Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells

Gastroenterology

Volumn 142, Issue 4, 2012, Pages

  Hinkel, Isabelle ^a,b   Duluc, Isabelle ^a,b   Martin, Elisabeth ^a,b   Guenot, Dominique ^b,c   Freund, Jeannoel ^a,b   Gross, Isabelle ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c EA4438   (France)

Author keywords

cdhr5; Colorectal Cancer; CRC; Tumor Suppressor

Indexed keywords

BETA CATENIN; CADHERIN; PROTOCADHERIN MUCIN AND CADHERIN LIKE; TRANSCRIPTION FACTOR CDX2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER INHIBITION; CARCINOGENESIS; CELL ASSAY; CELL DIFFERENTIATION; CELL PROLIFERATION; COLON CANCER; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE TARGETING; GENETIC TRANSCRIPTION; HOMEOSTASIS; HUMAN; HUMAN CELL; INTESTINE CELL; INTESTINE EPITHELIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION;

EID: 84859439016     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.12.037     Document Type: Article

References (47)

1. C. Crosnier, D. Stamataki, J. Lewis Organizing cell renewal in the intestine: stem cells, signals and combinatorial control Nat Rev Genet 7 2006 349 359
2. S.D. Markowitz, D.M. Dawson, J. Willis Focus on colon cancer Cancer Cell 1 2002 233 236
3. A. Jemal, R. Siegel, E. Ward Cancer statistics, 2006 CA Cancer J Clin 56 2006 106 130
4. W. de Lau, N. Barker, H. Clevers WNT signaling in the normal intestine and colorectal cancer Front Biosci 12 2007 471 491
5. S.L. Lai, A.J. Chien, R.T. Moon Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis Cell Res 19 2009 532 545
6. C. Subtil, E. Guerin, A. Schneider Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability Cancer Lett 247 2007 197 203
7. F. Beck, E.J. Stringer The role of Cdx genes in the gut and in axial development Biochem Soc Trans 38 2010 353 357
8. R.J. Guo, E.R. Suh, J.P. Lynch The role of Cdx proteins in intestinal development and cancer Cancer Biol Ther 3 2004 593 601
9. N. Gao, P. White, K.H. Kaestner Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2 Dev Cell 16 2009 588 599
10. N. Gao, K.H. Kaestner Cdx2 regulates endo-lysosomal function and epithelial cell polarity Genes Dev 24 2010 1295 1305
11. M.P. Verzi, H. Shin, L.L. Ho Essential and redundant functions of Caudal family proteins in activating adult intestinal genes Mol Cell Biol 31 2011 2026 2039
12. +/- compound mutant mice Nat Genet 35 2003 323 330
13. C. Bonhomme, I. Duluc, E. Martin The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development Gut 52 2003 1465 1471
14. I. Gross, I. Duluc, T. Benameur The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells Oncogene 27 2008 107 115
15. O. Lorentz, I. Duluc, A.D. Arcangelis Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation J Cell Biol 139 1997 1553 1565
16. E. Suh, P.G. Traber An intestine-specific homeobox gene regulates proliferation and differentiation Mol Cell Biol 16 1996 619 625
17. M.S. Keller, T. Ezaki, R.J. Guo Cdx1 or Cdx2 expression activates E-cadherin-mediated cell-cell adhesion and compaction in human COLO 205 cells Am J Physiol Gastrointest Liver Physiol 287 2004 G104 G114
18. G.V. Mallo, P. Soubeyran, J.C. Lissitzky Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells J Biol Chem 273 1998 14030 14036
19. M. Goldberg, C. Peshkovsky, A. Shifteh mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains J Biol Chem 275 2000 24622 24629
20. M. Goldberg, M. Wei, B. Tycko Identification and expression analysis of the human μ-protocadherin gene in fetal and adult kidneys Am J Physiol Renal Physiol 283 2002 F454 F463
21. D.E. Moulton, W. Crandall, R. Lakhani Expression of a novel cadherin in the mouse and human intestine Pediatr Res 55 2004 927 934
