메뉴 건너뛰기




Volumn 80, Issue 3, 2015, Pages 237-244

Chondrosenescence: Definition, hallmarks and potential role in the pathogenesis of osteoarthritis

Author keywords

Apoptosis; Cartilage; Chondrosenescence; Hallmark; Osteoarthritis

Indexed keywords

CALCIUM; INFLAMMASOME;

EID: 84922851321     PISSN: 03785122     EISSN: 18734111     Source Type: Journal    
DOI: 10.1016/j.maturitas.2014.12.003     Document Type: Review
Times cited : (177)

References (101)
  • 2
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • J. Campisi, and F. d'Adda di Fagagna Cellular senescence: when bad things happen to good cells Nat Rev Mol Cell Biol 8 2007 729 740
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 729-740
    • Campisi, J.1    D'Adda Di Fagagna, F.2
  • 5
    • 0034069237 scopus 로고    scopus 로고
    • Cancer, aging and cellular senescence
    • J. Campisi Cancer, aging and cellular senescence In Vivo 14 2000 183 188
    • (2000) In Vivo , vol.14 , pp. 183-188
    • Campisi, J.1
  • 6
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • L. Hayflick The limited in vitro lifetime of human diploid cell strains Exp Cell Res 37 1965 614 636
    • (1965) Exp Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 7
    • 0035059672 scopus 로고    scopus 로고
    • From cells to organisms: Can we learn about aging from cells in culture
    • J. Campisi From cells to organisms: can we learn about aging from cells in culture Exp Gerontol 36 2001 607 618
    • (2001) Exp Gerontol , vol.36 , pp. 607-618
    • Campisi, J.1
  • 8
    • 0030964277 scopus 로고    scopus 로고
    • The biology of replicative senescence
    • J. Campisi The biology of replicative senescence Eur J Cancer 33 1997 703 709
    • (1997) Eur J Cancer , vol.33 , pp. 703-709
    • Campisi, J.1
  • 9
    • 0030887851 scopus 로고    scopus 로고
    • Aging and cancer: The double-edged sword of replicative senescence
    • J. Campisi Aging and cancer: the double-edged sword of replicative senescence J Am Geriatr Soc 45 1997 482 488
    • (1997) J Am Geriatr Soc , vol.45 , pp. 482-488
    • Campisi, J.1
  • 11
    • 0031755297 scopus 로고    scopus 로고
    • The role of cellular senescence in skin aging
    • J. Campisi The role of cellular senescence in skin aging J Investig Dermatol Symp Proc 3 1998 1 5
    • (1998) J Investig Dermatol Symp Proc , vol.3 , pp. 1-5
    • Campisi, J.1
  • 12
    • 84863329778 scopus 로고    scopus 로고
    • Inflammaging: Disturbed interplay between autophagy and inflammasomes
    • A. Salminen, K. Kaarniranta, and A. Kauppinen Inflammaging: disturbed interplay between autophagy and inflammasomes Aging (Albany NY) 4 2012 166 175
    • (2012) Aging (Albany NY) , vol.4 , pp. 166-175
    • Salminen, A.1    Kaarniranta, K.2    Kauppinen, A.3
  • 13
    • 79955161193 scopus 로고    scopus 로고
    • Mitochondria Sovereign of inflammation?
    • J. Tschopp Mitochondria Sovereign of inflammation? Eur J Immunol 41 2011 1196 1202
    • (2011) Eur J Immunol , vol.41 , pp. 1196-1202
    • Tschopp, J.1
  • 14
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • R. Zhou, A.S. Yazdi, P. Menu, and J. Tschopp A role for mitochondria in NLRP3 inflammasome activation Nature 469 2011 221 225
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 15
    • 84865643438 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress activate inflammasomes: Impact on the aging process and age-related diseases
    • A. Salminen, J. Ojala, K. Kaarniranta, and A. Kauppinen Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases Cell Mol Life Sci 69 2012 2999 3013
    • (2012) Cell Mol Life Sci , vol.69 , pp. 2999-3013
    • Salminen, A.1    Ojala, J.2    Kaarniranta, K.3    Kauppinen, A.4
  • 16
    • 0037396614 scopus 로고    scopus 로고
    • Centenarians as a model for healthy aging
    • C. Franceschi, and M. Bonafe Centenarians as a model for healthy aging Biochem Soc Trans 31 2003 457 461
    • (2003) Biochem Soc Trans , vol.31 , pp. 457-461
    • Franceschi, C.1    Bonafe, M.2
  • 17
    • 33846111415 scopus 로고    scopus 로고
    • Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
