Acetaminophen attenuates glomerulosclerosis in obese Zucker rats via reactive oxygen species/p38MAPK signaling pathways

Free Radical Biology and Medicine

Volumn 81, Issue , 2015, Pages 47-57

  Wang, Cuifen ^a,b   Blough, Eric ^a   Arvapalli, Ravikumar ^a   Dai, Xiaoniu ^b   Triest, William E ^c   Leidy, John W ^c   Masannat, Yanal ^d   Wu, Miaozong ^a,d  

^a MARSHALL UNIVERSITY   (United States)

^b SOUTHEAST UNIVERSITY   (China)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaminophen; Free radicals; Glomerulosclerosis; Glutathione synthetase; Human renal mesangial cell; Obese; Oxidative stress p38MAPK; Zucker rat

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; DESMIN; FIBRONECTIN; GLUCOSE; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PARACETAMOL; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA; CTGF PROTEIN, RAT; LYMPHOTOXIN; NFE2L2 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BOWMAN CAPSULE; CELL DAMAGE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME INHIBITION; FOCAL GLOMERULOSCLEROSIS; GLOMERULUS; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INFLAMMATORY CELL; KIDNEY FIBROSIS; LONG TERM CARE; LOW DRUG DOSE; MALE; MESANGIUM CELL; METABOLIC SYNDROME X; NONHUMAN; OBESITY; OXIDATIVE STRESS; PODOCYTE INJURY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN URINE LEVEL; PROTEINURIA; RAT; RENAL PROTECTION; SIGNAL TRANSDUCTION; TREATMENT DURATION; URINARY EXCRETION; ZUCKER RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; METABOLISM; PATHOLOGY; PRIMARY CELL CULTURE;

ANIMALIA; RATTUS;

ACETAMINOPHEN; ANIMALS; CHEMOKINE CCL2; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTINS; FIBROSIS; GENE EXPRESSION REGULATION; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE; LYMPHOTOXIN-ALPHA; MALE; MESANGIAL CELLS; METABOLIC SYNDROME X; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PRIMARY CELL CULTURE; RATS; RATS, ZUCKER; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84923309129     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.01.008     Document Type: Article

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