-
1
-
-
0027537949
-
Retinitis pigmentosa: The Friedenwald lecture
-
Berson EL. Retinitis pigmentosa: The Friedenwald lecture. Invest Ophthal Vis Sci1993;34(5):1659-1676.
-
(1993)
Invest Ophthal Vis Sci
, vol.34
, Issue.5
, pp. 1659-1676
-
-
Berson, E.L.1
-
3
-
-
0035162582
-
Prevalence of mutations causing retinitis pigmentosa and other inherited retinopathies
-
Sohocki MM, Daiger SP, Bowne SJ, et al. Prevalence of mutations causing retinitis pigmentosa and other inherited retinopathies. Hum Mutat2001;17(1):42-51.
-
(2001)
Hum Mutat
, vol.17
, Issue.1
, pp. 42-51
-
-
Sohocki, M.M.1
Daiger, S.P.2
Bowne, S.J.3
-
4
-
-
20844442295
-
Adeno-associated virus-vectored gene therapy for retinal disease
-
Dinculescu A, Glushakova L, Min SH, Hauswirth WW. Adeno-associated virus-vectored gene therapy for retinal disease. Hum Gene Ther2005;16(6):649-663.
-
(2005)
Hum
, vol.16
, Issue.6
, pp. 649-663
-
-
Dinculescu, A.1
Glushakova, L.2
Min, S.H.3
Hauswirth, W.W.4
-
5
-
-
0038335879
-
Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy
-
Schlichtenbrede FC, da Cruz L, Stephens C, et al. Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy. J Gene Med2003;5(9):757-764.
-
(2003)
J Gene Med
, vol.5
, Issue.9
, pp. 757-764
-
-
Schlichtenbrede, F.C.1
Da Cruz, L.2
Stephens, C.3
-
6
-
-
44249120315
-
Effect of gene therapy on visual function in Leber’s congenital amaurosis
-
Bainbridge JW, Smith AJ, Barker SS, et al. Effect of gene therapy on visual function in Leber’s congenital amaurosis. N Engl J Med2008;358(21):2231-2239.
-
(2008)
N Engl J
, vol.358
, Issue.21
, pp. 2231-2239
-
-
Bainbridge, J.W.1
Smith, A.J.2
Barker, S.S.3
-
7
-
-
53449092841
-
Photoreceptor layer topography in children with Leber congenital amaurosis caused by RPE65 mutations
-
Jacobson SG, Cideciyan AV, Aleman TS, et al. Photoreceptor layer topography in children with Leber congenital amaurosis caused by RPE65 mutations. Invest Ophthalmol Vis Sci2008;49(10):4573-4577.
-
(2008)
Invest Ophthalmol Vis Sci
, vol.49
, Issue.10
, pp. 4573-4577
-
-
Jacobson, S.G.1
Cideciyan, A.V.2
Aleman, T.S.3
-
8
-
-
44249085878
-
Safety and efficacy of gene transfer for Leber’s congenital amaurosis
-
Maguire AM, Simonelli F, Pierce EA, et al. Safety and efficacy of gene transfer for Leber’s congenital amaurosis. N Engl J Med2008;358(21):2240-2248.
-
(2008)
N Engl J Med
, vol.358
, Issue.21
, pp. 2240-2248
-
-
Maguire, A.M.1
Simonelli, F.2
Pierce, E.A.3
-
9
-
-
84873453664
-
Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement
-
Cideciyan AV, Jacobson SG, Beltran WA, et al. Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement. Proc Natl Acad Sci U S A2013;110(6):E517-525.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.6
, pp. E517-E525
-
-
Cideciyan, A.V.1
Jacobson, S.G.2
Beltran, W.A.3
-
10
-
-
84875454136
-
Retinal gene therapy coming of age
-
Cepko CL, Vandenberghe LH. Retinal gene therapy coming of age. Hum Gene Ther2013;24(3):242-244.
-
(2013)
Hum Gene Ther
, vol.24
, Issue.3
, pp. 242-244
-
-
Cepko, C.L.1
Vandenberghe, L.H.2
-
11
-
-
0028939390
-
Mutation spectrum of the gene encoding the b subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa
-
McLaughlin ME, Ehrhart TL, Berson EL, Dryja TP. Mutation spectrum of the gene encoding the b subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa. Proc Nat Acad Sci U S A1995;92:3249-3253.
-
(1995)
Proc Nat Acad Sci U S A
, vol.92
, pp. 3249-3253
-
-
McLaughlin, M.E.1
Ehrhart, T.L.2
Berson, E.L.3
Dryja, T.P.4
-
12
-
-
0029035306
-
Retinal photoreceptor dystrophies: The LI. Edward Jackson Memorial Lecture
-
Bird AC. Retinal photoreceptor dystrophies: the LI. Edward Jackson Memorial Lecture. Am J Ophthalmol1995;119:543-562.