    • C. Franceschi, M. Capri, and D. Monti Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans Mech Ageing Dev 128 2007 92 105
    • (2007) Mech Ageing Dev , vol.128 , pp. 92-105
    • Franceschi, C.1    Capri, M.2    Monti, D.3
  • 18
    • 84871921917 scopus 로고    scopus 로고
    • Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)
    • F. Berenbaum Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!) Osteoarthritis Cartilage 21 2013 16 21
    • (2013) Osteoarthritis Cartilage , vol.21 , pp. 16-21
    • Berenbaum, F.1
  • 19
    • 84888399985 scopus 로고    scopus 로고
    • Is osteoarthritis a metabolic disease
    • J. Sellam, and F. Berenbaum Is osteoarthritis a metabolic disease Joint Bone Spine 80 2013 568 573
    • (2013) Joint Bone Spine , vol.80 , pp. 568-573
    • Sellam, J.1    Berenbaum, F.2
  • 20
    • 79751537155 scopus 로고    scopus 로고
    • Inflammaging: The driving force in osteoporosis
    • P. Lencel, and D. Magne Inflammaging: the driving force in osteoporosis Med Hypotheses 76 2011 317 321
    • (2011) Med Hypotheses , vol.76 , pp. 317-321
    • Lencel, P.1    Magne, D.2
  • 21
    • 77952302657 scopus 로고    scopus 로고
    • Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
    • M. Goto Inflammaging (inflammation + aging): a driving force for human aging based on an evolutionarily antagonistic pleiotropy theory? Biosci Trends 2 2008 218 230
    • (2008) Biosci Trends , vol.2 , pp. 218-230
    • Goto, M.1
  • 22
    • 80053900670 scopus 로고    scopus 로고
    • Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA
    • M.K. Lotz, and B. Carames Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA Nat Rev Rheumatol 7 2011 579 587
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 579-587
    • Lotz, M.K.1    Carames, B.2
  • 23
    • 77649128750 scopus 로고    scopus 로고
    • Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis
    • B. Carames, N. Taniguchi, S. Otsuki, F.J. Blanco, and M. Lotz Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis Arthritis Rheum 62 2010 791 801
    • (2010) Arthritis Rheum , vol.62 , pp. 791-801
    • Carames, B.1    Taniguchi, N.2    Otsuki, S.3    Blanco, F.J.4    Lotz, M.5
  • 24
    • 18644371961 scopus 로고    scopus 로고
    • Glucose transport and metabolism in chondrocytes: A key to understanding chondrogenesis, skeletal development and cartilage degradation in osteoarthritis
    • A. Mobasheri, S.J. Vannucci, and C.A. Bondy Glucose transport and metabolism in chondrocytes: a key to understanding chondrogenesis, skeletal development and cartilage degradation in osteoarthritis Histol Histopathol 17 2002 1239 1267
    • (2002) Histol Histopathol , vol.17 , pp. 1239-1267
    • Mobasheri, A.1    Vannucci, S.J.2    Bondy, C.A.3
  • 25
    • 58149170369 scopus 로고    scopus 로고
    • Facilitative glucose transporters in articular chondrocytes. Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines
    • A. Mobasheri, C.A. Bondy, and K. Moley Facilitative glucose transporters in articular chondrocytes. Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines Adv Anat Embryol Cell Biol 200 2008 1 84
    • (2008) Adv Anat Embryol Cell Biol , vol.200 , pp. 1-84
    • Mobasheri, A.1    Bondy, C.A.2    Moley, K.3
  • 27
    • 33847191703 scopus 로고    scopus 로고
    • Antioxidant to treat osteoarthritis: Dream or reality
    • Y. Henrotin, and B. Kurz Antioxidant to treat osteoarthritis: dream or reality Curr Drug Targets 8 2007 347 357
    • (2007) Curr Drug Targets , vol.8 , pp. 347-357
    • Henrotin, Y.1    Kurz, B.2
  • 28
    • 0141504018 scopus 로고    scopus 로고
    • The role of reactive oxygen species in homeostasis and degradation of cartilage
    • Y.E. Henrotin, P. Bruckner, and J.P. Pujol The role of reactive oxygen species in homeostasis and degradation of cartilage Osteoarthritis Cartilage 11 2003 747 755
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 747-755
    • Henrotin, Y.E.1    Bruckner, P.2    Pujol, J.P.3
  • 29
    • 34548364093 scopus 로고    scopus 로고
    • Hypoxia and osteoarthritis: How chondrocytes survive hypoxic environments
