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Volumn 21, Issue 5, 2015, Pages 1436-1443

Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities

Author keywords

Cancer; Development; DNA repair; Homeobox; Homeostasis; Intestine; RNA splicing; Signaling; Transcription

Indexed keywords

HOMEODOMAIN PROTEIN; MESSENGER RNA PRECURSOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX2; CDX2 PROTEIN, HUMAN;

EID: 84922575678     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v21.i5.1436     Document Type: Article
Times cited : (21)

References (68)
  • 1
    • 28844477866 scopus 로고    scopus 로고
    • The genesis and evolution of homeobox gene clusters
    • PMID: 16341069
    • Garcia-Fernàndez J. The genesis and evolution of homeobox gene clusters. Nat Rev Genet 2005; 6: 881-892 [PMID: 16341069 DOI: 10.1038/nrg1723]
    • (2005) Nat Rev Genet , vol.6 , pp. 881-892
    • Garcia-Fernàndez, J.1
  • 2
    • 0028879331 scopus 로고
    • Expression of Cdx-2 in the mouse embryo and placenta: Possible role in patterning of the extra-embryonic membranes
    • PMID: 8573715
    • Beck F, Erler T, Russell A, James R. Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes. Dev Dyn 1995; 204: 219-227 [PMID: 8573715 DOI: 10.1002/aja.1002040302]
    • (1995) Dev Dyn , vol.204 , pp. 219-227
    • Beck, F.1    Erler, T.2    Russell, A.3    James, R.4
  • 3
    • 0033769822 scopus 로고    scopus 로고
    • Cdx1 and cdx2 expression during intestinal development
    • PMID: 11040183
    • Silberg DG, Swain GP, Suh ER, Traber PG. Cdx1 and cdx2 expression during intestinal development. Gastroenterology 2000; 119: 961-971 [PMID: 11040183 DOI: 10.1053/gast.2000.18142]
    • (2000) Gastroenterology , vol.119 , pp. 961-971
    • Silberg, D.G.1    Swain, G.P.2    Suh, E.R.3    Traber, P.G.4
  • 5
    • 0030937750 scopus 로고    scopus 로고
    • Homeosis and intestinal tumours in Cdx2 mutant mice
    • PMID: 9052785
    • Chawengsaksophak K, James R, Hammond VE, Köntgen F, Beck F. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 1997; 386: 84-87 [PMID: 9052785 DOI: 10.1038/386084a0]
    • (1997) Nature , vol.386 , pp. 84-87
    • Chawengsaksophak, K.1    James, R.2    Hammond, V.E.3    Köntgen, F.4    Beck, F.5
  • 6
    • 28344436489 scopus 로고    scopus 로고
    • Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation
    • PMID: 16325584
    • Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R, Rossant J. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 2005; 123: 917-929 [PMID: 16325584 DOI: 10.1016/j.cell.2005.08.040]
    • (2005) Cell , vol.123 , pp. 917-929
    • Niwa, H.1    Toyooka, Y.2    Shimosato, D.3    Strumpf, D.4    Takahashi, K.5    Yagi, R.6    Rossant, J.7
  • 7
    • 38049045708 scopus 로고    scopus 로고
    • Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo
    • PMID: 18067887
    • Ralston A, Rossant J. Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo. Dev Biol 2008; 313: 614-629 [PMID: 18067887 DOI: 10.1016/j.ydbio.2007.10.054]
    • (2008) Dev Biol , vol.313 , pp. 614-629
    • Ralston, A.1    Rossant, J.2
  • 10
    • 64549114508 scopus 로고    scopus 로고
    • Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
    • PMID: 19386267
    • Gao N, White P, Kaestner KH. Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev Cell 2009; 16: 588-599 [PMID: 19386267 DOI: 10.1016/j.devcel.2009.02.010]
    • (2009) Dev Cell , vol.16 , pp. 588-599
    • Gao, N.1    White, P.2    Kaestner, K.H.3
  • 11
    • 77649188305 scopus 로고    scopus 로고
