CDX2 expression in the intestinal-type gastric epithelial neoplasia: Frequency and significance

Modern Pathology

Volumn 23, Issue 1, 2010, Pages 54-61

  Park, Do Youn ^a,b   Srivastava, Amitabh ^c   Kim, Gwang Ha ^b,d   Mino Kenudson, Mari ^a   Deshpande, Vikram ^a   Zukerberg, Lawrence R ^a   Song, Geum Am ^b,d   Lauwers, Gregory Y ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Pusan National University School of Medicine   (South Korea)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d Pusan National University   (South Korea)

Author keywords

CDX2; Dysplasia; Gastric cancer; Mucin

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; MUCIN 2; MUCIN 5AC; MUCIN 6; TRANSCRIPTION FACTOR CDX2;

ADENOMA; ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CANCER STAGING; CARCINOGENESIS; DISEASE CLASSIFICATION; DYSPLASIA; EARLY CANCER; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METAPLASIA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STOMACH CANCER; STOMACH EPITHELIUM; TUMOR LOCALIZATION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MALE; MIDDLE AGED; MUCIN 5AC; NEOPLASM STAGING; NEPRILYSIN; PHENOTYPE; PRECANCEROUS CONDITIONS; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 73949127446     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2009.135     Document Type: Article

References (30)

1. Stadtlander CT, Waterbor JW. Molecular epidemiology, pathogenesis and prevention of gastric cancer. Carci-nogenesis 1999;20:2195-2208.
2. Laurén P. The two histologic main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965;64:31-49.
3. Schlemper RJ, Riddell RH, Kato Y, et al. The Vienna classification of gastrointestinal epithelial neoplasia. Gut 2000;47:251-255.
4. Yuasa Y. Control of gut differentiation and intestinal-type gastric carcinogenesis. Nat Rev Cancer 2003;3:592-600.
5. Beck F, Chawengsaksophak K, Waring P, et al. Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice. Proc Natl Acad Sci USA 1999;96:7318-7323.
6. Silberg DG, Swain GP, Suh ER, et al. Cdx1 and cdx2 expression during intestinal development. Gastroen-terology 2000;119:961-971.
7. Bai YQ, Miyake S, Iwai T, et al. CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. Oncogene 2003;22:7942-7949.
8. Freund JN, Domon-Dell C, Kedinger M, et al. The Cdx-1 and Cdx-2 homeobox genes in the intestine. Biochem Cell Biol 1998;76:957-969.
9. Mallo GV, Soubeyran P, Lissitzky JC, et al. Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. J Biol Chem 1998;273:14030-14036.
10. Mallo GV, Rechreche H, Frigerio JM, et al. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int J Cancer 1997;74:35-44.
11. Vider BZ, Zimber A, Hirsch D, et al. Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression. Biochem Biophys Res Commun 1997;232:742-748.
12. Ha Kim G, Am Song G, Youn Park D, et al. CDX2 expression is increased in gastric cancers with less invasiveness and intestinal mucin phenotype. Scand J Gastroenterol 2006;41:880-886.
13. Mizoshita T, Tsukamoto T, Nakanishi H, et al. Expression of Cdx2 and the phenotype of advanced gastric cancers: relationship with prognosis. J Cancer Res Clin Oncol 2003;129:727-734.
14. Seno H, Oshima M, Taniguchi MA, et al. CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: prognostic implications. Int J Oncol 2002;21:769-774.
15. Kim HS, Lee JS, Freund JN, et al. CDX-2 homeobox gene expression in human gastric carcinoma and precursor lesions. J Gastroenterol Hepatol 2006;21:438-442.
16. Liu Q, Teh M, Ito K, et al. CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer. Mod Pathol 2007; 20:1286-1297.
17. Rugge M, Ingravallo G, Farinati F, et al. Re: CDX2 homeotic gene expression in gastric noninvasive neoplasia. Am J Surg Pathol 2004;28:834-835.
18. Van Klinken BJ, Dekker J, Buller HA, et al. Biosynthesis of mucins (MUC2-6) along the longitudinal axis of the human gastrointestinal tract. Am J Physiol 1997;273: G296-G302.
19. Jass JR, Walsh MD. Altered mucin expression in the gastrointestinal tract: a review. J Cell Mol Med 2001;5:327-351.
20. Jass JR. Mucin core proteins as differentiation markers in the gastrointestinal tract. Histopathology 2000;37: 561-564.
21. Corfield AP, Myerscough N, Longman R, et al. Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease. Gut 2000;47:589-594.
22. Machado JC, Nogueira AM, Carneiro F, et al. Gastric carcinoma exhibits distinct types of cell differentiation: an immunohistochemical study of trefoil peptides (TFF1 and TFF2) and mucins (MUC1, MUC2, MUC5AC, and MUC6). J Pathol 2000;190: 437-443.
23. Abraham SC, Montgomery EA, Singh VK, et al. Gastric adenomas: intestinal-type and gastric-type adenomas differ in the risk of adenocarcinoma and presence of background mucosal pathology. Am J Surg Pathol 2002;26:1276-1285.
24. Lewin KJ, Appleman HD. Carcinoma of the stomach In: Tumors of the Esophagus and Stomach. Atlas of Tumor Pathology (Third Series Fascicle 18) Armed Forces Institute of Pathology: Washington, DC, 1996, pp 245-330.
25. Park do Y, Srivastava A, Kim GH, et al. Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia. Am J Surg Pathol 2008;32:524-533.
26. Phillips RW, Frierson Jr HF, Moskaluk CA. Cdx 2 as a marker of epithelial intestinal differentiation in the esophagus. Am J Surg Pathol 2003;27:1442-1447.
27. Chawengsaksophak K, James R, Hammond VE, et al. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 1997;386:84-87.
28. Mallo GV, Soubeyran P, Lissitzky JC, et al. Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. J Biol Chem 1998;273:14030-14036.
29. Silberg DG, Sullivan J, Kang E, et al. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology 2002;122: 689-696.
30. Tajima Y, Yamazaki K, Makino R, et al. Gastric and intestinal phenotypic marker expression in early differentiated-type tumors of the stomach: clinico-pathologic significance and genetic background. Clin Cancer Res 2006;12:6469-6479.