-
(1995)
Am J Ophthalmol
, vol.119
, pp. 543-562
-
-
Bird, A.C.1
-
13
-
-
33846957381
-
Perspective on genes and mutations causing retinitis pigmentosa
-
Daiger SP, Bowne SJ, Sullivan LS. Perspective on genes and mutations causing retinitis pigmentosa. Arch Ophthalmol2007;125(2):151-158.
-
(2007)
Arch Ophthalmol
, vol.125
, Issue.2
, pp. 151-158
-
-
Daiger, S.P.1
Bowne, S.J.2
Sullivan, L.S.3
-
14
-
-
43049087002
-
Circulating tumor cells in peripheral blood samples from patients with increased serum prostate specific antigen: Initial results in early prostate cancer
-
discussion 2191
-
Davis JW, Nakanishi H, Kumar VS, et al. Circulating tumor cells in peripheral blood samples from patients with increased serum prostate specific antigen: initial results in early prostate cancer. J Urol2008;179(6):2187-2191; discussion 2191.
-
(2008)
J Urol
, vol.179
, Issue.6
, pp. 2187-2191
-
-
Davis, J.W.1
Nakanishi, H.2
Kumar, V.S.3
-
15
-
-
54449099289
-
A novel mutation and phenotypes in phosphodiesterase 6 deficiency
-
Tsang SH, Tsui I, Chou CL, et al. A novel mutation and phenotypes in phosphodiesterase 6 deficiency. Am J Ophthalmol2008;146(5):780-788.
-
(2008)
Am J Ophthalmol
, vol.146
, Issue.5
, pp. 780-788
-
-
Tsang, S.H.1
Tsui, I.2
Chou, C.L.3
-
16
-
-
39849089658
-
Modulation of phosphodiesterase6 turnoff during background illumination in mouse rod photoreceptors
-
Woodruff ML, Janisch KM, Peshenko IV, Dizhoor AM, Tsang SH, Fain GL. Modulation of phosphodiesterase6 turnoff during background illumination in mouse rod photoreceptors. J Neurosci2008;28(9):2064-2074.
-
(2008)
J Neurosci
, vol.28
, Issue.9
, pp. 2064-2074
-
-
Woodruff, M.L.1
Janisch, K.M.2
Peshenko, I.V.3
Dizhoor, A.M.4
Tsang, S.H.5
Fain, G.L.6
-
17
-
-
70450278740
-
Light-dependent phosphorylation of the gamma subunit of cGMP-phophodiesterase (PDE6gamma) at residue threonine 22 in intact photoreceptor neurons
-
Janisch KM, Kasanuki JM, Naumann MC, et al. Light-dependent phosphorylation of the gamma subunit of cGMP-phophodiesterase (PDE6gamma) at residue threonine 22 in intact photoreceptor neurons. Biochem Biophys Res Commun2009;390(4):1149-1153.
-
(2009)
Biochem Biophys Res Commun
, vol.390
, Issue.4
, pp. 1149-1153
-
-
Janisch, K.M.1
Kasanuki, J.M.2
Naumann, M.C.3
-
18
-
-
84865593219
-
Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors
-
Yang J, Naumann MC, Tsai YT, et al. Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors. PLoS One2012;7(8):e43889. doi:10.1371/journal.pone.0043889.
-
(2012)
Plos One
, vol.7
, Issue.8
-
-
Yang, J.1
Naumann, M.C.2
Tsai, Y.T.3
-
19
-
-
84862225379
-
Mice with a D190N mutation in the gene encoding rhodopsin: A model for human autosomal-dominant retinitis pigmentosa
-
Sancho-Pelluz J, Tosi J, Hsu CW, et al. Mice with a D190N mutation in the gene encoding rhodopsin: a model for human autosomal-dominant retinitis pigmentosa. Mol Med2012;18(1):549-555.
-
(2012)
Mol Med
, vol.18
, Issue.1
, pp. 549-555
-
-
Sancho-Pelluz, J.1
Tosi, J.2
Hsu, C.W.3
-
20
-
-
79551610546
-
ShRNA knockdown of guanylate cyclase 2e or cyclic nucleotide
-
Tosi J, Davis RJ, Wang NK, Naumann M, Lin CS, Tsang SH. shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa. J Cell Mol Med2011;15(8):1778-1787.
-
(2011)
J Cell
, vol.15
, Issue.8
, pp. 1778-1787
-
-
Tosi, J.1
Davis, R.J.2
Wang, N.K.3
Naumann, M.4
Lin, C.S.5
Tsang, S.H.6
-
21
-
-
80053439882
-
Lentivirus-mediated expression of cDNA and shRNA slows degeneration in retinitis pigmentosa
-
Tosi J, Sancho-Pelluz J, Davis RJ, et al. Lentivirus-mediated expression of cDNA and shRNA slows degeneration in retinitis pigmentosa. Exp Biol Med (Maywood)2011; 236(10):1211-1217.