    • D. Pfander, and K. Gelse Hypoxia and osteoarthritis: how chondrocytes survive hypoxic environments Curr Opin Rheumatol 19 2007 457 462
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 457-462
    • Pfander, D.1    Gelse, K.2
  • 30
    • 77749302262 scopus 로고    scopus 로고
    • Lack of oxygen in articular cartilage: Consequences for chondrocyte biology
    • J.E. Lafont Lack of oxygen in articular cartilage: consequences for chondrocyte biology Int J Exp Pathol 91 2010 99 106
    • (2010) Int J Exp Pathol , vol.91 , pp. 99-106
    • Lafont, J.E.1
  • 32
    • 0029363876 scopus 로고
    • Microvascular architecture and exchange in synovial joints
    • J.R. Levick Microvascular architecture and exchange in synovial joints Microcirculation 2 1995 217 233
    • (1995) Microcirculation , vol.2 , pp. 217-233
    • Levick, J.R.1
  • 33
    • 36448997363 scopus 로고    scopus 로고
    • Vascular pathology and osteoarthritis
    • D.M. Findlay Vascular pathology and osteoarthritis Rheumatology (Oxford) 46 2007 1763 1768
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 1763-1768
    • Findlay, D.M.1
  • 34
    • 0027016233 scopus 로고
    • Active oxygen species, articular inflammation and cartilage damage
    • Y. Henrotin, G. Deby-Dupont, C. Deby, P. Franchimont, and I. Emerit Active oxygen species, articular inflammation and cartilage damage EXS 62 1992 308 322
    • (1992) EXS , vol.62 , pp. 308-322
    • Henrotin, Y.1    Deby-Dupont, G.2    Deby, C.3    Franchimont, P.4    Emerit, I.5
  • 35
    • 0031726795 scopus 로고    scopus 로고
    • In situ detection of superoxide anions within porcine articular cartilage
    • T.S. Hiran, P.J. Moulton, and J.T. Hancock In situ detection of superoxide anions within porcine articular cartilage Br J Biomed Sci 55 1998 199 203
    • (1998) Br J Biomed Sci , vol.55 , pp. 199-203
    • Hiran, T.S.1    Moulton, P.J.2    Hancock, J.T.3
  • 36
    • 0030612396 scopus 로고    scopus 로고
    • Detection of superoxide and NADPH oxidase in porcine articular chondrocytes
    • T.S. Hiran, P.J. Moulton, and J.T. Hancock Detection of superoxide and NADPH oxidase in porcine articular chondrocytes Free Radic Biol Med 23 1997 736 743
    • (1997) Free Radic Biol Med , vol.23 , pp. 736-743
    • Hiran, T.S.1    Moulton, P.J.2    Hancock, J.T.3
  • 37
    • 51549116292 scopus 로고    scopus 로고
    • Osteoarthritis and nitric oxide
    • S.B. Abramson Osteoarthritis and nitric oxide Osteoarthritis Cartilage 16 Suppl 2 2008 S15 S20
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. S15-S20
    • Abramson, S.B.1
  • 39
    • 54249104477 scopus 로고    scopus 로고
    • Nitric oxide in inflammation and pain associated with osteoarthritis
    • S.B. Abramson Nitric oxide in inflammation and pain associated with osteoarthritis Arthritis Res Ther 10 Suppl 2 2008 S2
    • (2008) Arthritis Res Ther , vol.10 , pp. S2
    • Abramson, S.B.1
  • 40
    • 0035656866 scopus 로고    scopus 로고
    • Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis
    • S.B. Abramson, M. Attur, A.R. Amin, and R. Clancy Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis Curr Rheumatol Rep 3 2001 535 541
    • (2001) Curr Rheumatol Rep , vol.3 , pp. 535-541
    • Abramson, S.B.1    Attur, M.2    Amin, A.R.3    Clancy, R.4
  • 41
    • 0032007878 scopus 로고    scopus 로고
    • NADPH oxidase of chondrocytes contains an isoform of the gp91phox subunit
    • P.J. Moulton, M.B. Goldring, and J.T. Hancock NADPH oxidase of chondrocytes contains an isoform of the gp91phox subunit Biochem J 329 Pt 3 1998 449 451
    • (1998) Biochem J , vol.329 , Issue.PART 3 , pp. 449-451
    • Moulton, P.J.1    Goldring, M.B.2    Hancock, J.T.3
  • 42
    • 0030824879 scopus 로고    scopus 로고
    • Detection of protein and mRNA of various components of the NADPH oxidase complex in an immortalized human chondrocyte line
    • P.J. Moulton, T.S. Hiran, M.B. Goldring, and J.T. Hancock Detection of protein and mRNA of various components of the NADPH oxidase complex in an immortalized human chondrocyte line Br J Rheumatol 36 1997 522 529
    • (1997) Br J Rheumatol , vol.36 , pp. 522-529
