-
1
-
-
0025906410
-
Homeobox gene expression in the intestinal epithelium of adult mice
-
James R, Kazenwadel J. Homeobox gene expression in the intestinal epithelium of adult mice. J Biol Chem 1991;266:3246-51.
-
(1991)
J Biol Chem
, vol.266
, pp. 3246-3251
-
-
James, R.1
Kazenwadel, J.2
-
2
-
-
0023032871
-
A molecular gradient in early Drosophila embryos and its role in specifying the body pattern
-
Macdonald PM, Struhl G. A molecular gradient in early Drosophila embryos and its role in specifying the body pattern. Nature 1986;324:537-45.
-
(1986)
Nature
, vol.324
, pp. 537-545
-
-
MacDonald, P.M.1
Struhl, G.2
-
3
-
-
28344436489
-
Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation
-
Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R, et al. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 2005;123:917-29.
-
(2005)
Cell
, vol.123
, pp. 917-929
-
-
Niwa, H.1
Toyooka, Y.2
Shimosato, D.3
Strumpf, D.4
Takahashi, K.5
Yagi, R.6
-
4
-
-
0030937750
-
Homeosis and intestinal tumours in Cdx2 mutant mice
-
Chawengsaksophak K, James R, Hammond VE, Kontgen F, Beck F. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 1997;386:84-7.
-
(1997)
Nature
, vol.386
, pp. 84-87
-
-
Chawengsaksophak, K.1
James, R.2
Hammond, V.E.3
Kontgen, F.4
Beck, F.5
-
5
-
-
0033564467
-
Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice
-
Tamai Y, Nakajima R, Ishikawa T, Takaku K, Seldin MF, Taketo MM. Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice. Cancer Res 1999;59: 2965-70.
-
(1999)
Cancer Res
, vol.59
, pp. 2965-2970
-
-
Tamai, Y.1
Nakajima, R.2
Ishikawa, T.3
Takaku, K.4
Seldin, M.F.5
Taketo, M.M.6
-
7
-
-
16244388032
-
The role of Cdx proteins in intestinal development and cancer
-
Guo RJ, Suh ER, Lynch JP. The role of Cdx proteins in intestinal development and cancer. Cancer Biol Ther 2004;3:593-601.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 593-601
-
-
Guo, R.J.1
Suh, E.R.2
Lynch, J.P.3
-
8
-
-
77953952170
-
Cdx2 regulates endo-lysosomal function and epithelial cell polarity
-
Gao N, Kaestner KH. Cdx2 regulates endo-lysosomal function and epithelial cell polarity. Genes Dev 2010;24:1295-305.
-
(2010)
Genes Dev
, vol.24
, pp. 1295-1305
-
-
Gao, N.1
Kaestner, K.H.2
-
9
-
-
64549114508
-
Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
-
Gao N, White P, Kaestner KH. Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev Cell 2009;16:588-99.
-
(2009)
Dev Cell
, vol.16
, pp. 588-599
-
-
Gao, N.1
White, P.2
Kaestner, K.H.3
-
10
-
-
0029156944
-
Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma
-
Ee HC, Erler T, Bhathal PS, Young G. P, James R. J. Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma. Am J Pathol 1995;147:586-92.
-
(1995)
Am J Pathol
, vol.147
, pp. 586-592
-
-
Ee, H.C.1
Erler, T.2
Bhathal, P.S.3
Young, G.P.4
James, R.J.5
-
11
-
-
17344392128
-
Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis
-
Mallo GV, Rechreche H, Frigerio JM, Rocha D, Zweibaum A, Lacasa M, et al. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int J Cancer 1997;74:35-44.
-
(1997)
Int J Cancer
, vol.74
, pp. 35-44
-
-
Mallo, G.V.1
Rechreche, H.2
Frigerio, J.M.3
Rocha, D.4
Zweibaum, A.5
Lacasa, M.6
-
12
-
-
0344826531
-
Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Δ716Cdx2+/- compound mutant mice
-
Aoki K, Tamai Y, Horiike S, Oshima M, Taketo MM. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Δ716Cdx2+/- compound mutant mice. Nat Genet 2003;35: 323-30.
-
(2003)
Nat Genet
, vol.35
, pp. 323-330
-
-
Aoki, K.1
Tamai, Y.2
Horiike, S.3
Oshima, M.4
Taketo, M.M.5
-
13
-
-
0029047954
-
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
-
Oshima M, Oshima H, Kitagawa K, Kobayashi M, Itakura C, Taketo M. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci U S A 1995;92:4482-6.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 4482-4486
-
-
Oshima, M.1
Oshima, H.2
Kitagawa, K.3
Kobayashi, M.4
Itakura, C.5
Taketo, M.6
-
14
-
-
0141869045
-
The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development
-
Bonhomme C, Duluc I, Martin E, Chawengsaksophak K, Chenard MP, Kedinger M, et al. The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Gut 2003;52:1465-71.
