-
1
-
-
27544453376
-
Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF
-
Emuss V, Garnett M, Mason C, Marais R: Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF. Cancer Res 2005, 65: 9719-9726. 10.1158/0008-5472.CAN-05-1683
-
(2005)
Cancer Res
, vol.65
, pp. 9719-9726
-
-
Emuss, V.1
Garnett, M.2
Mason, C.3
Marais, R.4
-
2
-
-
77952867730
-
Targets of Raf in tumorigenesis
-
Niault TS, Baccarini M: Targets of Raf in tumorigenesis. Carcinogenesis 2010, 31: 1165-1174. 10.1093/carcin/bgp337
-
(2010)
Carcinogenesis
, vol.31
, pp. 1165-1174
-
-
Niault, T.S.1
Baccarini, M.2
-
4
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, et al.: Mutations of the BRAF gene in human cancer. Nature 2002, 417: 949-954. 10.1038/nature00766
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
-
5
-
-
16344395995
-
Mutation analysis of B-RAF gene in human gliomas
-
Basto D, Trovisco V, Lopes JM, Martins A, Pardal F, Soares P, Reis RM: Mutation analysis of B-RAF gene in human gliomas. Acta Neuropathol 2005, 109: 207-210. 10.1007/s00401-004-0936-x
-
(2005)
Acta Neuropathol
, vol.109
, pp. 207-210
-
-
Basto, D.1
Trovisco, V.2
Lopes, J.M.3
Martins, A.4
Pardal, F.5
Soares, P.6
Reis, R.M.7
-
6
-
-
34547100321
-
RAS/RAF pathway activation in gliomas: the result of copy number gains rather than activating mutations
-
Jeuken J, van den Broecke C, Gijsen S, Boots-Sprenger S, Wesseling P: RAS/RAF pathway activation in gliomas: the result of copy number gains rather than activating mutations. Acta Neuropathol 2007, 114: 121-133. 10.1007/s00401-007-0239-0
-
(2007)
Acta Neuropathol
, vol.114
, pp. 121-133
-
-
Jeuken, J.1
van den Broecke, C.2
Gijsen, S.3
Boots-Sprenger, S.4
Wesseling, P.5
-
7
-
-
8844252330
-
Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas
-
Knobbe CB, Reifenberger J, Reifenberger G: Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas. Acta Neuropathol 2004, 108: 467-470. 10.1007/s00401-004-0929-9
-
(2004)
Acta Neuropathol
, vol.108
, pp. 467-470
-
-
Knobbe, C.B.1
Reifenberger, J.2
Reifenberger, G.3
-
8
-
-
84871704107
-
Analysis of the BRAF(V600E) Mutation in Central Nervous System Tumors
-
Myung JK, Cho H, Park CK, Kim SK, Lee SH, Park SH: Analysis of the BRAF(V600E) Mutation in Central Nervous System Tumors. Transl Oncol 2012, 5: 430-436.
-
(2012)
Transl Oncol
, vol.5
, pp. 430-436
-
-
Myung, J.K.1
Cho, H.2
Park, C.K.3
Kim, S.K.4
Lee, S.H.5
Park, S.H.6
-
9
-
-
79954441895
-
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
-
Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, et al.: Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol 2011, 121: 397-405. 10.1007/s00401-011-0802-6
-
(2011)
Acta Neuropathol
, vol.121
, pp. 397-405
-
-
Schindler, G.1
Capper, D.2
Meyer, J.3
Janzarik, W.4
Omran, H.5
Herold-Mende, C.6
Schmieder, K.7
Wesseling, P.8
Mawrin, C.9
Hasselblatt, M.10
-
10
-
-
78149467927
-
Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas
-
