Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer

Biochemical and Biophysical Research Communications

Volumn 315, Issue 1, 2004, Pages 93-99

  Kim, Sang Pyo ^a   Park, Jong Wook ^a   Lee, Sung Hee ^a   Lim, Jun Hee ^a   Jang, Byeong Churl ^a   Lee, Sang Han ^b   Jang, In Hwan ^c   Freund, Jean Noel ^d   Suh, Seong Il ^a   Mun, Kyo Cheol ^a   Song, Dae Kyu ^a   Ha, Eun Mi ^c   Lee, Won Jae ^c   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Ewha Womans University   (South Korea)

^d INSERM   (France)

Author keywords

Carcinogenesis; CDX2; Colorectal cancer; COX 2; Expression

Indexed keywords

CYCLOOXYGENASE 2; HOMEODOMAIN PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR CDX2; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; COLORECTAL CANCER; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; TUMOR SUPPRESSOR GENE; UPREGULATION;

EID: 10744228075     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.01.020     Document Type: Article

References (32)

1. Silberg D.G., Swain G.P., Suh E.R., Traber P.G. Cdx1 and cdx2 expression during intestinal development. Gastroenterology. 119:2000;961-971.
2. Chawengsaksophak K., James R., Hammond V.E., Kontgen F., Beck F. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature. 386:1997;84-87.
3. Tamai Y., Nakajima R., Ishikawa T., Takaku K., Seldin M.F., Taketo M.M. Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice. Cancer Res. 59:1999;2965-2970.
4. Ee H.C., Erler T., Bhathal P.S., Young G.P., James R.J. Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma. Am. J. Pathol. 147:1995;586-592.
5. Mallo G.V., Rechreche H., Frigerio J.M., Rocha D., Zweibaum A., Lacasa M., Jordan B.R., Dusetti N.J., Dagorn J.C., Iovanna J.L. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int. J. Cancer. 74:1997;35-44.
6. Suh E., Traber P.G. An intestine-specific homeobox gene regulates proliferation and differentiation. Mol. Cell. Biol. 16:1996;619-625.
7. Mallo G.V., Soubeyran P., Lissitzky J.C., Andre F., Farnarier C., Marvaldi J., Dagorn J.C., Iovanna J.L. Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. J. Biol. Chem. 273:1998;14030-14036.
8. Lorentz O., Cadoret A., Duluc I., Capeau J., Gespach C., Cherqui G., Freund J.N. Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras. Oncogene. 18:1999;87-92.
9. Smith W.L., Marnett L.J. Prostaglandin endoperoxide synthase: structure and catalysis. Biochim. Biophys. Acta. 1083:1991;1-17.
10. Jones D.A., Carlton D.P., McIntyre T.M.P., Zimmerman G.A., Prescott S.M. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J. Biol. Chem. 268:1993;9049-9054.
11. DuBois R.N., Tsujii M., Bishop P., Awad J.A., Makita K., Lanahan A. Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells. Am. J. Physiol. 266:1994;G822-G827.
12. Hla T., Neilson K. Human cyclooxygenase-2 cDNA. Proc. Natl. Acad. Sci. USA. 89:1992;7384-7388.
13. Sano H., Kawahito Y., Wilder R.L., Hashiramoto A., Mukai S., Asai K., Kimura S., Kato H., Kondo M., Hla T. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res. 55:1995;3785-3789.
14. Dimberg J., Samuelsson A., Hugander A., Soderkvist P. Differential expression of cyclooxygenase 2 in human colorectal cancer. Gut. 45:1999;730-732.
15. Eberhart C.E., Coffey R.J., Radhika A., Giardiello F.M., Ferrenbach S., DuBois R.N. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology. 107:1994;1183-1188.
16. Inoue H., Yokoyama C., Hara S., Tone Y., Tanabe T. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element. J. Biol. Chem. 270:1995;24965-24971.
17. Cheng G., Baltimore D. TANK, a co-inducer with TRAF2 of TNF- and CD40L-mediated NF-κB activation. Genes Dev. 10:1996;963-973.
18. Fujita T., Nolan G.P., Ghosh S., Baltimore D. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB. Genes Dev. 6:1992;775-787.
19. Giroux M., Descoteaux A. Cyclooxygenase-2 expression in macrophages: modulation by protein kinase C-alpha. J. Immunol. 165:2000;3985-3991.
20. Jobin C., Panja A., Hellerbrand C., Limuro Y., Didonato J., Brenner D.A., Sartor R.B. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kB super-repressor in human intestinal epithelial cells. J. Immunol. 160:1998;410-418.
21. Hinoi T., Tani M., Lucas P.C., Caca K., Dunn R.L., Macri E., Loda M., Appelman H.D., Cho K.R., Fearon E.R. Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon. Am. J. Pathol. 159:2001;2239-2248.
22. Bai Y.Q., Yamamoto H., Akiyama Y., Tanaka H., Takizawa T., Koike M., Kenji Y.O., Saitoh K., Takeshita K., Iwai T., Yuasa Y. Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett. 176:2002;47-55.
23. Eda A., Osawa H., Yanaka I., Satoh K., Mutoh H., Kihira K., Sugano K. Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. J. Gastroenterol. 37:2002;94-100.
24. Almeida R., Silva E., Santos-Silva F., Silberg D.G., Wang J., De Bolos C., David L. Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J. Pathol. 199:2003;36-40.
25. Williams C.S., Mann M., DuBois R.N. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene. 18:1999;7908-7916.
26. Tsujii M., DuBois R.N. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 83:1995;493-501.
27. Tsujii M., Kawano S., Tsuji S., Sawaoka H., Hori M., DuBois R.N. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell. 93:1998;705-716.
28. Lukiw W.J., Pelaez R.P., Martinez J., Bazan N.G. Budesonide epimer R or dexamethasone selectively inhibit platelet-activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes. Proc. Natl. Acad. Sci. USA. 95:1998;3914-3919.
29. Kim Y., Fischer S.M. Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/enhancer-binding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissues. J. Biol. Chem. 273:1998;27686-27694.
30. Xie W., Herschman H.R. Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum. J. Biol. Chem. 271:1996;31742-31748.
31. Guan Z., Buckman S.Y., Pentland A.P., Templeton D.J., Morrison A.R. Induction of cyclooxygenase-2 by the activated MEKK1. → SEK1/MKK4 → p38 mitogen-activated protein kinase pathway J. Biol. Chem. 273:1998;12901- 12908.
32. Adderley S.R., Fitzgerald D.J. Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2. J. Biol. Chem. 274:1999;5038-5046.