-
(2011)
Exp Biol Med (Maywood)
, vol.236
, Issue.10
, pp. 1211-1217
-
-
Tosi, J.1
Sancho-Pelluz, J.2
Davis, R.J.3
-
22
-
-
84872369306
-
Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa
-
Wert KJ, Davis RJ, Sancho-Pelluz J, Nishina PM, Tsang SH. Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa. Hum Mol Genet2013;22(3):558-567.
-
(2013)
Hum Mol Genet
, vol.22
, Issue.3
, pp. 558-567
-
-
Wert, K.J.1
Davis, R.J.2
Sancho-Pelluz, J.3
Nishina, P.M.4
Tsang, S.H.5
-
23
-
-
0000087516
-
The inheritance of a retinal abnormality in white mice
-
Keeler CE. The inheritance of a retinal abnormality in white mice. Proc Natl Acad Sci U S A1924;10:329-333.
-
(1924)
Proc Natl Acad Sci U S A
, vol.10
, pp. 329-333
-
-
Keeler, C.E.1
-
24
-
-
0013893075
-
Retinal degeneration in the mouse is rodless retina
-
Keeler C. Retinal degeneration in the mouse is rodless retina. J Hered1966;57:47-50.
-
(1966)
J Hered
, vol.57
, pp. 47-50
-
-
Keeler, C.1
-
25
-
-
54449092672
-
Molecular physiology and pathology of the retina
-
Tasman W, Jaeger EA, eds, Philadelphia: Lippincott, chap 2
-
Tsang SH, Gouras P. Molecular physiology and pathology of the retina. In: Tasman W, Jaeger EA, eds. Duane’s Clinical Ophthalmology. Vol 3. Philadelphia: Lippincott; 1996:chap 2.
-
(1996)
Duane’s Clinical
, vol.3
-
-
Tsang, S.H.1
Gouras, P.2
-
26
-
-
0032475826
-
Role for the target enzyme in deactivation of photoreceptor G protein in vivo
-
Tsang SH, Burns ME, Calvert PD, et al. Role for the target enzyme in deactivation of photoreceptor G protein in vivo. Science1998;282(5386):117-121.
-
(1998)
Science
, vol.282
, Issue.5386
, pp. 117-121
-
-
Tsang, S.H.1
Burns, M.E.2
Calvert, P.D.3
-
27
-
-
33847656947
-
Removal of phosphorylation sites of gamma subunit of phosphodiesterase 6 alters rod light response
-
Tsang SH, Woodruff ML, Janisch KM, Cilluffo MC, Farber DB, Fain GL. Removal of phosphorylation sites of gamma subunit of phosphodiesterase 6 alters rod light response. J Physiol2007;579(Pt 2):303-312.
-
(2007)
J Physiol
, vol.579
, pp. 303-312
-
-
Tsang, S.H.1
Woodruff, M.L.2
Janisch, K.M.3
Cilluffo, M.C.4
Farber, D.B.5
Fain, G.L.6
-
28
-
-
85043223062
-
Toward repair of retinal degenerations with differentiated and embryonic stem (ES) cells
-
Tsang S, Salchow D, Jiang M, et al. Toward repair of retinal degenerations with differentiated and embryonic stem (ES) cells. Am J Hum Genet2001;69:A2836.
-
(2001)
Am J Hum Genet
, vol.69
-
-
Tsang, S.1
Salchow, D.2
Jiang, M.3
-
29
-
-
0036183704
-
The positive role of the carboxyl terminus of the gamma subunit of retinal cGMP-phosphodiesterase in maintaining phosphodiesterase activity in vivo
-
Tsang SH, Yamashita CK, Lee WH, et al. The positive role of the carboxyl terminus of the gamma subunit of retinal cGMP-phosphodiesterase in maintaining phosphodiesterase activity in vivo. Vision Res2002;42(4):439-445.
-
(2002)
Vision Res
, vol.42
, Issue.4
, pp. 439-445
-
-
Tsang, S.H.1
Yamashita, C.K.2
Lee, W.H.3
-
30
-
-
0035138836
-
Adaptation in vertebrate photoreceptors.
-
Fain GL, Matthews HR, Cornwall MC, Koutalos Y. Adaptation in vertebrate photoreceptors. Physiol Rev 2001;81(1):117-151.
-
(2001)
Physiol Rev
, vol.81
, Issue.1
, pp. 117-151
-
-
Fain, G.L.1
Matthews, H.R.2
Cornwall, M.C.3
Koutalos, Y.4
-
31
-
-
0025822625
-
Visual excitation and recovery
-
Stryer L. Visual excitation and recovery. J Biol Chem1991;266:10711-10714.
