p38 MAPK and MAPK kinase 3/6 mRNA and activities are increased in early diabetic glomeruli

Kidney International

Volumn 60, Issue 2, 2001, Pages 543-552

  Kang, Shin Wook ^a,b   Adler, Sharon G ^a,b   LaPage, Janine ^a,b   Natarajan, Rama ^a,b  

^a Harbor UCLA Research   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

CREB; Extracellular matrix; Hypertrophy; p38 MAPK; Renal glomeruli

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVITY; GLOMERULUS; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 0034924523     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.060002543.x     Document Type: Article

References (60)

1. High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule
2. mRNA expression of growth factors in glomeruli from diabetic rats
3. Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium
4. Early increased renal procollagen α1 (IV) mRNA levels in streptozotocin induced diabetes
5. Gene expression of metalloproteinase and its inhibitor in mesangial cells exposed to high glucose
6. Exposure of human renal proximal tubular cells to glucose leads to accumulation of type IV collagen and fibronectin by decreased degradation
7. Protein kinase C is activated in glomeruli from streptozotocin diabetic rats: Possible mediation by glucose
8. Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells
9. Role of protein kinase C and cyclic AMP/protein kinase A in high glucose-stimulated transcriptional activation of collagen alpha 1(IV) in glomerular mesangial cells
10. The mitogen-activated protein kinase signal transduction pathway
11. The stress-activated protein kinase subfamily of c-Jun kinases
12. The MAPK signaling cascade
13. ERKs, extracellular signal-regulated MAP-2 kinases
14. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
15. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
16. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
17. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
18. Components of a new human protein kinase signal transduction pathway
19. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
20. Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-jun N-terminal kinase activity and AP-1-dependent gene activation
21. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
22. p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets
23. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways
24. Angiotensin II signaling in vascular smooth muscle cells under high glucose conditions
25. Effect of glucose on stress-activated protein kinase activity in mesangial cells and diabetic glomeruli
26. Activation of mesangial cell signaling cascades in response to mechanical strain
27. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
28. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinases MKK3 and MKK6
29. CREB is activated by UVC through a p38/HOG-1-dependent protein kinase
30. RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)
31. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2
32. Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells
33. 12-Lipoxygenase is increased in glucose-stimulated mesangial cells and in experimental diabetic nephropathy
34. Phosphorylation of cAMP responsive element binding protein after treatment of mesangial cells with high glucose plus TGF beta or PMA
35. Angiotensin induction of fibronectin synthesis in cultured human mesangial cells: Association with CREB transcription factor activation
36. Structural-functional relationships in diabetic nephropathy
37. Structure-function relationships associated with extracellular matrix alterations in diabetic glomerulopathy
38. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
39. P38 mitogen activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II
40. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression
41. Mechanical stretch-induced fibronectin and transforming growth factor β1 production in human mesangial cells is p38 mitogen activated protein kinase-dependent
42. Mesangial cell signaling cascades in response to mechanical strain and glucose
43. The mitogen-activated protein (MAP) kinase p38 and its upstream activator MAP kinase kinase 6 are involved in the activation of signal transducer and activator of transcription by hyperosmolarity
44. Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils
45. Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions
46. The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase
47. The coordinated action of protein tyrosine phosphatases and kinases in cell signaling
48. Angiotensin II induces 3CH134, a protein-tyrosine phosphatase, in vascular smooth muscle cells
49. - in vascular smooth muscle cells
50. Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase
51. High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation
52. Mechanisms of mitogen-activated protein kinase activation in experimental diabetes
53. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase
54. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
55. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors
56. Characterization of three different elements in the 5′-flanking region of the fibronectin gene which mediate a transcriptional response to cAMP
57. TGF-beta in kidney fibrosis: A target for gene therapy
58. Potential role of TGF-β in diabetic nephropathy
59. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
60. TGF-beta signaling from cell membrane to nucleus through SMAD proteins