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Volumn 58, Issue 9, 2009, Pages 1250-1259

Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; INSULIN RECEPTOR SUBSTRATE 2; KRUPPEL LIKE FACTOR 4; MESSENGER RNA; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR CDX2;

EID: 68849100416     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2008.158386     Document Type: Article
Times cited : (20)

References (52)
  • 1
    • 0034080251 scopus 로고    scopus 로고
    • Gut instincts: Thoughts on intestinal epithelial stem cells
    • Booth C, Potten CS. Gut instincts: thoughts on intestinal epithelial stem cells. J Clin Invest 2000;105:1493-9.
    • (2000) J Clin Invest , vol.105 , pp. 1493-1499
    • Booth, C.1    Potten, C.S.2
  • 2
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006;127:469-80.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 3
    • 0032562603 scopus 로고    scopus 로고
    • Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    • Behrens J, Jerchow BA, Wurtele M, et al. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 1998;280:596-9.
    • (1998) Science , vol.280 , pp. 596-599
    • Behrens, J.1    Jerchow, B.A.2    Wurtele, M.3
  • 4
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • He TC, Sparks AB, Rago C, et al. Identification of c-MYC as a target of the APC pathway. Science 1998;281:1509-12.
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1    Sparks, A.B.2    Rago, C.3
  • 5
    • 2942668475 scopus 로고    scopus 로고
    • Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
    • Sansom OJ, Reed KR, Hayes AJ, et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev 2004;18:1385-90.
    • (2004) Genes Dev , vol.18 , pp. 1385-1390
    • Sansom, O.J.1    Reed, K.R.2    Hayes, A.J.3
  • 6
    • 0025817880 scopus 로고
    • Identification of FAP locus genes from chromosome 5q21
    • Kinzler KW, Nilbert MC, Su LK, et al. Identification of FAP locus genes from chromosome 5q21. Science 1991;253:661-5.
    • (1991) Science , vol.253 , pp. 661-665
    • Kinzler, K.W.1    Nilbert, M.C.2    Su, L.K.3
  • 7
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-67.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 8
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-70.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 9
    • 0342503644 scopus 로고    scopus 로고
    • CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling
    • da Costa LT, He TC, Yu J, et al. CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. Oncogene 1999;18:5010-4.
    • (1999) Oncogene , vol.18 , pp. 5010-5014
    • da Costa, L.T.1    He, T.C.2    Yu, J.3
  • 10
    • 0035833319 scopus 로고    scopus 로고
    • Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2
    • Dang DT, Mahatan CS, Dang LH, et al. Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. Oncogene 2001;20:4884- 90.
    • (2001) Oncogene , vol.20 , pp. 4884-4890
    • Dang, D.T.1    Mahatan, C.S.2    Dang, L.H.3
  • 11
    • 0030937750 scopus 로고    scopus 로고
    • Homeosis and intestinal tumours in Cdx2 mutant mice
    • Chawengsaksophak K, James R, Hammond VE, et al. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 1997;386:84-7.
    • (1997) Nature , vol.386 , pp. 84-87
    • Chawengsaksophak, K.1    James, R.2    Hammond, V.E.3
  • 12
    • 0033769822 scopus 로고    scopus 로고
    • Cdx1 and cdx2 expression during intestinal development
    • Silberg DG, Swain GP, Suh ER, et al. Cdx1 and cdx2 expression during intestinal development. Gastroenterology 2000;119:961-71.
    • (2000) Gastroenterology , vol.119 , pp. 961-971
    • Silberg, D.G.1    Swain, G.P.2    Suh, E.R.3
  • 13
    • 0033594940 scopus 로고    scopus 로고
    • Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice
    • Beck F, Chawengsaksophak K, Waring P, et al. Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice. Proc Natl Acad Sci USA 1999;96:7318-23.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7318-7323
    • Beck, F.1    Chawengsaksophak, K.2    Waring, P.3
  • 14
    • 0028080881 scopus 로고
    • A homeodomain protein related to caudal regulates intestine-specific gene transcription
    • Suh E, Chen L, Taylor J, et al. A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol 1994;14:7340-51.
    • (1994) Mol Cell Biol , vol.14 , pp. 7340-7351
    • Suh, E.1    Chen, L.2    Taylor, J.3
  • 15
    • 0344687341 scopus 로고    scopus 로고
    • CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene
    • Bai YQ, Miyake S, Iwai T, et al. CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. Oncogene 2003;22:7942-9.