-
(1991)
J Biol Chem
, vol.266
, pp. 10711-10714
-
-
Stryer, L.1
-
32
-
-
0028332848
-
Transduction mechanisms of vertebrate and invertebrate photoreceptors
-
May , 20
-
Yarfitz S, Hurley JB. Transduction mechanisms of vertebrate and invertebrate photoreceptors. J Biol Chem1994;269(May 20):14329-14332.
-
(1994)
J Biol Chem
, vol.269
, pp. 14329-14332
-
-
Yarfitz, S.1
Hurley, J.B.2
-
33
-
-
0034917522
-
Activation, deactivation, and adaptation in vertebrate photoreceptor cells
-
Burns ME, Baylor DA. Activation, deactivation, and adaptation in vertebrate photoreceptor cells. Annu Rev Neurosci2001;24:779-805.
-
(2001)
Annu Rev Neurosci
, vol.24
, pp. 779-805
-
-
Burns, M.E.1
Baylor, D.A.2
-
34
-
-
27644548928
-
Beyond counting photons: Trials and trends in vertebrate visual transduction
-
Burns ME, Arshavsky VY. Beyond counting photons: trials and trends in vertebrate visual transduction. Neuron2005;48(3):387-401.
-
(2005)
Neuron
, vol.48
, Issue.3
, pp. 401
-
-
Burns, M.E.1
Arshavsky, V.Y.2
-
35
-
-
0000519923
-
Flow of information in the light-triggered cyclic nucleotide cascade of vision
-
Fung BK-K, Hurley JB, Stryer L. Flow of information in the light-triggered cyclic nucleotide cascade of vision. Proc Natl Acad Sci U S A1981;78:152-156.
-
(1981)
Proc Natl Acad
, vol.78
, pp. 152-156
-
-
Fung, B.-K.1
Hurley, J.B.2
Stryer, L.3
-
37
-
-
29044433945
-
CGMP signaling in vertebrate retinal photoreceptor cells
-
Zhang X, Cote RH. cGMP signaling in vertebrate retinal photoreceptor cells. Front Biosci 2005;10:1191-1204.
-
(2005)
Front Biosci
, vol.10
, pp. 1191-1204
-
-
Zhang, X.1
Cote, R.H.2
-
40
-
-
16844363748
-
Asymmetric interaction between rod cyclic GMP phosphodiesterase gamma subunits and alpha/beta subunits
-
Guo LW, Grant JE, Hajipour AR, et al. Asymmetric interaction between rod cyclic GMP phosphodiesterase gamma subunits and alpha/beta subunits. J Biol Chem2005;280(13):12585-12592.
-
(2005)
J Biol Chem
, vol.280
, Issue.13
, pp. 12585-12592
-
-
Guo, L.W.1
Grant, J.E.2
Hajipour, A.R.3
-
41
-
-
33744964886
-
The inhibitory gamma subunit of the rod cGMP phosphodiesterase binds the catalytic subunits in an extended linear structure
-
Guo LW, Muradov H, Hajipour AR, Sievert MK, Artemyev NO, Ruoho AE. The inhibitory gamma subunit of the rod cGMP phosphodiesterase binds the catalytic subunits in an extended linear structure. J Biol Chem2006;281(22):15412-15422.
-
(2006)
J Biol Chem
, vol.281
, Issue.22
, pp. 15412-15422
-
-
Guo, L.W.1
Muradov, H.2
Hajipour, A.R.3
Sievert, M.K.4
Artemyev, N.O.5
Ruoho, A.E.6
-
42
-
-
0017081995
-
Enzyme basis for cyclic GMP accumulation in degenerative photoreceptor cells of mouse retina
-
Farber DB, Lolley RN. Enzyme basis for cyclic GMP accumulation in degenerative photoreceptor cells of mouse retina. J Cyclic Nucleotide Res1976;2:139-148.
-
(1976)
J Cyclic
, vol.2
, pp. 139-148
-
-
Farber, D.B.1
Lolley, R.N.2
-
43
-
-
0028890926
-
From mice to men: The cyclic GMP phosphodiesterase gene in vision and disease. The Proctor Lecture
-
Feb
-
Farber DB. From mice to men: the cyclic GMP phosphodiesterase gene in vision and disease. The Proctor Lecture. InvestOpthalmol Vis Sci1995;36(Feb):263-275.
-
(1995)
Invest
, vol.36
, pp. 263-275
-
-
Farber, D.B.1
-
44
-
-
33644876008
-
Effect of gene expression on cone survival in retinitis pigmentosa
-
Cepko CL. Effect of gene expression on cone survival in retinitis pigmentosa. Retina2005;25(8 Suppl):S21-S24.