    • Moulton, P.J.1    Hiran, T.S.2    Goldring, M.B.3    Hancock, J.T.4
  • 43
    • 41049117461 scopus 로고    scopus 로고
    • Osteoarthritis in the context of ageing and evolution. Loss of chondrocyte differentiation block during ageing
    • P.M. van der Kraan, and W.B. van den Berg Osteoarthritis in the context of ageing and evolution. Loss of chondrocyte differentiation block during ageing Ageing Res Rev 7 2008 106 113
    • (2008) Ageing Res Rev , vol.7 , pp. 106-113
    • Van Der Kraan, P.M.1    Van Den Berg, W.B.2
  • 44
    • 0038753871 scopus 로고    scopus 로고
    • The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair
    • J.A. Martin, and J.A. Buckwalter The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair J Bone Joint Surg Am 85-A Suppl 2 2003 106 110
    • (2003) J Bone Joint Surg Am , vol.85 A , pp. 106-110
    • Martin, J.A.1    Buckwalter, J.A.2
  • 45
    • 0031602467 scopus 로고    scopus 로고
    • Articular cartilage: Degeneration and osteoarthritis, repair, regeneration, and transplantation
    • J.A. Buckwalter, and H.J. Mankin Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation Instr Course Lect 47 1998 487 504
    • (1998) Instr Course Lect , vol.47 , pp. 487-504
    • Buckwalter, J.A.1    Mankin, H.J.2
  • 46
    • 67650383738 scopus 로고    scopus 로고
    • Aging and osteoarthritis: The role of chondrocyte senescence and aging changes in the cartilage matrix
    • R.F. Loeser Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix Osteoarthritis Cartilage 17 2009 971 979
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 971-979
    • Loeser, R.F.1
  • 47
    • 0023491915 scopus 로고
    • Apoptosis: Cell death in tissue regulation
    • A.H. Wyllie Apoptosis: cell death in tissue regulation J Pathol 153 1987 313 316
    • (1987) J Pathol , vol.153 , pp. 313-316
    • Wyllie, A.H.1
  • 48
    • 0028796225 scopus 로고
    • Defining apoptosis
    • D. Hockenbery Defining apoptosis Am J Pathol 146 1995 16 19
    • (1995) Am J Pathol , vol.146 , pp. 16-19
    • Hockenbery, D.1
  • 49
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • J.F. Kerr, A.H. Wyllie, and A.R. Currie Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics Br J Cancer 26 1972 239 257
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 50
    • 0024536234 scopus 로고
    • Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages
    • J.S. Savill, A.H. Wyllie, J.E. Henson, M.J. Walport, P.M. Henson, and C. Haslett Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages J Clin Invest 83 1989 865 875
    • (1989) J Clin Invest , vol.83 , pp. 865-875
    • Savill, J.S.1    Wyllie, A.H.2    Henson, J.E.3    Walport, M.J.4    Henson, P.M.5    Haslett, C.6
  • 51
    • 0029126857 scopus 로고
    • Apoptosis in rheumatoid arthritis synovium
    • G.S. Firestein, M. Yeo, and N.J. Zvaifler Apoptosis in rheumatoid arthritis synovium J Clin Invest 96 1995 1631 1638
    • (1995) J Clin Invest , vol.96 , pp. 1631-1638
    • Firestein, G.S.1    Yeo, M.2    Zvaifler, N.J.3
  • 52
    • 0029764395 scopus 로고    scopus 로고
    • Ultrastructural demonstration of apoptosis, Fas and Bcl-2 expression of rheumatoid synovial fibroblasts
    • S. Matsumoto, U. Muller-Ladner, R.E. Gay, K. Nishioka, and S. Gay Ultrastructural demonstration of apoptosis, Fas and Bcl-2 expression of rheumatoid synovial fibroblasts J Rheumatol 23 1996 1345 1352
    • (1996) J Rheumatol , vol.23 , pp. 1345-1352
    • Matsumoto, S.1    Muller-Ladner, U.2    Gay, R.E.3    Nishioka, K.4    Gay, S.5
  • 53
    • 0030272623 scopus 로고    scopus 로고
    • Expression of Fas antigen and Fas ligand in the rheumatoid synovial tissue
    • H. Asahara, T. Hasumuna, and T. Kobata Expression of Fas antigen and Fas ligand in the rheumatoid synovial tissue Clin Immunol Immunopathol 81 1996 27 34
    • (1996) Clin Immunol Immunopathol , vol.81 , pp. 27-34
    • Asahara, H.1    Hasumuna, T.2    Kobata, T.3
  • 54
    • 0029834812 scopus 로고    scopus 로고
    • Apoptosis in rheumatoid arthritis: P53 overexpression in rheumatoid arthritis synovium
