Acetaminophen attenuates obesity-related renal injury through ER-mediated stress mechanisms

Cellular Physiology and Biochemistry

Volumn 33, Issue 4, 2014, Pages 1139-1148

  Wang, Cuifen ^a,b   Wu, Miaozong ^a,b,c   Arvapalli, Ravikumar ^a,b   Dai, Xiaoniu ^d   Mahmood, Muhammad ^c   Driscoll, Henry ^c   Rice, Kevin M ^a   Blough, Eric ^a,b,c  

^a MARSHALL UNIVERSITY   (United States)

^b University of Maryland Shady Grove Campus   (United States)

^c MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

Acetaminophen; Apoptosis; Endoplasmic reticulum stress; Kidney; Lipotoxicity; Obesity

Indexed keywords

CASPASE 12; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PARACETAMOL; ACTIVATING TRANSCRIPTION FACTOR 4; ANALGESIC AGENT; ATF4 PROTEIN, RAT; DDIT3 PROTEIN, RAT; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN; HSPA5 PROTEIN, RAT; INITIATION FACTOR 2; ALBUMIN; CELL NUCLEUS DNA; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; STRESS ACTIVATED PROTEIN KINASE;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; KIDNEY CELL; KIDNEY INJURY; LIPID STORAGE; LIPOTOXICITY; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; ANIMAL; COMPLICATION; DRUG EFFECTS; ENDOPLASMIC RETICULUM; KIDNEY DISEASES; LIPID METABOLISM; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; ZUCKER RAT; DNA FRAGMENTATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; PROTEIN EXPRESSION; RENAL PROTECTION; ZUCKER FATTY RAT; ZUCKER LEAN RAT;

RATTUS;

ACETAMINOPHEN; ACTIVATING TRANSCRIPTION FACTOR 4; ALBUMINURIA; ANALGESICS, NON-NARCOTIC; ANIMALS; APOPTOSIS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; HEAT-SHOCK PROTEINS; KIDNEY DISEASES; LIPID METABOLISM; MALE; OBESITY; PHOSPHORYLATION; RATS; RATS, ZUCKER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP;

EID: 84897967553     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000358683     Document Type: Article

References (35)