-
(2005)
Retina
, vol.25
, Issue.8
, pp. S21-S24
-
-
Cepko, C.L.1
-
45
-
-
0028220321
-
The rd mouse story: Seventy years of research on an animal model of inherited retinal degeneration
-
Farber DB, Flannery JG, Bowes-Rickman C. The rd mouse story: seventy years of research on an animal model of inherited retinal degeneration. Prog Retinal Res1994;13:31-64.
-
(1994)
Prog Retinal Res
, vol.13
, pp. 31-64
-
-
Farber, D.B.1
Flannery, J.G.2
Bowes-Rickman, C.3
-
46
-
-
4744338189
-
Multidestructive pathways triggered in photoreceptor cell death of the rd mouse as determined through gene expression profiling
-
Rohrer B, Pinto FR, Hulse KE, Lohr HR, Zhang L, Almeida JS. Multidestructive pathways triggered in photoreceptor cell death of the rd mouse as determined through gene expression profiling. J Biol Chem2004;279(40):41903-41910.
-
(2004)
J Biol Chem
, vol.279
, Issue.40
, pp. 41903-41910
-
-
Rohrer, B.1
Pinto, F.R.2
Hulse, K.E.3
Lohr, H.R.4
Zhang, L.5
Almeida, J.S.6
-
47
-
-
33744913540
-
Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death
-
Lohr HR, Kuntchithapautham K, Sharma AK, Rohrer B. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Exp Eye Res2006;83(2):380-389.
-
(2006)
Exp Eye Res
, vol.83
, Issue.2
, pp. 380-389
-
-
Lohr, H.R.1
Kuntchithapautham, K.2
Sharma, A.K.3
Rohrer, B.4
-
48
-
-
9144222598
-
Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse
-
Takano Y, Ohguro H, Dezawa M, et al. Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse. Biochem Biophys Res Commun2004;313(4):1015-1022.
-
(2004)
Biochem Biophys Res Commun
, vol.313
, Issue.4
, pp. 1015-1022
-
-
Takano, Y.1
Ohguro, H.2
Dezawa, M.3
-
49
-
-
0016295763
-
Cyclic guanosine monophosphate: Elevations in degenerating photoreceptor cells of the C3H mouse retina
-
Farber DB, Lolley RN. Cyclic guanosine monophosphate: elevations in degenerating photoreceptor cells of the C3H mouse retina. Science1974;186:449-451.
-
(1974)
Science
, vol.186
, pp. 449-451
-
-
Farber, D.B.1
Lolley, R.N.2
-
50
-
-
27244441667
-
Genotype-phenotype correlation of mouse pde6b mutations
-
Hart AW, McKie L, Morgan JE, et al. Genotype-phenotype correlation of mouse pde6b mutations. Invest Ophthalmol Vis Sci2005;46(9):3443-3450.
-
(2005)
Invest Ophthalmol Vis Sci
, vol.46
, Issue.9
, pp. 3443-3450
-
-
Hart, A.W.1
McKie, L.2
Morgan, J.E.3
-
51
-
-
56149099510
-
Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q)
-
Davis R, Tosi J, Janisch K, et al. Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q). Invest Ophthalmol Vis Sci2008;49(11):5067-5076.
-
(2008)
Invest Ophthalmol Vis Sci
, vol.49
, Issue.11
, pp. 5067-5076
-
-
Davis, R.1
Tosi, J.2
Janisch, K.3
-
52
-
-
33846018863
-
CNTF+BDNF treatment and neuroprotective pathways in the rd1 mouse retina
-
Azadi S, Johnson LE, Paquet-Durand F, et al. CNTF+BDNF treatment and neuroprotective pathways in the rd1 mouse retina. Brain Res2007;1129(1):116-129.
-
(2007)
Brain Res
, vol.1129
, Issue.1
, pp. 116-129
-
-
Azadi, S.1
Johnson, L.E.2
Paquet-Durand, F.3
-
53
-
-
33646013922
-
Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse
-
Jomary C, Cullen J, Jones SE. Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse. Invest Ophthalmol Vis Sci2006;47(4):1620-1629.
-
(2006)
Invest Ophthalmol Vis Sci
, vol.47
, Issue.4
, pp. 1620-1629
-
-
Jomary, C.1
Cullen, J.2
Jones, S.E.3
-
54
-
-
18844370917
-
Differential Akt activation in the photoreceptors of normal and rd1 mice
-
Johnson LE, van Veen T, Ekstrom PA. Differential Akt activation in the photoreceptors of normal and rd1 mice. Cell Tissue Res2005;320(2):213-222.
