Development and optimization of a cell-based assay for the selection of synthetic compounds that potentiate bone morphogenetic protein-2 activity

Cell Biochemistry and Function

Volumn 27, Issue 8, 2009, Pages 526-534

  Okada, Motohiro ^a,b,c   Sangadala, Sreedhara ^a,b   Liu, Yunshan ^a,b   Yoshida, Munehito ^c   Reddy, Boojala Vijay B ^d   Titus, Louisa ^a,b   Boden, Scott D ^a,b  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^d CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

BMP 2; LMP 1; Potentiation; Smad; Smurf1

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; DRUG; LIM MINERALIZATION PROTEIN 1; LIM PROTEIN; MESSENGER RNA; MUTANT LIM MINERALIZATION PROTEIN 1 SMAD UBIQUITIN REGULATORY FACTOR 1; MUTANT PROTEIN; OSTEOCALCIN; SMAD PROTEIN; SMAD UBIQUITIN REGULATORY FACTOR 1; SMAD1 PROTEIN; SVAK 3; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL CELL; ARTICLE; CELL ASSAY; CELL DIFFERENTIATION; COMPUTER ANALYSIS; COMPUTER SIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SCREENING; ENZYME ACTIVITY; GENE EXPRESSION; MOLECULAR DOCKING; MOUSE; NONHUMAN; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REPORTER GENE; VALIDATION PROCESS; WILD TYPE;

ANIMALS; BIOLOGICAL ASSAY; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELL LINE; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION; GENES, REPORTER; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; UBIQUITIN-PROTEIN LIGASES;

EID: 71949124553     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1615     Document Type: Article

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