Dougherty MJ, Santi M, Brose MS, Ma C, Resnick AC, Sievert AJ, Storm PB, Biegel JA: Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas. Neuro Oncol 2010, 12: 621-630. 10.1093/neuonc/noq007
-
(2010)
Neuro Oncol
, vol.12
, pp. 621-630
-
-
Dougherty, M.J.1
Santi, M.2
Brose, M.S.3
Ma, C.4
Resnick, A.C.5
Sievert, A.J.6
Storm, P.B.7
Biegel, J.A.8
-
11
-
-
66849099801
-
Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas
-
Forshew T, Tatevossian RG, Lawson AR, Ma J, Neale G, Ogunkolade BW, Jones TA, Aarum J, Dalton J, Bailey S, et al.: Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas. J Pathol 2009, 218: 172-181. 10.1002/path.2558
-
(2009)
J Pathol
, vol.218
, pp. 172-181
-
-
Forshew, T.1
Tatevossian, R.G.2
Lawson, A.R.3
Ma, J.4
Neale, G.5
Ogunkolade, B.W.6
Jones, T.A.7
Aarum, J.8
Dalton, J.9
Bailey, S.10
-
12
-
-
84655167688
-
BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants
-
Lin A, Rodriguez FJ, Karajannis MA, Williams SC, Legault G, Zagzag D, Burger PC, Allen JC, Eberhart CG, Bar EE: BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants. J Neuropathol Exp Neurol 2012, 71: 66-72. 10.1097/NEN.0b013e31823f2cb0
-
(2012)
J Neuropathol Exp Neurol
, vol.71
, pp. 66-72
-
-
Lin, A.1
Rodriguez, F.J.2
Karajannis, M.A.3
Williams, S.C.4
Legault, G.5
Zagzag, D.6
Burger, P.C.7
Allen, J.C.8
Eberhart, C.G.9
Bar, E.E.10
-
13
-
-
84865656646
-
BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper
-
Rodriguez FJ, Ligon AH, Horkayne-Szakaly I, Rushing EJ, Ligon KL, Vena N, Garcia DI, Cameron JD, Eberhart CG: BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper. J Neuropathol Exp Neurol 2012, 71: 789-794. 10.1097/NEN.0b013e3182656ef8
-
(2012)
J Neuropathol Exp Neurol
, vol.71
, pp. 789-794
-
-
Rodriguez, F.J.1
Ligon, A.H.2
Horkayne-Szakaly, I.3
Rushing, E.J.4
Ligon, K.L.5
Vena, N.6
Garcia, D.I.7
Cameron, J.D.8
Eberhart, C.G.9
-
14
-
-
79953184268
-
BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications
-
Dias-Santagata D, Lam Q, Vernovsky K, Vena N, Lennerz JK, Borger DR, Batchelor TT, Ligon KL, Iafrate AJ, Ligon AH, et al.: BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications. PLoS One 2011, 6: e17948. 10.1371/journal.pone.0017948
-
(2011)
PLoS One
, vol.6
-
-
Dias-Santagata, D.1
Lam, Q.2
Vernovsky, K.3
Vena, N.4
Lennerz, J.K.5
Borger, D.R.6
Batchelor, T.T.7
Ligon, K.L.8
Iafrate, A.J.9
Ligon, A.H.10
-
15
-
-
84878608078
-
Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells
-
Koelsche C, Wöhrer A, Jeibmann A, Schittenhelm J, Schindler G, Preusser M, Lasitschka F, Deimling A, Capper D: Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells. Acta Neuropathol 2013, 125: 891-900. 10.1007/s00401-013-1100-2
-
(2013)
Acta Neuropathol
, vol.125
, pp. 891-900
-
-
Koelsche, C.1
Wöhrer, A.2
Jeibmann, A.3
Schittenhelm, J.4
Schindler, G.5
Preusser, M.6
Lasitschka, F.7
Deimling, A.8
Capper, D.9
-
16
-
-
84882238982
-
Dysembryoplastic Neuroepithelial Tumors Share with Pleomorphic Xanthoastrocytomas and Gangliogliomas BRAF Mutation and Expression.
