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Volumn 206, Issue 2, 2013, Pages 153-165

Ursolic acid inhibits tumor angiogenesis and induces apoptosis through mitochondrial-dependent pathway in Ehrlich ascites carcinoma tumor

Author keywords

Caspase 3; CD31; Ehrlich ascites carcinoma; Ursolic acid; VEGF

Indexed keywords

CASPASE 3; CATALASE; CD31 ANTIGEN; CYCLOPHOSPHAMIDE; GLUTATHIONE; HEMOGLOBIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR ALPHA; URSOLIC ACID; VASCULOTROPIN;

EID: 84885337258     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.09.004     Document Type: Article
Times cited : (78)

References (73)
  • 2
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • DOI 10.1038/nm0603-653
    • P. Carmeliet Angiogenesis in health and disease Nat. Med. 9 2003 653 660 (Pubitemid 36749213)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 653-660
    • Carmeliet, P.1
  • 4
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • P. Carmeliet, and R.K. Jain Angiogenesis in cancer and other diseases Nature 407 2000 249 257
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 5
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • DOI 10.1210/er.18.1.4
    • N. Ferrara, and T. Davis-Smyth The biology of vascular endothelial growth factor Endocr. Rev. 18 1997 4 25 (Pubitemid 27076453)
    • (1997) Endocrine Reviews , vol.18 , Issue.1 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 7
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • DOI 10.1210/er.2003-0027
    • N. Ferrara Vascular endothelial growth factor: basic science and clinical progress Endocr. Rev. 25 2004 581 611 (Pubitemid 39099316)
    • (2004) Endocrine Reviews , vol.25 , Issue.4 , pp. 581-611
    • Ferrara, N.1
  • 8
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • D.W. Leung, G. Cachianes, W.J. Kuang, D.V. Goeddel, and N. Ferrara Vascular endothelial growth factor is a secreted angiogenic mitogen Science 246 1989 1306 1309 (Pubitemid 20066716)
    • (1989) Science , vol.246 , Issue.4935 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.-J.3    Goeddel, D.V.4    Ferrara, N.5
  • 9
    • 0029965081 scopus 로고    scopus 로고
    • Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain
    • S. Soker, H. Fidder, G. Neufeld, and M. Klagsbrun Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain J. Biol. Chem. 271 1996 5761 5767
    • (1996) J. Biol. Chem. , vol.271 , pp. 5761-5767
    • Soker, S.1    Fidder, H.2    Neufeld, G.3    Klagsbrun, M.4
  • 10
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • DOI 10.1038/362841a0
    • K.J. Kim, B. Li, J. Winer, M. Armanini, N. Gillett, H.S. Phillips, and N. Ferrara Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo Nature 362 1993 841 844 (Pubitemid 23132159)
    • (1993) Nature , vol.362 , Issue.6423 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 11
  • 12
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
    • C. de Vries, J.A. Escobedo, H. Ueno, K. Houck, N. Ferrara, and L.T. Williams The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor Science 255 1992 989 991
    • (1992) Science , vol.255 , pp. 989-991
    • De Vries, C.1    Escobedo, J.A.2    Ueno, H.3    Houck, K.4    Ferrara, N.5    Williams, L.T.6
  • 13
    • 0023157363 scopus 로고
    • Angiogenic factors
    • J. Folkman, and M. Klagsbrun Angiogenic factors Science 235 1987 442 447 (Pubitemid 17009577)
    • (1987) Science , vol.235 , Issue.4787 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 14
    • 2142828490 scopus 로고    scopus 로고
