-
1
-
-
85027948565
-
International society of neuropathology-haarlem consensus guidelines, for nervous system tumor classification and grading
-
Louis DN, Perry A, Burger P, et al. International Society of Neuropathology-Haarlem Consensus Guidelines, for nervous system tumor classification and grading. Brain Pathol. 2014;24: 429-435.
-
(2014)
Brain Pathol
, vol.24
, pp. 429-435
-
-
Louis, D.N.1
Perry, A.2
Burger, P.3
-
2
-
-
84862777410
-
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
-
Wu G, Broniscer A, McEachron TA, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet. 2012;44:251-253.
-
(2012)
Nat Genet
, vol.44
, pp. 251-253
-
-
Wu, G.1
Broniscer, A.2
McEachron, T.A.3
-
3
-
-
84862777348
-
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
-
Schwartzentruber J, Korshunov A, Liu XY, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature. 2012;482:226-231.
-
(2012)
Nature
, vol.482
, pp. 226-231
-
-
Schwartzentruber, J.1
Korshunov, A.2
Liu, X.Y.3
-
4
-
-
52649172327
-
Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma
-
Bar EE, Lin A, Tihan T, et al. Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma. J Neuropathol Exp Neurol. 2008;67:878-887.
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, pp. 878-887
-
-
Bar, E.E.1
Lin, A.2
Tihan, T.3
-
5
-
-
55349107544
-
Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
-
Jones DT, Kocialkowski S, Liu L, et al. Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. Cancer Res. 2008;68: 8673-8677.
-
(2008)
Cancer Res
, vol.68
, pp. 8673-8677
-
-
Jones, D.T.1
Kocialkowski, S.2
Liu, L.3
-
6
-
-
43049124130
-
BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas
-
Pfister S, Janzarik WG, Remke M, et al. BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. J Clin Investig. 2008; 118:1739-1749.
-
(2008)
J Clin Investig
, vol.118
, pp. 1739-1749
-
-
Pfister, S.1
Janzarik, W.G.2
Remke, M.3
-
7
-
-
66949147222
-
Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene
-
Sievert AJ, Jackson EM, Gai X, et al. Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene. Brain Pathol. 2009;19:449-458.
-
(2009)
Brain Pathol
, vol.19
, pp. 449-458
-
-
Sievert, A.J.1
Jackson, E.M.2
Gai, X.3
-
8
-
-
84878723078
-
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
-
Zhang J, Wu G, Miller CP, et al. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet. 2013;45:602-612.
-
(2013)
Nat Genet
, vol.45
, pp. 602-612
-
-
Zhang, J.1
Wu, G.2
Miller, C.P.3
-
9
-
-
84880983541
-
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
-
Jones DT, Hutter B, Jager N, et al. Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet. 2013;45:927-932.
-
(2013)
Nat Genet
, vol.45
, pp. 927-932
-
-
Jones, D.T.1
Hutter, B.2
Jager, N.3
-
10
-
-
79958087774
-
Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
-
Cin H, Meyer C, Herr R, et al. Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma. Acta Neuropathol. 2011;121:763-774.
-
(2011)
Acta Neuropathol
, vol.121
, pp. 763-774
-
-
Cin, H.1
Meyer, C.2
Herr, R.3
-
11
-
-
85067722715
-
Chromosome band 7q34 deletions resulting in KIAA1549-BRAF and FAM131BBRAF fusions in pediatric low grade gliomas
-
[Epub ahead of print]
-
Roth JJ, Santi M, Pollock AN, et al. Chromosome band 7q34 deletions resulting in KIAA1549-BRAF and FAM131BBRAF fusions in pediatric low grade gliomas. Brain Pathol. 2014. [Epub ahead of print].
-
(2014)
Brain Pathol
-
-
Roth, J.J.1
Santi, M.2
Pollock, A.N.3
-
12
-
-
84355161678
-
Pathologic characteristics of pediatric intracranial pilocytic astrocytomas and their impact on outcome in 3 countries: A multi-institutional study
-
Tihan T, Ersen A, Qaddoumi I, et al. Pathologic characteristics of pediatric intracranial pilocytic astrocytomas and their impact on outcome in 3 countries: a multi-institutional study. Am J Surg Pathol. 2012;36:43-55.
