Local unfolding of Cu, Zn superoxide dismutase monomer determines the morphology of fibrillar aggregates

Journal of Molecular Biology

Volumn 421, Issue 4-5, 2012, Pages 548-560

  Ding, Feng ^a   Furukawa, Yoshiaki ^b   Nukina, Nobuyuki ^c   Dokholyan, Nikolay V ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b KEIO UNIVERSITY   (Japan)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

aggregation building block; fibrillar aggregate; molecular dynamics; multiscale modeling; SOD1 misfolding and aggregation

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; HYDROGEN BOND; MASS SPECTROMETRY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FOLDING; SIMULATION;

EID: 84864288165     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.12.029     Document Type: Article

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