    • G.S. Firestein, K. Nguyen, K.R. Aupperle, M. Yeo, D.L. Boyle, and N.J. Zvaifler Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium Am J Pathol 149 1996 2143 2151
    • (1996) Am J Pathol , vol.149 , pp. 2143-2151
    • Firestein, G.S.1    Nguyen, K.2    Aupperle, K.R.3    Yeo, M.4    Boyle, D.L.5    Zvaifler, N.J.6
  • 55
    • 0031020293 scopus 로고    scopus 로고
    • Accumulation of soluble Fas in inflamed joints of patients with rheumatoid arthritis
    • T. Hasunuma, N. Kayagaki, and H. Asahara Accumulation of soluble Fas in inflamed joints of patients with rheumatoid arthritis Arthritis Rheum 40 1997 80 86
    • (1997) Arthritis Rheum , vol.40 , pp. 80-86
    • Hasunuma, T.1    Kayagaki, N.2    Asahara, H.3
  • 56
    • 0030951831 scopus 로고    scopus 로고
    • Identification of apoptotic changes in osteocytes in normal and pathological human bone
    • B.S. Noble, H. Stevens, N. Loveridge, and J. Reeve Identification of apoptotic changes in osteocytes in normal and pathological human bone Bone 20 1997 273 282
    • (1997) Bone , vol.20 , pp. 273-282
    • Noble, B.S.1    Stevens, H.2    Loveridge, N.3    Reeve, J.4
  • 57
    • 0031913045 scopus 로고    scopus 로고
    • Focally regulated endothelial proliferation and cell death in human synovium
    • D.A. Walsh, M. Wade, P.I. Mapp, and D.R. Blake Focally regulated endothelial proliferation and cell death in human synovium Am J Pathol 152 1998 691 702
    • (1998) Am J Pathol , vol.152 , pp. 691-702
    • Walsh, D.A.1    Wade, M.2    Mapp, P.I.3    Blake, D.R.4
  • 59
    • 0030854379 scopus 로고    scopus 로고
    • Fas/Fas ligand expression and induction of apoptosis in chondrocytes
    • S. Hashimoto, M. Setareh, R.L. Ochs, and M. Lotz Fas/Fas ligand expression and induction of apoptosis in chondrocytes Arthritis Rheum 40 1997 1749 1755
    • (1997) Arthritis Rheum , vol.40 , pp. 1749-1755
    • Hashimoto, S.1    Setareh, M.2    Ochs, R.L.3    Lotz, M.4
  • 60
    • 0031900570 scopus 로고    scopus 로고
    • Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis
    • H. Hashimoto, M. Tanaka, and T. Suda Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis Arthritis Rheum 41 1998 657 662
    • (1998) Arthritis Rheum , vol.41 , pp. 657-662
    • Hashimoto, H.1    Tanaka, M.2    Suda, T.3
  • 61
    • 0031886742 scopus 로고    scopus 로고
    • Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology
    • F.J. Blanco, R. Guitian, E. Vazquez-Martul, F.J. de Toro, and F. Galdo Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology Arthritis Rheum 41 1998 284 289
    • (1998) Arthritis Rheum , vol.41 , pp. 284-289
    • Blanco, F.J.1    Guitian, R.2    Vazquez-Martul, E.3    De Toro, F.J.4    Galdo, F.5
  • 62
    • 0031658981 scopus 로고    scopus 로고
    • Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis
    • S. Hashimoto, R.L. Ochs, S. Komiya, and M. Lotz Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis Arthritis Rheum 41 1998 1632 1638
    • (1998) Arthritis Rheum , vol.41 , pp. 1632-1638
    • Hashimoto, S.1    Ochs, R.L.2    Komiya, S.3    Lotz, M.4
  • 63
    • 0031837375 scopus 로고    scopus 로고
    • Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis
    • S. Hashimoto, K. Takahashi, D. Amiel, R.D. Coutts, and M. Lotz Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis Arthritis Rheum 41 1998 1266 1274
    • (1998) Arthritis Rheum , vol.41 , pp. 1266-1274
    • Hashimoto, S.1    Takahashi, K.2    Amiel, D.3    Coutts, R.D.4    Lotz, M.5
  • 64
    • 0031833414 scopus 로고    scopus 로고
    • The role of nitric oxide in articular cartilage breakdown in osteoarthritis
    • A.R. Amin, and S.B. Abramson The role of nitric oxide in articular cartilage breakdown in osteoarthritis Curr Opin Rheumatol 10 1998 263 268
    • (1998) Curr Opin Rheumatol , vol.10 , pp. 263-268
    • Amin, A.R.1    Abramson, S.B.2
  • 65
    • 0032539821 scopus 로고    scopus 로고
    • Chondrocyte-derived apoptotic bodies and calcification of articular cartilage
    • S. Hashimoto, R.L. Ochs, and F. Rosen Chondrocyte-derived apoptotic bodies and calcification of articular cartilage Proc Natl Acad Sci USA 95 1998 3094 3099