-
(2012)
Am J Surg Pathol
, vol.36
, pp. 43-55
-
-
Tihan, T.1
Ersen, A.2
Qaddoumi, I.3
-
13
-
-
77953020697
-
Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas
-
Horbinski C, Hamilton RL, Nikiforov Y, et al. Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas. Acta Neuropathol. 2010;119:641-649.
-
(2010)
Acta Neuropathol
, vol.119
, pp. 641-649
-
-
Horbinski, C.1
Hamilton, R.L.2
Nikiforov, Y.3
-
14
-
-
84871995861
-
To BRAF or not to BRAF: Is that even a question anymore
-
Horbinski C. To BRAF or not to BRAF: is that even a question anymore? J Neuropathol Exp Neurol. 2013;72:2-7.
-
(2013)
J Neuropathol Exp Neurol
, vol.72
, pp. 2-7
-
-
Horbinski, C.1
-
15
-
-
79960388615
-
BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma
-
Hawkins C, Walker E, Mohamed N, et al. BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma. Clin Cancer Res. 2011;17:4790-4798.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4790-4798
-
-
Hawkins, C.1
Walker, E.2
Mohamed, N.3
-
16
-
-
84862193195
-
Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas
-
Horbinski C, Nikiforova MN, Hagenkord JM, et al. Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas. Neuro Oncol. 2012;14:777-789.
-
(2012)
Neuro Oncol
, vol.14
, pp. 777-789
-
-
Horbinski, C.1
Nikiforova, M.N.2
Hagenkord, J.M.3
-
17
-
-
79954441895
-
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
-
Schindler G, Capper D, Meyer J, et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol. 2011;121:397-405.
-
(2011)
Acta Neuropathol
, vol.121
, pp. 397-405
-
-
Schindler, G.1
Capper, D.2
Meyer, J.3
-
18
-
-
84898540842
-
BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression
-
Koelsche C, Sahm F, Wohrer A, et al. BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression. Brain Pathol. 2013;24:221-229.
-
(2013)
Brain Pathol
, vol.24
, pp. 221-229
-
-
Koelsche, C.1
Sahm, F.2
Wohrer, A.3
-
19
-
-
85005929942
-
Immunohistochemistry is highly sensitive and specific for detection of BRAF V600E mutation in pleomorphic xanthoastrocytoma
-
Ida CM, Vrana JA, Rodriguez FJ, et al. Immunohistochemistry is highly sensitive and specific for detection of BRAF V600E mutation in pleomorphic xanthoastrocytoma. Acta Neuropathol Commun. 2013;1:20.
-
(2013)
Acta Neuropathol Commun
, vol.1
, pp. 20
-
-
Ida, C.M.1
Vrana, J.A.2
Rodriguez, F.J.3
-
20
-
-
79953184268
-
BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: Diagnostic and therapeutic implications
-
Dias-Santagata D, Lam Q, Vernovsky K, et al. BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications. PloS One. 2011;6: e17948.
-
(2011)
PloS One
, vol.6
, pp. e17948
-
-
Dias-Santagata, D.1
Lam, Q.2
Vernovsky, K.3
-
21
-
-
84882238982
-
Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression
-
Chappe C, Padovani L, Scavarda D, et al. Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression. Brain Pathol. 2013;23:574-583.
-
(2013)
Brain Pathol
, vol.23
, pp. 574-583
-
-
Chappe, C.1
Padovani, L.2
Scavarda, D.3
-
22
-
-
84878545588
-
BRAF(V600E) mutation is a negative prognosticator in pediatric ganglioglioma
-
Dahiya S, Haydon DH, Alvarado D, et al. BRAF(V600E) mutation is a negative prognosticator in pediatric ganglioglioma. Acta Neuropathol. 2013;125:901-910.
-
(2013)
Acta Neuropathol
, vol.125
, pp. 901-910
-
-
Dahiya, S.1
Haydon, D.H.2
Alvarado, D.3
-
23
-
-
84875421249
-
Exploring mechanisms of FGF signalling through the lens of structural biology
-
Goetz R, Mohammadi M. Exploring mechanisms of FGF signalling through the lens of structural biology. Nat Rev Mol Cell Biol. 2013;14:166-180.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 166-180
-
-
Goetz, R.1
Mohammadi, M.2
-
24
-
-
84887314100
-
The molecular landscape of diffuse glioma and prospects for biomarker development
-
Huse JT, Aldape KD. The molecular landscape of diffuse glioma and prospects for biomarker development. Expert Opin Med Diagn. 2013;7:573-587.
