Curcumin binds to the pre-fibrillar aggregates of Cu/Zn superoxide dismutase (SOD1) and alters its amyloidogenic pathway resulting in reduced cytotoxicity

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1854, Issue 5, 2015, Pages 426-436

  Bhatia, Nidhi K ^a   Srivastava, Ankit ^a   Katyal, Nidhi ^a   Jain, Nidhi ^a   Khan, M Ashhar I ^a   Kundu, Bishwajit ^a   Deep, Shashank ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

Author keywords

Amyloid; Curcumin; Inhibitor; Microscopy; Superoxide dismutase; Amyotrophic Lateral Sclerosis

Indexed keywords

AMYLOID PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; CURCUMIN; NANOPARTICLE; AMYLOID; PROTEIN AGGREGATES; PROTEIN BINDING; SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE 1;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; BINDING ASSAY; BINDING SITE; CYTOTOXICITY; FLUORESCENCE ANALYSIS; HUMAN; LIGHT SCATTERING; MICROSCOPY; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; TRANSMISSION ELECTRON MICROSCOPY; CELLS, CULTURED; CHEMISTRY; CYTOPROTECTION; DRUG EFFECTS; HUMANS; METABOLIC NETWORKS AND PATHWAYS; METABOLISM; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; PROTEIN MULTIMERIZATION;

AMYLOID; CELLS, CULTURED; CURCUMIN; CYTOPROTECTION; HUMANS; METABOLIC NETWORKS AND PATHWAYS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; PROTEIN AGGREGATES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; SUPEROXIDE DISMUTASE;

EID: 84923233755     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2015.01.014     Document Type: Article

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