    • (2003) Oncogene , vol.22 , pp. 7942-7949
    • Bai, Y.Q.1    Miyake, S.2    Iwai, T.3
  • 16
    • 0029156944 scopus 로고
    • Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma
    • Ee HC, Erler T, Bhathal PS, et al. Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma. Am J Pathol 1995;147:586-92.
    • (1995) Am J Pathol , vol.147 , pp. 586-592
    • Ee, H.C.1    Erler, T.2    Bhathal, P.S.3
  • 17
    • 33846920172 scopus 로고    scopus 로고
    • Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability
    • Subtil C, Guerin E, Schneider A, et al. Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability. Cancer Lett 2007;247:197-203.
    • (2007) Cancer Lett , vol.247 , pp. 197-203
    • Subtil, C.1    Guerin, E.2    Schneider, A.3
  • 18
    • 4944240215 scopus 로고    scopus 로고
    • Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: An active role for the tumor environment in malignant tumor progression
    • Brabletz T, Spaderna S, Kolb J, et al. Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression. Cancer Res 2004;64:6973-7.
    • (2004) Cancer Res , vol.64 , pp. 6973-6977
    • Brabletz, T.1    Spaderna, S.2    Kolb, J.3
  • 19
    • 0344826531 scopus 로고    scopus 로고
    • Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice
    • Aoki K, Tamai Y, Horiike S, et al. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat Genet 2003;35:323-30.
    • (2003) Nat Genet , vol.35 , pp. 323-330
    • Aoki, K.1    Tamai, Y.2    Horiike, S.3
  • 20
    • 0141869045 scopus 로고    scopus 로고
    • The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development
    • Bonhomme C, Duluc I, Martin E, et al. The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Gut 2003;52:1465-71.
    • (2003) Gut , vol.52 , pp. 1465-1471
    • Bonhomme, C.1    Duluc, I.2    Martin, E.3
  • 21
    • 37849029160 scopus 로고    scopus 로고
    • The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells
    • Gross I, Duluc I, Benameur T, et al. The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. Oncogene 2008;27:107-15.
    • (2008) Oncogene , vol.27 , pp. 107-115
    • Gross, I.1    Duluc, I.2    Benameur, T.3
  • 22
    • 29344458031 scopus 로고    scopus 로고
    • The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas
    • Witek ME, Nielsen K, Walters R, et al. The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas. Clin Cancer Res 2005;11:8549-56.
    • (2005) Clin Cancer Res , vol.11 , pp. 8549-8556
    • Witek, M.E.1    Nielsen, K.2    Walters, R.3
  • 23
    • 36348970735 scopus 로고    scopus 로고
    • Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types
    • Martin ES, Tonon G, Sinha R, et al. Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Res 2007;67:10736-43.
    • (2007) Cancer Res , vol.67 , pp. 10736-10743
    • Martin, E.S.1    Tonon, G.2    Sinha, R.3
  • 24
    • 33645743572 scopus 로고    scopus 로고
    • CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48
    • Dang LH, Chen F, Ying C, et al. CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48. Oncogene 2006;25:2264-72.
    • (2006) Oncogene , vol.25 , pp. 2264-2272
    • Dang, L.H.1    Chen, F.2    Ying, C.3
  • 25
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: Insights into insulin action
    • Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006;7:85-96.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 26
    • 0034699544 scopus 로고    scopus 로고
    • Burks DJ, Font dM, Schubert M, et al. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 2000;407:377-82.
    • Burks DJ, Font dM, Schubert M, et al. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 2000;407:377-82.
  • 27
    • 9644260563 scopus 로고    scopus 로고
    • Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes
    • Lin X, Taguchi A, Park S, et al. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest 2004;114:908-16.
    • (2004) J Clin Invest , vol.114 , pp. 908-916
    • Lin, X.1    Taguchi, A.2    Park, S.3
  • 28
    • 9644260562 scopus 로고    scopus 로고
    • Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus
    • Kubota N, Terauchi Y, Tobe K, et al. Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest 2004;114:917-27.
    • (2004) J Clin Invest , vol.114 , pp. 917-927
    • Kubota, N.1    Terauchi, Y.2    Tobe, K.3
  • 29
    • 0032567937 scopus 로고    scopus 로고
    • Disruption of IRS-2 causes type 2 diabetes in mice
    • Withers DJ, Gutierrez JS, Towery H, et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998;391:900-4.