22. F. Benahmed, I. Gross, D. Guenot The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells Am J Pathol 170 2007 733 744
23. F. Beck, K. Chawengsaksophak, P. Waring Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice Proc Natl Acad Sci U S A 96 1999 7318 7323
24. S. Colnot, M. Niwa-Kawakita, G. Hamard Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers Lab Invest 84 2004 1619 1630
25. A. Kikuchi Regulation of beta-catenin signaling in the Wnt pathway Biochem Biophys Res Commun 268 2000 243 248
26. O. Soderberg, K.J. Leuchowius, M. Gullberg Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay Methods 45 2008 227 232
27. -/- colon carcinoma Science 275 1997 1784 1787
28. T. Hinoi, P.C. Lucas, R. Kuick CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia Gastroenterology 123 2002 1565 1577
29. E. Ruoslahti, J.C. Reed Anchorage dependence, integrins, and apoptosis Cell 77 1994 477 478
30. S. Parenti, F. Ferrarini, R. Zini Mesalazine inhibits the β-catenin signalling pathway acting through the up-regulation of μ-protocadherin gene in colo-rectal cancer cells Aliment Pharmacol Ther 31 2010 108 119
31. L. Losi, S. Parenti, F. Ferrarini Down-regulation of μ-protocadherin expression is a common event in colorectal carcinogenesis Hum Pathol 42 2011 960 971
32. F. Benahmed, I. Gross, S.J. Gaunt Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene Gastroenterology 135 2008 1238 1247 e13
33. T. Ezaki, R.J. Guo, H. Li The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing β- and p120-catenin tyrosine phosphorylation Am J Physiol Gastrointest Liver Physiol 293 2007 G54 G65
34. R.J. Guo, E. Huang, T. Ezaki Cdx1 inhibits human colon cancer cell proliferation by reducing β-catenin/T-cell factor transcriptional activity J Biol Chem 279 2004 36865 36875
35. B.M. Kim, J. Mao, M.M. Taketo Phases of canonical Wnt signaling during the development of mouse intestinal epithelium Gastroenterology 133 2007 529 538
36. T. Brabletz, S. Spaderna, J. Kolb Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression Cancer Res 64 2004 6973 6977
37. T. Brabletz, A. Jung, S. Spaderna Opinion: migrating cancer stem cells: an integrated concept of malignant tumour progression Nat Rev Cancer 5 2005 744 749
38. I. Chantret, A. Rodolosse, A. Barbat Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: evidence for glucose-dependent negative regulation J Cell Sci 107 1994 213 225
39. -/- colon carcinoma Science 275 1997 1784 1787
40. F.T. Kolligs, G. Hu, C.V. Dang Neoplastic transformation of RK3E by mutant β-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression Mol Cell Biol 19 1999 5696 5706
41. K. Le Brigand, R. Russell, C. Moreilhon An open-access long oligonucleotide microarray resource for analysis of the human and mouse transcriptomes Nucleic Acids Res 34 2006 e87
42. I. Gross, B. Lhermitte, C. Domon-Dell Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation Oncogene 24 2005 7955 7963
43. J.F. Launay, A. Jellali, M.T. Vanier Glyceraldehyde-3-phosphate dehydrogenase is a microtubule binding protein in a human colon tumor cell line Biochim Biophys Acta 996 1989 103 109
44. I. Gross, I. Duluc, T. Benameur The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells Oncogene 27 2008 107 115
45. S. Colnot, M. Niwa-Kawakita, G. Hamard Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers Lab Invest 84 2004 1619 1630
46. F. Beck, K. Chawengsaksophak, P. Waring Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice Proc Natl Acad Sci U S A 96 1999 7318 7323
47. C. Bonhomme, I. Duluc, E. Martin The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development Gut 52 2003 1465 1471