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Volumn 289, Issue 41, 2014, Pages 28421-28432

Transcriptional regulation of the intestinal nuclear bile acid Farnesoid X Receptor (FXR) by the caudal-related homeobox 2 (CDX2)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; DETOXIFICATION; DISEASES; TRANSCRIPTION; TRANSCRIPTION FACTORS;

EID: 84907637331     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.571513     Document Type: Article
Times cited : (12)

References (50)
  • 1
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling in development and disease
    • Clevers, H. (2006) Wnt/β-catenin signaling in development and disease. Cell 127, 469-480
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 2
    • 0344687341 scopus 로고    scopus 로고
    • CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene
    • Bai, Y. Q., Miyake, S., Iwai, T., and Yuasa, Y. (2003) CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. Oncogene 22, 7942-7949
    • (2003) Oncogene , vol.22 , pp. 7942-7949
    • Bai, Y.Q.1    Miyake, S.2    Iwai, T.3    Yuasa, Y.4
  • 3
    • 0035833319 scopus 로고    scopus 로고
    • Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2
    • Dang, D. T., Mahatan, C. S., Dang, L. H., Agboola, I. A., and Yang, V. W. (2001) Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. Oncogene 20, 4884-4890
    • (2001) Oncogene , vol.20 , pp. 4884-4890
    • Dang, D.T.1    Mahatan, C.S.2    Dang, L.H.3    Agboola, I.A.4    Yang, V.W.5
  • 7
    • 64549114508 scopus 로고    scopus 로고
    • Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
    • Gao, N., White, P., and Kaestner, K. H. (2009) Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev. Cell 16, 588-599
    • (2009) Dev. Cell , vol.16 , pp. 588-599
    • Gao, N.1    White, P.2    Kaestner, K.H.3
  • 9
    • 78149485097 scopus 로고    scopus 로고
    • Dif-ferentiation- specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2
    • Verzi, M. P., Shin, H., He, H. H., Sulahian, R., Meyer, C. A., Montgomery, R. K., Fleet, J. C., Brown, M., Liu, X. S., and Shivdasani, R. A. (2010) Dif-ferentiation- specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2. Dev. Cell 19, 713-726
    • (2010) Dev. Cell , vol.19 , pp. 713-726
    • Verzi, M.P.1    Shin, H.2    He, H.H.3    Sulahian, R.4    Meyer, C.A.5    Montgomery, R.K.6    Fleet, J.C.7    Brown, M.8    Liu, X.S.9    Shivdasani, R.A.10
  • 10
    • 0035877760 scopus 로고    scopus 로고
    • Intestinal epithelial cell differentiation involves activation of p38 mitogenactivated protein kinase that regulates the homeobox transcription factor CDX2
    • Houde, M., Laprise, P., Jean, D., Blais, M., Asselin, C., and Rivard, N. (2001) Intestinal epithelial cell differentiation involves activation of p38 mitogenactivated protein kinase that regulates the homeobox transcription factor CDX2. J. Biol. Chem. 276, 21885-21894
    • (2001) J. Biol. Chem. , vol.276 , pp. 21885-21894
    • Houde, M.1    Laprise, P.2    Jean, D.3    Blais, M.4    Asselin, C.5    Rivard, N.6
  • 11
    • 0035214124 scopus 로고    scopus 로고
    • Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity
    • Rings, E. H., Boudreau, F., Taylor, J. K., Moffett, J., Suh, E. R., and Traber, P. G. (2001) Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity. Gastroenterology 121, 1437-1450
    • (2001) Gastroenterology , vol.121 , pp. 1437-1450
    • Rings, E.H.1    Boudreau, F.2    Taylor, J.K.3    Moffett, J.4    Suh, E.R.5    Traber, P.G.6
  • 12
    • 37849029160 scopus 로고    scopus 로고
    • The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells
    • Gross, I., Duluc, I., Benameur, T., Calon, A., Martin, E., Brabletz, T., Kedinger, M., Domon-Dell, C., and Freund, J. N. (2008) The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. Oncogene 27, 107-115
    • (2008) Oncogene , vol.27 , pp. 107-115
