Why ser and not Thr brokers catalysis in the trypsin fold

Biochemistry

Volumn 54, Issue 7, 2015, Pages 1457-1464

  Pelc, Leslie A ^a   Chen, Zhiwei ^a   Gohara, David W ^a   Vogt, Austin D ^a   Pozzi, Nicola ^a   Di Cera, Enrico ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; FUNCTIONAL GROUPS; GLYCOPROTEINS;

ACTIVATED PROTEIN C; ALLOSTERIC EFFECT; ALLOSTERIC REGULATION; EVOLUTIONARY SELECTION; HUMAN GENOMES; MOLECULAR BASIS; THROMBOMODULIN; X-RAY STRUCTURE;

CATALYST ACTIVITY;

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 10A; METHYL GROUP; MUTANT PROTEIN; NUCLEOPHILE; PROTEINASE; SERINE; THREONINE; THROMBIN; THROMBOMODULIN; TRYPSIN; TRYPTASE; PEPTIDE CHLOROMETHYL KETONE; PHENYLALANYL-PROLYL-ARGININE-CHLOROMETHYL KETONE;

ACYLATION; ALLOSTERISM; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MUTATION; PRIORITY JOURNAL; PROTEIN FOLDING; STEREOSPECIFICITY; AMINO ACID SUBSTITUTION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; POINT MUTATION; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; AMINO ACID CHLOROMETHYL KETONES; AMINO ACID SUBSTITUTION; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; POINT MUTATION; PROTEIN CONFORMATION; SERINE; THREONINE; THROMBIN; TRYPSIN;

EID: 84923370191     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00014     Document Type: Article

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