-
(2005)
Cell Tissue Res
, vol.320
, Issue.2
, pp. 213-222
-
-
Johnson, L.E.1
Van Veen, T.2
Ekstrom, P.A.3
-
55
-
-
33644678324
-
Differential modification of phosducin protein in degenerating rd1 retina is associated with constitutively active Ca2+/calmodulin kinase II in rod outer segments
-
Hauck SM, Ekstrom PA, Ahuja-Jensen P, et al. Differential modification of phosducin protein in degenerating rd1 retina is associated with constitutively active Ca2+/calmodulin kinase II in rod outer segments. Mol Cell Proteomics2006;5(2):324-336.
-
(2006)
Mol Cell Proteomics
, vol.5
, Issue.2
, pp. 324-336
-
-
Hauck, S.M.1
Ekstrom, P.A.2
Ahuja-Jensen, P.3
-
57
-
-
33846254038
-
Comparison of kinome profiles of Barrett’s esophagus with normal squamous esophagus and normal gastric cardia
-
van Baal JW, Diks SH, Wanders RJ, et al. Comparison of kinome profiles of Barrett’s esophagus with normal squamous esophagus and normal gastric cardia. Cancer Res2006;66(24):11605-11612.
-
(2006)
Cancer Res
, vol.66
, Issue.24
, pp. 11605-11612
-
-
Van Baal, J.W.1
Diks, S.H.2
Wanders, R.J.3
-
58
-
-
10344223002
-
Kinome profiling for studying lipopolysaccharide signal transduction in human peripheral blood mononuclear cells
-
Diks SH, Kok K, O’Toole T, et al. Kinome profiling for studying lipopolysaccharide signal transduction in human peripheral blood mononuclear cells. J Biol Chem2004;279(47):49206-49213.
-
(2004)
J Biol Chem
, vol.279
, Issue.47
, pp. 49206-49213
-
-
Diks, S.H.1
Kok, K.2
O’Toole, T.3
-
59
-
-
84881500484
-
Therapeutic margins in a novel preclinical model of retinitis pigmentosa
-
Davis RJ, Hsu CW, Tsai YT, et al. Therapeutic margins in a novel preclinical model of retinitis pigmentosa. J Neurosci2013;33(33):13475-13483.
-
(2013)
J Neurosci
, vol.33
, Issue.33
, pp. 13475-13483
-
-
Davis, R.J.1
Hsu, C.W.2
Tsai, Y.T.3
-
60
-
-
65349106533
-
Cellular and molecular origin of circumpapillary dysgenesis of the pigment epithelium
-
Tosi J, Janisch KM, Wang NK, et al. Cellular and molecular origin of circumpapillary dysgenesis of the pigment epithelium. Ophthalmology2009;116(5):971-980.
-
(2009)
Ophthalmology
, vol.116
, Issue.5
, pp. 971-980
-
-
Tosi, J.1
Janisch, K.M.2
Wang, N.K.3
-
61
-
-
79551610546
-
ShRNA knockdown of guanylate cyclase 2e or cyclic nucleotide
-
Tosi J, Davis RJ, Wang NK, Naumann M, Lin CS, Tsang SH. shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa. J Cell Mol Med2011;15(8):1778-1887.
-
(2011)
J Cell
, vol.15
, Issue.8
, pp. 1778-1887
-
-
Tosi, J.1
Davis, R.J.2
Wang, N.K.3
Naumann, M.4
Lin, C.S.5
Tsang, S.H.6
-
62
-
-
33646843031
-
GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase
-
Tsang SH, Woodruff ML, Chen CK, et al. GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase. J Neurosci2006;26(17):4472-4480.
-
(2006)
J Neurosci
, vol.26
, Issue.17
, pp. 4472-4480
-
-
Tsang, S.H.1
Woodruff, M.L.2
Chen, C.K.3
-
63
-
-
79960745154
-
Function of the asparagine 74 residue of the inhibitory gamma-subunit of retinal rod cGMP-phophodiesterase (PDE) in vivo
-
Tsang SH, Woodruff ML, Hsu CW, et al. Function of the asparagine 74 residue of the inhibitory gamma-subunit of retinal rod cGMP-phophodiesterase (PDE) in vivo. Cell Signal2011;23(10):1584-1589.
-
(2011)
Cell Signal
, vol.23
, Issue.10
, pp. 1584-1589
-
-
Tsang, S.H.1
Woodruff, M.L.2
Hsu, C.W.3
-
64
-
-
33847176595
-
Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindness
-
Tsang SH, Woodruff ML, Jun L, et al. Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindness. Hum Mutat2007;28(3):243-254.
-
(2007)
Hum Mutat
, vol.28
, Issue.3
, pp. 254
-
-
Tsang, S.H.1
Woodruff, M.L.2
Jun, L.3
-
65
-
-
80755132261
-
Effect of the ILE86TER mutation in the gamma subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling
-
Tsang SH, Woodruff ML, Lin CS, et al. Effect of the ILE86TER mutation in the gamma subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling. Cell Signal2012;24(1):181-188.