-
(2003)
Gut
, vol.52
, pp. 1465-1471
-
-
Bonhomme, C.1
Duluc, I.2
Martin, E.3
Chawengsaksophak, K.4
Chenard, M.P.5
Kedinger, M.6
-
15
-
-
75149137841
-
CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium
-
Kakizaki F, Aoki K, Miyoshi H, Carrasco N, Aoki M, Taketo MM. CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium. Gastroenterology 2010;138:627-35.
-
(2010)
Gastroenterology
, vol.138
, pp. 627-635
-
-
Kakizaki, F.1
Aoki, K.2
Miyoshi, H.3
Carrasco, N.4
Aoki, M.5
Taketo, M.M.6
-
16
-
-
18644373146
-
The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
-
van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, et al. The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002;111:241-50.
-
(2002)
Cell
, vol.111
, pp. 241-250
-
-
Van De Wetering, M.1
Sancho, E.2
Verweij, C.3
De Lau, W.4
Oving, I.5
Hurlstone, A.6
-
17
-
-
20444374445
-
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
-
Samuels Y, Diaz LA Jr, Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 2005;7:561-73.
-
(2005)
Cancer Cell
, vol.7
, pp. 561-573
-
-
Samuels, Y.1
Diaz Jr., L.A.2
Schmidt-Kittler, O.3
Cummins, J.M.4
Delong, L.5
Cheong, I.6
Et Al, .7
-
18
-
-
0036829210
-
CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia
-
Hinoi T, Lucas PC, Kuick R, Hanash S, Cho KR, Fearon ER, CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. Gastroenterology 2002; 123:1565-77.
-
(2002)
Gastroenterology
, vol.123
, pp. 1565-1577
-
-
Hinoi, T.1
Lucas, P.C.2
Kuick, R.3
Hanash, S.4
Cho, K.R.5
Fearon, E.R.6
-
19
-
-
17144407567
-
CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium
-
Hinoi T, Gesina G, Akyol A, Kuick R, Hanash S, Giordano TJ, et al. CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium. Gastroenterology 2005;128:946-61.
-
(2005)
Gastroenterology
, vol.128
, pp. 946-961
-
-
Hinoi, T.1
Gesina, G.2
Akyol, A.3
Kuick, R.4
Hanash, S.5
Giordano, T.J.6
Et Al, .7
-
20
-
-
0028103855
-
Homeodomain-DNA recognition
-
Gehring WJ, Qian YQ, Billeter M, Furukubo-Tokunaga K, Schier AF, Resendez-Perez D, et al. Homeodomain-DNA recognition. Cell 1994;78:211-23.
-
(1994)
Cell
, vol.78
, pp. 211-223
-
-
Gehring, W.J.1
Qian, Y.Q.2
Billeter, M.3
Furukubo-Tokunaga, K.4
Schier, A.F.5
Resendez-Perez, D.6
-
21
-
-
21444446875
-
Homeodomain revisited: A lesson from disease-causing mutations
-
Chi, Y. I. Homeodomain revisited: a lesson from disease-causing mutations. Hum Genet 2005;116: 433-444.
-
(2005)
Hum Genet
, vol.116
, pp. 433-444
-
-
Chi, Y.I.1
-
22
-
-
0035214124
-
Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity
-
Rings EH, Boudreau F, Taylor JK, Moffett J, Suh ER, Traber PG. Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity. Gastroenterology 2001;121:1437-50.
-
(2001)
Gastroenterology
, vol.121
, pp. 1437-1450
-
-
Rings, E.H.1
Boudreau, F.2
Taylor, J.K.3
Moffett, J.4
Suh, E.R.5
Traber, P.G.6
-
23
-
-
0033564697
-
CDK inhibitors: Positive and negative regulators of G1-phase progression
-
Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999;13:1501-12.
-
(1999)
Genes Dev
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
24
-
-
0030847760
-
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
-
Vlach J, Hennecke S, Amati B. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J 1997; 16:5334-44.
-
(1997)
EMBO J
, vol.16
, pp. 5334-5344
-
-
Vlach, J.1
Hennecke, S.2
Amati, B.3
-
25
-
-
41149150219
-
The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy
-
Chu IM, Hengst L, Slingerland JM. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat Rev Cancer 2008;8:253-67.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 253-267
-
-
Chu, I.M.1
Hengst, L.2
Slingerland, J.M.3
-
26
-
-
0033135878
-
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
-
Montagnoli A, Fiore F, Eytan E, Carrano AC, Draetta GF, Hershko A, et al. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev 1999;13: 1181-9.
-
(1999)
Genes Dev
, vol.13
, pp. 1181-1189
-
-
Montagnoli, A.1
Fiore, F.2
Eytan, E.3
Carrano, A.C.4
Draetta, G.F.5
Hershko, A.6
-
27
-
-
0033176887
-
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
-
Carrano AC, Eytan E, Hershko A, Pagano M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1999;1:193-9.
