Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways

Neurobiology of Learning and Memory

Volumn 96, Issue 2, 2011, Pages 156-165

  Wang, Yong Jian ^a   Lu, Jun ^a   Wu, Dong mei ^a   Zheng, Zi hui ^b   Zheng, Yuan Lin ^a   Wang, Xiao hui ^a   Ruan, Jie ^a   Sun, Xiao ^a   Shan, Qun ^a   Zhang, Zi feng ^a  

^a JIANGSU NORMAL UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Cognitive deficits; Inflammatory response; LPS; P38 NF B pathways; Ursolic acid

Indexed keywords

CYCLOOXYGENASE 2; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; I KAPPA B ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; URSOLIC ACID;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN REGION; CELL NUCLEUS; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; MALE; MAZE TEST; MOUSE; NEUROPROTECTION; NONHUMAN; OPEN FIELD BEHAVIOR; PASSIVE AVOIDANCE; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; BRAIN; COGNITION; INFLAMMATION; LIPOPOLYSACCHARIDES; MAZE LEARNING; MICE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 79960840149     PISSN: 10747427     EISSN: 10959564     Source Type: Journal    
DOI: 10.1016/j.nlm.2011.03.010     Document Type: Article

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