메뉴 건너뛰기




Volumn 7, Issue 6, 2013, Pages 573-587

The molecular landscape of diffuse glioma and prospects for biomarker development

Author keywords

Biomarkers; Genomics; Glioma; Prognosis

Indexed keywords

BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 2A; ISOCITRATE DEHYDROGENASE 1; MESSENGER RNA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN P53; RETINOBLASTOMA BINDING PROTEIN 1;

EID: 84887314100     PISSN: 17530059     EISSN: 17530067     Source Type: Journal    
DOI: 10.1517/17530059.2013.846321     Document Type: Review
Times cited : (9)

References (119)
  • 1
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med 2008;359:492-507
    • (2008) N Engl J Med , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 2
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352(10):987-96
    • (2005) N Engl J Med , vol.352 , Issue.10 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 3
    • 20344407807 scopus 로고    scopus 로고
    • Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
    • Ohgaki H, Kleihues P. Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol 2005;64(6):479-89
    • (2005) J Neuropathol Exp Neurol , vol.64 , Issue.6 , pp. 479-489
    • Ohgaki, H.1    Kleihues, P.2
  • 4
    • 0034871451 scopus 로고    scopus 로고
    • A multivariate analysis of 416 patients with glioblastoma multiforme: Prognosis, extent of resection, and survival
    • Lacroix M, Abi-Said D, Fourney DR, et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 2001;95(2):190-8
    • (2001) J Neurosurg , vol.95 , Issue.2 , pp. 190-198
    • Lacroix, M.1    Abi-Said, D.2    Fourney, D.R.3
  • 5
    • 0036711451 scopus 로고    scopus 로고
    • Radiotherapy for newly diagnosed malignant glioma in adults: A systematic review
    • Laperriere N, Zuraw L, Cairncross G. Radiotherapy for newly diagnosed malignant glioma in adults: a systematic review. Radiother Oncol 2002;64(3):259-73
    • (2002) Radiother Oncol , vol.64 , Issue.3 , pp. 259-273
    • Laperriere, N.1    Zuraw, L.2    Cairncross, G.3
  • 6
    • 84865785710 scopus 로고    scopus 로고
    • Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: Initial results of RTOG 9802
    • Shaw EG, Wang M, Coons SW, et al. Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802. J Clin Oncol 2012;30(25):3065-70
    • (2012) J Clin Oncol , vol.30 , Issue.25 , pp. 3065-3070
    • Shaw, E.G.1    Wang, M.2    Coons, S.W.3
  • 7
    • 24944439786 scopus 로고    scopus 로고
    • Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: The EORTC 22845 randomised trial
    • van den Bent MJ, Afra D, de Witte O, et al. Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial. Lancet 2005;366(9490):985-90
    • (2005) Lancet , vol.366 , Issue.9490 , pp. 985-990
    • Van Den Bent, M.J.1    Afra, D.2    De Witte, O.3
  • 8
    • 77952108366 scopus 로고    scopus 로고
    • Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    • Noushmehr H, Weisenberger DJ, Diefes K, et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 2010;17(5):510-22
    • (2010) Cancer Cell , vol.17 , Issue.5 , pp. 510-522
    • Noushmehr, H.1    Weisenberger, D.J.2    Diefes, K.3
  • 9
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • The Cancer Genome Atlas Research Network
    • The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008;455:1061-8
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 10
    • 73649123907 scopus 로고    scopus 로고
    • An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RGW, Hoadley KA, Purdom E, et al. An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2009;17:98-110
    • (2009) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.W.1    Hoadley, K.A.2    Purdom, E.3
  • 11
    • 34547122001 scopus 로고    scopus 로고
    • The 2007 WHO classification of tumours of the central nervous system
    • Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114(2):97-109
    • (2007) Acta Neuropathol , vol.114 , Issue.2 , pp. 97-109
    • Louis, D.N.1    Ohgaki, H.2    Wiestler, O.D.3
  • 12
    • 79957927593 scopus 로고    scopus 로고
    • Genetic modeling of gliomas in mice: New tools to tackle old problems
    • Hambardzumyan D, Parada LF, Holland EC, Charest A. Genetic modeling of gliomas in mice: new tools to tackle old problems. Glia 2011;59(8):1155-68
    • (2011) Glia , vol.59 , Issue.8 , pp. 1155-1168
    • Hambardzumyan, D.1    Parada, L.F.2    Holland, E.C.3    Charest, A.4
  • 13
    • 57449096198 scopus 로고    scopus 로고
    • Genetically engineered mouse models of brain cancer and the promise of preclinical testing
    • Huse JT, Holland EC. Genetically engineered mouse models of brain cancer and the promise of preclinical testing. Brain Pathol 2009;19(1):132-43
    • (2009) Brain Pathol , vol.19 , Issue.1 , pp. 132-143
    • Huse, J.T.1    Holland, E.C.2
  • 14
    • 0028123442 scopus 로고
    • The p53 gene and protein in human brain tumors
    • Louis DN. The p53 gene and protein in human brain tumors. J Neuropathol Exp Neurol 1994;53:11-21
    • (1994) J Neuropathol Exp Neurol , vol.53 , pp. 11-21
    • Louis, D.N.1
  • 15
    • 0027943938 scopus 로고
    • The retinoblastoma gene is involved in the malignant progression of astrocytomas
    • Henson JW, Schnitker BL, Correa KM, et al. The retinoblastoma gene is involved in the malignant progression of astrocytomas. Ann Neurol 1994;36:714-21