-
(2012)
Cell Signal
, vol.24
, Issue.1
, pp. 181-188
-
-
Tsang, S.H.1
Woodruff, M.L.2
Lin, C.S.3
-
66
-
-
84898826569
-
Mid-stage intervention achieves similar efficacy as conventional early-stage treatment using gene therapy in a pre-clinical model of retinitis pigmentosa
-
Wert KJ, Sancho-Pelluz J, Tsang SH. Mid-stage intervention achieves similar efficacy as conventional early-stage treatment using gene therapy in a pre-clinical model of retinitis pigmentosa. Hum Mol Genet2014;23(2):514-523.
-
(2014)
Hum Mol Genet
, vol.23
, Issue.2
, pp. 514-523
-
-
Wert, K.J.1
Sancho-Pelluz, J.2
Tsang, S.H.3
-
67
-
-
0017645989
-
Cyclic GMP accumulation causes degeneration of photoreceptor cells: Simulation of an inherited disease
-
Lolley R, Farber D, Rayborn M, Hollyfield J. Cyclic GMP accumulation causes degeneration of photoreceptor cells: simulation of an inherited disease. Science1977;196:664-666.
-
(1977)
Science
, vol.196
, pp. 664-666
-
-
Lolley, R.1
Farber, D.2
Rayborn, M.3
Hollyfield, J.4
-
68
-
-
84873938366
-
Subretinal injection of gene therapy vectors and stem cells in the
-
Nov 25
-
Wert KJ, Skeie JM, Davis RJ, Tsang SH, Mahajan VB. Subretinal injection of gene therapy vectors and stem cells in the perinatal mouse eye. J Vis Exp 2012 Nov 25;(69).
-
(2012)
J Vis Exp
, Issue.69
-
-
Wert, K.J.1
Skeie, J.M.2
Davis, R.J.3
Tsang, S.H.4
Mahajan, V.B.5
-
69
-
-
80755132261
-
Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling
-
Tsang S, Woodruff M, Lin C, et al. Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling. Cell Signal2012;24(1):181-188.
-
(2012)
Cell Signal
, vol.24
, Issue.1
, pp. 181-188
-
-
Tsang, S.1
Woodruff, M.2
Lin, C.3
-
70
-
-
70450278740
-
Light-dependent phosphorylation of the gamma subunit of cGMP-phosphodiesterase (PDE6gamma) at residue threonine 22 in intact photoreceptor neurons
-
Janisch KM, Kasanuki JM, Naumann MC, et al. Light-dependent phosphorylation of the gamma subunit of cGMP-phosphodiesterase (PDE6gamma) at residue threonine 22 in intact photoreceptor neurons. Biochem Biophys Res Commun2009;390(4):1149-1153.
-
(2009)
Biochem Biophys Res Commun
, vol.390
, Issue.4
, pp. 1149-1153
-
-
Janisch, K.M.1
Kasanuki, J.M.2
Naumann, M.C.3
-
71
-
-
39849089658
-
Modulation of phosphodiesterase6 turnoff during background illumination in mouse rod photoreceptors
-
Woodruff ML, Janisch KM, Peshenko IV, Dizhoor AM, Tsang SH, Fain GL. Modulation of phosphodiesterase6 turnoff during background illumination in mouse rod photoreceptors. J Neurosci2008;28(9):2064-2074.
-
(2008)
J Neurosci
, vol.28
, Issue.9
, pp. 2064-2074
-
-
Woodruff, M.L.1
Janisch, K.M.2
Peshenko, I.V.3
Dizhoor, A.M.4
Tsang, S.H.5
Fain, G.L.6
-
72
-
-
78049531174
-
Rapid and noninvasive imaging of retinal ganglion cells in live mouse models of glaucoma
-
Tosi J, Wang NK, Zhao J, et al. Rapid and noninvasive imaging of retinal ganglion cells in live mouse models of glaucoma. Mol Imaging Biol2010;12(4):386-393.
-
(2010)
Mol
, vol.12
, Issue.4
, pp. 386-393
-
-
Tosi, J.1
Wang, N.K.2
Zhao, J.3
-
73
-
-
77951268630
-
Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa
-
Wang NK, Tosi J, Kasanuki JM, et al. Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa. Transplantation2010;89(8):911-919.
-
(2010)
Transplantation
, vol.89
, Issue.8
, pp. 911-919
-
-
Wang, N.K.1
Tosi, J.2
Kasanuki, J.M.3
-
74
-
-
83455195460
-
Mouse eye enucleation for remote high-throughput phenotyping
-
Nov 19
-
Mahajan VB, Skeie JM, Assefnia AH, Mahajan M, Tsang SH. Mouse eye enucleation for remote high-throughput phenotyping. J Vis Exp2011 Nov 19;(57).
