Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q)

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 11, 2008, Pages 5067-5076

  Davis, Richard J ^a   Tosi, Joaquin ^a   Janisch, Kerstin M ^a   Kasanuki, J Mie ^a   Wang, Nan Kai ^a   Kong, Jian ^a,b   Tsui, Ilene ^c   Cilluffo, Marianne ^d   Woodruff, Michael L ^d,e   Fain, Gordon L ^d,e   Lin, Chyuan Sheng ^a   Tsang, Stephen H ^a  

^a Columbia University ^*  (United States)

^b New York Presbyterian Hospital   (United States)

^c WELLESLEY COLLEGE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e JULES STEIN EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CYCLIC GMP; LENTIVIRUS VECTOR; OPSIN; PHOSPHODIESTERASE VI; CALCIUM; DNA; PDE6B PROTEIN, MOUSE; PHOSPHODIESTERASE 6;

ALLELE; ANIMAL MODEL; ARTICLE; ASSAY; BIRTH; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DEATH; ELECTRORETINOGRAM; ENZYME ACTIVITY; GENE THERAPY; GENETIC TRANSDUCTION; HISTOCHEMISTRY; HOMOZYGOSITY; IMMUNOBLOTTING; LENTIVIRINAE; LIGHT DARK CYCLE; MOUSE; NONHUMAN; PHENOTYPE; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA ROD; ANIMAL; C3H MOUSE; C57BL MOUSE; CELL DEATH; CELL LINE; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; DBA MOUSE; ELECTRON MICROSCOPY; ELECTRORETINOGRAPHY; GENE EXPRESSION; GENETICS; HOMOZYGOTE; INTRACELLULAR FLUID; METABOLISM; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; RETINA DEGENERATION; RETINA ROD OUTER SEGMENT; SIGNAL TRANSDUCTION; ULTRASTRUCTURE; WESTERN BLOTTING;

ALLELES; ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL DEATH; CELL LINE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ELECTRORETINOGRAPHY; GENE EXPRESSION; HOMOZYGOTE; INTRACELLULAR FLUID; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MUTATION; RETINAL DEGENERATION; ROD OUTER SEGMENTS; SIGNAL TRANSDUCTION;

EID: 56149099510     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-1422     Document Type: Article

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