    • (1994) Ann Neurol , vol.36 , pp. 714-721
    • Henson, J.W.1    Schnitker, B.L.2    Correa, K.M.3
  • 16
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science (New York, NY) 2008;321:1807-12
    • (2008) Science (New York, NY) , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 17
    • 0032494479 scopus 로고    scopus 로고
    • Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas
    • Cairncross JG, Ueki K, Zlatescu MC, et al. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst 1998;90:1473-9
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1473-1479
    • Cairncross, J.G.1    Ueki, K.2    Zlatescu, M.C.3
  • 18
    • 0030070484 scopus 로고    scopus 로고
    • CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated
    • Ueki K, Ono Y, Henson JW, et al. CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res 1996;56:150-3
    • (1996) Cancer Res , vol.56 , pp. 150-153
    • Ueki, K.1    Ono, Y.2    Henson, J.W.3
  • 19
    • 77954596239 scopus 로고    scopus 로고
    • Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease
    • Paugh BS, Qu C, Jones C, et al. Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease. J Clin Oncol 2010;28(18):3061-8
    • (2010) J Clin Oncol , vol.28 , Issue.18 , pp. 3061-3068
    • Paugh, B.S.1    Qu, C.2    Jones, C.3
  • 20
    • 80054771090 scopus 로고    scopus 로고
    • Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma
    • Paugh BS, Broniscer A, Qu C, et al. Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma. J Clin Oncol 2011;29(30):3999-4006
    • (2011) J Clin Oncol , vol.29 , Issue.30 , pp. 3999-4006
    • Paugh, B.S.1    Broniscer, A.2    Qu, C.3
  • 21
    • 0034163550 scopus 로고    scopus 로고
    • Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
    • Frederick L, Wang XY, Eley G, James CD. Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res 2000;60:1383-7
    • (2000) Cancer Res , vol.60 , pp. 1383-1387
    • Frederick, L.1    Wang, X.Y.2    Eley, G.3    James, C.D.4
  • 22
    • 0026548240 scopus 로고
    • Structural alterations of the epidermal growth factor receptor gene in human gliomas
    • Wong AJ, Ruppert JM, Bigner SH, et al. Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci USA 1992;89:2965-9
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2965-2969
    • Wong, A.J.1    Ruppert, J.M.2    Bigner, S.H.3
  • 23
    • 33845926387 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain
    • Lee JC, Vivanco I, Beroukhim R, et al. Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS Med 2006;3(12):e485
    • (2006) PLoS Med , vol.3 , Issue.12
    • Lee, J.C.1    Vivanco, I.2    Beroukhim, R.3
  • 24
    • 77957667714 scopus 로고    scopus 로고
    • PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas
    • Ozawa T, Brennan CW, Wang L, et al. PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas. Genes Dev 2010;24(19):2205-18
    • (2010) Genes Dev , vol.24 , Issue.19 , pp. 2205-2218
    • Ozawa, T.1    Brennan, C.W.2    Wang, L.3
  • 25
    • 77950487385 scopus 로고    scopus 로고
    • Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets
    • Zarghooni M, Bartels U, Lee E, et al. Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets. J Clin Oncol 2010;28(8):1337-44
    • (2010) J Clin Oncol , vol.28 , Issue.8 , pp. 1337-1344
    • Zarghooni, M.1    Bartels, U.2    Lee, E.3
  • 26
    • 83455176258 scopus 로고    scopus 로고
    • Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma
    • Snuderl M, Fazlollahi L, Le LP, et al. Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. Cancer Cell 2011;20(6):810-17
    • (2011) Cancer Cell , vol.20 , Issue.6 , pp. 810-817
    • Snuderl, M.1    Fazlollahi, L.2    Le, L.P.3
  • 27
    • 84857397985 scopus 로고    scopus 로고
    • Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
    • Szerlip NJ, Pedraza A, Chakravarty D, et al. Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proc Natl Acad Sci USA 2012;109(8):3041-6
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.8 , pp. 3041-3046
    • Szerlip, N.J.1    Pedraza, A.2    Chakravarty, D.3
  • 28
    • 0031951740 scopus 로고    scopus 로고
    • Platelet-derived growth factor and its receptor expression in human oligodendrogliomas
    • Di Rocco F, Carroll RS, Zhang J, Black PM. Platelet-derived growth factor and its receptor expression in human oligodendrogliomas. Neurosurgery 1998;42:341-6
    • (1998) Neurosurgery , vol.42 , pp. 341-346
    • Di Rocco, F.1    Carroll, R.S.2    Zhang, J.3    Black, P.M.4
  • 29
    • 84860528433 scopus 로고    scopus 로고
    • IDH mutation and neuroglial developmental features define clinically distinct subclasses of lower grade diffuse astrocytic glioma
    • Gorovets D, Kannan K, Shen R, et al. IDH mutation and neuroglial developmental features define clinically distinct subclasses of lower grade diffuse astrocytic glioma. Clin Cancer Res 2012;18(9):2490-501
    • (2012) Clin Cancer Res , vol.18 , Issue.9 , pp. 2490-2501
    • Gorovets, D.1    Kannan, K.2    Shen, R.3
  • 30
    • 0029401049 scopus 로고
    • Platelet-derived growth factor in human glioma
    • Westermark B, Heldin CH, Nister M. Platelet-derived growth factor in human glioma. Glia 1995;15:257-63
    • (1995) Glia , vol.15 , pp. 257-263
    • Westermark, B.1    Heldin, C.H.2    Nister, M.3
  • 31
    • 70849122697 scopus 로고    scopus 로고
    • Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    • Brennan C, Momota H, Hambardzumyan D, et al. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS One 2009;4:e7752
    • (2009) PLoS One , vol.4
    • Brennan, C.1    Momota, H.2    Hambardzumyan, D.3
  • 32
    • 34247131323 scopus 로고    scopus 로고
    • Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors
    • Faury D, Nantel A, Dunn SE, et al. Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors. J Clin Oncol 2007;25(10):1196-208
    • (2007) J Clin Oncol , vol.25 , Issue.10 , pp. 1196-1208
    • Faury, D.1    Nantel, A.2    Dunn, S.E.3
  • 33
    • 66149173789 scopus 로고    scopus 로고
    • The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
    • Huse JT, Brennan C, Hambardzumyan D, et al. The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev 2009;23(11):1327-37
    • (2009) Genes Dev , vol.23 , Issue.11 , pp. 1327-1337
    • Huse, J.T.1    Brennan, C.2    Hambardzumyan, D.3
  • 34
    • 76649130555 scopus 로고    scopus 로고
    • Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship
    • Kim H, Huang W, Jiang X, et al. Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proc Natl Acad Sci USA 2010;107(5):2183-8
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.5 , pp. 2183-2188
    • Kim, H.1    Huang, W.2    Jiang, X.3
  • 35
    • 77949265515 scopus 로고    scopus 로고
    • Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival
    • McBride SM, Perez DA, Polley MY, et al. Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival. J Neurooncol 2010;97(1):33-40
    • (2010) J Neurooncol , vol.97 , Issue.1 , pp. 33-40
    • McBride, S.M.1    Perez, D.A.2    Polley, M.Y.3
  • 36
    • 34547432233 scopus 로고    scopus 로고
    • Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma
    • Wiencke JK, Zheng S, Jelluma N, et al. Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. Neuro Oncol 2007;9(3):271-9
    • (2007) Neuro Oncol , vol.9 , Issue.3 , pp. 271-279
    • Wiencke, J.K.1    Zheng, S.2    Jelluma, N.3
  • 38
    • 0028006633 scopus 로고
    • Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p
    • Reifenberger G, Reifenberger J, Liu L, et al. Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. Am J Pathol 1994;145:1175-90
    • (1994) Am J Pathol , vol.145 , pp. 1175-1190
    • Reifenberger, G.1    Reifenberger, J.2    Liu, L.3
  • 39
    • 0028799791 scopus 로고
    • Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma
    • Kraus JA, Koopmann J, Kaskel P, et al. Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma. J Neuropathol Exp Neurol 1995;54(1):91-5
    • (1995) J Neuropathol Exp Neurol , vol.54 , Issue.1 , pp. 91-95
    • Kraus, J.A.1    Koopmann, J.2    Kaskel, P.3
  • 40
    • 0033566061 scopus 로고    scopus 로고
    • Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype
    • Smith JS, Alderete B, Minn Y, et al. Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype. Oncogene 1999;18(28):4144-52
    • (1999) Oncogene , vol.18 , Issue.28 , pp. 4144-4152
    • Smith, J.S.1    Alderete, B.2    Minn, Y.3
  • 41
    • 80052608062 scopus 로고    scopus 로고
    • Mutations in CIC and FUBP1 contribute to human oligodendroglioma
    • Bettegowda C, Agrawal N, Jiao Y, et al. Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science (New York, NY) 2011;333(6048):1453-5
    • (2011) Science (New York, NY) , vol.333 , Issue.6048 , pp. 1453-1455
    • Bettegowda, C.1    Agrawal, N.2    Jiao, Y.3
  • 42
    • 82755194965 scopus 로고    scopus 로고
    • Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers
    • Yip S, Butterfield YS, Morozova O, et al. Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. J Pathol 2012;226(1):7-16
    • (2012) J Pathol , vol.226 , Issue.1 , pp. 7-16
    • Yip, S.1    Butterfield, Y.S.2    Morozova, O.3
  • 43
    • 0142250368 scopus 로고    scopus 로고
    • Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course
    • Watanabe T, Katayama Y, Yoshino A, et al. Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course. Clin Cancer Res 2003;9(13):4884-90
    • (2003) Clin Cancer Res , vol.9 , Issue.13 , pp. 4884-4890
    • Watanabe, T.1    Katayama, Y.2    Yoshino, A.3
  • 44
    • 0035213384 scopus 로고    scopus 로고
    • Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendroglioma
    • Watanabe T, Yokoo H, Yokoo M, et al. Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendroglioma. J Neuropathol Exp Neurol 2001;60:1181-90
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 1181-1190
    • Watanabe, T.1    Yokoo, H.2    Yokoo, M.3
  • 45
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005;352(10):997-1003
    • (2005) N Engl J Med , vol.352 , Issue.10 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 46
    • 43749094544 scopus 로고    scopus 로고
    • MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients
    • Brandes AA, Franceschi E, Tosoni A, et al. MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients. J Clin Oncol 2008;26(13):2192-7
    • (2008) J Clin Oncol , vol.26 , Issue.13 , pp. 2192-2197
    • Brandes, A.A.1    Franceschi, E.2    Tosoni, A.3
  • 47
    • 3543148964 scopus 로고    scopus 로고
    • Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression
    • de Wit MC, de Bruin HG, Eijkenboom W, et al. Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression. Neurology 2004;63(3):535-7