    • Interleukin-12 Inhibits Tumor Growth in a Novel Angiogenesis Canine Hemangiosarcoma Xenograft Model
    • DOI 10.1593/neo.03334
    • N. Akhtar, M.L. Padilla, E.B. Dickerson, H. Steinberg, M. Breen, R. Auerbach, and S.C. Helfand Interleukin-12 inhibits tumor growth in a novel angiogenesis canine hemangiosarcoma xenograft model Neoplasia 6 2004 106 116 (Pubitemid 38544598)
    • (2004) Neoplasia , vol.6 , Issue.2 , pp. 106-116
    • Akhtar, N.1    Padilla, M.L.2    Dickerson, E.B.3    Steinberg, H.4    Breen, M.5    Auerbach, R.6    Helfand, S.C.7
  • 15
    • 0028970060 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • G. Trinchieri Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity Annu. Rev. Immunol. 131 1995 251 276
    • (1995) Annu. Rev. Immunol. , vol.131 , pp. 251-276
    • Trinchieri, G.1
  • 16
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • T.A. Fong, L.K. Shawver, L. Sun, C. Tang, H. App, T.J. Powell, Y.H. Kim, R. Schreck, X. Wang, W. Risau, A. Ullrich, K.P. Hirth, and G. McMahon SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types Cancer Res. 59 1999 99 106 (Pubitemid 29062964)
    • (1999) Cancer Research , vol.59 , Issue.1 , pp. 99-106
    • Fong, T.A.T.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5    Powell, T.J.6    Kim, Y.H.7    Schreck, R.8    Wang, X.9    Risau, W.10    Ullrich, A.11    Hirth, K.P.12    McMahon, G.13
  • 17
    • 0034569527 scopus 로고    scopus 로고
    • Executionary pathway for apoptosis: Lessons from mutant mice
    • M. Woo, M. Hakem, and T.W. Mak Executionary pathway for apoptosis: lessons from mutant mice Cell Res. 10 2000 267 278
    • (2000) Cell Res. , vol.10 , pp. 267-278
    • Woo, M.1    Hakem, M.2    Mak, T.W.3
  • 18
    • 0034320568 scopus 로고    scopus 로고
    • Mechanisms of apoptosis
    • J.C. Reed Mechanisms of apoptosis Am. J. Pathol. 157 2000 1415 1430
    • (2000) Am. J. Pathol. , vol.157 , pp. 1415-1430
    • Reed, J.C.1
  • 19
    • 33845528108 scopus 로고    scopus 로고
    • Antiproliferative and antiviral mechanisms of ursolic acid and dexamethasone in cervical carcinoma cell lines
    • E.K. Yim, M.J. Lee, K.H. Lee, S.J. Um, and J.S. Park Antiproliferative and antiviral mechanisms of ursolic acid and dexamethasone in cervical carcinoma cell lines Int. J. Gynecol. Cancer 16 2006 2023 2031
    • (2006) Int. J. Gynecol. Cancer , vol.16 , pp. 2023-2031
    • Yim, E.K.1    Lee, M.J.2    Lee, K.H.3    Um, S.J.4    Park, J.S.5
  • 22
    • 63449089496 scopus 로고    scopus 로고
    • Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis
    • C. Tang, Y.H. Lu, J.H. Xie, F. Wang, J.N. Zou, J.S. Yang, Y.Y. Xing, and T. Xi Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis Anticancer Drugs 20 2009 249 258
    • (2009) Anticancer Drugs , vol.20 , pp. 249-258
    • Tang, C.1    Lu, Y.H.2    Xie, J.H.3    Wang, F.4    Zou, J.N.5    Yang, J.S.6    Xing, Y.Y.7    Xi, T.8
  • 23
    • 77951660302 scopus 로고    scopus 로고
    • Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro
    • Y. Zhang, C. Kong, Y. Zeng, L. Wang, Z. Li, H. Wang, C. Xu, and Y. Sun Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro Mol. Carcinog. 49 2010 374 385
    • (2010) Mol. Carcinog. , vol.49 , pp. 374-385
    • Zhang, Y.1    Kong, C.2    Zeng, Y.3    Wang, L.4    Li, Z.5    Wang, H.6    Xu, C.7    Sun, Y.8
  • 27
    • 77952300961 scopus 로고    scopus 로고
    • Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats
    • R. Gayathri, D.K. Priya, G.R. Gunassekaran, and D. Sakthisekaran Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats Asian Pac. J. Cancer Prev. 10 2009 933 938