-
(2013)
Expert Opin Med Diagn
, vol.7
, pp. 573-587
-
-
Huse, J.T.1
Aldape, K.D.2
-
25
-
-
78651061485
-
MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas
-
Tatevossian RG, Tang B, Dalton J, et al. MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas. Acta Neuropathol. 2010;120:731-743.
-
(2010)
Acta Neuropathol
, vol.120
, pp. 731-743
-
-
Tatevossian, R.G.1
Tang, B.2
Dalton, J.3
-
26
-
-
84877866746
-
Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1
-
Ramkissoon LA, Horowitz PM, Craig JM, et al. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci USA. 2013;110: 8188-8193.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 8188-8193
-
-
Ramkissoon, L.A.1
Horowitz, P.M.2
Craig, J.M.3
-
27
-
-
84875893063
-
Pathological and molecular advances in pediatric low-grade astrocytoma
-
Rodriguez FJ, Lim KS, Bowers D, et al. Pathological and molecular advances in pediatric low-grade astrocytoma. Annu Rev Pathol. 2013;8:361-379.
-
(2013)
Annu Rev Pathol
, vol.8
, pp. 361-379
-
-
Rodriguez, F.J.1
Lim, K.S.2
Bowers, D.3
-
28
-
-
84866516735
-
MEK is a key regulator of gliogenesis in the developing brain
-
Li XY, Newbern JM, Wu YH, et al. MEK is a key regulator of gliogenesis in the developing brain. Neuron. 2012;75: 1035-1050.
-
(2012)
Neuron
, vol.75
, pp. 1035-1050
-
-
Li, X.Y.1
Newbern, J.M.2
Wu, Y.H.3
-
29
-
-
77957120399
-
ERK1 and ERK2 are required for radial glial maintenance and cortical lamination
-
Imamura O, Pages G, Pouyssegur J, et al. ERK1 and ERK2 are required for radial glial maintenance and cortical lamination. Genes Cells. 2010;15:1072-1088.
-
(2010)
Genes Cells
, vol.15
, pp. 1072-1088
-
-
Imamura, O.1
Pages, G.2
Pouyssegur, J.3
-
30
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008;321: 1807-1812.
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
-
31
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360:765-773.
-
(2009)
N Engl J Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
-
32
-
-
56749156414
-
Analysis of the IDH1 codon 132 mutation in brain tumors
-
Balss J, Meyer J, Mueller W, et al. Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol. 2008;116: 597-602.
-
(2008)
Acta Neuropathol
, vol.116
, pp. 597-602
-
-
Balss, J.1
Meyer, J.2
Mueller, W.3
-
33
-
-
70449518400
-
Monoclonal antibody specific for IDH1 R132H mutation
-
Capper D, Zentgraf H, Balss J, et al. Monoclonal antibody specific for IDH1 R132H mutation. Acta Neuropathol. 2009;118:599-601.
-
(2009)
Acta Neuropathol
, vol.118
, pp. 599-601
-
-
Capper, D.1
Zentgraf, H.2
Balss, J.3
-
34
-
-
69949114447
-
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: A study of 1,010 diffuse gliomas
-
Hartmann C, Meyer J, Balss J, et al. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol. 2009;118:469-474.
-
(2009)
Acta Neuropathol
, vol.118
, pp. 469-474
-
-
Hartmann, C.1
Meyer, J.2
Balss, J.3
-
35
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009;462: 739-744.
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
-
36
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
Ward PS, Patel J, Wise DR, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010;17:225-234.
-
(2010)
Cancer Cell
, vol.17
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
-
37
-
-
65349150503
-
IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
-
Watanabe T, Nobusawa S, Kleihues P, et al. IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am J Pathol. 2009;174:1149-1153.
-
(2009)
Am J Pathol
, vol.174
, pp. 1149-1153
-
-
Watanabe, T.1
Nobusawa, S.2
Kleihues, P.3
-
38
-
-
82955165744
-
IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors
-
Mellai M, Piazzi A, Caldera V, et al. IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors. J Neurooncol. 2011;105:345-357.
-
(2011)
J Neurooncol
, vol.105
, pp. 345-357
-
-
Mellai, M.1
Piazzi, A.2
Caldera, V.3
-
39
-
-
78651067051
-
Absence of IDH mutation identifies a novel radiologic and molecular subtype of WHO grade II gliomas with dismal prognosis
-
Metellus P, Coulibaly B, Colin C, et al. Absence of IDH mutation identifies a novel radiologic and molecular subtype of WHO grade II gliomas with dismal prognosis. Acta Neuropathol. 2010;120:719-729.