    • (2004) Neurology , vol.63 , Issue.3 , pp. 535-537
    • De Wit, M.C.1    De Bruin, H.G.2    Eijkenboom, W.3
  • 48
    • 0033587747 scopus 로고    scopus 로고
    • CpG island methylator phenotype in colorectal cancer
    • Toyota M, Ahuja N, Ohe-Toyota M, et al. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 1999;96(15):8681-6
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.15 , pp. 8681-8686
    • Toyota, M.1    Ahuja, N.2    Ohe-Toyota, M.3
  • 49
    • 0033229890 scopus 로고    scopus 로고
    • Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
    • Toyota M, Ahuja N, Suzuki H, et al. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res 1999;59(21):5438-42
    • (1999) Cancer Res , vol.59 , Issue.21 , pp. 5438-5442
    • Toyota, M.1    Ahuja, N.2    Suzuki, H.3
  • 50
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009;462(7274):739-44
    • (2009) Nature , vol.462 , Issue.7274 , pp. 739-744
    • Dang, L.1    White, D.W.2    Gross, S.3
  • 51
    • 84858796262 scopus 로고    scopus 로고
    • IDH mutation impairs histone demethylation and results in a block to cell differentiation
    • Lu C, Ward PS, Kapoor GS, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 2012;483(7390):474-8
    • (2012) Nature , vol.483 , Issue.7390 , pp. 474-478
    • Lu, C.1    Ward, P.S.2    Kapoor, G.S.3
  • 52
    • 84858796263 scopus 로고    scopus 로고
    • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    • Turcan S, Rohle D, Goenka A, et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 2012;483(7390):479-83
    • (2012) Nature , vol.483 , Issue.7390 , pp. 479-483
    • Turcan, S.1    Rohle, D.2    Goenka, A.3
  • 53
    • 84862777348 scopus 로고    scopus 로고
    • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
    • Schwartzentruber J, Korshunov A, Liu XY, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 2012;482(7384):226-31
    • (2012) Nature , vol.482 , Issue.7384 , pp. 226-231
    • Schwartzentruber, J.1    Korshunov, A.2    Liu, X.Y.3
  • 54
    • 84862777410 scopus 로고    scopus 로고
    • Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
    • Wu G, Broniscer A, McEachron TA, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet 2012;44(3):251-3
    • (2012) Nat Genet , vol.44 , Issue.3 , pp. 251-253
    • Wu, G.1    Broniscer, A.2    McEachron, T.A.3
  • 55
    • 70350500219 scopus 로고    scopus 로고
    • Polycomb group proteins: Navigators of lineage pathways led astray in cancer
    • Bracken AP, Helin K. Polycomb group proteins: navigators of lineage pathways led astray in cancer. Nat Rev 2009;9(11):773-84
    • (2009) Nat Rev , vol.9 , Issue.11 , pp. 773-784
    • Bracken, A.P.1    Helin, K.2
  • 56
    • 84856120332 scopus 로고    scopus 로고
    • Understanding the language of Lys36 methylation at histone H3
    • Wagner EJ, Carpenter PB. Understanding the language of Lys36 methylation at histone H3. Nat Rev Mol Cell Biol 2012;13(2):115-26
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.2 , pp. 115-126
    • Wagner, E.J.1    Carpenter, P.B.2
  • 57
    • 84867606428 scopus 로고    scopus 로고
    • Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
    • Sturm D, Witt H, Hovestadt V, et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 2012;22(4):425-37
    • (2012) Cancer Cell , vol.22 , Issue.4 , pp. 425-437
    • Sturm, D.1    Witt, H.2    Hovestadt, V.3
  • 58
    • 77649099092 scopus 로고    scopus 로고
    • Distinct factors control histone variant H3.3 localization at specific genomic regions
    • Goldberg AD, Banaszynski LA, Noh KM, et al. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell 2010;140(5):678-91
    • (2010) Cell , vol.140 , Issue.5 , pp. 678-691
    • Goldberg, A.D.1    Banaszynski, L.A.2    Noh, K.M.3
  • 59
    • 77956282773 scopus 로고    scopus 로고
    • Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
    • Lewis PW, Elsaesser SJ, Noh KM, et al. Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci USA 2010;107(32):14075-80
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.32 , pp. 14075-14080
    • Lewis, P.W.1    Elsaesser, S.J.2    Noh, K.M.3
  • 60
    • 79960700556 scopus 로고    scopus 로고
    • Altered telomeres in tumors with ATRX and DAXX mutations
    • Heaphy CM, de Wilde RF, Jiao Y, et al. Altered telomeres in tumors with ATRX and DAXX mutations. Science (New York, NY) 2011;333(6041):425
    • (2011) Science (New York, NY) , vol.333 , Issue.6041 , pp. 425
    • Heaphy, C.M.1    De Wilde, R.F.2    Jiao, Y.3
  • 61
    • 84864619205 scopus 로고    scopus 로고
    • Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway
    • Lovejoy CA, Li W, Reisenweber S, et al. Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet 2012;8(7):e1002772
    • (2012) PLoS Genet , vol.8 , Issue.7
    • Lovejoy, C.A.1    Li, W.2    Reisenweber, S.3
  • 62
    • 38749117849 scopus 로고    scopus 로고
    • Loss of ATRX leads to chromosome cohesion and congression defects
    • Ritchie K, Seah C, Moulin J, et al. Loss of ATRX leads to chromosome cohesion and congression defects. J Cell Biol 2008;180(2):315-24
    • (2008) J Cell Biol , vol.180 , Issue.2 , pp. 315-324
    • Ritchie, K.1    Seah, C.2    Moulin, J.3
  • 63
    • 77649262618 scopus 로고    scopus 로고
    • ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells
    • Wong LH, McGhie JD, Sim M, et al. ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells. Genome Res 2010;20(3):351-60