-
(2011)
J Vis Exp
, Issue.57
-
-
Mahajan, V.B.1
Skeie, J.M.2
Assefnia, A.H.3
Mahajan, M.4
Tsang, S.H.5
-
75
-
-
33745098277
-
Tuberin negatively affects BCL-2’s cell survival function
-
Freilinger A, Rosner M, Hengstschlager M. Tuberin negatively affects BCL-2’s cell survival function. Amino Acids2006;30(4):391-396.
-
(2006)
Amino Acids
, vol.30
, Issue.4
, pp. 391-396
-
-
Freilinger, A.1
Rosner, M.2
Hengstschlager, M.3
-
76
-
-
33846475008
-
Akt regulates nuclear/cytoplasmic localization of tuberin
-
Rosner M, Freilinger A, Hengstschlager M. Akt regulates nuclear/cytoplasmic localization of tuberin. Oncogene2007;26(4):521-531.
-
(2007)
Oncogene
, vol.26
, Issue.4
, pp. 531
-
-
Rosner, M.1
Freilinger, A.2
Hengstschlager, M.3
-
77
-
-
27944446526
-
Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis
-
Kolb TM, Duan L, Davis MA. Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis. Toxicol Sci2005;88(2):331-339.
-
(2005)
Toxicol Sci
, vol.88
, Issue.2
, pp. 331-339
-
-
Kolb, T.M.1
Duan, L.2
Davis, M.A.3
-
78
-
-
58149141478
-
Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa
-
Punzo C, Kornacker K, Cepko CL. Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat Neurosci2009;12(1):44-52.
-
(2009)
Nat Neurosci
, vol.12
, Issue.1
, pp. 44-52
-
-
Punzo, C.1
Kornacker, K.2
Cepko, C.L.3
-
79
-
-
24944464482
-
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
-
Ruvinsky I, Sharon N, Lerer T, et al. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev2005;19(18):2199-2211.
-
(2005)
Genes Dev
, vol.19
, Issue.18
, pp. 2199-2211
-
-
Ruvinsky, I.1
Sharon, N.2
Lerer, T.3
-
80
-
-
0032590225
-
Light, Ca2+, and photoreceptor death: New evidence for the equivalent- light hypothesis from arrestin
-
Fain GL, Lisman JE. Light, Ca2+, and photoreceptor death: new evidence for the equivalent- light hypothesis from arrestin knockout mice. Invest Ophthalmol Vis Sci1999;40(12):2770-2772.
-
(1999)
Invest Ophthalmol Vis Sci
, vol.40
, Issue.12
, pp. 2770-2772
-
-
Fain, G.L.1
Lisman, J.E.2
-
81
-
-
85043214943
-
Apoptotic photoreceptor death in gene targeted mutant mice and its deceleration by gene therapy
-
Oct
-
Tsang SH, Chen J, Yamashita CK, et al. Apoptotic photoreceptor death in gene targeted mutant mice and its deceleration by gene therapy. Am J Hum Genet1996;59(Oct):A54.
-
(1996)
Am J Hum Genet
, vol.59
-
-
Tsang, S.H.1
Chen, J.2
Yamashita, C.K.3
-
82
-
-
78650510609
-
MTOR: From growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011;12(1):21-35.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, Issue.1
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
84
-
-
79958696336
-
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
-
Yu Y, Yoon SO, Poulogiannis G, et al. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science2011;332(6035):1322-1326.
-
(2011)
Science
, vol.332
, Issue.6035
, pp. 1322-1326
-
-
Yu, Y.1
Yoon, S.O.2
Poulogiannis, G.3
-
85
-
-
79960349522
-
MTOR kinase domain phosphorylation promotes
-
Ekim B, Magnuson B, Acosta-Jaquez HA, Keller JA, Feener EP, Fingar DC. mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression. Mol Cell Biol2011;31(14):2787-2801.
-
(2011)
Mol Cell Biol
, vol.31
, Issue.14
, pp. 2787-2801
-
-
Ekim, B.1
Magnuson, B.2
Acosta-Jaquez, H.A.3
Keller, J.A.4
Feener, E.P.5
Fingar, D.C.6
-
86
-
-
0041920901
-
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
-
Brugarolas JB, Vazquez F, Reddy A, Sellers WR, Kaelin WG Jr. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell2003;4(2):147-158.
-
(2003)
Cancer Cell
, vol.4
, Issue.2
, pp. 147-158
-
-
Brugarolas, J.B.1
Vazquez, F.2
Reddy, A.3
Sellers, W.R.4
Kaelin, W.G.5
|