TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 34, 2010, Pages 15157-15162

  Verzi, Michael P ^a,b   Hatzis, Pantelis ^c   Sulahian, Rita ^a,b   Philips, Juliet ^a   Schuijers, Jurian ^c   Shin, Hyunjin ^a   Freed, Ellen ^a   Lynch, John P ^d   Dang, Duyen T ^e   Brown, Myles ^a,b   Clevers, Hans ^c   Liu, X Shirley ^a   Shivdasani, Ramesh A ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HUBRECHT INSTITUTE   (Netherlands)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Context specificity of signaling; Genome wide chromatin immunoprecipitation; Signaling; Tissue specific gene regulation; Wnt signaling in intestine

Indexed keywords

CIS ACTING ELEMENT; DNA; MYC PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR TCF4; UNCLASSIFIED DRUG; WNT PROTEIN; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; CDX2 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; MESSENGER RNA; RNA; TCF4 PROTEIN, HUMAN;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CANCER RISK; CHROMATIN IMMUNOPRECIPITATION; COLON; COLORECTAL CANCER; CONTROLLED STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM; INTESTINE FUNCTION; MAMMAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESTRICTION SITE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; UBIQUITINATION; BINDING SITE; CELL STRAIN CACO 2; COLON TUMOR; GENETIC COMPLEMENTATION; GENETICS; INTESTINE; METABOLISM; MOLECULAR GENETICS; REGULATORY SEQUENCE;

MAMMALIA;

BASE SEQUENCE; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BINDING SITES; CACO-2 CELLS; COLONIC NEOPLASMS; GENETIC COMPLEMENTATION TEST; HOMEODOMAIN PROTEINS; HUMANS; INTESTINES; MOLECULAR SEQUENCE DATA; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; RNA, NEOPLASM; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; WNT PROTEINS;

EID: 77956988273     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003822107     Document Type: Article

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