    • (2010) Genome Res , vol.20 , Issue.3 , pp. 351-360
    • Wong, L.H.1    McGhie, J.D.2    Sim, M.3
  • 64
    • 84874191269 scopus 로고    scopus 로고
    • TERT promoter mutations in familial and sporadic melanoma
    • Horn S, Figl A, Rachakonda PS, et al. TERT promoter mutations in familial and sporadic melanoma. Science (New York, NY) 2013;339(6122):959-61
    • (2013) Science (New York, NY) , vol.339 , Issue.6122 , pp. 959-961
    • Horn, S.1    Figl, A.2    Rachakonda, P.S.3
  • 65
    • 84874189784 scopus 로고    scopus 로고
    • Highly recurrent TERT promoter mutations in human melanoma
    • Huang FW, Hodis E, Xu MJ, et al. Highly recurrent TERT promoter mutations in human melanoma. Science (New York, NY) 2013;339(6122):957-9
    • (2013) Science (New York, NY) , vol.339 , Issue.6122 , pp. 957-959
    • Huang, F.W.1    Hodis, E.2    Xu, M.J.3
  • 66
    • 84876067164 scopus 로고    scopus 로고
    • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
    • Killela PJ, Reitman ZJ, Jiao Y, et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci USA 2013;110(15):6021-6
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.15 , pp. 6021-6026
    • Killela, P.J.1    Reitman, Z.J.2    Jiao, Y.3
  • 67
    • 84868625787 scopus 로고    scopus 로고
    • Frequent ATRX, CIC, and FUBP1 mutations refine the classification of malignant gliomas
    • Jiao Y, Killela PJ, Reitman ZJ, et al. Frequent ATRX, CIC, and FUBP1 mutations refine the classification of malignant gliomas. Oncotarget 2012;3:709-22
    • (2012) Oncotarget , vol.3 , pp. 709-722
    • Jiao, Y.1    Killela, P.J.2    Reitman, Z.J.3
  • 68
    • 84872788316 scopus 로고    scopus 로고
    • Whole exome sequencing identified ATRX mutation as a key molecular determinant in lower-grade glioma
    • Kannan K, Inagaki A, Silber J, et al. Whole exome sequencing identified ATRX mutation as a key molecular determinant in lower-grade glioma. Oncotarget 2012;3:1194-203
    • (2012) Oncotarget , vol.3 , pp. 1194-1203
    • Kannan, K.1    Inagaki, A.2    Silber, J.3
  • 69
    • 84871020024 scopus 로고    scopus 로고
    • Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations
    • Liu XY, Gerges N, Korshunov A, et al. Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations. Acta Neuropathol 2012;124(5):615-25
    • (2012) Acta Neuropathol , vol.124 , Issue.5 , pp. 615-625
    • Liu, X.Y.1    Gerges, N.2    Korshunov, A.3
  • 70
    • 0036132668 scopus 로고    scopus 로고
    • Molecular classification of human diffuse gliomas by multidimensional scaling analysis of gene expression profiles parallels morphology-based classification, correlates with survival, and reveals clinically-relevant novel glioma subsets
    • Fuller GN, Hess KR, Rhee CH, et al. Molecular classification of human diffuse gliomas by multidimensional scaling analysis of gene expression profiles parallels morphology-based classification, correlates with survival, and reveals clinically-relevant novel glioma subsets. Brain Pathol 2002;12(1):108-16
    • (2002) Brain Pathol , vol.12 , Issue.1 , pp. 108-116
    • Fuller, G.N.1    Hess, K.R.2    Rhee, C.H.3
  • 71
    • 0345240919 scopus 로고    scopus 로고
    • Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: A revelation by parallel gene expression profiling
    • Fuller GN, Rhee CH, Hess KR, et al. Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: a revelation by parallel gene expression profiling. Cancer Res 1999;59(17):4228-32
    • (1999) Cancer Res , vol.59 , Issue.17 , pp. 4228-4232
    • Fuller, G.N.1    Rhee, C.H.2    Hess, K.R.3
  • 72
    • 33645694302 scopus 로고    scopus 로고
    • Different angiogenic phenotypes in primary and secondary glioblastomas
    • Karcher S, Steiner HH, Ahmadi R, et al. Different angiogenic phenotypes in primary and secondary glioblastomas. Int J Cancer 2006;118(9):2182-9
    • (2006) Int J Cancer , vol.118 , Issue.9 , pp. 2182-2189
    • Karcher, S.1    Steiner, H.H.2    Ahmadi, R.3
  • 73
    • 0742299049 scopus 로고    scopus 로고
    • Identification of combination gene sets for glioma classification
    • Kim S, Dougherty ER, Shmulevich I, et al. Identification of combination gene sets for glioma classification. Mol Cancer Ther 2002;1(13):1229-36
    • (2002) Mol Cancer Ther , vol.1 , Issue.13 , pp. 1229-1236
    • Kim, S.1    Dougherty, E.R.2    Shmulevich, I.3
  • 74
    • 20244387732 scopus 로고    scopus 로고
    • Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme
    • Liang Y, Diehn M, Watson N, et al. Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc Natl Acad Sci USA 2005;102(16):5814-19
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.16 , pp. 5814-5819
    • Liang, Y.1    Diehn, M.2    Watson, N.3
  • 75
    • 0035884608 scopus 로고    scopus 로고
    • Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis
    • Rickman DS, Bobek MP, Misek DE, et al. Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis. Cancer Res 2001;61(18):6885-91
    • (2001) Cancer Res , vol.61 , Issue.18 , pp. 6885-6891
    • Rickman, D.S.1    Bobek, M.P.2    Misek, D.E.3
  • 76
    • 0034544537 scopus 로고    scopus 로고
    • Identification of differentially expressed genes in human gliomas by DNA microarray and tissue chip techniques
    • Sallinen SL, Sallinen PK, Haapasalo HK, et al. Identification of differentially expressed genes in human gliomas by DNA microarray and tissue chip techniques. Cancer Res 2000;60(23):6617-22