    • Cdx2 regulates patterning of the intestinal epithelium
    • PMID: 20043902
    • Grainger S, Savory JG, Lohnes D. Cdx2 regulates patterning of the intestinal epithelium. Dev Biol 2010; 339: 155-165 [PMID: 20043902 DOI: 10.1016/j.ydbio.2009.12.025]
    • (2010) Dev Biol , vol.339 , pp. 155-165
    • Grainger, S.1    Savory, J.G.2    Lohnes, D.3
  • 13
    • 79956111870 scopus 로고    scopus 로고
    • Essential and redundant functions of caudal family proteins in activating adult intestinal genes
    • PMID: 21402776
    • Verzi MP, Shin H, Ho LL, Liu XS, Shivdasani RA. Essential and redundant functions of caudal family proteins in activating adult intestinal genes. Mol Cell Biol 2011; 31: 2026-2039 [PMID: 21402776 DOI: 10.1128/MCB.01250-10]
    • (2011) Mol Cell Biol , vol.31 , pp. 2026-2039
    • Verzi, M.P.1    Shin, H.2    Ho, L.L.3    Liu, X.S.4    Shivdasani, R.A.5
  • 15
    • 79251574656 scopus 로고    scopus 로고
    • Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development
    • e8, PMID: 21081128
    • Crissey MA, Guo RJ, Funakoshi S, Kong J, Liu J, Lynch JP. Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development. Gastroenterology 2011; 140: 517-528.e8 [PMID: 21081128 DOI: 10.1053/j.gastro.2010.11.033]
    • (2011) Gastroenterology , vol.140 , pp. 517-528
    • Crissey, M.A.1    Guo, R.J.2    Funakoshi, S.3    Kong, J.4    Liu, J.5    Lynch, J.P.6
  • 16
    • 4944240215 scopus 로고    scopus 로고
    • Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: An active role for the tumor environment in malignant tumor progression
    • PMID: 15466189
    • Brabletz T, Spaderna S, Kolb J, Hlubek F, Faller G, Bruns CJ, Jung A, Nentwich J, Duluc I, Domon-Dell C, Kirchner T, Freund JN. Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression. Cancer Res 2004; 64 : 6973-6977 [PMID: 15466189 DOI: 10.1158/0008-5472.CAN-04-1132]
    • (2004) Cancer Res , vol.64 , pp. 6973-6977
    • Brabletz, T.1    Spaderna, S.2    Kolb, J.3    Hlubek, F.4    Faller, G.5    Bruns, C.J.6    Jung, A.7    Nentwich, J.8    Duluc, I.9    Domon-Dell, C.10    Kirchner, T.11    Freund, J.N.12
  • 19
    • 0141869045 scopus 로고    scopus 로고
    • The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development
    • PMID: 12970140
    • Bonhomme C, Duluc I, Martin E, Chawengsaksophak K, Chenard MP, Kedinger M, Beck F, Freund JN, Domon-Dell C. The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Gut 2003; 52 : 1465-1471 [PMID: 12970140 DOI: 10.1136/gut.52.10.1465]
    • (2003) Gut , vol.52 , pp. 1465-1471
    • Bonhomme, C.1    Duluc, I.2    Martin, E.3    Chawengsaksophak, K.4    Chenard, M.P.5    Kedinger, M.6    Beck, F.7    Freund, J.N.8    Domon-Dell, C.9
  • 20
    • 0344826531 scopus 로고    scopus 로고
    • Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice
    • PMID: 14625550
    • Aoki K, Tamai Y, Horiike S, Oshima M, Taketo MM. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat Genet 2003; 35: 323-330 [PMID: 14625550 DOI: 10.1038/ng1265]
    • (2003) Nat Genet , vol.35 , pp. 323-330
    • Aoki, K.1    Tamai, Y.2    Horiike, S.3    Oshima, M.4    Taketo, M.M.5
  • 21
    • 37849029160 scopus 로고    scopus 로고
    • The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells
    • PMID: 17599044
    • Gross I, Duluc I, Benameur T, Calon A, Martin E, Brabletz T, Kedinger M, Domon-Dell C, Freund JN. The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. Oncogene 2008; 27: 107-115 [PMID: 17599044 DOI: 10.1038/sj.onc.1210601]
    • (2008) Oncogene , vol.27 , pp. 107-115