-
(2010)
Acta Neuropathol
, vol.120
, pp. 719-729
-
-
Metellus, P.1
Coulibaly, B.2
Colin, C.3
-
40
-
-
83355163405
-
Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
-
Lai A, Kharbanda S, Pope WB, et al. Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J Clin Oncol. 2011;29:4482-4490.
-
(2011)
J Clin Oncol
, vol.29
, pp. 4482-4490
-
-
Lai, A.1
Kharbanda, S.2
Pope, W.B.3
-
41
-
-
78149249554
-
IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas
-
Houillier C, Wang X, Kaloshi G, et al. IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas. Neurology. 2010;75:1560-1566.
-
(2010)
Neurology
, vol.75
, pp. 1560-1566
-
-
Houillier, C.1
Wang, X.2
Kaloshi, G.3
-
42
-
-
84860528433
-
IDH mutation and neuroglial developmental features define clinically distinct subclasses of lower grade diffuse astrocytic glioma
-
Gorovets D, Kannan K, Shen RL, et al. IDH mutation and neuroglial developmental features define clinically distinct subclasses of lower grade diffuse astrocytic glioma. Clin Cancer Res. 2012;18:2490-2501.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 2490-2501
-
-
Gorovets, D.1
Kannan, K.2
Shen, R.L.3
-
43
-
-
84875735943
-
IDH/MGMT-driven molecular classification of low-grade glioma is a strong predictor for long-term survival
-
Leu S, von Felten S, Frank S, et al. IDH/MGMT-driven molecular classification of low-grade glioma is a strong predictor for long-term survival. Neuro Oncol. 2013;15: 469-479.
-
(2013)
Neuro Oncol
, vol.15
, pp. 469-479
-
-
Leu, S.1
Von Felten, S.2
Frank, S.3
-
44
-
-
84879076377
-
Prognostic significance of IDH mutation in adult low-grade gliomas: A meta-analysis
-
Sun HR, Yin LH, Li SW, et al. Prognostic significance of IDH mutation in adult low-grade gliomas: a meta-analysis. J Neurooncol. 2013;113:277-284.
-
(2013)
J Neurooncol
, vol.113
, pp. 277-284
-
-
Sun, H.R.1
Yin, L.H.2
Li, S.W.3
-
45
-
-
84902500037
-
Analysis of IDH mutation, 1p/19q deletion, and PTEN loss delineates prognosis in clinical low-grade diffuse gliomas
-
Sabha N, Knobbe CB, Maganti M, et al. Analysis of IDH mutation, 1p/19q deletion, and PTEN loss delineates prognosis in clinical low-grade diffuse gliomas. Neuro Oncol. 2014;16: 914-923.
-
(2014)
Neuro Oncol
, vol.16
, pp. 914-923
-
-
Sabha, N.1
Knobbe, C.B.2
Maganti, M.3
-
46
-
-
77952108366
-
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
-
Noushmehr H, Weisenberger DJ, Diefes K, et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell. 2010;17:510-522.
-
(2010)
Cancer Cell
, vol.17
, pp. 510-522
-
-
Noushmehr, H.1
Weisenberger, D.J.2
Diefes, K.3
-
47
-
-
79951611375
-
Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis
-
Laffaire J, Everhard S, Idbaih A, et al. Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis. Neuro Oncol. 2011;13:84-98.
-
(2011)
Neuro Oncol
, vol.13
, pp. 84-98
-
-
Laffaire, J.1
Everhard, S.2
Idbaih, A.3
-
48
-
-
79251470741
-
DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma
-
Christensen BC, Smith AA, Zheng S, et al. DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma. J Nat Cancer Inst. 2011;103:143-153.
-
(2011)
J Nat Cancer Inst
, vol.103
, pp. 143-153
-
-
Christensen, B.C.1
Smith, A.A.2
Zheng, S.3
-
49
-
-
84858796263
-
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
-
Turcan S, Rohle D, Goenka A, et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature. 2012;483:479-483.
-
(2012)
Nature
, vol.483
, pp. 479-483
-
-
Turcan, S.1
Rohle, D.2
Goenka, A.3
-
50
-
-
84870538996
-
A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation
-
Duncan CG, Barwick BG, Jin G, et al. A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation. Genome Res. 2012;22:2339-2355.