-
Epub ahead of print
-
Chappe C, Padovani L, Scavarda D, Forest F, Nanni-Metellus I, Loundou A, Mercurio S, Fina F, Lena G, Colin C, Figarella-Branger D: Dysembryoplastic Neuroepithelial Tumors Share with Pleomorphic Xanthoastrocytomas and Gangliogliomas BRAF Mutation and Expression. Brain Pathol 2013. Epub ahead of print
-
(2013)
Brain Pathol
-
-
Chappe, C.1
Padovani, L.2
Scavarda, D.3
Forest, F.4
Nanni-Metellus, I.5
Loundou, A.6
Mercurio, S.7
Fina, F.8
Lena, G.9
Colin, C.10
Figarella-Branger, D.11
-
17
-
-
84863643140
-
Incidence of BRAF p.Val600Glu and p.Val600Lys mutations in a consecutive series of 183 metastatic melanoma patients from a high incidence region
-
Amanuel B, Grieu F, Kular J, Millward M, Iacopetta B: Incidence of BRAF p.Val600Glu and p.Val600Lys mutations in a consecutive series of 183 metastatic melanoma patients from a high incidence region. Pathology 2012, 44: 357-359. 10.1097/PAT.0b013e3283532565
-
(2012)
Pathology
, vol.44
, pp. 357-359
-
-
Amanuel, B.1
Grieu, F.2
Kular, J.3
Millward, M.4
Iacopetta, B.5
-
18
-
-
84871619722
-
Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma
-
Long GV, Wilmott JS, Capper D, Preusser M, Zhang YE, Thompson JF, Kefford RF, von Deimling A, Scolyer RA: Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma. Am J Surg Pathol 2013, 37: 61-65. 10.1097/PAS.0b013e31826485c0
-
(2013)
Am J Surg Pathol
, vol.37
, pp. 61-65
-
-
Long, G.V.1
Wilmott, J.S.2
Capper, D.3
Preusser, M.4
Zhang, Y.E.5
Thompson, J.F.6
Kefford, R.F.7
von Deimling, A.8
Scolyer, R.A.9
-
19
-
-
84862584008
-
Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma
-
Menzies AM, Haydu LE, Visintin L, Carlino MS, Howle JR, Thompson JF, Kefford RF, Scolyer RA, Long GV: Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma. Clin Cancer Res 2012, 18: 3242-3249. 10.1158/1078-0432.CCR-12-0052
-
(2012)
Clin Cancer Res
, vol.18
, pp. 3242-3249
-
-
Menzies, A.M.1
Haydu, L.E.2
Visintin, L.3
Carlino, M.S.4
Howle, J.R.5
Thompson, J.F.6
Kefford, R.F.7
Scolyer, R.A.8
Long, G.V.9
-
20
-
-
84865001178
-
Detection of BRAF V600E mutations in skin metastases of malignant melanoma by monoclonal antibody VE1
-
Skorokhod A, Capper D, von Deimling A, Enk A, Helmbold P: Detection of BRAF V600E mutations in skin metastases of malignant melanoma by monoclonal antibody VE1. J Am Acad Dermatol 2012, 67: 488-491. 10.1016/j.jaad.2012.03.022
-
(2012)
J Am Acad Dermatol
, vol.67
, pp. 488-491
-
-
Skorokhod, A.1
Capper, D.2
von Deimling, A.3
Enk, A.4
Helmbold, P.5
-
21
-
-
80054790555
-
BRAF mutations in advanced cancers: clinical characteristics and outcomes
-
El-Osta H, Falchook G, Tsimberidou A, Hong D, Naing A, Kim K, Wen S, Janku F, Kurzrock R: BRAF mutations in advanced cancers: clinical characteristics and outcomes. PLoS One 2011, 6: e25806. 10.1371/journal.pone.0025806
-
(2011)
PLoS One
, vol.6
-
-
El-Osta, H.1
Falchook, G.2
Tsimberidou, A.3
Hong, D.4
Naing, A.5
Kim, K.6
Wen, S.7
Janku, F.8
Kurzrock, R.9
-
22
-
-
84879175213
-
Exomic Sequencing of Four Rare Central Nervous System Tumor Types
-
Bettegowda C, Agrawal N, Jiao Y, Wang Y, Wood LD, Rodriguez FJ, Hruban RH, Gallia GL, Binder ZA, Riggins CJ, et al.: Exomic Sequencing of Four Rare Central Nervous System Tumor Types. Oncotarget 2013, 4: 572-583.
-
(2013)
Oncotarget
, vol.4
, pp. 572-583
-
-
Bettegowda, C.1
Agrawal, N.2
Jiao, Y.3
Wang, Y.4
Wood, L.D.5
Rodriguez, F.J.6
Hruban, R.H.7
Gallia, G.L.8
Binder, Z.A.9
Riggins, C.J.10
-
24
-
-
0033135352
-
Pleomorphic xanthoastrocytoma: what do we really know about it?
-
Giannini C, Scheithauer BW, Burger PC, Brat DJ, Wollan PC, Lach B, O'Neill BP: Pleomorphic xanthoastrocytoma: what do we really know about it? Cancer 1999, 85: 2033-2045.