    • Gross, I.1    Duluc, I.2    Benameur, T.3    Calon, A.4    Martin, E.5    Brabletz, T.6    Kedinger, M.7    Domon-Dell, C.8    Freund, J.N.9
  • 22
    • 0141742109 scopus 로고    scopus 로고
    • Cdx2 protein expression in normal and malignant human tissues: An immunohistochemical survey using tissue microarrays
    • PMID: 13679455
    • Moskaluk CA, Zhang H, Powell SM, Cerilli LA, Hampton GM, Frierson HF. Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays. Mod Pathol 2003; 16: 913-919 [PMID: 13679455 DOI: 10.1097/01.MP.0000086073.92773.55]
    • (2003) Mod Pathol , vol.16 , pp. 913-919
    • Moskaluk, C.A.1    Zhang, H.2    Powell, S.M.3    Cerilli, L.A.4    Hampton, G.M.5    Frierson, H.F.6
  • 26
    • 0036783226 scopus 로고    scopus 로고
    • CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: Prognostic implications
    • PMID: 12239615
    • Seno H, Oshima M, Taniguchi MA, Usami K, Ishikawa TO, Chiba T, Taketo MM. CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: Prognostic implications. Int J Oncol 2002; 21: 769-774 [PMID: 12239615 DOI: 10.3892/ijo.21.4.769]
    • (2002) Int J Oncol , vol.21 , pp. 769-774
    • Seno, H.1    Oshima, M.2    Taniguchi, M.A.3    Usami, K.4    Ishikawa, T.O.5    Chiba, T.6    Taketo, M.M.7
  • 27
    • 45549103908 scopus 로고    scopus 로고
    • Expression of Cdx2 and claudin-2 in the multistage tissue of gastric carcinogenesis
    • PMID: 18500171
    • Xin S, Huixin C, Benchang S, Aiping B, Jinhui W, Xiaoyan L, Yu WB, Minhu C. Expression of Cdx2 and claudin-2 in the multistage tissue of gastric carcinogenesis. Oncology 2007; 73 : 357-365 [PMID: 18500171 DOI: 10.1159/000135351]
    • (2007) Oncology , vol.73 , pp. 357-365
    • Xin, S.1    Huixin, C.2    Benchang, S.3    Aiping, B.4    Jinhui, W.5    Xiaoyan, L.6    Yu, W.B.7    Minhu, C.8
  • 28
    • 64849091405 scopus 로고    scopus 로고
    • Expression of osteopontin and CDX2: Indications of phenotypes and prognosis in advanced gastric cancer
    • PMID: 19212618
    • Zhang X, Tsukamoto T, Mizoshita T, Ban H, Suzuki H, Toyoda T, Tatematsu M. Expression of osteopontin and CDX2: indications of phenotypes and prognosis in advanced gastric cancer. Oncol Rep 2009; 21: 609-613 [PMID: 19212618]
    • (2009) Oncol Rep , vol.21 , pp. 609-613
    • Zhang, X.1    Tsukamoto, T.2    Mizoshita, T.3    Ban, H.4    Suzuki, H.5    Toyoda, T.6    Tatematsu, M.7
  • 31
    • 84856850645 scopus 로고    scopus 로고
    • The homeodomain resource: A comprehensive collection of sequence, structure, interaction, genomic and functional information on the homeodomain protein family
    • PMID: 20157477
    • Moreland RT, Ryan JF, Pan C, Baxevanis AD. The Homeodomain Resource: a comprehensive collection of sequence, structure, interaction, genomic and functional information on the homeodomain protein family. Database (Oxford) 2009; 2009 : bap004 [PMID: 20157477 DOI: 10.1093/database/bap004]
    • (2009) Database (Oxford) , vol.2009
    • Moreland, R.T.1    Ryan, J.F.2    Pan, C.3    Baxevanis, A.D.4
  • 32
    • 0025906410 scopus 로고
    • Homeobox gene expression in the intestinal epithelium of adult mice
    • PMID: 1671571
    • James R, Kazenwadel J. Homeobox gene expression in the intestinal epithelium of adult mice. J Biol Chem 1991; 266 : 3246-3251 [PMID: 1671571]
    • (1991) J Biol Chem , vol.266 , pp. 3246-3251
    • James, R.1    Kazenwadel, J.2
  • 33
    • 0026471057 scopus 로고
    • Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: Building a functional insulin minienhancer complex
    • PMID: 1358758
