gavrilin, M.A.2    Lee, H.H.3
  • 36
    • 79952004257 scopus 로고    scopus 로고
    • Induction of Fas receptor and Fas ligand by nodularin is mediated by NF-kappaB in HepG2 cells
    • Feng G, Li Y, Bai Y. Induction of Fas receptor and Fas ligand by nodularin is mediated by NF-kappaB in HepG2 cells. Toxicol Appl Pharmacol 2011;251:245-52.
    • (2011) Toxicol Appl Pharmacol , vol.251 , pp. 245-252
    • Feng, G.1    Li, Y.2    Bai, Y.3
  • 37
    • 11144357466 scopus 로고    scopus 로고
    • IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    • Hu MC, Lee DF, Xia W, et al. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004;117:225-37.
    • (2004) Cell , vol.117 , pp. 225-237
    • Hu, M.C.1    Lee, D.F.2    Xia, W.3
  • 38
    • 84859104051 scopus 로고    scopus 로고
    • IKK-beta mediates chemoresistance by sequestering FOXO3; A critical factor for cell survival and death
    • Tezil T, Bodur C, Kutuk O, et al. IKK-beta mediates chemoresistance by sequestering FOXO3; A critical factor for cell survival and death. Cell Signal 2012;24:1361-8.
    • (2012) Cell Signal , vol.24 , pp. 1361-1368
    • Tezil, T.1    Bodur, C.2    Kutuk, O.3
  • 39
    • 36749009085 scopus 로고    scopus 로고
    • A role for IkappaB kinase 2 in bipolar spindle assembly
    • Irelan JT, Murphy TJ, DeJesus PD, et al. A role for IkappaB kinase 2 in bipolar spindle assembly. Proc Natl Acad Sci USA 2007;104:16940-45.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 16940-16945
    • Irelan, J.T.1    Murphy, T.J.2    DeJesus, P.D.3
  • 40
    • 35848947429 scopus 로고    scopus 로고
    • The IKK inhibitor BMS-345541 affects multiple mitotic cell cycle transitions
    • Blazkova H, von Schubert C, Mikule K, et al. The IKK inhibitor BMS-345541 affects multiple mitotic cell cycle transitions. Cell Cycle 2007;6:2531-40.
    • (2007) Cell Cycle , vol.6 , pp. 2531-2540
    • Blazkova, H.1    von Schubert, C.2    Mikule, K.3
  • 41
    • 62449257012 scopus 로고    scopus 로고
    • Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP
    • Xia Y, Padre RC, De Mendoza TH, et al. Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP. Proc Natl Acad Sci USA 2009;106:2629-34.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2629-2634
    • Xia, Y.1    Padre, R.C.2    De Mendoza, T.H.3
  • 43
    • 43749120045 scopus 로고    scopus 로고
    • DNA repair deficiency as a therapeutic target in cancer
    • Martin SA, Lord CJ, Ashworth A. DNA repair deficiency as a therapeutic target in cancer. Curr Opin Genet Dev 2008;18:80-6.
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 80-86
    • Martin, S.A.1    Lord, C.J.2    Ashworth, A.3
  • 44
    • 79954550410 scopus 로고    scopus 로고
    • IKKbeta regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells
    • Wu L, Shao L, An N, et al. IKKbeta regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells. PLoS One 2011;6:e18447.
    • (2011) PLoS One , vol.6
    • Wu, L.1    Shao, L.2    An, N.3
  • 45
    • 0037449711 scopus 로고    scopus 로고
    • BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NFkappa B-dependent transcription in mice
    • Burke JR, Pattoli MA, Gregor KR, et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NFkappa B-dependent transcription in mice. J Biol Chem 2003;278:1450-6.
    • (2003) J Biol Chem , vol.278 , pp. 1450-1456
    • Burke, J.R.1    Pattoli, M.A.2    Gregor, K.R.3
  • 46
    • 77956394195 scopus 로고    scopus 로고
    • IKK and NF-kappaBmediated regulation of Claspin impacts on ATR checkpoint function
    • Kenneth NS, Mudie S, Rocha S. IKK and NF-kappaBmediated regulation of Claspin impacts on ATR checkpoint function. EMBO J 2010;29:2966-78.
    • (2010) EMBO J , vol.29 , pp. 2966-2978
    • Kenneth, N.S.1    Mudie, S.2    Rocha, S.3
  • 47
    • 77449151205 scopus 로고    scopus 로고
    • Physiological and oncogenic Aurora-A pathway
    • Saeki T, Ouchi M, Ouchi T. Physiological and oncogenic Aurora-A pathway. Int J Biol Sci 2009;5:758-62.
    • (2009) Int J Biol Sci , vol.5 , pp. 758-762
    • Saeki, T.1    Ouchi, M.2    Ouchi, T.3
  • 48
    • 48449094278 scopus 로고    scopus 로고
    • Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation
    • Suzuki K, Verma IM. Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Cell 2008;134:485-95.
    • (2008) Cell , vol.134 , pp. 485-495
    • Suzuki, K.1    Verma, I.M.2
  • 49
    • 77955997469 scopus 로고    scopus 로고
    • Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation
    • Tsuchiya Y, Asano T, Nakayama K, et al. Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation. Mol Cell 2010;39:570-82.