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3094-3099
    • Hashimoto, S.1    Ochs, R.L.2    Rosen, F.3
  • 66
    • 79955141040 scopus 로고    scopus 로고
    • Chondrocyte apoptosis: A cause or consequence of osteoarthritis
    • Z. Zamli, and M. Sharif Chondrocyte apoptosis: a cause or consequence of osteoarthritis Int J Rheum Dis 14 2011 159 166
    • (2011) Int J Rheum Dis , vol.14 , pp. 159-166
    • Zamli, Z.1    Sharif, M.2
  • 68
    • 78751569921 scopus 로고    scopus 로고
    • Characterization of apoptosis in articular cartilage derived from the knee joints of patients with osteoarthritis
    • G. Musumeci, C. Loreto, M.L. Carnazza, and G. Martinez Characterization of apoptosis in articular cartilage derived from the knee joints of patients with osteoarthritis Knee Surg Sports Traumatol Arthrosc 19 2011 307 313
    • (2011) Knee Surg Sports Traumatol Arthrosc , vol.19 , pp. 307-313
    • Musumeci, G.1    Loreto, C.2    Carnazza, M.L.3    Martinez, G.4
  • 69
    • 0033048814 scopus 로고    scopus 로고
    • The apoptosis cascade - Morphological and immunohistochemical methods for its visualization
    • B. Huppertz, H.G. Frank, and P. Kaufmann The apoptosis cascade - morphological and immunohistochemical methods for its visualization Anat Embryol (Berl) 200 1999 1 18
    • (1999) Anat Embryol (Berl) , vol.200 , pp. 1-18
    • Huppertz, B.1    Frank, H.G.2    Kaufmann, P.3
  • 70
    • 13144261687 scopus 로고    scopus 로고
    • Chondrocyte apoptosis in development, aging and disease
    • W.E. Horton Jr., L. Feng, and C. Adams Chondrocyte apoptosis in development, aging and disease Matrix Biol 17 1998 107 115
    • (1998) Matrix Biol , vol.17 , pp. 107-115
    • Horton, Jr.W.E.1    Feng, L.2    Adams, C.3
  • 71
    • 3142722961 scopus 로고    scopus 로고
    • Chondroptosis: A variant of apoptotic cell death in chondrocytes
    • H.I. Roach, T. Aigner, and J.B. Kouri Chondroptosis: a variant of apoptotic cell death in chondrocytes Apoptosis 9 2004 265 277
    • (2004) Apoptosis , vol.9 , pp. 265-277
    • Roach, H.I.1    Aigner, T.2    Kouri, J.B.3
  • 72
    • 80053333636 scopus 로고    scopus 로고
    • OA cartilage derived chondrocytes encapsulated in poly(ethylene glycol) diacrylate (PEGDA) for the evaluation of cartilage restoration and apoptosis in an in vitro model
    • G. Musumeci, C. Loreto, M.L. Carnazza, I. Strehin, and J. Elisseeff OA cartilage derived chondrocytes encapsulated in poly(ethylene glycol) diacrylate (PEGDA) for the evaluation of cartilage restoration and apoptosis in an in vitro model Histol Histopathol 26 2011 1265 1278
    • (2011) Histol Histopathol , vol.26 , pp. 1265-1278
    • Musumeci, G.1    Loreto, C.2    Carnazza, M.L.3    Strehin, I.4    Elisseeff, J.5
  • 73
    • 33847194975 scopus 로고    scopus 로고
    • Cell death and apoptosis in osteoarthritic cartilage
    • H.A. Kim, and F.J. Blanco Cell death and apoptosis in osteoarthritic cartilage Curr Drug Targets 8 2007 333 345
    • (2007) Curr Drug Targets , vol.8 , pp. 333-345
    • Kim, H.A.1    Blanco, F.J.2
  • 74
  • 75
    • 84883246797 scopus 로고    scopus 로고
    • Calcium signalling in chondrogenesis: Implications for cartilage repair
    • C. Matta, and R. Zakany Calcium signalling in chondrogenesis: implications for cartilage repair Front Biosci (Schol Ed) 5 2013 305 324
    • (2013) Front Biosci (Schol Ed) , vol.5 , pp. 305-324
    • Matta, C.1    Zakany, R.2
  • 77
    • 79952502660 scopus 로고    scopus 로고
    • Aging differentially modifies agonist-evoked mouse detrusor contraction and calcium signals
    • P.J. Gomez-Pinilla, M.J. Pozo, and P.J. Camello Aging differentially modifies agonist-evoked mouse detrusor contraction and calcium signals Age (Dordr) 33 2011 81 88
    • (2011) Age (Dordr) , vol.33 , pp. 81-88
    • Gomez-Pinilla, P.J.1    Pozo, M.J.2    Camello, P.J.3
  • 78
    • 84878659590 scopus 로고    scopus 로고
    • Effect of aging on calcium signaling in C57Bl6J mouse cerebral arteries
    • C. Georgeon-Chartier, C. Menguy, A. Prevot, and J.L. Morel Effect of aging on calcium signaling in C57Bl6J mouse cerebral arteries Pflugers Arch 465 2013 829 838