    • German MS, Wang J, Chadwick RB, Rutter WJ. Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. Genes Dev 1992; 6 : 2165-2176 [PMID: 1358758 DOI: 10.1101/gad.6.11.2165]
    • (1992) Genes Dev , vol.6 , pp. 2165-2176
    • German, M.S.1    Wang, J.2    Chadwick, R.B.3    Rutter, W.J.4
  • 34
    • 0028080881 scopus 로고
    • A homeodomain protein related to caudal regulates intestine-specific gene transcription
    • PMID: 7935448
    • Suh E, Chen L, Taylor J, Traber PG. A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol 1994; 14: 7340-7351 [PMID: 7935448 DOI: 10.1128/MCB.14.11.7340]
    • (1994) Mol Cell Biol , vol.14 , pp. 7340-7351
    • Suh, E.1    Chen, L.2    Taylor, J.3    Traber, P.G.4
  • 35
    • 0026742321 scopus 로고
    • Novel DNA-binding proteins regulate intestine-specific transcription of the sucrase-isomaltase gene
    • PMID: 1378530
    • Traber PG, Wu GD, Wang W. Novel DNA-binding proteins regulate intestine-specific transcription of the sucrase-isomaltase gene. Mol Cell Biol 1992; 12: 3614-3627 [PMID: 1378530 DOI: 10.1128/MCB.12.8.3614]
    • (1992) Mol Cell Biol , vol.12 , pp. 3614-3627
    • Traber, P.G.1    Wu, G.D.2    Wang, W.3
  • 36
    • 0027364769 scopus 로고
    • Isolation and characterization of target sequences of the chicken CdxA homeobox gene
    • PMID: 7909943
    • Margalit Y, Yarus S, Shapira E, Gruenbaum Y, Fainsod A. Isolation and characterization of target sequences of the chicken CdxA homeobox gene. Nucleic Acids Res 1993; 21: 4915-4922 [PMID: 7909943]
    • (1993) Nucleic Acids Res , vol.21 , pp. 4915-4922
    • Margalit, Y.1    Yarus, S.2    Shapira, E.3    Gruenbaum, Y.4    Fainsod, A.5
  • 37
    • 78149485097 scopus 로고    scopus 로고
    • Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2
    • PMID: 21074721
    • Verzi MP, Shin H, He HH, Sulahian R, Meyer CA, Montgomery RK, Fleet JC, Brown M, Liu XS, Shivdasani RA. Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2. Dev Cell 2010; 19 : 713-726 [PMID: 21074721 DOI: 10.1016/j.devcel.2010.10.006]
    • (2010) Dev Cell , vol.19 , pp. 713-726
    • Verzi, M.P.1    Shin, H.2    He, H.H.3    Sulahian, R.4    Meyer, C.A.5    Montgomery, R.K.6    Fleet, J.C.7    Brown, M.8    Liu, X.S.9    Shivdasani, R.A.10
  • 38
    • 0030785632 scopus 로고    scopus 로고
    • Activation of enhancer elements by the homeobox gene Cdx2 is cell line specific
    • PMID: 9171078
    • Taylor JK, Levy T, Suh ER, Traber PG. Activation of enhancer elements by the homeobox gene Cdx2 is cell line specific. Nucleic Acids Res 1997; 25: 2293-2300 [PMID: 9171078]
    • (1997) Nucleic Acids Res , vol.25 , pp. 2293-2300
    • Taylor, J.K.1    Levy, T.2    Suh, E.R.3    Traber, P.G.4
  • 39
    • 0033605281 scopus 로고    scopus 로고
    • Identification of domains mediating transcriptional activation and cytoplasmic export in the caudal homeobox protein Cdx-3
    • PMID: 10026228
    • Trinh KY, Jin T, Drucker DJ. Identification of domains mediating transcriptional activation and cytoplasmic export in the caudal homeobox protein Cdx-3. J Biol Chem 1999; 274 : 6011-6019 [PMID: 10026228 DOI: 10.1074/jbc.274.9.6011]
    • (1999) J Biol Chem , vol.274 , pp. 6011-6019
    • Trinh, K.Y.1    Jin, T.2    Drucker, D.J.3
  • 40
    • 0035214124 scopus 로고    scopus 로고
    • Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity
    • PMID: 11729123
    • Rings EH, Boudreau F, Taylor JK, Moffett J, Suh ER, Traber PG. Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity. Gastroenterology 2001; 121 : 1437-1450 [PMID: 11729123 DOI: 10.1053/gast.2001.29618]