    • (2009) Asian Pac. J. Cancer Prev. , vol.10 , pp. 933-938
    • Gayathri, R.1    Priya, D.K.2    Gunassekaran, G.R.3    Sakthisekaran, D.4
  • 28
    • 77149131832 scopus 로고    scopus 로고
    • Effects of ursolic acid on the proliferation and apoptosis of human ovarian
    • X. Wang, L. Li, B. Wang, and J. Xiang Effects of ursolic acid on the proliferation and apoptosis of human ovarian J. Huazhong Univ. Sci. Technol. Med. Sci. 29 2009 761 764
    • (2009) J. Huazhong Univ. Sci. Technol. Med. Sci. , vol.29 , pp. 761-764
    • Wang, X.1    Li, L.2    Wang, B.3    Xiang, J.4
  • 29
    • 78649573167 scopus 로고    scopus 로고
    • Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway
    • Y.X. Yu, Z.L. Gu, J.L. Yin, W.H. Chou, C.Y. Kwok, Z.H. Qin, and Z.Q. Liang Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway Chin. Med. J. 123 2010 1915 1923
    • (2010) Chin. Med. J. , vol.123 , pp. 1915-1923
    • Yu, Y.X.1    Gu, Z.L.2    Yin, J.L.3    Chou, W.H.4    Kwok, C.Y.5    Qin, Z.H.6    Liang, Z.Q.7
  • 30
    • 78249242752 scopus 로고    scopus 로고
    • Anti-tumor effects of ursolic acid in a mouse model of postmenopausal breast cancer
    • R.E. De Angel, S.M. Smith, R.D. Glickman, S.N. Perkins, and S.D. Hursting Anti-tumor effects of ursolic acid in a mouse model of postmenopausal breast cancer Nutr. Cancer 62 2010 1074 1086
    • (2010) Nutr. Cancer , vol.62 , pp. 1074-1086
    • De Angel, R.E.1    Smith, S.M.2    Glickman, R.D.3    Perkins, S.N.4    Hursting, S.D.5
  • 31
    • 79960833790 scopus 로고    scopus 로고
    • Antitumor properties of boswellic acid against Ehrlich ascites cells bearing mouse
    • S.S. Agrawal, S. Saraswati, R. Mathur, and M. Pandey Antitumor properties of boswellic acid against Ehrlich ascites cells bearing mouse Food Chem. Toxicol. 49 2011 1924 1934
    • (2011) Food Chem. Toxicol. , vol.49 , pp. 1924-1934
    • Agrawal, S.S.1    Saraswati, S.2    Mathur, R.3    Pandey, M.4
  • 32
    • 80051781849 scopus 로고    scopus 로고
    • Cytotoxic and antitumor effects of brucine on Ehrlich ascites tumor and human cancer cell line
    • S.S. Agrawal, S. Saraswati, R. Mathur, and M. Pandey Cytotoxic and antitumor effects of brucine on Ehrlich ascites tumor and human cancer cell line Life Sci. 89 2011 147 158
    • (2011) Life Sci. , vol.89 , pp. 147-158
    • Agrawal, S.S.1    Saraswati, S.2    Mathur, R.3    Pandey, M.4
  • 33
    • 84875270769 scopus 로고    scopus 로고
    • Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo
    • S. Saraswati, and S.S. Agrawal Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo Cancer Lett. 332 2013 83 93
    • (2013) Cancer Lett. , vol.332 , pp. 83-93
    • Saraswati, S.1    Agrawal, S.S.2
  • 34
    • 84880884074 scopus 로고    scopus 로고
    • Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2-mediated angiogenesis
    • S. Saraswati, P.K. Kanuajia, S. Kumar, R. Kumar, and A.A. Alhaider Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2-mediated angiogenesis Mol. Cancer 12 2013 82
    • (2013) Mol. Cancer , vol.12 , pp. 82
    • Saraswati, S.1    Kanuajia, P.K.2    Kumar, S.3    Kumar, R.4    Alhaider, A.A.5
  • 35
    • 0035157543 scopus 로고    scopus 로고
    • 2 consumption, and tumor interstitial fluid pressure
    • 2 consumption, and tumor interstitial fluid pressure Anticancer Res. 21 2001 2827 2833 (Pubitemid 33054463)
    • (2001) Anticancer Research , vol.21 , Issue.4 A , pp. 2827-2833
    • Lee, I.1    Lee, J.2    Lee, Y.H.3    Leonard, J.4
  • 36