-
(1999)
Cancer
, vol.85
, pp. 2033-2045
-
-
Giannini, C.1
Scheithauer, B.W.2
Burger, P.C.3
Brat, D.J.4
Wollan, P.C.5
Lach, B.6
O'Neill, B.P.7
-
25
-
-
84876680857
-
Epithelioid GBMs Show a High Percentage of BRAF V600E Mutation
-
Kleinschmidt-Demasters BK, Aisner DL, Birks DK, Foreman NK: Epithelioid GBMs Show a High Percentage of BRAF V600E Mutation. Am J Surg Pathol 2013, 37: 685-698. 10.1097/PAS.0b013e31827f9c5e
-
(2013)
Am J Surg Pathol
, vol.37
, pp. 685-698
-
-
Kleinschmidt-Demasters, B.K.1
Aisner, D.L.2
Birks, D.K.3
Foreman, N.K.4
-
26
-
-
79959580390
-
Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody
-
Capper D, Preusser M, Habel A, Sahm F, Ackermann U, Schindler G, Pusch S, Mechtersheimer G, Zentgraf H, von Deimling A: Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol 2011, 122: 11-19. 10.1007/s00401-011-0841-z
-
(2011)
Acta Neuropathol
, vol.122
, pp. 11-19
-
-
Capper, D.1
Preusser, M.2
Habel, A.3
Sahm, F.4
Ackermann, U.5
Schindler, G.6
Pusch, S.7
Mechtersheimer, G.8
Zentgraf, H.9
von Deimling, A.10
-
27
-
-
84875410796
-
Detection of BRAF p.V600E mutations in melanomas: comparison of four methods argues for sequential use of immunohistochemistry and pyrosequencing
-
Colomba E, Helias-Rodzewicz Z, Von Deimling A, Marin C, Terrones N, Pechaud D, Surel S, Cote JF, Peschaud F, Capper D, et al.: Detection of BRAF p.V600E mutations in melanomas: comparison of four methods argues for sequential use of immunohistochemistry and pyrosequencing. J Mol Diagn 2013, 15: 94-100. 10.1016/j.jmoldx.2012.09.001
-
(2013)
J Mol Diagn
, vol.15
, pp. 94-100
-
-
Colomba, E.1
Helias-Rodzewicz, Z.2
Von Deimling, A.3
Marin, C.4
Terrones, N.5
Pechaud, D.6
Surel, S.7
Cote, J.F.8
Peschaud, F.9
Capper, D.10
-
28
-
-
84875230025
-
Immunohistochemistry with a mutation-specific monoclonal antibody as a screening tool for the BRAFV600E mutational status in primary cutaneous malignant melanoma
-
Feller JK, Yang S, Mahalingam M: Immunohistochemistry with a mutation-specific monoclonal antibody as a screening tool for the BRAFV600E mutational status in primary cutaneous malignant melanoma. Mod Pathol 2013, 26: 414-420. 10.1038/modpathol.2012.168
-
(2013)
Mod Pathol
, vol.26
, pp. 414-420
-
-
Feller, J.K.1
Yang, S.2
Mahalingam, M.3
-
29
-
-
84869220840
-
Utilization of a MAB for BRAF(V600E) detection in papillary thyroid carcinoma
-
Bullock M, O'Neill C, Chou A, Clarkson A, Dodds T, Toon C, Sywak M, Sidhu SB, Delbridge LW, Robinson BG, et al.: Utilization of a MAB for BRAF(V600E) detection in papillary thyroid carcinoma. Endocr Relat Cancer 2012, 19: 779-784. 10.1530/ERC-12-0239
-
(2012)
Endocr Relat Cancer
, vol.19
, pp. 779-784
-
-
Bullock, M.1
O'Neill, C.2
Chou, A.3
Clarkson, A.4
Dodds, T.5
Toon, C.6
Sywak, M.7
Sidhu, S.B.8
Delbridge, L.W.9
Robinson, B.G.10
-
30
-
-
84862109270
-
Immunohistochemical detection of the BRAF V600E-mutated protein in papillary thyroid carcinoma
-
Koperek O, Kornauth C, Capper D, Berghoff AS, Asari R, Niederle B, von Deimling A, Birner P, Preusser M: Immunohistochemical detection of the BRAF V600E-mutated protein in papillary thyroid carcinoma. Am J Surg Pathol 2012, 36: 844-850. 10.1097/PAS.0b013e318246b527
-
(2012)
Am J Surg Pathol
, vol.36
, pp. 844-850
-
-
Koperek, O.1
Kornauth, C.2
Capper, D.3
Berghoff, A.S.4
Asari, R.5
Niederle, B.6
von Deimling, A.7
Birner, P.8
Preusser, M.9
-
31
-
-
84870067191
-
Application of a BRAF V600E mutation-specific antibody for the diagnosis of hairy cell leukemia