    • (2001) Gastroenterology , vol.121 , pp. 1437-1450
    • Rings, E.H.1    Boudreau, F.2    Taylor, J.K.3    Moffett, J.4    Suh, E.R.5    Traber, P.G.6
  • 41
    • 0035877760 scopus 로고    scopus 로고
    • Intestinal epithelial cell differentiation involves activation of p38 mitogen-activated protein kinase that regulates the homeobox transcription factor CDX2
    • PMID: 11283019
    • Houde M, Laprise P, Jean D, Blais M, Asselin C, Rivard N. Intestinal epithelial cell differentiation involves activation of p38 mitogen-activated protein kinase that regulates the homeobox transcription factor CDX2. J Biol Chem 2001; 276: 21885-21894 [PMID: 11283019 DOI: 10.1074/jbc.M100236200]
    • (2001) J Biol Chem , vol.276 , pp. 21885-21894
    • Houde, M.1    Laprise, P.2    Jean, D.3    Blais, M.4    Asselin, C.5    Rivard, N.6
  • 42
    • 28544433626 scopus 로고    scopus 로고
    • Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation
    • PMID: 16027724
    • Gross I, Lhermitte B, Domon-Dell C, Duluc I, Martin E, Gaiddon C, Kedinger M, Freund JN. Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. Oncogene 2005; 24 : 7955-7963 [PMID: 16027724 DOI: 10.1038/sj.onc.1208945]
    • (2005) Oncogene , vol.24 , pp. 7955-7963
    • Gross, I.1    Lhermitte, B.2    Domon-Dell, C.3    Duluc, I.4    Martin, E.5    Gaiddon, C.6    Kedinger, M.7    Freund, J.N.8
  • 43
    • 0030973758 scopus 로고    scopus 로고
    • Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2
    • PMID: 9148757
    • Troelsen JT, Mitchelmore C, Spodsberg N, Jensen AM, Norén O, Sjöström H. Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2. Biochem J 1997; 322 (Pt 3): 833-838 [PMID: 9148757]
    • (1997) Biochem J , vol.322 , pp. 833-838
    • Troelsen, J.T.1    Mitchelmore, C.2    Spodsberg, N.3    Jensen, A.M.4    Norén, O.5    Sjöström, H.6
  • 44
    • 17144407567 scopus 로고    scopus 로고
    • CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium
    • PMID: 15825077
    • Hinoi T, Gesina G, Akyol A, Kuick R, Hanash S, Giordano TJ, Gruber SB, Fearon ER. CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium. Gastroenterology 2005; 128 : 946-961 [PMID: 15825077 DOI: 10.1053/j.gastro.2005.01.003]
    • (2005) Gastroenterology , vol.128 , pp. 946-961
    • Hinoi, T.1    Gesina, G.2    Akyol, A.3    Kuick, R.4    Hanash, S.5    Giordano, T.J.6    Gruber, S.B.7    Fearon, E.R.8
  • 45
    • 83755186759 scopus 로고    scopus 로고
    • Regulation of the gene encoding the intestinal bile acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2
    • PMID: 22016432
    • Ma L, Jüttner M, Kullak-Ublick GA, Eloranta JJ. Regulation of the gene encoding the intestinal bile acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2. Am J Physiol Gastrointest Liver Physiol 2012; 302: G123-G133 [PMID: 22016432 DOI: 10.1152/ajpgi.00102.2011]
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302 , pp. G123-G133
    • Ma, L.1    Jüttner, M.2    Kullak-Ublick, G.A.3    Eloranta, J.J.4
  • 47
    • 34547940716 scopus 로고    scopus 로고
    • The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells
    • PMID: 17553805
    • Jonckheere N, Vincent A, Perrais M, Ducourouble MP, Male AK, Aubert JP, Pigny P, Carraway KL, Freund JN, Renes IB, Van Seuningen I. The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. J Biol Chem 2007; 282 : 22638-22650 [PMID: 17553805 DOI: 10.1074/jbc.M700905200]
    • (2007) J Biol Chem , vol.282 , pp. 22638-22650