    • (2000) Cancer Res , vol.60 , Issue.23 , pp. 6617-6622
    • Sallinen, S.L.1    Sallinen, P.K.2    Haapasalo, H.K.3
  • 77
    • 0042567193 scopus 로고    scopus 로고
    • Gene expression profiling identifies molecular subtypes of gliomas
    • Shai R, Shi T, Kremen TJ, et al. Gene expression profiling identifies molecular subtypes of gliomas. Oncogene 2003;22(31):4918-23
    • (2003) Oncogene , vol.22 , Issue.31 , pp. 4918-4923
    • Shai, R.1    Shi, T.2    Kremen, T.J.3
  • 78
    • 0036682413 scopus 로고    scopus 로고
    • Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma
    • Tanwar MK, Gilbert MR, Holland EC. Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma. Cancer Res 2002;62(15):4364-8
    • (2002) Cancer Res , vol.62 , Issue.15 , pp. 4364-4368
    • Tanwar, M.K.1    Gilbert, M.R.2    Holland, E.C.3
  • 79
    • 31544467538 scopus 로고    scopus 로고
    • Distinct transcription profiles of primary and secondary glioblastoma subgroups
    • Tso CL, Freije WA, Day A, et al. Distinct transcription profiles of primary and secondary glioblastoma subgroups. Cancer Res 2006;66(1):159-67
    • (2006) Cancer Res , vol.66 , Issue.1 , pp. 159-167
    • Tso, C.L.1    Freije, W.A.2    Day, A.3
  • 80
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • Phillips HS, Kharbanda S, Chen R, et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006;9(3):157-73
    • (2006) Cancer Cell , vol.9 , Issue.3 , pp. 157-173
    • Phillips, H.S.1    Kharbanda, S.2    Chen, R.3
  • 81
    • 79957905986 scopus 로고    scopus 로고
    • Molecular subclassification of diffuse gliomas: Seeing order in the chaos
    • Huse JT, Phillips HS, Brennan CW. Molecular subclassification of diffuse gliomas: seeing order in the chaos. Glia 2011;59(8):1190-9
    • (2011) Glia , vol.59 , Issue.8 , pp. 1190-1199
    • Huse, J.T.1    Phillips, H.S.2    Brennan, C.W.3
  • 82
    • 79955514336 scopus 로고    scopus 로고
    • A developmental taxonomy of glioblastoma defined and maintained by MicroRNAs
    • Kim TM, Huang W, Park R, et al. A developmental taxonomy of glioblastoma defined and maintained by MicroRNAs. Cancer Res 2011;71(9):3387-99
    • (2011) Cancer Res , vol.71 , Issue.9 , pp. 3387-3399
    • Kim, T.M.1    Huang, W.2    Park, R.3
  • 83
    • 84859992638 scopus 로고    scopus 로고
    • Integrative subtype discovery in glioblastoma using iCluster
    • In press
    • Shen R, Mo Q, Schultz N, et al. Integrative subtype discovery in glioblastoma using iCluster. PLoS One 2012; In press
    • (2012) PLoS One
    • Shen, R.1    Mo, Q.2    Schultz, N.3
  • 84
    • 77958527996 scopus 로고    scopus 로고
    • The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas
    • Cooper LA, Gutman DA, Long Q, et al. The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas. PLoS One 2010;5(9):e12548
    • (2010) PLoS One , vol.5 , Issue.9
    • Cooper, L.A.1    Gutman, D.A.2    Long, Q.3
  • 85
    • 78650022211 scopus 로고    scopus 로고
    • Gone FISHing: Clinical lessons learned in brain tumor molecular diagnostics over the last decade
    • Horbinski C, Miller CR, Perry A. Gone FISHing: clinical lessons learned in brain tumor molecular diagnostics over the last decade. Brain Pathol 2011;21(1):57-73
    • (2011) Brain Pathol , vol.21 , Issue.1 , pp. 57-73
    • Horbinski, C.1    Miller, C.R.2    Perry, A.3
  • 86
    • 0034231944 scopus 로고    scopus 로고
    • Analysis of genomic rearrangements associated with EGRFvIII expression suggests involvement of Alu repeat elements
    • Frederick L, Eley G, Wang XY, James CD. Analysis of genomic rearrangements associated with EGRFvIII expression suggests involvement of Alu repeat elements. Neuro Oncol 2000;2(3):159-63
    • (2000) Neuro Oncol , vol.2 , Issue.3 , pp. 159-163
    • Frederick, L.1    Eley, G.2    Wang, X.Y.3    James, C.D.4
  • 87
    • 34548147443 scopus 로고    scopus 로고
    • Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfate restriction analysis
    • Mikeska T, Bock C, El-Maarri O, et al. Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfate restriction analysis. J Mol Diagn 2007;9(3):368-81
    • (2007) J Mol Diagn , vol.9 , Issue.3 , pp. 368-381
    • Mikeska, T.1    Bock, C.2    El-Maarri, O.3
  • 88
    • 0034326238 scopus 로고    scopus 로고
    • Predicting lung cancer by detecting aberrant promoter methylation in sputum
    • Palmisano WA, Divine KK, Saccomanno G, et al. Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res 2000;60(21):5954-8
    • (2000) Cancer Res , vol.60 , Issue.21 , pp. 5954-5958
    • Palmisano, W.A.1    Divine, K.K.2    Saccomanno, G.3
  • 89
    • 79959928424 scopus 로고    scopus 로고
    • Excavation of a buried treasure-DNA, mRNA, miRNA and protein analysis in formalin fixed, paraffin embedded tissues
    • Klopfleisch R, Weiss AT, Gruber AD. Excavation of a buried treasure-DNA, mRNA, miRNA and protein analysis in formalin fixed, paraffin embedded tissues. Histol Histopathol 2011;26(6):797-810
    • (2011) Histol Histopathol , vol.26 , Issue.6 , pp. 797-810
    • Klopfleisch, R.1    Weiss, A.T.2    Gruber, A.D.3
  • 91
    • 0036590151 scopus 로고    scopus 로고
    • Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools
    • Norton N, Williams NM, Williams HJ, et al. Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Hum Genet 2002;110(5):471-8