    • 44849133593 scopus 로고    scopus 로고
    • Nitrite and nitrate measurement by Griess reagent in human plasma: Evaluation of interferences and standardization
    • D. Giustarini, R. Rossi, A. Milzani, and I. Dalle-Donne Nitrite and nitrate measurement by Griess reagent in human plasma: evaluation of interferences and standardization Methods Enzymol. 440 2008 361 380
    • (2008) Methods Enzymol. , vol.440 , pp. 361-380
    • Giustarini, D.1    Rossi, R.2    Milzani, A.3    Dalle-Donne, I.4
  • 37
    • 0017184389 scopus 로고
    • A dye binding assay for protein
    • M.M. Bradford A dye binding assay for protein Anal. Biochem. 72 1976 248 254
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 39
    • 0028273864 scopus 로고
    • Tea plant root extract (TRE) as an antineoplastic agent
    • P. Sur, and D.K. Ganguly Tea plant roots extract (TRE) as an antineoplastic agent Planta Med. 60 1994 106 109 (Pubitemid 24120889)
    • (1994) Planta Medica , vol.60 , Issue.2 , pp. 106-109
    • Sur, P.1    Ganguly, D.K.2
  • 40
    • 0034907881 scopus 로고    scopus 로고
    • The angiotensin-I-converting enzyme inhibitor perindopril suppresses tumor growth and angiogenesis: Possible role of the vascular endothelial growth factor
    • H. Yoshiji, S. Kuriyama, M. Kawata, J. Yoshii, Y. Ikenaka, R. Noguchi, T. Nakatani, H. Tsujinoue, and H. Fukui The angiotensin-I-converting enzyme inhibitor perindopril suppresses tumor growth and angiogenesis: possible role of the vascular endothelial growth factor Clin. Cancer Res. 7 2001 1073 1078 (Pubitemid 32708747)
    • (2001) Clinical Cancer Research , vol.7 , Issue.4 , pp. 1073-1078
    • Yoshiji, H.1    Kuriyama, S.2    Kawata, M.3    Yoshii, J.4    Ikenaka, Y.5    Noguchi, R.6    Nakatani, T.7    Tsujinoue, H.8    Fukui, H.9
  • 42
    • 0037134709 scopus 로고    scopus 로고
    • Clinical application of antiangiogenic therapy: Microvessel density, what it does and doen't tell us
    • L. Hlkatky, P. Hahnfeldt, and J. Folkman Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us J. Natl. Cancer Inst. 94 2002 883 893 (Pubitemid 34778087)
    • (2002) Journal of the National Cancer Institute , vol.94 , Issue.12 , pp. 883-893
    • Hlatky, L.1    Hahnfeldt, P.2    Folkman, J.3
  • 43
    • 78651053052 scopus 로고
    • Tests of compounds against the Ehrlich mouse ascites tumor
    • H. Lettre Tests of compounds against the Ehrlich mouse ascites tumor Cancer Res. 2 1955 125 128
    • (1955) Cancer Res. , vol.2 , pp. 125-128
    • Lettre, H.1
  • 44
    • 77953200744 scopus 로고
    • Effect of various compounds on the Ehrlich ascites carcinoma
    • K. Sugiura Effect of various compounds on the Ehrlich ascites carcinoma Cancer Res. 13 1953 431 441
    • (1953) Cancer Res. , vol.13 , pp. 431-441
    • Sugiura, K.1
  • 45
    • 33846660840 scopus 로고    scopus 로고
    • Vascular permeability induced by VEGF family members in vivo: Role of endogenous PAF and NO synthesis
    • DOI 10.1002/jcb.21124
    • A. Brkovic, and M.G. Sirois Vascular permeability induced by VEGF family members in vivo: role of endogenous PAF and NO synthesis J. Cell. Biochem. 100 2007 727 737 (Pubitemid 46187709)
    • (2007) Journal of Cellular Biochemistry , vol.100 , Issue.3 , pp. 727-737
    • Brkovic, A.1    Sirois, M.G.2
  • 46
    • 0033119963 scopus 로고    scopus 로고
    • Molecular mechanism of action of butyric acid in Ehrlich Ascites Tumor cells
    • DOI 10.1016/S0271-5317(99)00024-X, PII S027153179900024X