-
Andrulis M, Penzel R, Weichert W, von Deimling A, Capper D: Application of a BRAF V600E mutation-specific antibody for the diagnosis of hairy cell leukemia. Am J Surg Pathol 2012, 36: 1796-1800. 10.1097/PAS.0b013e3182549b50
-
(2012)
Am J Surg Pathol
, vol.36
, pp. 1796-1800
-
-
Andrulis, M.1
Penzel, R.2
Weichert, W.3
von Deimling, A.4
Capper, D.5
-
32
-
-
84873715417
-
Detection of the BRAF V600E mutation in serous ovarian tumors: a comparative analysis of immunohistochemistry with a mutation-specific monoclonal antibody and allele-specific PCR
-
Bosmuller H, Fischer A, Pham DL, Fehm T, Capper D, von Deimling A, Bonzheim I, Staebler A, Fend F: Detection of the BRAF V600E mutation in serous ovarian tumors: a comparative analysis of immunohistochemistry with a mutation-specific monoclonal antibody and allele-specific PCR. Hum Pathol 2013, 44: 329-335. 10.1016/j.humpath.2012.07.010
-
(2013)
Hum Pathol
, vol.44
, pp. 329-335
-
-
Bosmuller, H.1
Fischer, A.2
Pham, D.L.3
Fehm, T.4
Capper, D.5
von Deimling, A.6
Bonzheim, I.7
Staebler, A.8
Fend, F.9
-
33
-
-
84874581453
-
Diagnostic value of immunohistochemistry for the detection of the BRAFV600E mutation in primary lung adenocarcinoma Caucasian patients
-
Ilie M, Long E, Hofman V, Dadone B, Marquette CH, Mouroux J, Vignaud JM, Begueret H, Merlio JP, Capper D, et al.: Diagnostic value of immunohistochemistry for the detection of the BRAFV600E mutation in primary lung adenocarcinoma Caucasian patients. Ann Oncol 2013, 24: 742-748. 10.1093/annonc/mds534
-
(2013)
Ann Oncol
, vol.24
, pp. 742-748
-
-
Ilie, M.1
Long, E.2
Hofman, V.3
Dadone, B.4
Marquette, C.H.5
Mouroux, J.6
Vignaud, J.M.7
Begueret, H.8
Merlio, J.P.9
Capper, D.10
-
34
-
-
84857030136
-
Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases
-
Capper D, Berghoff AS, Magerle M, Ilhan A, Wohrer A, Hackl M, Pichler J, Pusch S, Meyer J, Habel A, et al.: Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases. Acta Neuropathol 2012, 123: 223-233. 10.1007/s00401-011-0887-y
-
(2012)
Acta Neuropathol
, vol.123
, pp. 223-233
-
-
Capper, D.1
Berghoff, A.S.2
Magerle, M.3
Ilhan, A.4
Wohrer, A.5
Hackl, M.6
Pichler, J.7
Pusch, S.8
Meyer, J.9
Habel, A.10
-
35
-
-
84878562188
-
VE1 immunohistochemistry in pituitary adenomas is not associated with BRAF V600E mutation
-
Sperveslage J, Gierke M, Capper D, Honegger J, Sipos B, Beschorner R, Schittenhelm J: VE1 immunohistochemistry in pituitary adenomas is not associated with BRAF V600E mutation. Acta Neuropathol 2013, 125: 911-912. 10.1007/s00401-013-1118-5
-
(2013)
Acta Neuropathol
, vol.125
, pp. 911-912
-
-
Sperveslage, J.1
Gierke, M.2
Capper, D.3
Honegger, J.4
Sipos, B.5
Beschorner, R.6
Schittenhelm, J.7
-
36
-
-
0017360990
-
The measurement of observer agreement for categorical data
-
Landis JR, Koch GG: The measurement of observer agreement for categorical data. Biometrics 1977, 33: 159-174. 10.2307/2529310
-
(1977)
Biometrics
, vol.33
, pp. 159-174
-
-
Landis, J.R.1
Koch, G.G.2
-
38
-
-
58149409073
-
Large sample variance of kappa in the case of different sets of raters
-
Fleiss JL, Nee JC, Landis JR: Large sample variance of kappa in the case of different sets of raters. Psychol Bull 1979, 86: 974-977.
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(1979)
Psychol Bull
, vol.86
, pp. 974-977
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Fleiss, J.L.1
Nee, J.C.2
Landis, J.R.3
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