-
(2012)
Genome Res
, vol.22
, pp. 2339-2355
-
-
Duncan, C.G.1
Barwick, B.G.2
Jin, G.3
-
51
-
-
79955547561
-
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
-
Chowdhury R, Yeoh KK, Tian YM, et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep. 2011;12:463-469.
-
(2011)
EMBO Rep
, vol.12
, pp. 463-469
-
-
Chowdhury, R.1
Yeoh, K.K.2
Tian, Y.M.3
-
52
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
-
Xu W, Yang H, Liu Y, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011;19:17-30.
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
-
53
-
-
39349105090
-
Expanding chemical biology of 2-oxoglutarate oxygenases
-
Loenarz C, Schofield CJ. Expanding chemical biology of 2-oxoglutarate oxygenases. Nat Chem Biol. 2008;4:152-156.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 152-156
-
-
Loenarz, C.1
Schofield, C.J.2
-
54
-
-
84863534997
-
Metabolic regulation of epigenetics
-
Lu CThompson CB. Metabolic regulation of epigenetics. Cell Metab. 2012;16:9-17.
-
(2012)
Cell Metab
, vol.16
, pp. 9-17
-
-
Lu Cthompson, C.B.1
-
55
-
-
84877136671
-
Histone 3 lysine 9 trimethylation is differentially associated with isocitrate dehydrogenase mutations in oligodendrogliomas and high-grade astrocytomas
-
Venneti S, Felicella MM, Coyne T, et al. Histone 3 lysine 9 trimethylation is differentially associated with isocitrate dehydrogenase mutations in oligodendrogliomas and high-grade astrocytomas. J Neuropathol Exp Neurol. 2013;72:298-306.
-
(2013)
J Neuropathol Exp Neurol
, vol.72
, pp. 298-306
-
-
Venneti, S.1
Felicella, M.M.2
Coyne, T.3
-
56
-
-
0033951824
-
Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas
-
Smith JS, Perry A, Borell TJ, et al. Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. J Clin Oncol. 2000;18:636-645.
-
(2000)
J Clin Oncol
, vol.18
, pp. 636-645
-
-
Smith, J.S.1
Perry, A.2
Borell, T.J.3
-
57
-
-
33750563258
-
A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma
-
Jenkins RB, Blair H, Ballman KV, et al. A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma. Cancer Res. 2006;66:9852-9861.
-
(2006)
Cancer Res
, vol.66
, pp. 9852-9861
-
-
Jenkins, R.B.1
Blair, H.2
Ballman, K.V.3
-
59
-
-
80052608062
-
Mutations in CIC and FUBP1 contribute to human oligodendroglioma
-
Bettegowda C, Agrawal N, Jiao Y, et al. Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science (New York, NY. 2011;333:1453-1455.
-
(2011)
Science (New York, NY
, vol.333
, pp. 1453-1455
-
-
Bettegowda, C.1
Agrawal, N.2
Jiao, Y.3
-
60
-
-
82755194965
-
Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers
-
Yip S, Butterfield YS, Morozova O, et al. Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. J Pathol. 2012; 226:7-16.
-
(2012)
J Pathol
, vol.226
, pp. 7-16
-
-
Yip, S.1
Butterfield, Y.S.2
Morozova, O.3
-
61
-
-
84868625787
-
Frequent ATRX, CIC, and FUBP1 mutations refine the classification of malignant gliomas
-
Jiao Y, Killela PJ, Reitman ZJ, et al. Frequent ATRX, CIC, and FUBP1 mutations refine the classification of malignant gliomas. Oncotarget. 2012;3:709-722.
-
(2012)
Oncotarget
, vol.3
, pp. 709-722
-
-
Jiao, Y.1
Killela, P.J.2
Reitman, Z.J.3
-
62
-
-
84866411339
-
CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas
-
Sahm F, Koelsche C, Meyer J, et al. CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas. Acta Neuropathol. 2012;123:853-860.
-
(2012)
Acta Neuropathol
, vol.123
, pp. 853-860
-
-
Sahm, F.1
Koelsche, C.2
Meyer, J.3
-
63
-
-
84884691994
-
Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing
-
Eisenreich S, Abou-El-Ardat K, Szafranski K, et al. Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing. PLoS One. 2013;8:e76623.