    • (2002) Hum Genet , vol.110 , Issue.5 , pp. 471-478
    • Norton, N.1    Williams, N.M.2    Williams, H.J.3
  • 92
    • 25444529450 scopus 로고    scopus 로고
    • Whole genome SNP arrays using DNA derived from formalin-fixed, paraffin-embedded ovarian tumor tissue
    • Thompson ER, Herbert SC, Forrest SM, Campbell IG. Whole genome SNP arrays using DNA derived from formalin-fixed, paraffin-embedded ovarian tumor tissue. Hum Mutat 2005;26(4):384-9
    • (2005) Hum Mutat , vol.26 , Issue.4 , pp. 384-389
    • Thompson, E.R.1    Herbert, S.C.2    Forrest, S.M.3    Campbell, I.G.4
  • 93
    • 84862504151 scopus 로고    scopus 로고
    • DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues
    • Craig JM, Vena N, Ramkissoon S, et al. DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues. PLoS One 2012;7(6):e38881
    • (2012) PLoS One , vol.7 , Issue.6
    • Craig, J.M.1    Vena, N.2    Ramkissoon, S.3
  • 94
    • 7244245443 scopus 로고    scopus 로고
    • Quantitative gene expression profiling in formalin-fixed, paraffin-embedded tissues using universal bead arrays
    • Bibikova M, Talantov D, Chudin E, et al. Quantitative gene expression profiling in formalin-fixed, paraffin-embedded tissues using universal bead arrays. Am J Pathol 2004;165(5):1799-807
    • (2004) Am J Pathol , vol.165 , Issue.5 , pp. 1799-1807
    • Bibikova, M.1    Talantov, D.2    Chudin, E.3
  • 95
    • 80052593539 scopus 로고    scopus 로고
    • Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samples
    • Chow ML, Li HR, Winn ME, et al. Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samples. BMC Genomics 2011;12:449
    • (2011) BMC Genomics , vol.12 , pp. 449
    • Chow, M.L.1    Li, H.R.2    Winn, M.E.3
  • 96
    • 79951818662 scopus 로고    scopus 로고
    • Gene expression profiles from formalin fixed paraffin embedded breast cancer tissue are largely comparable to fresh frozen matched tissue
    • Mittempergher L, de Ronde JJ, Nieuwland M, et al. Gene expression profiles from formalin fixed paraffin embedded breast cancer tissue are largely comparable to fresh frozen matched tissue. PLoS One 2011;6(2):e17163
    • (2011) PLoS One , vol.6 , Issue.2
    • Mittempergher, L.1    De Ronde, J.J.2    Nieuwland, M.3
  • 98
    • 40449100030 scopus 로고    scopus 로고
    • Direct multiplexed measurement of gene expression with color-coded probe pairs
    • Geiss GK, Bumgarner RE, Birditt B, et al. Direct multiplexed measurement of gene expression with color-coded probe pairs. Nat Biotechnol 2008;26(3):317-25
    • (2008) Nat Biotechnol , vol.26 , Issue.3 , pp. 317-325
    • Geiss, G.K.1    Bumgarner, R.E.2    Birditt, B.3
  • 99
    • 84865833740 scopus 로고    scopus 로고
    • High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing
    • Wagle N, Berger MF, Davis MJ, et al. High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Cancer Discov 2012;2(1):82-93
    • (2012) Cancer Discov , vol.2 , Issue.1 , pp. 82-93
    • Wagle, N.1    Berger, M.F.2    Davis, M.J.3
  • 100
    • 84868016827 scopus 로고    scopus 로고
    • Statistical challenges associated with detecting copy number variations with next-generation sequencing
    • Teo SM, Pawitan Y, Ku CS, et al. Statistical challenges associated with detecting copy number variations with next-generation sequencing. Bioinformatics 2012;28(21):2711-18
    • (2012) Bioinformatics , vol.28 , Issue.21 , pp. 2711-2718
    • Teo, S.M.1    Pawitan, Y.2    Ku, C.S.3
  • 101
    • 84867707134 scopus 로고    scopus 로고
    • Next-generation sequencing in the clinic: Are we ready?
    • Biesecker LG, Burke W, Kohane I, et al. Next-generation sequencing in the clinic: are we ready? Nat Rev Genet 2012;13(11):818-24
    • (2012) Nat Rev Genet , vol.13 , Issue.11 , pp. 818-824
    • Biesecker, L.G.1    Burke, W.2    Kohane, I.3
  • 102
    • 78651082266 scopus 로고    scopus 로고
    • Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: Implications for classification of gliomas
    • Hartmann C, Hentschel B, Wick W, et al. Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas. Acta Neuropathol 2010;120(6):707-18
    • (2010) Acta Neuropathol , vol.120 , Issue.6 , pp. 707-718
    • Hartmann, C.1    Hentschel, B.2    Wick, W.3
  • 103
    • 78650226575 scopus 로고    scopus 로고
    • Molecular classification of low-grade diffuse gliomas
    • Kim YH, Nobusawa S, Mittelbronn M, et al. Molecular classification of low-grade diffuse gliomas. Am J Pathol 2010;177(6):2708-14
    • (2010) Am J Pathol , vol.177 , Issue.6 , pp. 2708-2714
    • Kim, Y.H.1    Nobusawa, S.2    Mittelbronn, M.3
  • 104
    • 70249097408 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas
    • Sanson M, Marie Y, Paris S, et al. Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas. J Clin Oncol 2009;27(25):4150-4
    • (2009) J Clin Oncol , vol.27 , Issue.25 , pp. 4150-4154
    • Sanson, M.1    Marie, Y.2    Paris, S.3
  • 105
    • 84855493663 scopus 로고    scopus 로고
    • IDH1 mutations in grade II astrocytomas are associated with unfavorable progression-free survival and prolonged postrecurrence survival
    • Thon N, Eigenbrod S, Kreth S, et al. IDH1 mutations in grade II astrocytomas are associated with unfavorable progression-free survival and prolonged postrecurrence survival. Cancer 2011;118(2):452-60
