The linker connecting the two kringles plays a key role in prothrombin activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 21, 2014, Pages 7630-7635

  Pozzi, Nicola ^a   Chen, Zhiwei ^a   Pelc, Leslie A ^a   Shropshire, Daniel B ^a   Di Cera, Enrico ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Clotting factor; Structural biology; Zymogen activation

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; PROTEINASE; PROTHROMBIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BLOOD CLOTTING; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; KRINGLE DOMAIN; MEMBRANE BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE;

CLOTTING FACTOR; STRUCTURAL BIOLOGY; ZYMOGEN ACTIVATION;

ANIMALS; CALCIUM; CELL LINE; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, ION EXCHANGE; CLONING, MOLECULAR; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FACTOR VA; FACTOR XA; HUMANS; HYDROLYSIS; KINETICS; KRINGLES; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTHROMBIN; SEQUENCE ANALYSIS, PROTEIN;

EID: 84901650152     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1403779111     Document Type: Article

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