-
(2013)
PLoS One
, vol.8
, pp. e76623
-
-
Eisenreich, S.1
Abou-El-Ardat, K.2
Szafranski, K.3
-
64
-
-
84861209129
-
The capicua repressor-A general sensor of RTK signaling in development and disease
-
Jimenez G, Shvartsman SYParoush Z. The capicua repressor-A general sensor of RTK signaling in development and disease. J Cel Sci. 2012;125:1383-1391.
-
(2012)
J Cel Sci
, vol.125
, pp. 1383-1391
-
-
Jimenez, G.1
Shvartsman, S.2
Yparoush, Z.3
-
65
-
-
84879421217
-
Far upstream element binding protein 1: A commander of transcription, translation and beyond
-
Zhang J, Chen QM. Far upstream element binding protein 1: a commander of transcription, translation and beyond. Oncogene. 2013;32:2907-2916.
-
(2013)
Oncogene
, vol.32
, pp. 2907-2916
-
-
Zhang, J.1
Chen, Q.M.2
-
66
-
-
0029827343
-
ATRX encodes a novel member of the SNF2 family of proteins: Mutations point to a common mechanism underlying the ATR-X syndrome
-
Picketts DJ, Higgs DR, Bachoo S, et al. ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome. Hum Mol Genet. 1996;5:1899-1907.
-
(1996)
Hum Mol Genet
, vol.5
, pp. 1899-1907
-
-
Picketts, D.J.1
Higgs, D.R.2
Bachoo, S.3
-
67
-
-
0028939603
-
Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)
-
Gibbons RJ, Picketts DJ, Villard L, et al. Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome). Cell. 1995;80:837-845.
-
(1995)
Cell
, vol.80
, pp. 837-845
-
-
Gibbons, R.J.1
Picketts, D.J.2
Villard, L.3
-
68
-
-
77649099092
-
Distinct factors control histone variant H3.3 localization at specific genomic regions
-
Goldberg AD, Banaszynski LA, Noh KM, et al. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell. 2010;140:678-691.
-
(2010)
Cell
, vol.140
, pp. 678-691
-
-
Goldberg, A.D.1
Banaszynski, L.A.2
Noh, K.M.3
-
69
-
-
77956282773
-
DAXX is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
-
Lewis PW, Elsaesser SJ, Noh KM, et al. DAXX is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci USA. 2010;107:14075-14080.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 14075-14080
-
-
Lewis, P.W.1
Elsaesser, S.J.2
Noh, K.M.3
-
70
-
-
84872788316
-
Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma
-
Kannan K, Inagaki A, Silber J, et al. Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma. Oncotarget. 2012;3:1194-1203.
-
(2012)
Oncotarget
, vol.3
, pp. 1194-1203
-
-
Kannan, K.1
Inagaki, A.2
Silber, J.3
-
71
-
-
84865863019
-
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
-
Khuong-Quang DA, Buczkowicz P, Rakopoulos P, et al. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol. 2012;124:439-447.
-
(2012)
Acta Neuropathol
, vol.124
, pp. 439-447
-
-
Khuong-Quang, D.A.1
Buczkowicz, P.2
Rakopoulos, P.3
-
72
-
-
84871020024
-
Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations
-
Liu XY, Gerges N, Korshunov A, et al. Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations. Acta Neuropathol. 2012;124:615-625.
-
(2012)
Acta Neuropathol
, vol.124
, pp. 615-625
-
-
Liu, X.Y.1
Gerges, N.2
Korshunov, A.3
-
73
-
-
84876294049
-
Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas
-
Nguyen DN, Heaphy CM, de Wilde RF, et al. Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas. Brain Pathol. 23:237-243.
-
Brain Pathol
, vol.23
, pp. 237-243
-
-
Nguyen, D.N.1
Heaphy, C.M.2
De Wilde, R.F.3
-
74
-
-
84887123502
-
The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: A multi-institutional study of 214 astrocytomas
-
Abedalthagafi M, Phillips JJ, Kim GE, et al. The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas. Modern Pathology: an Official Journal of the United States and Canadian Academy of Pathology, Inc. 2013;26:1425-1432.
-
(2013)
Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
, vol.26
, pp. 1425-1432
-
-
Abedalthagafi, M.1
Phillips, J.J.2
Kim, G.E.3
-
75
-
-
84874191269
-
TERT promoter mutations in familial and sporadic melanoma
-
Horn S, Figl A, Rachakonda PS, et al. TERT promoter mutations in familial and sporadic melanoma. Science (New York, N.Y. 2013;339:959-961.