    • (2011) Cancer , vol.118 , Issue.2 , pp. 452-460
    • Thon, N.1    Eigenbrod, S.2    Kreth, S.3
  • 106
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009;360(8):765-73
    • (2009) N Engl J Med , vol.360 , Issue.8 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 107
    • 0033951824 scopus 로고    scopus 로고
    • Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas
    • Smith JS, Perry A, Borell TJ, et al. Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. J Clin Oncol 2000;18(3):636-45
    • (2000) J Clin Oncol , vol.18 , Issue.3 , pp. 636-645
    • Smith, J.S.1    Perry, A.2    Borell, T.J.3
  • 108
    • 75849146316 scopus 로고    scopus 로고
    • MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma
    • Rivera AL, Pelloski CE, Gilbert MR, et al. MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma. Neuro Oncol 2010;12(2):116-21
    • (2010) Neuro Oncol , vol.12 , Issue.2 , pp. 116-121
    • Rivera, A.L.1    Pelloski, C.E.2    Gilbert, M.R.3
  • 109
    • 84862895654 scopus 로고    scopus 로고
    • Current clinical development of PI3K pathway inhibitors in glioblastoma
    • Wen PY, Lee EQ, Reardon DA, et al. Current clinical development of PI3K pathway inhibitors in glioblastoma. Neuro Oncol 2012;14(7):819-29
    • (2012) Neuro Oncol , vol.14 , Issue.7 , pp. 819-829
    • Wen, P.Y.1    Lee, E.Q.2    Reardon, D.A.3
  • 110
    • 79957924324 scopus 로고    scopus 로고
    • Signal transduction inhibitors and antiangiogenic therapies for malignant glioma
    • Mellinghoff IK, Lassman AB, Wen PY. Signal transduction inhibitors and antiangiogenic therapies for malignant glioma. Glia 2011;59(8):1205-12
    • (2011) Glia , vol.59 , Issue.8 , pp. 1205-1212
    • Mellinghoff, I.K.1    Lassman, A.B.2    Wen, P.Y.3
  • 111
    • 69949120572 scopus 로고    scopus 로고
    • EGFRvIII-targeted vaccination therapy of malignant glioma
    • Choi BD, Archer GE, Mitchell DA, et al. EGFRvIII-targeted vaccination therapy of malignant glioma. Brain Pathol 2009;19(4):713-23
    • (2009) Brain Pathol , vol.19 , Issue.4 , pp. 713-723
    • Choi, B.D.1    Archer, G.E.2    Mitchell, D.A.3
  • 112
    • 77957336097 scopus 로고    scopus 로고
    • Proteomic analysis of PAXgene-fixed tissues
    • Ergin B, Meding S, Langer R, et al. Proteomic analysis of PAXgene-fixed tissues. J Proteome Res 2010;9(10):5188-96
    • (2010) J Proteome Res , vol.9 , Issue.10 , pp. 5188-5196
    • Ergin, B.1    Meding, S.2    Langer, R.3
  • 113
    • 81155150455 scopus 로고    scopus 로고
    • Histological assessment of PAXgene tissue fixation and stabilization reagents
    • Kap M, Smedts F, Oosterhuis W, et al. Histological assessment of PAXgene tissue fixation and stabilization reagents. PLoS One 2011;6(11):e27704
    • (2011) PLoS One , vol.6 , Issue.11
    • Kap, M.1    Smedts, F.2    Oosterhuis, W.3
  • 114
    • 55049089416 scopus 로고    scopus 로고
    • A portrait of tissue phosphoprotein stability in the clinical tissue procurement process
    • Espina V, Edmiston KH, Heiby M, et al. A portrait of tissue phosphoprotein stability in the clinical tissue procurement process. Mol Cell Proteomics 2008;7(10):1998-2018
    • (2008) Mol Cell Proteomics , vol.7 , Issue.10 , pp. 1998-2018
    • Espina, V.1    Edmiston, K.H.2    Heiby, M.3
  • 115
    • 84856250078 scopus 로고    scopus 로고
    • Identification of microRNAs in the cerebrospinal fluid as biomarker for the diagnosis of glioma
    • Baraniskin A, Kuhnhenn J, Schlegel U, et al. Identification of microRNAs in the cerebrospinal fluid as biomarker for the diagnosis of glioma. Neuro Oncol 2012;14(1):29-33
    • (2012) Neuro Oncol , vol.14 , Issue.1 , pp. 29-33
    • Baraniskin, A.1    Kuhnhenn, J.2    Schlegel, U.3
  • 116
    • 80052746574 scopus 로고    scopus 로고
    • Proteomics of gliomas: Initial biomarker discovery and evolution of technology
    • Kalinina J, Peng J, Ritchie JC, Van Meir EG. Proteomics of gliomas: initial biomarker discovery and evolution of technology. Neuro Oncol 2011;13(9):926-42
    • (2011) Neuro Oncol , vol.13 , Issue.9 , pp. 926-942
    • Kalinina, J.1    Peng, J.2    Ritchie, J.C.3    Van Meir, E.G.4
  • 117
    • 84876926672 scopus 로고    scopus 로고
    • GC/MS-based metabolomic analysis of cerebrospinal fluid (CSF) from glioma patients
    • Nakamizo S, Sasayama T, Shinohara M, et al. GC/MS-based metabolomic analysis of cerebrospinal fluid (CSF) from glioma patients. J Neurooncol 2013;113(1):65-74
    • (2013) J Neurooncol , vol.113 , Issue.1 , pp. 65-74
    • Nakamizo, S.1    Sasayama, T.2    Shinohara, M.3
  • 118
    • 84862192105 scopus 로고    scopus 로고
    • MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity
    • Teplyuk NM, Mollenhauer B, Gabriely G, et al. MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity. Neuro Oncol 2012;14(6):689-700
    • (2012) Neuro Oncol , vol.14 , Issue.6 , pp. 689-700
    • Teplyuk, N.M.1    Mollenhauer, B.2    Gabriely, G.3
  • 119
    • 10244261646 scopus 로고    scopus 로고
    • Tumor marker utility grading system: A framework to evaluate clinical utility of tumor markers
    • Hayes DF, Bast RC, Desch CE, et al. Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers. J Natl Cancer Inst 1996;88(20):1456-66
    • (1996) J Natl Cancer Inst , vol.88 , Issue.20 , pp. 1456-1466
    • Hayes, D.F.1    Bast, R.C.2    Desch, C.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.