    • (1998) Nature , vol.391 , pp. 900-904
    • Withers, D.J.1    Gutierrez, J.S.2    Towery, H.3
  • 30
    • 37549028057 scopus 로고    scopus 로고
    • IRS-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9
    • Ramocki NM, Wilkins HR, Magness ST, et al. IRS-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9. Endocrinology 2008;149:261-7.
    • (2008) Endocrinology , vol.149 , pp. 261-267
    • Ramocki, N.M.1    Wilkins, H.R.2    Magness, S.T.3
  • 31
    • 36348994146 scopus 로고    scopus 로고
    • Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells
    • Shi B, Sepp-Lorenzino L, Prisco M, et al. Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells. J Biol Chem 2007;282:32582-90.
    • (2007) J Biol Chem , vol.282 , pp. 32582-32590
    • Shi, B.1    Sepp-Lorenzino, L.2    Prisco, M.3
  • 32
    • 3142770705 scopus 로고    scopus 로고
    • Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer
    • Slattery ML, Samowitz W, Curtin K, et al. Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer. Cancer Epidemiol Biomarkers Prev 2004;13:1206-14.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 1206-1214
    • Slattery, M.L.1    Samowitz, W.2    Curtin, K.3
  • 33
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood LD, Parsons DW, Jones S, et al. The genomic landscapes of human breast and colorectal cancers. Science 2007;318:1108-13.
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3
  • 34
    • 0028943821 scopus 로고
    • Multiplex PCR analysis and genotype-phenotype correlations of frequent APC mutations
    • Cama A, Palmirotta R, Curia MC, et al. Multiplex PCR analysis and genotype-phenotype correlations of frequent APC mutations. Hum Mutat 1995;5:144-52.
    • (1995) Hum Mutat , vol.5 , pp. 144-152
    • Cama, A.1    Palmirotta, R.2    Curia, M.C.3
  • 35
    • 18644373146 scopus 로고    scopus 로고
    • The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • Van de Wetering M, Sancho E, Verweij C, et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002;111:241-50.
    • (2002) Cell , vol.111 , pp. 241-250
    • Van de Wetering, M.1    Sancho, E.2    Verweij, C.3
  • 36
    • 11144318237 scopus 로고    scopus 로고
    • Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
    • Moschetta A, Bookout AL, Mangelsdorf DJ. Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat Med 2004;10:1352-8.
    • (2004) Nat Med , vol.10 , pp. 1352-1358
    • Moschetta, A.1    Bookout, A.L.2    Mangelsdorf, D.J.3
  • 37
    • 34147107042 scopus 로고    scopus 로고
    • The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis
    • Scholl C, Bansal D, Dohner K, et al. The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J Clin Invest 2007;117:1037-48.
    • (2007) J Clin Invest , vol.117 , pp. 1037-1048
    • Scholl, C.1    Bansal, D.2    Dohner, K.3
  • 38
    • 34547446534 scopus 로고    scopus 로고
    • A real-time PCR method to rapidly titer adenovirus stocks
    • Thomas MA, Lichtenstein DL, Krajcsi P, et al. A real-time PCR method to rapidly titer adenovirus stocks. Methods Mol Med 2007;130:185-92.
    • (2007) Methods Mol Med , vol.130 , pp. 185-192
    • Thomas, M.A.1    Lichtenstein, D.L.2    Krajcsi, P.3
  • 39
    • 0036366991 scopus 로고    scopus 로고
    • Identification of a single nucleotide polymorphism showing no insulin-mediated suppression of the promoter activity in the human insulin receptor substrate 2 gene
    • Iwamoto K, Mori H, Okazawa H, et al. Identification of a single nucleotide polymorphism showing no insulin-mediated suppression of the promoter activity in the human insulin receptor substrate 2 gene. Diabetologia 2002;45:1182-95.
    • (2002) Diabetologia , vol.45 , pp. 1182-1195
    • Iwamoto, K.1    Mori, H.2    Okazawa, H.3
  • 40
    • 0036070818 scopus 로고    scopus 로고
    • Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system
    • Qualtrough D, Hinoi T, Fearon E, et al. Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system. Gut 2002;51:184-90.