-
(2013)
Science (New York, N.Y
, vol.339
, pp. 959-961
-
-
Horn, S.1
Figl, A.2
Rachakonda, P.S.3
-
76
-
-
84874189784
-
Highly recurrent TERT promoter mutations in human melanoma
-
Huang FW, Hodis E, Xu MJ, et al. Highly recurrent TERT promoter mutations in human melanoma. Science (New York, N.Y. 2013;339:957-959.
-
(2013)
Science (New York, N.Y
, vol.339
, pp. 957-959
-
-
Huang, F.W.1
Hodis, E.2
Xu, M.J.3
-
77
-
-
84876067164
-
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
-
Killela PJ, Reitman ZJ, Jiao Y, et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A. 2013;110:6021-6026.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 6021-6026
-
-
Killela, P.J.1
Reitman, Z.J.2
Jiao, Y.3
-
78
-
-
84881095932
-
Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss
-
Arita H, Narita Y, Fukushima S, et al. Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss. Acta Neuropathol. 2013;126:267-276.
-
(2013)
Acta Neuropathol
, vol.126
, pp. 267-276
-
-
Arita, H.1
Narita, Y.2
Fukushima, S.3
-
79
-
-
84885074034
-
The somatic genomic landscape of glioblastoma
-
Brennan CW, Verhaak RG, McKenna A, et al. The somatic genomic landscape of glioblastoma. Cell. 2013;155:462-477.
-
(2013)
Cell
, vol.155
, pp. 462-477
-
-
Brennan, C.W.1
Verhaak, R.G.2
McKenna, A.3
-
80
-
-
84877967061
-
Highly prevalent TERT promoter mutations in bladder cancer and glioblastoma
-
Liu X, Wu G, Shan Y, et al. Highly prevalent TERT promoter mutations in bladder cancer and glioblastoma. Cell Cycle. 2013;12:1637-1638.
-
(2013)
Cell Cycle
, vol.12
, pp. 1637-1638
-
-
Liu, X.1
Wu, G.2
Shan, Y.3
-
81
-
-
84896874742
-
TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours
-
Lindsey JC, Schwalbe EC, Potluri S, et al. TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours. Acta Neuropathol. 2014;127:307-309.
-
(2014)
Acta Neuropathol
, vol.127
, pp. 307-309
-
-
Lindsey, J.C.1
Schwalbe, E.C.2
Potluri, S.3
-
82
-
-
84892590846
-
Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system
-
Koelsche C, Sahm F, Capper D, et al. Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system. Acta Neuropathol. 2013;126:907-915.
-
(2013)
Acta Neuropathol
, vol.126
, pp. 907-915
-
-
Koelsche, C.1
Sahm, F.2
Capper, D.3
-
83
-
-
71549122009
-
Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors
-
Capper D, Weissert S, Balss J, et al. Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol. 2010;20:245-254.
-
(2010)
Brain Pathol
, vol.20
, pp. 245-254
-
-
Capper, D.1
Weissert, S.2
Balss, J.3
-
84
-
-
77955142776
-
Application of mutant IDH1 antibody to differentiate diffuse glioma from nonneoplastic central nervous system lesions and therapy-induced changes
-
Capper D, Sahm F, Hartmann C, et al. Application of mutant IDH1 antibody to differentiate diffuse glioma from nonneoplastic central nervous system lesions and therapy-induced changes. Am J Surg Pathol. 2010;34:1199-1204.
-
(2010)
Am J Surg Pathol
, vol.34
, pp. 1199-1204
-
-
Capper, D.1
Sahm, F.2
Hartmann, C.3
-
85
-
-
80052022841
-
Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas
-
Horbinski C, Kofler J, Yeaney G, et al. Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas. Brain Pathol. 2011;21:564-574.
-
(2011)
Brain Pathol
, vol.21
, pp. 564-574
-
-
Horbinski, C.1
Kofler, J.2
Yeaney, G.3
-
86
-
-
79251601011
-
A sensitive and specific diagnostic panel to distinguish diffuse astrocytoma from astrocytosis: Chromosome 7 gain with mutant isocitrate dehydrogenase 1 and p53
-
Camelo-Piragua S, Jansen M, Ganguly A, et al. A sensitive and specific diagnostic panel to distinguish diffuse astrocytoma from astrocytosis: chromosome 7 gain with mutant isocitrate dehydrogenase 1 and p53. J Neuropathol Exp Neurol. 2011;70:110-115.