    • B.P. Salimath, A. Tabassum, E.G. Anupama, Bindumalini, G.B. Preethi, and P.V. Salimath Molecular mechanism of action of butyric acid in Ehrlich ascites tumor cells Nutr. Res. 19 1999 589 600 (Pubitemid 29205541)
    • (1999) Nutrition Research , vol.19 , Issue.4 , pp. 589-600
    • Salimath, B.P.1    Tabassum, A.2    Anupama, E.G.3    Bindumalini4    Preeti, G.B.5    Salimath, P.V.6
  • 47
    • 0029567968 scopus 로고
    • Pharmacology of oleanolic and ursolic acid
    • J. Liu Pharmacology of oleanolic and ursolic acid J. Ethnopharmacol. 49 1995 57 68
    • (1995) J. Ethnopharmacol. , vol.49 , pp. 57-68
    • Liu, J.1
  • 48
    • 0030578756 scopus 로고    scopus 로고
    • Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest
    • PII S0304383596043121
    • D. Es-saady, A. Simon, M. Ollier, J.C. Maurizis, A.J. Chulia, and C. Delage Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest Cancer Lett. 10 1996 193 197 (Pubitemid 126745145)
    • (1996) Cancer Letters , vol.106 , Issue.2 , pp. 193-197
    • Es-saady, D.1    Simon, A.2    Ollier, M.3    Maurizis, J.C.4    Chulia, A.J.5    Delage, C.6
  • 49
    • 0036280433 scopus 로고    scopus 로고
    • Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15
    • J. Li, W.J. Guo, and Q.Y. Yang Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15 World J. Gastroenterol. 8 2002 93 495
    • (2002) World J. Gastroenterol. , vol.8 , pp. 93-495
    • Li, J.1    Guo, W.J.2    Yang, Q.Y.3
  • 50
    • 0035897081 scopus 로고    scopus 로고
    • Growth inhibitory effect of green tea extract and (-)-epigallocatechin in Ehrlich ascites tumor cells involves a cellular thiol-dependent activation of mitogenic-activated protein kinases
    • DOI 10.1016/S0009-2797(00)00251-9, PII S0009279700002519
    • D.O. Kennedy, A. Kojima, T. Hasuma, Y. Yano, S. Otani, and Y.I. Matsui Growth inhibitory effect of green tea extract and (-)-epigallocatechin in Ehrlich ascites tumor cells involves a cellular thiol-dependent activation of mitogenic-activated protein kinases Chem. Biol. 134 2001 113 133 (Pubitemid 32304506)
    • (2001) Chemico-Biological Interactions , vol.134 , Issue.2 , pp. 113-133
    • Opare Kennedy, D.1    Kojima, A.2    Hasuma, T.3    Yano, Y.4    Otani, S.5    Matsui-Yuasa, I.6
  • 51
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • DOI 10.1038/nrd2115, PII NRD2115
    • J. Folkman Angiogenesis: an organizing principle for drug discovery Nat. Rev. Drug Discov. 6 2007 273 286 (Pubitemid 46505878)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.4 , pp. 273-286
    • Folkman, J.1
  • 52
    • 0005419856 scopus 로고    scopus 로고
    • Significant expression of vascular endothelial growth factor/vascular permeability factor in mouse ascites tumors
    • J.C. Luo, S. Yamaguchi, A. Shinkai, K. Shitara, and M. Shibuya Significant expression of vascular endothelial growth factor/vascular permeability factor in mouse ascites tumors Cancer Res. 58 1998 2652 2660 (Pubitemid 28275440)
    • (1998) Cancer Research , vol.58 , Issue.12 , pp. 2652-2660
    • Luo, J.C.1    Yamaguchi, S.2    Shinkai, A.3    Shitara, K.4    Shibuya, M.5
  • 53
    • 21244466505 scopus 로고    scopus 로고
    • Angiogenesis in hereditary hemorrhagic telangiectasia: VEGF165 plasma concentration in correlation to the VEGF expression and microvessel density
    • H. Sadick, R. Naim, U. Gossler, K. Hormann, and F. Riedel Angiogenesis in hereditary hemorrhagic telangiectasia: VEGF165 plasma concentration in correlation to the VEGF expression and microvessel density Int. J. Mol. Med. 15 2005 15 19
    • (2005) Int. J. Mol. Med. , vol.15 , pp. 15-19