-
(1999)
Nat Cell Biol
, vol.1
, pp. 193-199
-
-
Carrano, A.C.1
Eytan, E.2
Hershko, A.3
Pagano, M.4
-
30
-
-
12544259437
-
Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation
-
Kotake Y, Nakayama K, Ishida N, Nakayama KI. Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. J Biol Chem 2005;280: 1095-102.
-
(2005)
J Biol Chem
, vol.280
, pp. 1095-1102
-
-
Kotake, Y.1
Nakayama, K.2
Ishida, N.3
Nakayama, K.I.4
-
31
-
-
29944440513
-
Kip1 stability, subcellular localization, and tumor suppression
-
Kip1 stability, subcellular localization, and tumor suppression. Genes Dev 2006;20:47-64.
-
(2006)
Genes Dev
, vol.20
, pp. 47-64
-
-
Besson, A.1
Gurian-West, M.2
Chen, X.3
Kelly-Spratt, K.S.4
Kemp, C.J.5
Roberts, J.M.6
-
33
-
-
33947250696
-
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
-
Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 2007;9:218-24.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 218-224
-
-
Liang, J.1
Shao, S.H.2
Xu, Z.X.3
Hennessy, B.4
Ding, Z.5
Larrea, M.6
-
34
-
-
33646528191
-
Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation
-
Berthet C, Klarmann KD, Hilton MB, Suh HC, Keller JR, Kiyokawa H, et al. Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell 2006;10:563-73.
-
(2006)
Dev Cell
, vol.10
, pp. 563-573
-
-
Berthet, C.1
Klarmann, K.D.2
Hilton, M.B.3
Suh, H.C.4
Keller, J.R.5
Kiyokawa, H.6
-
35
-
-
0026802989
-
Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
-
Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 1992;70:993-1006.
-
(1992)
Cell
, vol.70
, pp. 993-1006
-
-
Hinds, P.W.1
Mittnacht, S.2
Dulic, V.3
Arnold, A.4
Reed, S.I.5
Weinberg, R.A.6
-
36
-
-
33846268807
-
P27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
-
Chu I, Sun J, Arnaout A, Kahn H, Hanna W, Narod S, et al. p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell 2007;128:281-94.
-
(2007)
Cell
, vol.128
, pp. 281-294
-
-
Chu, I.1
Sun, J.2
Arnaout, A.3
Kahn, H.4
Hanna, W.5
Narod, S.6
-
37
-
-
0031048236
-
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
-
Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF, et al. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med 1997;3:231-4.
-
(1997)
Nat Med
, vol.3
, pp. 231-234
-
-
Loda, M.1
Cukor, B.2
Tam, S.W.3
Lavin, P.4
Fiorentino, M.5
Draetta, G.F.6
-
38
-
-
0036559462
-
Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice
-
Philipp-Staheli J, Kim KH, Payne SR, Gurley KE, Liggitt D, Longton G, et al. Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice. Cancer Cell 2002;1:355-68.
-
(2002)
Cancer Cell
, vol.1
, pp. 355-368
-
-
Philipp-Staheli, J.1
Kim, K.H.2
Payne, S.R.3
Gurley, K.E.4
Liggitt, D.5
Longton, G.6
-
39
-
-
33846600427
-
PTENdeficient intestinal stem cells initiate intestinal polyposis
-
He X C, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, et al. PTENdeficient intestinal stem cells initiate intestinal polyposis. Nat Genet 2007;39:189-98.
-
(2007)
Nat Genet
, vol.39
, pp. 189-198
-
-
He, X.C.1
Yin, T.2
Grindley, J.C.3
Tian, Q.4
Sato, T.5
Tao, W.A.6
-
40
-
-
20244364236
-
Wnt signalling induces maturation of Paneth cells in intestinal crypts
-
van Es J H, Jay P, Gregorieff A, van Gijn ME, Jonkheer S, Hatzis P, et al. Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol 2005;7:381-6.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 381-386
-
-
Van Es, J.H.1
Jay, P.2
Gregorieff, A.3
Van Gijn, M.E.4
Jonkheer, S.5
Hatzis, P.6
-
41
-
-
0026713875
-
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15
-
Gu Y, Rosenblatt J, Morgan DO. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.EMBOJ 1992;11:3995-4005.
-
(1992)
EMBOJ
, vol.11
, pp. 3995-4005
-
-
Gu, Y.1
Rosenblatt, J.2
Morgan, D.O.3
-
42
-
-
0034682818
-
Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability
-
Ishida N, Kitagawa M, Hatakeyama S, Nakayama K. Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability. J Biol Chem 2000;275:25146-54.
-
(2000)
J Biol Chem
, vol.275
, pp. 25146-25154
-
-
Ishida, N.1
Kitagawa, M.2
Hatakeyama, S.3
Nakayama, K.4
|