    • (2013) Pflugers Arch , vol.465 , pp. 829-838
    • Georgeon-Chartier, C.1    Menguy, C.2    Prevot, A.3    Morel, J.L.4
  • 79
    • 84857742047 scopus 로고    scopus 로고
    • Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice
    • R.F. Loeser, A.L. Olex, and M.A. McNulty Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice Arthritis Rheum 64 2012 705 717
    • (2012) Arthritis Rheum , vol.64 , pp. 705-717
    • Loeser, R.F.1    Olex, A.L.2    McNulty, M.A.3
  • 80
    • 67349283365 scopus 로고    scopus 로고
    • Ionotropic purinergic receptor P2X4 is involved in the regulation of chondrogenesis in chicken micromass cell cultures
    • J. Fodor, C. Matta, and T. Juhasz Ionotropic purinergic receptor P2X4 is involved in the regulation of chondrogenesis in chicken micromass cell cultures Cell Calcium 45 2009 421 430
    • (2009) Cell Calcium , vol.45 , pp. 421-430
    • Fodor, J.1    Matta, C.2    Juhasz, T.3
  • 81
    • 84922927078 scopus 로고    scopus 로고
    • Purinergic signalling is required for calcium oscillations in migratory chondrogenic progenitor cells
    • C. Matta, J. Fodor, and N. Miosge Purinergic signalling is required for calcium oscillations in migratory chondrogenic progenitor cells Pflugers Arch 467 2014 429 442
    • (2014) Pflugers Arch , vol.467 , pp. 429-442
    • Matta, C.1    Fodor, J.2    Miosge, N.3
  • 83
    • 0034193415 scopus 로고    scopus 로고
    • Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: Ion-channel dependent transduction of matrix deformation signals
    • Q.Q. Wu, and Q. Chen Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals Exp Cell Res 256 2000 383 391
    • (2000) Exp Cell Res , vol.256 , pp. 383-391
    • Wu, Q.Q.1    Chen, Q.2
  • 84
    • 84865594048 scopus 로고    scopus 로고
    • + channel gating contribute to modified intrinsic neuronal excitability
    • + channel gating contribute to modified intrinsic neuronal excitability Neurobiol Aging 33 2012 2715 2720
    • (2012) Neurobiol Aging , vol.33 , pp. 2715-2720
    • Randall, A.D.1    Booth, C.2    Brown, J.T.3
  • 85
    • 84872621463 scopus 로고    scopus 로고
    • Alterations in ventricular K(ATP) channel properties during aging
    • L. Bao, E. Taskin, and M. Foster Alterations in ventricular K(ATP) channel properties during aging Aging Cell 12 2013 167 176
    • (2013) Aging Cell , vol.12 , pp. 167-176
    • Bao, L.1    Taskin, E.2    Foster, M.3
  • 86
    • 84879133940 scopus 로고    scopus 로고
    • Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: Possible role in glucose sensing
    • A.T. Rufino, S.C. Rosa, F. Judas, A. Mobasheri, M.C. Lopes, and A.F. Mendes Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: possible role in glucose sensing J Cell Biochem 114 2013 1879 1889
    • (2013) J Cell Biochem , vol.114 , pp. 1879-1889
    • Rufino, A.T.1    Rosa, S.C.2    Judas, F.3    Mobasheri, A.4    Lopes, M.C.5    Mendes, A.F.6
  • 87
    • 0036176237 scopus 로고    scopus 로고
    • Genes, telomeres and mammalian ageing
    • M.H. Goyns Genes, telomeres and mammalian ageing Mech Ageing Dev 123 2002 791 799
    • (2002) Mech Ageing Dev , vol.123 , pp. 791-799
    • Goyns, M.H.1
  • 88
    • 0035071327 scopus 로고    scopus 로고
    • Telomere erosion and senescence in human articular cartilage chondrocytes
    • J.A. Martin, and J.A. Buckwalter Telomere erosion and senescence in human articular cartilage chondrocytes J Gerontol A Biol Sci Med Sci 56 2001 B172 B179
    • (2001) J Gerontol A Biol Sci Med Sci , vol.56 , pp. B172-B179
    • Martin, J.A.1    Buckwalter, J.A.2
  • 89
    • 0015089140 scopus 로고
    • Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases
    • P.S. Treuhaft, and D.J. McCarty Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases Arthritis Rheum 14 1971 475 484
    • (1971) Arthritis Rheum , vol.14 , pp. 475-484
    • Treuhaft, P.S.1    McCarty, D.J.2
  • 90
    • 34249680844 scopus 로고    scopus 로고
    • Oxygen consumption of equine articular chondrocytes: Influence of applied oxygen tension and glucose concentration during culture
