Metabolic syndrome-induced tubulointerstitial injury: Role of oxidative stress and preventive effects of acetaminophen

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 1417-1426

  Wang, Cuifen ^a,b   Blough, Eric R ^a   Arvapalli, Ravikumar ^a   Dai, Xiaoniu ^b   Paturi, Satyanarayana ^a   Manne, Nandini ^a,c   Addagarla, Hari ^a   Triest, William E ^d   Olajide, Omolola ^c   Wu, Miaozong ^a,c  

^a MARSHALL UNIVERSITY   (United States)

^b SOUTHEAST UNIVERSITY   (China)

^c MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Acetaminophen; Cell death; Epithelial to mesenchymal transition; Metabolic syndrome; Oxidative stress; Tubulointerstitial injury

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CASPASE 3; CONNECTIVE TISSUE GROWTH FACTOR; LAMININ; PARACETAMOL; PROTEIN BAX; PROTEIN BCL 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SUPEROXIDE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL INFILTRATION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; KIDNEY FIBROSIS; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; LIPID PEROXIDATION; LOW DRUG DOSE; LYMPHOCYTE; MACROPHAGE; MALE; METABOLIC SYNDROME X; NICK END LABELING; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; TUBULOINTERSTITIAL INJURY; WESTERN BLOTTING;

ANIMALIA; RATTUS;

4-HNE; 4-HYDROXYNONENAL; 8-HYDROXYDEOXYGUANOSINE; 8-OHDG; ACETAMINOPHEN; APAP; CELL DEATH; CHRONIC KIDNEY DISEASE; CKD; CONNECTIVE TISSUE GROWTH FACTOR; CTGF; DHE; DIHYDROETHIDIUM; DIMETHYL SULFOXIDE; DMSO; ECM; END-STAGE RENAL DISEASE; EPITHELIAL-TO-MESENCHYMAL TRANSITION; ESRD; EXTRACELLULAR MATRIX; GAPDH; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; METABOLIC SYNDROME; NAG; OXIDATIVE STRESS; PICRO-SIRIUS RED; PSR; REACTIVE OXYGEN SPECIES; ROS; TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE DUTP NICK-END LABELING; TGF-Β; TRANSFORMING GROWTH FACTOR Β; TUBULOINTERSTITIAL INJURY; TUNEL; Α-SMA; Α-SMOOTH MUSCLE ACTIN; Β-N-ACETYLGLUCOSAMINIDASE;

ACETAMINOPHEN; ACTINS; ANALGESICS, NON-NARCOTIC; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CONNECTIVE TISSUE GROWTH FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROSIS; GENE EXPRESSION; INFLAMMATION; KIDNEY TUBULES; LAMININ; MALE; MEMBRANE GLYCOPROTEINS; METABOLIC SYNDROME X; NADPH OXIDASE; NEPHRITIS, INTERSTITIAL; OXIDATIVE STRESS; RATS; RATS, ZUCKER; TRANSFORMING GROWTH FACTOR BETA;

EID: 84887194508     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.10.005     Document Type: Article

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