    • (2002) Gut , vol.51 , pp. 184-190
    • Qualtrough, D.1    Hinoi, T.2    Fearon, E.3
  • 41
    • 3543031024 scopus 로고    scopus 로고
    • The bile acid nuclear receptor FXR and the bile acid binding protein IBABP are differently expressed in colon cancer
    • de Gottardi A, Touri F, Maurer CA, et al. The bile acid nuclear receptor FXR and the bile acid binding protein IBABP are differently expressed in colon cancer. Dig Dis Sci 2004;49:982-9.
    • (2004) Dig Dis Sci , vol.49 , pp. 982-989
    • de Gottardi, A.1    Touri, F.2    Maurer, C.A.3
  • 42
    • 0036278758 scopus 로고    scopus 로고
    • Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells
    • Domon-Dell C, Wang Q, Kim S, et al. Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells. Gut 2002;50:525-9.
    • (2002) Gut , vol.50 , pp. 525-529
    • Domon-Dell, C.1    Wang, Q.2    Kim, S.3
  • 43
    • 40849120759 scopus 로고    scopus 로고
    • Abnormalities of insulin-like growth factor-I signaling and impaired cell proliferation in osteoblasts from subjects with osteoporosis
    • Perrini S, Natalicchio A, Laviola L, et al. Abnormalities of insulin-like growth factor-I signaling and impaired cell proliferation in osteoblasts from subjects with osteoporosis. Endocrinology 2008;149:1302-13.
    • (2008) Endocrinology , vol.149 , pp. 1302-1313
    • Perrini, S.1    Natalicchio, A.2    Laviola, L.3
  • 44
    • 0027264068 scopus 로고
    • Association between wild type and mutant APC gene products
    • Su LK, Johnson KA, Smith KJ, et al. Association between wild type and mutant APC gene products. Cancer Res 1993;53:2728- 31.
    • (1993) Cancer Res , vol.53 , pp. 2728-2731
    • Su, L.K.1    Johnson, K.A.2    Smith, K.J.3
  • 46
    • 0026742321 scopus 로고
    • Novel DNA-binding proteins regulate intestine-specific transcription of the sucrase-isomaltase gene
    • Traber PG, Wu GD, Wang W. Novel DNA-binding proteins regulate intestine-specific transcription of the sucrase-isomaltase gene. Mol Cell Biol 1992;12:3614-27.
    • (1992) Mol Cell Biol , vol.12 , pp. 3614-3627
    • Traber, P.G.1    Wu, G.D.2    Wang, W.3
  • 47
    • 0344305782 scopus 로고    scopus 로고
    • Insulin signaling in health and disease
    • White MF. Insulin signaling in health and disease. Science 2003;302:1710-1.
    • (2003) Science , vol.302 , pp. 1710-1711
    • White, M.F.1
  • 48
    • 0034605463 scopus 로고    scopus 로고
    • Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women
    • Kaaks R, Toniolo P, Akhmedkhanov A, et al. Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women. J Natl Cancer Inst 2000;92:1592-600.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1592-1600
    • Kaaks, R.1    Toniolo, P.2    Akhmedkhanov, A.3
  • 49
    • 0027327503 scopus 로고
    • Insulinlike growth factors and binding proteins in colon cancer
    • Singh P, Rubin N. Insulinlike growth factors and binding proteins in colon cancer. Gastroenterology 1993;105:1218-37.
    • (1993) Gastroenterology , vol.105 , pp. 1218-1237
    • Singh, P.1    Rubin, N.2
  • 50
    • 0344734066 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis
    • Werner H, Le Roith D. The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis. Crit Rev Oncog 1997;8:71-92.
    • (1997) Crit Rev Oncog , vol.8 , pp. 71-92
    • Werner, H.1    Le Roith, D.2
  • 51
    • 23844436626 scopus 로고    scopus 로고
    • Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin
    • Chen J, Wu A, Sun H, et al. Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin. J Biol Chem 2005;280:29912- 20.
    • (2005) J Biol Chem , vol.280 , pp. 29912-29920
    • Chen, J.1    Wu, A.2    Sun, H.3
  • 52
    • 36148998002 scopus 로고    scopus 로고
    • Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth
    • Simmons JG, Ling Y, Wilkins H, et al. Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth. Am J Physiol Gastrointest Liver Physiol 2007;293:G995- 1003.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.293
    • Simmons, J.G.1    Ling, Y.2    Wilkins, H.3


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