-
(2011)
J Neuropathol Exp Neurol
, vol.70
, pp. 110-115
-
-
Camelo-Piragua, S.1
Jansen, M.2
Ganguly, A.3
-
87
-
-
77953023663
-
Mutant IDH1-specific immunohistochemistry distinguishes diffuse astrocytoma from astrocytosis
-
Camelo-Piragua S, Jansen M, Ganguly A, et al. Mutant IDH1-specific immunohistochemistry distinguishes diffuse astrocytoma from astrocytosis. Acta Neuropathol. 2010;119: 509-511.
-
(2010)
Acta Neuropathol
, vol.119
, pp. 509-511
-
-
Camelo-Piragua, S.1
Jansen, M.2
Ganguly, A.3
-
88
-
-
84883464949
-
ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis
-
Wiestler B, Capper D, Holland-Letz T, et al. ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis. Acta neuropathologica. 2013;126:443-451.
-
(2013)
Acta Neuropathologica
, vol.126
, pp. 443-451
-
-
Wiestler, B.1
Capper, D.2
Holland-Letz, T.3
-
89
-
-
84862840727
-
BRAF alterations are frequent in cerebellar low-grade astrocytomas with diffuse growth pattern
-
Ida CM, Lambert SR, Rodriguez FJ, et al. BRAF alterations are frequent in cerebellar low-grade astrocytomas with diffuse growth pattern. J Neuropathol Exp Neurol. 2012;71:631-639.
-
(2012)
J Neuropathol Exp Neurol
, vol.71
, pp. 631-639
-
-
Ida, C.M.1
Lambert, S.R.2
Rodriguez, F.J.3
-
90
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med. 2010;363:809-819.
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
-
91
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364:2507-2516.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
92
-
-
84863116743
-
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
-
Sosman JA, Kim KB, Schuchter L, et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med. 2012;366:707-714.
-
(2012)
N Engl J Med
, vol.366
, pp. 707-714
-
-
Sosman, J.A.1
Kim, K.B.2
Schuchter, L.3
-
93
-
-
84055212088
-
Targeted therapy for BRAFV600E malignant astrocytoma
-
Nicolaides TP, Li H, Solomon DA, et al. Targeted therapy for BRAFV600E malignant astrocytoma. Clin Cancer Res. 2011;17: 7595-7604.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 7595-7604
-
-
Nicolaides, T.P.1
Li, H.2
Solomon, D.A.3
-
94
-
-
84861918640
-
Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy
-
Huillard E, Hashizume R, Phillips JJ, et al. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A. 2012;109: 8710-8715.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 8710-8715
-
-
Huillard, E.1
Hashizume, R.2
Phillips, J.J.3
-
95
-
-
84899485468
-
Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy
-
Robinson GW, Orr BA, Gajjar A. Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy. BMC cancer. 2014; 14:258.
-
(2014)
BMC Cancer
, vol.14
, pp. 258
-
-
Robinson, G.W.1
Orr, B.A.2
Gajjar, A.3
-
96
-
-
84904888606
-
Systemic treatment for BRAF-mutant melanoma: Where do we go next
-
Menzies AM, Long GV. Systemic treatment for BRAF-mutant melanoma: where do we go next? The Lancet Oncology. 2014;15:e371-e381.
-
(2014)
The Lancet Oncology
, vol.15
, pp. e371-e381
-
-
Menzies, A.M.1
Long, G.V.2
-
97
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
Rohle D, Popovici-Muller J, Palaskas N, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science (New York, N.Y. 2013;340:626-630.
-
(2013)
Science (New York, N.Y
, vol.340
, pp. 626-630
-
-
Rohle, D.1
Popovici-Muller, J.2
Palaskas, N.3
-
98
-
-
84906557615
-
A vaccine targeting mutant IDH1 induces antitumour immunity
-
Schumacher T, Bunse L, Pusch S, et al. A vaccine targeting mutant IDH1 induces antitumour immunity. Nature. 2014; 512:324-327.
-
(2014)
Nature
, vol.512
, pp. 324-327
-
-
Schumacher, T.1
Bunse, L.2
Pusch, S.3
|