Nitric oxide in osteoarthritis

Osteoarthritis and Cartilage

Volumn 7, Issue 4, 1999, Pages 377-379

  Studer, R ^a   Jaffurs, D ^a   Stefanovic Racic, M ^a   Robbins, P D ^a   Evans, C H ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cartilage; NO; Osteoarthritis

Indexed keywords

COLLAGEN; INTERLEUKIN 1; NITRIC OXIDE; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; CARTILAGE CELL; COLLAGEN SYNTHESIS; CONFERENCE PAPER; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; OSTEOARTHRITIS; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0033166185     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.1998.0216     Document Type: Conference Paper

References (18)

1. Farrell AJ, Blake DR, Palmer RMJ, Moncada S. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 1992;51:1219-22.
2. Renoux M, Hiliquin P, Galoppin L, et al. Release of mast cell mediators and nitrites into knee joint fluid in osteoarthritis - Comparison with articular chondrocalcinosis and rheumatoid arthritis. Osteoarthritis Cartilage 1996;4:175-9.
3. Stadler J, Stefanovic-Racic M, Billiar TR, et al. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol 1991;147:3915-20.
4. Amin AR, Attur M, Patel RN, et al. Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. J Clin Invest 1997;99:1231-7.
5. Amin AR, DiCesare P, Vyas P, et al. The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: Evidence for upregulated neuronal nitric oxide synthase. J Exp Med 1995;182:2097-102.
6. Charles IG, Palmer RMJ, Mickey MS, et al. Cloning, characterization and expression of a cDNa encoding an inducible nitric oxide synthase from the human chondrocyte. Proc Natl Acad Sci USA 1993; 90:11 419-23.
7. Taskiran D, Stefanovic-Racic M, Georgescu HI, Evans CH. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Commun 1994;200:142-8.
8. Stefanovic-Racic M, Morales TI, Taskiran D, et al. The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures. J Immunol 1996;156:1213-20.
9. Murrell GAC, Jang D, Williams RJ. Nitric oxide activates metalloproteinase enzymes in articular cartilage. Biochem Biophys Res Commun 1995;206: 15-21.
10. Bird JL, Wells T, Platt D, Bayliss MT. IL-1β induces the degradation of equine articular cartilage by a mechanism that is not mediated by nitric oxide. Biochem Biophys Res Commun 1997;238:81-5.
11. Sasaki K, Hattori T, Fujisawa T, et al. Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes. J Biochem 1998;123:431-9.
12. Blanco FJ, Ochs RL, Schwarz H, Lotz M. Chondrocyte apoptosis induced by nitric oxide. Am J Pathol 1995;146:75-85.
13. Hashimoto S, Ochs RL, Rosen F, et al. Chondrocyte-derived apoptotic bodies and calcification of articular cartilage. Proc Natl Acad Sci USA 1998;95:3094-9.
14. Craven PA, Studer RK, Felder J, et al. Nitric oxide inhibition of transforming growth factor-β and collagen synthesis in mesangial cells. Diabetes 1997; 46:671-81.
15. Studer RK, Georgescu HI, Miller LA, Evans CH. Nitric oxide inhibits TGF-β production by chondrocytes: implications for matrix synthesis. Arthritis Rheum 1999;42:248-257.
16. Martel-Pelletier J, Di Battista JA, Lajeunesse D, Pelletier JP. IGF/IGF BP axis in cartilage and bone in osteoarthritis pathogenesis. Inflamm Res 1998; 47:90-100.
17. Lafeber FPJG, Van der Kraan PM, Huber-Brunig O, et al. Osteoarthritic human cartilage is more sensitive to transforming growth factor β than is normal cartilage. Br J Rheum 1993;32:281-6.
18. Van de Loo FAJ, Arntz OJ, Van Enckevort FHJ, et al. Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NO2-deficient mice and in anti-interleukin-1 treated wild-type mice with unabated joint inflammation. Arthritis Rheum 1998;41:634-46.