1. Flegal KM, Carroll MD, Kit BK, Ogden CL: Prevalence of obesity and trends in the distribution of body mass index among us adults, 1999-2010. JAMA 2012;307:491-497.
2. Wahba IM, Mak RH: Obesity and obesity-initiated metabolic syndrome: Mechanistic links to chronic kidney disease. Clin J Am Soc Nephrol 2007;2:550-562.
3. rd , Saran R, Hedgeman E, Saydah SH, Williams DE, Powe NR: Prevalence of chronic kidney disease in persons with undiagnosed or prehypertension in the united states. Hypertension 2010;55:1102-1109.
4. Ejerblad E, Fored CM, Lindblad P, Fryzek J, McLaughlin JK, Nyren O: Obesity and risk for chronic renal failure. J Am Soc Nephrol 2006;17:1695-1702.
5. Unger RH: Longevity, lipotoxicity and leptin: The adipocyte defense against feasting and famine. Biochimie 2005;87:57-64.
6. Dominguez J, Wu P, Packer CS, Temm C, Kelly KJ: Lipotoxic and inflammatory phenotypes in rats with uncontrolled metabolic syndrome and nephropathy. Am J Physiol Renal Physiol 2007;293:F670-679.
7. Leamy AK, Egnatchik RA, Young JD: Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease. Prog Lipid Res 2013;52:165-174.
8. Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS: Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004;306:457-461.
9. Fu S, Yang L, Li P, Hofmann J, Dicker L, Hide W, Lin X, Watkins SM, Ivanov AR, Hotamisligil GS: Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity Nature 2011;473:528-531.
10. Shertzer HG, Schneider SN, Kendig EL, Clegg DJ, DAlessio DA, Genter MB: Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. Biochem Pharmacol 2008;75:1402-1410.
11. Kendig EL, Schneider SN, Clegg DJ, Genter MB, Shertzer HG: Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet. Biochem Pharmacol 2008;76:216-224.
12. Shertzer HG, Kendig EL, Nasrallah HA, Johansson E, Genter MB: Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole. Int J Obes (Lond) 2010;34:970-979.
13. Wang C, Blough ER, Arvapalli R, Dai X, Paturi S, Manne N, Addagarla H, Triest WE, Olajide O, Wu M: Metabolic syndrome-induced tubulointerstitial injury: Role of oxidative stress and preventive effects of acetaminophen. Free Radic Biol Med 2013;65:1417-1426.
14. Wang Y, Wu M, Al-Rousan R, Liu H, Fannin J, Paturi S, Arvapalli RK, Katta A, Kakarla SK, Rice KM, Triest WE, Blough ER: Iron-induced cardiac damage: Role of apoptosis and deferasirox intervention. J Pharmacol Exp Ther 2011;336:56-63.
15. Zhang K, Kaufman RJ: Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem 2004;279:25935-25938.
16. Szegezdi E, Logue SE, Gorman AM, Samali A: Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 2006;7:880-885.
17. Wu M, Liu H, Fannin J, Katta A, Wang Y, Arvapalli RK, Paturi S, Karkala SK, Rice KM, Blough ER: Acetaminophen improves protein translational signaling in aged skeletal muscle. Rejuvenation Res 2010;13:571-579.
18. Wu M, Katta A, Gadde MK, Liu H, Kakarla SK, Fannin J, Paturi S, Arvapalli RK, Rice KM, Wang Y, Blough ER: Aging-associated dysfunction of akt/protein kinase b: S-nitrosylation and acetaminophen intervention. PLoS One 2009;4:e6430.
19. Dickhout JG, Carlisle RE, Austin RC: Interrelationship between cardiac hypertrophy, heart failure, and chronic kidney disease: Endoplasmic reticulum stress as a mediator of pathogenesis. Circ Res 2011;108:629-642.
20. Cunard R, Sharma K: The endoplasmic reticulum stress response and diabetic kidney disease. Am J Physiol Renal Physiol 2011;300:F1054-1061.
21. van der Kallen CJ, van Greevenbroek MM, Stehouwer CD, Schalkwijk CG: Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: Is there a role for adipose tissue and liver? Apoptosis 2009;14:1424-1434.
22. Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M, Kilberg MS, Sartor MA, Kaufman RJ: Er-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol 2013;15:481-490.
23. Yoneda T, Imaizumi K, Oono K, Yui D, Gomi F, Katayama T, Tohyama M: Activation of caspase-12, an endoplastic reticulum (er) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the er stress. J Biol Chem 2001;276:13935-13940.
24. Mathew AV, Okada S, Sharma K: Obesity related kidney disease. Curr Diabetes Rev 2011;7:41-49.
25. National Kidney Foundation: K/doqi clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis 2002;39:Sl-266.
26. Howard S, Bottino C, Brooke S, Cheng E, Giffard RG, Sapolsky R: Neuroprotective effects of bcl-2 overexpression in hippocampal cultures: Interactions with pathways of oxidative damage. J Neurochem 2002;83:914-923.
27. Abrass CK: Cellular lipid metabolism and the role of lipids in progressive renal disease. Am J Nephrol 2004;24:46-53.
28. Mehlem A, Hagberg CE, Muhl L, Eriksson U, Falkevall A: Imaging of neutral lipids by oil red o for analyzing the metabolic status in health and disease. Nat Protoc 2013;8:1149-1154.
29. Kambham N, Markowitz GS, Valeri AM, Lin J, DAgati VD: Obesity-related glomerulopathy: An emerging epidemic. Kidney Int 2001;59:1498-1509.
30. Boini KM, Zhang C, Xia M, Poklis JL, Li PL: Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet. J Pharmacol Exp Ther 2010;334:839-846.
31. Ebenezer PJ, Mariappan N, Elks CM, Haque M, Francis J: Diet-induced renal changes in zucker rats are ameliorated by the superoxide dismutase mimetic tempol. Obesity (Silver Spring) 2009;17:1994-2002.
32. Katsoulieris E, Mabley JG, Samai M, Sharpe MA, Green IC, Chatterjee PK: Lipotoxicity in renal proximal tubular cells: Relationship between endoplasmic reticulum stress and oxidative stress pathways. Free Radic Biol Med 2010;48:1654-1662.
33. Hotamisligil GS: Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010;140:900-917.
34. Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS: Chemical chaperones reduce er stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006;313:1137-1140.
35. Reagan-Shaw S, Nihal M, Ahmad N: Dose translation from animal to human studies revisited. FASEB ] 2008;22:659-661.