    • Gross, I.1    Duluc, I.2    Benameur, T.3    Calon, A.4    Martin, E.5    Brabletz, T.6    Kedinger, M.7    Domon-Dell, C.8    Freund, J.N.9
  • 13
  • 14
    • 0029156944 scopus 로고
    • Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma
    • Ee, H. C., Erler, T., Bhathal, P. S., Young, G. P., and James, R. J. (1995) Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma. Am. J. Pathol. 147, 586-592
    • (1995) Am. J. Pathol. , vol.147 , pp. 586-592
    • Ee, H.C.1    Erler, T.2    Bhathal, P.S.3    Young, G.P.4    James, R.J.5
  • 19
    • 0141869045 scopus 로고    scopus 로고
    • The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development
    • Bonhomme, C., Duluc, I., Martin, E., Chawengsaksophak, K., Chenard, M. P., Kedinger, M., Beck, F., Freund, J. N., and Domon-Dell, C. (2003) The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Gut 52, 1465-1471
    • (2003) Gut , vol.52 , pp. 1465-1471
    • Bonhomme, C.1    Duluc, I.2    Martin, E.3    Chawengsaksophak, K.4    Chenard, M.P.5    Kedinger, M.6    Beck, F.7    Freund, J.N.8    Domon-Dell, C.9
  • 24
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang, H., Chen, J., Hollister, K., Sowers, L. C., and Forman, B. M. (1999) Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol. Cell 3, 543-553
    • (1999) Mol. Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 26
    • 0037414757 scopus 로고    scopus 로고
    • Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation
    • Zhang, Y., Kast-Woelbern, H. R., and Edwards, P. A. (2003) Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. J. Biol. Chem. 278, 104-110
    • (2003) J. Biol. Chem. , vol.278 , pp. 104-110
    • Zhang, Y.1    Kast-Woelbern, H.R.2    Edwards, P.A.3
  • 27
    • 30844445030 scopus 로고    scopus 로고
    • FXR regulates organic solute transporters α and β in the adrenal gland, kidney, and intestine
    • Lee, H., Zhang, Y., Lee, F. Y., Nelson, S. F., Gonzalez, F. J., and Edwards, P. A. (2006) FXR regulates organic solute transporters α and β in the adrenal gland, kidney, and intestine. J. Lipid Res. 47, 201-214
    • (2006) J. Lipid Res. , vol.47 , pp. 201-214
    • Lee, H.1    Zhang, Y.2    Lee, F.Y.3    Nelson, S.F.4    Gonzalez, F.J.5    Edwards, P.A.6
  • 28
    • 34447098081 scopus 로고    scopus 로고
    • Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
    • Kim, I., Morimura, K., Shah, Y., Yang, Q., Ward, J. M., and Gonzalez, F. J. (2007) Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis 28, 940-946
    • (2007) Carcinogenesis , vol.28 , pp. 940-946
    • Kim, I.1    Morimura, K.2    Shah, Y.3    Yang, Q.4    Ward, J.M.5    Gonzalez, F.J.6
  • 29
    • 57149118460 scopus 로고    scopus 로고
    • Nuclear bile acid receptor FXR protects against intestinal tumorigenesis
    • Modica, S., Murzilli, S., Salvatore, L., Schmidt, D. R., and Moschetta, A. (2008) Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. Cancer Res. 68, 9589-9594
    • (2008) Cancer Res. , vol.68 , pp. 9589-9594
    • Modica, S.1    Murzilli, S.2    Salvatore, L.3    Schmidt, D.R.4    Moschetta, A.5
  • 30
    • 33847044019 scopus 로고    scopus 로고
    • Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor
    • Yang, F., Huang, X., Yi, T., Yen, Y., Moore, D. D., and Huang, W. (2007) Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res. 67, 863-867
    • (2007) Cancer Res. , vol.67 , pp. 863-867
    • Yang, F.1    Huang, X.2    Yi, T.3    Yen, Y.4    Moore, D.D.5    Huang, W.6
  • 31
    • 80052771111 scopus 로고    scopus 로고
    • Bile acids and colon cancer: Solving the puzzle with nuclear receptors
    • Degirolamo, C., Modica, S., Palasciano, G., and Moschetta, A. (2011) Bile acids and colon cancer: solving the puzzle with nuclear receptors. Trends Mol. Med. 17, 564-572
    • (2011) Trends Mol. Med. , vol.17 , pp. 564-572
    • Degirolamo, C.1    Modica, S.2    Palasciano, G.3    Moschetta, A.4
  • 35
    • 0033570028 scopus 로고    scopus 로고
    • Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene: Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer
    • Grober, J., Zaghini, I., Fujii, H., Jones, S. A., Kliewer, S. A., Willson, T. M., Ono, T., and Besnard, P. (1999) Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene: involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. J. Biol. Chem. 274, 29749-29754
    • (1999) J. Biol. Chem. , vol.274 , pp. 29749-29754
    • Grober, J.1    Zaghini, I.2    Fujii, H.3    Jones, S.A.4    Kliewer, S.A.5    Willson, T.M.6    Ono, T.7    Besnard, P.8
  • 37
    • 63849322336 scopus 로고    scopus 로고
    • Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio
    • Modica, S., Bellafante, E., and Moschetta, A. (2009) Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio. Front. Biosci. 14, 4719-4745
    • (2009) Front. Biosci. , vol.14 , pp. 4719-4745
    • Modica, S.1    Bellafante, E.2    Moschetta, A.3
  • 41
    • 84859439016 scopus 로고    scopus 로고
    • Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells
    • Hinkel, I., Duluc, I., Martin, E., Guenot, D., Freund, J. N., and Gross, I. (2012) Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells. Gastroenterology 142, 875-885.e3
    • (2012) Gastroenterology , vol.142 , pp. 875-885.e3
    • Hinkel, I.1    Duluc, I.2    Martin, E.3    Guenot, D.4    Freund, J.N.5    Gross, I.6
  • 42
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E. R., and Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell 61, 759-767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 43
    • 0033769822 scopus 로고    scopus 로고
    • Cdx1 and cdx2 expression during intestinal development
    • Silberg, D. G., Swain, G. P., Suh, E. R., and Traber, P. G. (2000) Cdx1 and cdx2 expression during intestinal development. Gastroenterology 119, 961-971
    • (2000) Gastroenterology , vol.119 , pp. 961-971
    • Silberg, D.G.1    Swain, G.P.2    Suh, E.R.3    Traber, P.G.4
  • 44
    • 0031440118 scopus 로고    scopus 로고
    • Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation
    • Lorentz, O., Duluc, I., Arcangelis, A. D., Simon-Assmann, P., Kedinger, M., and Freund, J. N. (1997) Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation. J. Cell Biol. 139, 1553-1565
    • (1997) J. Cell Biol. , vol.139 , pp. 1553-1565
    • Lorentz, O.1    Duluc, I.2    Arcangelis, A.D.3    Simon-Assmann, P.4    Kedinger, M.5    Freund, J.N.6
  • 45
    • 0030032310 scopus 로고    scopus 로고
    • An intestine-specific homeobox gene regulates proliferation and differentiation
    • Suh, E., and Traber, P. G. (1996) An intestine-specific homeobox gene regulates proliferation and differentiation. Mol. Cell Biol. 16, 619-625
    • (1996) Mol. Cell Biol. , vol.16 , pp. 619-625
    • Suh, E.1    Traber, P.G.2
  • 46
    • 0032960673 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation
    • Taupin, D., and Podolsky, D. K. (1999) Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation. Gastroenterology 116, 1072-1080
    • (1999) Gastroenterology , vol.116 , pp. 1072-1080
    • Taupin, D.1    Podolsky, D.K.2
  • 47
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., and Gonzalez, F. J. (2000) Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102, 731-744
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 50
    • 29244432794 scopus 로고    scopus 로고
    • Bile acids directly augment caudal related homeobox gene Cdx2 expression in oesophageal keratinocytes in Barrett's epithelium
    • Kazumori, H., Ishihara, S., Rumi, M. A., Kadowaki, Y., and Kinoshita, Y. (2006) Bile acids directly augment caudal related homeobox gene Cdx2 expression in oesophageal keratinocytes in Barrett's epithelium. Gut 55, 16-25
    • (2006) Gut , vol.55 , pp. 16-25
    • Kazumori, H.1    Ishihara, S.2    Rumi, M.A.3    Kadowaki, Y.4    Kinoshita, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.