    • N. Schneider, A. Mouithys-Mickalad, and J.P. Lejeune Oxygen consumption of equine articular chondrocytes: Influence of applied oxygen tension and glucose concentration during culture Cell Biol Int 31 2007 878 886
    • (2007) Cell Biol Int , vol.31 , pp. 878-886
    • Schneider, N.1    Mouithys-Mickalad, A.2    Lejeune, J.P.3
  • 91
    • 0035499204 scopus 로고    scopus 로고
    • Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival
    • E. Schipani, H.E. Ryan, S. Didrickson, T. Kobayashi, M. Knight, and R.S. Johnson Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival Genes Dev 15 2001 2865 2876
    • (2001) Genes Dev , vol.15 , pp. 2865-2876
    • Schipani, E.1    Ryan, H.E.2    Didrickson, S.3    Kobayashi, T.4    Knight, M.5    Johnson, R.S.6
  • 92
    • 0036388628 scopus 로고    scopus 로고
    • Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9
    • A. Mobasheri, G. Neama, S. Bell, S. Richardson, and S.D. Carter Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9 Cell Biol Int 26 2002 297 300
    • (2002) Cell Biol Int , vol.26 , pp. 297-300
    • Mobasheri, A.1    Neama, G.2    Bell, S.3    Richardson, S.4    Carter, S.D.5
  • 93
    • 0037321673 scopus 로고    scopus 로고
    • Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes: Stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation
    • S. Richardson, G. Neama, and T. Phillips Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes: stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation Osteoarthritis Cartilage 11 2003 92 101
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 92-101
    • Richardson, S.1    Neama, G.2    Phillips, T.3
  • 94
    • 14044268899 scopus 로고    scopus 로고
    • Differential regulation of the GLUT1 and GLUT3 glucose transporters by growth factors and pro-inflammatory cytokines in equine articular chondrocytes
    • T. Phillips, I. Ferraz, S. Bell, P.D. Clegg, S.D. Carter, and A. Mobasheri Differential regulation of the GLUT1 and GLUT3 glucose transporters by growth factors and pro-inflammatory cytokines in equine articular chondrocytes Vet J 169 2005 216 222
    • (2005) Vet J , vol.169 , pp. 216-222
    • Phillips, T.1    Ferraz, I.2    Bell, S.3    Clegg, P.D.4    Carter, S.D.5    Mobasheri, A.6
  • 96
    • 63349105399 scopus 로고    scopus 로고
    • Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1 gene expression in pathologic cartilage in vivo
    • S. Peansukmanee, A. Vaughan-Thomas, and S.D. Carter Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1 gene expression in pathologic cartilage in vivo J Orthop Res 27 2009 529 535
    • (2009) J Orthop Res , vol.27 , pp. 529-535
    • Peansukmanee, S.1    Vaughan-Thomas, A.2    Carter, S.D.3
  • 97
    • 0021741035 scopus 로고
    • Zonal analysis of cytoplasmic components of articular cartilage chondrocytes
    • C.T. Brighton, T. Kitajima, and R.M. Hunt Zonal analysis of cytoplasmic components of articular cartilage chondrocytes Arthritis Rheum 27 1984 1290 1299
    • (1984) Arthritis Rheum , vol.27 , pp. 1290-1299
    • Brighton, C.T.1    Kitajima, T.2    Hunt, R.M.3
  • 98
    • 0036398455 scopus 로고    scopus 로고
    • Aging, articular cartilage chondrocyte senescence and osteoarthritis
    • J.A. Martin, and J.A. Buckwalter Aging, articular cartilage chondrocyte senescence and osteoarthritis Biogerontology 3 2002 257 264
    • (2002) Biogerontology , vol.3 , pp. 257-264
    • Martin, J.A.1    Buckwalter, J.A.2
  • 100
    • 77955491633 scopus 로고    scopus 로고
    • Age-related changes in the musculoskeletal system and the development of osteoarthritis
    • R.F. Loeser Age-related changes in the musculoskeletal system and the development of osteoarthritis Clin Geriatr Med 26 2010 371 386
    • (2010) Clin Geriatr Med , vol.26 , pp. 371-386
    • Loeser, R.F.1
  • 101
    • 0036283579 scopus 로고    scopus 로고
    • Human chondrocyte senescence and osteoarthritis
    • J.A. Martin, and J.A. Buckwalter Human chondrocyte senescence and osteoarthritis Biorheology 39 2002 145 152
    • (2002) Biorheology , vol.39 , pp. 145-152
    • Martin, J.A.1    Buckwalter, J.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.