    • Sadick, H.1    Naim, R.2    Gossler, U.3    Hormann, K.4    Riedel, F.5
  • 54
    • 0031719516 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in ovarian cancer: Inhibition of ascites formation by immunoneutralization
    • S. Mesiano, N. Ferrara, and R.B. Jaffe Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization Am. J. Pathol. 153 1998 1249 1256 (Pubitemid 28465848)
    • (1998) American Journal of Pathology , vol.153 , Issue.4 , pp. 1249-1256
    • Mesiano, S.1    Ferrara, N.2    Jaffe, R.B.3
  • 55
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
    • K.J. Kim, B. Li, J. Winer, M. Armanini, N. Gillet, H.S. Phillips, and N. Ferrara Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo Nature 362 1993 841 842
    • (1993) Nature , vol.362 , pp. 841-842
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillet, N.5    Phillips, H.S.6    Ferrara, N.7
  • 56
    • 0036005890 scopus 로고    scopus 로고
    • Interleukin-12 in anti-tumor immunity and immunotherapy
    • DOI 10.1016/S1359-6101(01)00032-6, PII S1359610101000326
    • M.P. Colombo, and G. Trinchieri Interleukin-12 in anti-tumor immunity and immunotherapy Cytokine Growth Factor Rev. 13 2002 155 168 (Pubitemid 34229390)
    • (2002) Cytokine and Growth Factor Reviews , vol.13 , Issue.2 , pp. 155-168
    • Colombo, M.P.1    Trinchieri, G.2
  • 57
    • 0035877968 scopus 로고    scopus 로고
    • Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKbeta-mediated NF-kappaB activation
    • T. Syrovets, M. Jendrach, A. Rohwedder, A. Schüle, and T. Simmet Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKbeta-mediated NF-kappaB activation Blood 97 2001 3941 3950
    • (2001) Blood , vol.97 , pp. 3941-3950
    • Syrovets, T.1    Jendrach, M.2    Rohwedder, A.3    Schüle, A.4    Simmet, T.5
  • 58
    • 0006740945 scopus 로고
    • Preliminary screening of antineoplastic drugs
    • B.D. Clarkson, and J.H. Burchenal Preliminary screening of antineoplastic drugs Prog. Clin. Cancer 1 1965 625 629
    • (1965) Prog. Clin. Cancer , vol.1 , pp. 625-629
    • Clarkson, B.D.1    Burchenal, J.H.2
  • 59
    • 77956845283 scopus 로고
    • The role of viruses in the production of cancer
    • C. Oberling, and M. Guerin The role of viruses in the production of cancer Adv. Cancer Res. 2 1954 323 353
    • (1954) Adv. Cancer Res. , vol.2 , pp. 323-353
    • Oberling, C.1    Guerin, M.2
  • 60
    • 4043089533 scopus 로고
    • Lipid peroxidation levels and lipid content of serum lipoprotein fractions of pregnant subjects with or without pre-eclampsia
    • M. Maseki, I. Nishiagaki, M. Hagishara, Y. Tamoda, and K. Yagi Lipid peroxidation levels and lipid content of serum lipoprotein fractions of pregnant subjects with or without pre-eclampsia Clin. Chim. Acta 41 1981 424 426
    • (1981) Clin. Chim. Acta , vol.41 , pp. 424-426
    • Maseki, M.1    Nishiagaki, I.2    Hagishara, M.3    Tamoda, Y.4    Yagi, K.5
  • 61
    • 0001200742 scopus 로고
    • Anemia in cancer
    • J.P. Greenstein, A. Haddow, Academic Press New York
    • V.E. Price, and R.E. Greenfield Anemia in cancer J.P. Greenstein, A. Haddow, Advances in Cancer Research 1950 Academic Press New York 199 200
    • (1950) Advances in Cancer Research , pp. 199-200
    • Price, V.E.1    Greenfield, R.E.2
  • 63
    • 77953410033 scopus 로고    scopus 로고
    • The central nervous system depressant activities of Mycotoxin MT81 and its acetylated and benzoylated analogues
    • S.M. Choudhury, G. Roy, M. Gupta, and U.K. Majumder The central nervous system depressant activities of Mycotoxin MT81 and its acetylated and benzoylated analogues Al Ameen J. Med. Sci. 1 2008 104 114