    • Jonckheere, N.1    Vincent, A.2    Perrais, M.3    Ducourouble, M.P.4    Male, A.K.5    Aubert, J.P.6    Pigny, P.7    Carraway, K.L.8    Freund, J.N.9    Renes, I.B.10    Van Seuningen, I.11
  • 48
    • 0036829210 scopus 로고    scopus 로고
    • CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia
    • PMID: 12404231
    • Hinoi T, Lucas PC, Kuick R, Hanash S, Cho KR, Fearon ER. CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. Gastroenterology 2002; 123: 1565-1577 [PMID: 12404231 DOI: 10.1053/gast.2002.36598]
    • (2002) Gastroenterology , vol.123 , pp. 1565-1577
    • Hinoi, T.1    Lucas, P.C.2    Kuick, R.3    Hanash, S.4    Cho, K.R.5    Fearon, E.R.6
  • 49
    • 0037077248 scopus 로고    scopus 로고
    • Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha
    • PMID: 11934881
    • Sakaguchi T, Gu X, Golden HM, Suh E, Rhoads DB, Reinecker HC. Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha. J Biol Chem 2002; 277 : 21361-21370 [PMID: 11934881 DOI: 10.1074/jbc.M110261200]
    • (2002) J Biol Chem , vol.277 , pp. 21361-21370
    • Sakaguchi, T.1    Gu, X.2    Golden, H.M.3    Suh, E.4    Rhoads, D.B.5    Reinecker, H.C.6
  • 50
    • 84859439016 scopus 로고    scopus 로고
    • Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells
    • e3, PMID: 22202456
    • Hinkel I, Duluc I, Martin E, Guenot D, Freund JN, Gross I. Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells. Gastroenterology 2012; 142: 875-885.e3 [PMID: 22202456 DOI: 10.1053/j.gastro.2011.12.037]
    • (2012) Gastroenterology , vol.142 , pp. 875-885
    • Hinkel, I.1    Duluc, I.2    Martin, E.3    Guenot, D.4    Freund, J.N.5    Gross, I.6
  • 51
    • 1542620935 scopus 로고    scopus 로고
    • Identifying target genes regulated downstream of Cdx2 by microarray analysis
    • PMID: 15019784
    • Uesaka T, Kageyama N, Watanabe H. Identifying target genes regulated downstream of Cdx2 by microarray analysis. J Mol Biol 2004; 337 : 647-660 [PMID: 15019784 DOI: 10.1016/j.jmb.2004.01.061]
    • (2004) J Mol Biol , vol.337 , pp. 647-660
    • Uesaka, T.1    Kageyama, N.2    Watanabe, H.3
  • 54
    • 0029655778 scopus 로고    scopus 로고
    • Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3
    • PMID: 8524295
    • Jin T, Drucker DJ. Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3. Mol Cell Biol 1996; 16 : 19-28 [PMID: 8524295]
    • (1996) Mol Cell Biol , vol.16 , pp. 19-28
    • Jin, T.1    Drucker, D.J.2
  • 56
    • 0031440118 scopus 로고    scopus 로고
    • Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation
    • PMID: 9396760
    • Lorentz O, Duluc I, Arcangelis AD, Simon-Assmann P, Kedinger M, Freund JN. Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation. J Cell Biol 1997; 139: 1553-1565 [PMID: 9396760 DOI: 10.1083/jcb.139.6.1553]
    • (1997) J Cell Biol , vol.139 , pp. 1553-1565
    • Lorentz, O.1    Duluc, I.2    Arcangelis, A.D.3    Simon-Assmann, P.4    Kedinger, M.5    Freund, J.N.6
  • 57
    • 0032577692 scopus 로고    scopus 로고
    • Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells
    • PMID: 9593754
    • Mallo GV, Soubeyran P, Lissitzky JC, André F, Farnarier C, Marvaldi J, Dagorn JC, Iovanna JL. Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. J Biol Chem 1998; 273: 14030-14036 [PMID: 9593754 DOI: 10.1074/jbc.273.22.14030]
    • (1998) J Biol Chem , vol.273 , pp. 14030-14036
    • Mallo, G.V.1    Soubeyran, P.2    Lissitzky, J.C.3    André, F.4    Farnarier, C.5    Marvaldi, J.6    Dagorn, J.C.7    Iovanna, J.L.8
  • 58
    • 0344687341 scopus 로고    scopus 로고
    • CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene
    • PMID: 12970742
    • Bai YQ, Miyake S, Iwai T, Yuasa Y. CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. Oncogene 2003; 22: 7942-7949 [PMID: 12970742 DOI: 10.1038/sj.onc.1206634]
    • (2003) Oncogene , vol.22 , pp. 7942-7949
    • Bai, Y.Q.1    Miyake, S.2    Iwai, T.3    Yuasa, Y.4
  • 59
    • 78751520560 scopus 로고    scopus 로고
    • Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1
    • PMID: 21224344
    • Aoki K, Kakizaki F, Sakashita H, Manabe T, Aoki M, Taketo MM. Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1. Cancer Res 2011; 71: 593-602 [PMID: 21224344 DOI: 10.1158/0008-5472.CAN-10-2842]
    • (2011) Cancer Res , vol.71 , pp. 593-602
    • Aoki, K.1    Kakizaki, F.2    Sakashita, H.3    Manabe, T.4    Aoki, M.5    Taketo, M.M.6
  • 60
    • 77649224168 scopus 로고    scopus 로고
    • The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex
    • PMID: 19734199
    • Guo RJ, Funakoshi S, Lee HH, Kong J, Lynch JP. The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex. Carcinogenesis 2010; 31 : 159-166 [PMID: 19734199 DOI: 10.1093/carcin/bgp213]
    • (2010) Carcinogenesis , vol.31 , pp. 159-166
    • Guo, R.J.1    Funakoshi, S.2    Lee, H.H.3    Kong, J.4    Lynch, J.P.5
  • 62
    • 34648831940 scopus 로고    scopus 로고
    • Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB
    • PMID: 17876541
    • Mutoh H, Hayakawa H, Sakamoto H, Sugano K. Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB. J Gastroenterol 2007; 42: 719-729 [PMID: 17876541 DOI: 10.1007/s00535-007-2088-y]
    • (2007) J Gastroenterol , vol.42 , pp. 719-729
    • Mutoh, H.1    Hayakawa, H.2    Sakamoto, H.3    Sugano, K.4
  • 65
    • 72549085096 scopus 로고    scopus 로고
    • Transcription-independent p53 apoptosis: An alternative route to death
    • PMID: 19879762
    • Speidel D. Transcription-independent p53 apoptosis: an alternative route to death. Trends Cell Biol 2010; 20: 14-24 [PMID: 19879762 DOI: 10.1016/j.tcb.2009.10.002]
    • (2010) Trends Cell Biol , vol.20 , pp. 14-24
    • Speidel, D.1
  • 66
    • 52449101436 scopus 로고    scopus 로고
    • Transcription-independent functions of MYC: Regulation of translation and DNA replication
    • PMID: 18698328
    • Cole MD, Cowling VH. Transcription-independent functions of MYC: regulation of translation and DNA replication. Nat Rev Mol Cell Biol 2008; 9: 810-815 [PMID: 18698328 DOI: 10.1038/nrm2467]
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 810-815
    • Cole, M.D.1    Cowling, V.H.2
  • 67
    • 84855394410 scopus 로고    scopus 로고
    • Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage
    • PMID: 22180494
    • Biswas AK, Johnson DG. Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage. Cancer Res 2012; 72 : 13-17 [PMID: 22180494 DOI: 10.1158/0008-5472.CAN-11-2196]
    • (2012) Cancer Res , vol.72 , pp. 13-17
    • Biswas, A.K.1    Johnson, D.G.2
  • 68
    • 0022383992 scopus 로고
    • Characteristics of the binding of aminoglycoside antibiotics to teichoic acids. A potential model system for interaction of aminoglycosides with polyanions
    • PMID: 2411558
    • Kusser W, Zimmer K, Fiedler F. Characteristics of the binding of aminoglycoside antibiotics to teichoic acids. A potential model system for interaction of aminoglycosides with polyanions. Eur J Biochem 1985; 151 : 601-605 [PMID: 2411558 DOI: 10.1002/dvdy.24060]
    • (1985) Eur J Biochem , vol.151 , pp. 601-605
    • Kusser, W.1    Zimmer, K.2    Fiedler, F.3


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