    • (2010) Mol Cell , vol.39 , pp. 570-582
    • Tsuchiya, Y.1    Asano, T.2    Nakayama, K.3
  • 50
    • 34249815846 scopus 로고    scopus 로고
    • ATM-NF-kappaB connection as a target for tumor radiosensitization
    • Ahmed KM, Li JJ. ATM-NF-kappaB connection as a target for tumor radiosensitization. Curr Cancer Drug Targets 2007;7:335-42.
    • (2007) Curr Cancer Drug Targets , vol.7 , pp. 335-342
    • Ahmed, K.M.1    Li, J.J.2
  • 51
    • 53249129484 scopus 로고    scopus 로고
    • Advances in targeting IKK and IKK-related kinases for cancer therapy
    • Lee DF, Hung MC. Advances in targeting IKK and IKK-related kinases for cancer therapy. Clin Cancer Res 2008;14:5656-62.
    • (2008) Clin Cancer Res , vol.14 , pp. 5656-5662
    • Lee, D.F.1    Hung, M.C.2
  • 53
    • 33646767823 scopus 로고    scopus 로고
    • A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells
    • Wen D, Nong Y, Morgan JG, et al. A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells. J Pharmacol Exp Ther 2006;317:989-1001.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 989-1001
    • Wen, D.1    Nong, Y.2    Morgan, J.G.3
  • 54
    • 0034680928 scopus 로고    scopus 로고
    • Inhibition of NFkappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase
    • Kapahi P, Takahashi T, Natoli G, et al. Inhibition of NFkappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem 2000;275:36062-6.
    • (2000) J Biol Chem , vol.275 , pp. 36062-36066
    • Kapahi, P.1    Takahashi, T.2    Natoli, G.3
  • 55
    • 0034879173 scopus 로고    scopus 로고
    • The antiinflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase
    • Kwok BH, Koh B, Ndubuisi MI, et al. The antiinflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol 2001;8:759-66.
    • (2001) Chem Biol , vol.8 , pp. 759-766
    • Kwok, B.H.1    Koh, B.2    Ndubuisi, M.I.3
  • 56
    • 33644968734 scopus 로고    scopus 로고
    • The NF-kappaB pathway blockade by the IKK inhibitor PS1145 can overcome imatinib resistance
    • Cilloni D, Messa F, Arruga F, et al. The NF-kappaB pathway blockade by the IKK inhibitor PS1145 can overcome imatinib resistance. Leukemia 2006;20:61-7.
    • (2006) Leukemia , vol.20 , pp. 61-67
    • Cilloni, D.1    Messa, F.2    Arruga, F.3
  • 57
    • 30944470249 scopus 로고    scopus 로고
    • Effects of IKK inhibitor PS1145 on NF-kappaB function, proliferation, apoptosis and invasion activity in prostate carcinoma cells
    • Yemelyanov A, Gasparian A, Lindholm P, et al. Effects of IKK inhibitor PS1145 on NF-kappaB function, proliferation, apoptosis and invasion activity in prostate carcinoma cells. Oncogene 2006;25:387-98.
    • (2006) Oncogene , vol.25 , pp. 387-398
    • Yemelyanov, A.1    Gasparian, A.2    Lindholm, P.3
  • 58
    • 19944428834 scopus 로고    scopus 로고
    • Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling
    • Lam LT, Davis RE, Pierce J, et al. Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling. Clin Cancer Res 2005;11:28-40.
    • (2005) Clin Cancer Res , vol.11 , pp. 28-40
    • Lam, L.T.1    Davis, R.E.2    Pierce, J.3
  • 59
    • 32944468414 scopus 로고    scopus 로고
    • BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways
    • Yang J, Amiri KI, Burke JR, et al. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res 2006;12:950-60.
    • (2006) Clin Cancer Res , vol.12 , pp. 950-960
    • Yang, J.1    Amiri, K.I.2    Burke, J.R.3
  • 60
    • 70350443427 scopus 로고    scopus 로고
    • Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis
    • Gillooly KM, Pattoli MA, Taylor TL, et al. Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis. J Pharmacol Exp Ther 2009;331:349-60.
    • (2009) J Pharmacol Exp Ther , vol.331 , pp. 349-360
    • Gillooly, K.M.1    Pattoli, M.A.2    Taylor, T.L.3
  • 61
    • 1942504246 scopus 로고    scopus 로고
    • A highly selective inhibitor of IkappaB kinase, BMS-345541, augments graft survival mediated by suboptimal immunosuppression in a murine model of cardiac graft rejection
    • Townsend RM, Postelnek J, Susulic V, et al. A highly selective inhibitor of IkappaB kinase, BMS-345541, augments graft survival mediated by suboptimal immunosuppression in a murine model of cardiac graft rejection. Transplantation 2004;77:1090-4.
    • (2004) Transplantation , vol.77 , pp. 1090-1094
    • Townsend, R.M.1    Postelnek, J.2    Susulic, V.3
  • 62
    • 0141676361 scopus 로고    scopus 로고
    • A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice
    • McIntyre KW, Shuster DJ, Gillooly KM, et al. A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum 2003;48:2652-9.
    • (2003) Arthritis Rheum , vol.48 , pp. 2652-2659
    • McIntyre, K.W.1    Shuster, D.J.2    Gillooly, K.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.