    • (2008) Al Ameen J. Med. Sci. , vol.1 , pp. 104-114
    • Choudhury, S.M.1    Roy, G.2    Gupta, M.3    Majumder, U.K.4
  • 64
    • 0027938689 scopus 로고
    • Oxy-radicals and cancer
    • DOI 10.1016/S0140-6736(94)92832-0
    • P.A. Cerutti Oxy-radicals and cancer Lancet 344 1994 862 863 (Pubitemid 24290388)
    • (1994) Lancet , vol.344 , Issue.8926 , pp. 862-863
    • Cerutti, P.A.1
  • 65
    • 0024264526 scopus 로고
    • Glutathione metabolism and its selective modification
    • A. Meister Glutathione metabolism and its selective modification J. Biochem. 263 1988 17205 17208 (Pubitemid 19029311)
    • (1988) Journal of Biological Chemistry , vol.263 , Issue.33 , pp. 17205-17208
    • Meister, A.1
  • 68
    • 0037141345 scopus 로고    scopus 로고
    • Intra-tumoural microvessel density in human solid tumours
    • DOI 10.1038/sj.bjc.6600315
    • J. Hasan, R. Byers, and G.C. Jayson Intra-tumoral microvessel density in human solid tumors Br. J. Cancer 86 2002 1566 1577 (Pubitemid 34628110)
    • (2002) British Journal of Cancer , vol.86 , Issue.10 , pp. 1566-1577
    • Hasan, J.1    Byers, R.2    Jayson, G.C.3
  • 69
    • 0030797727 scopus 로고    scopus 로고
    • Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death
    • DOI 10.1083/jcb.139.1.205
    • T.M. Miller, K.L. Moulder, C.M. Knudson, D.J. Creedon, M. Deshmukh, S.J. Korsmeyer, and E.M. Johnson Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death J. Cell Biol. 139 1997 205 217 (Pubitemid 27444092)
    • (1997) Journal of Cell Biology , vol.139 , Issue.1 , pp. 205-217
    • Miller, T.M.1    Moulder, K.L.2    Knudson, C.M.3    Creedon, D.J.4    Deshmukh, M.5    Korsmeyer, S.J.6    Johnson Jr., E.M.7
  • 70
    • 0032484687 scopus 로고    scopus 로고
    • Bax and Bak proteins require caspase activity to trigger apoptosis in sympathetic neurons
    • M. Missotten, P.A. Fernandez, R. Sadoul, and J.C. Martinou Bax and Bak proteins require caspase activity to trigger apoptosis in sympathetic neurons Neuroreport 9 1998 15 19 (Pubitemid 28046646)
    • (1998) NeuroReport , vol.9 , Issue.1 , pp. 15-19
    • Martinou, I.1    Missotten, M.2    Fernandez, P.-A.3    Sadoul, R.4    Martinou, J.-C.5
  • 71
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • N.A. Thornberry, and Y. Lazebnik Caspases: enemies within Science 281 1998 1312 1316 (Pubitemid 28406817)
    • (1998) Science , vol.281 , Issue.5381 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 72
    • 33746886979 scopus 로고    scopus 로고
    • Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
    • DOI 10.1038/sj.onc.1209608, PII 1209608
    • S. Fulda, and K.M. Debatin Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy Oncogene 25 2006 4798 4811 (Pubitemid 44187627)
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4798-4811
    • Fulda, S.1    Debatin, K.-M.2
  • 73
    • 77954958831 scopus 로고    scopus 로고
    • Gomes, A lethal cardiotoxic-cytotoxic protein from the Indian monocellate cobra (Naja kaouthia) venom
    • A. Debnath, A. Saha, S. Gomes, P. Biswas, B. Chakrabarti, A.K. Giri, S.D. Biswas, and A. Gupta Gomes, A lethal cardiotoxic-cytotoxic protein from the Indian monocellate cobra (Naja kaouthia) venom Toxicon 56 2010 569 579
    • (2010) Toxicon , vol.56 , pp. 569-579
    • Debnath, A.1    Saha, A.2    Gomes, S.3    Biswas, P.4    Chakrabarti, B.5    Giri, A.K.6    Biswas, S.D.7    Gupta, A.8


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