Crystal structures of prethrombin-2 reveal alternative conformations under identical solution conditions and the mechanism of zymogen activation

Biochemistry

Volumn 50, Issue 47, 2011, Pages 10195-10202

  Pozzi, Nicola ^a   Chen, Zhiwei ^a   Zapata, Fatima ^a   Pelc, Leslie A ^a   Barranco Medina, Sergio ^a   Di Cera, Enrico ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ELECTROSTATIC COUPLING; FREEFORMS; IONIC INTERACTION; PROTHROMBIN ACTIVATION; PROTHROMBINASE; SIDE-CHAINS; SNAKE VENOMS; SOLUTION CONDITIONS; SPACE GROUPS; STRUCTURAL OBSERVATIONS; SUBSTRATE BINDING; TRIPLE MUTANTS; X-RAY STRUCTURE; ZYMOGEN ACTIVATION;

BIOCHEMISTRY; CHEMISTRY;

ENZYMES;

BLOOD CLOTTING FACTOR 9; ENZYME PRECURSOR; PRETHROMBIN 2; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MUTANT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; KINETICS; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTHROMBIN;

EID: 81855199864     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2015019     Document Type: Article

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