Reduction of hRNase H2 activity in Aicardi-Goutières syndrome cells leads to replication stress and genome instability

Human Molecular Genetics

Volumn 24, Issue 3, 2015, Pages 649-658

  Pizzi, Sara ^a   Sertic, Sarah ^a   Orcesi, Simona ^b   Cereda, Cristina ^b   Bianchi, Marika ^b   Jackson, Andrew P ^c   Lazzaro, Federico ^a   Plevani, Paolo ^a   Muzi Falconi, Marco ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; GENOMIC DNA; RIBONUCLEASE H; RIBONUCLEASE H2; UNCLASSIFIED DRUG; DNA; RIBONUCLEASE HII; RIBONUCLEOTIDE;

AICARDI GOUTIERES SYNDROME; ARTICLE; CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DIVISION; CELL PROLIFERATION; CELL STRESS; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; MITOSIS; PHENOTYPE; POSTREPLICATION REPAIR; PRIORITY JOURNAL; RNA INTERFERENCE; CELL LINE; CHEMISTRY; DNA REPAIR; DNA REPLICATION; GENE SILENCING; GENETICS; HELA CELL LINE; METABOLISM; NERVOUS SYSTEM MALFORMATION; NEUROLOGIC DISEASE; PATHOLOGY;

AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; CELL LINE; CELL PROLIFERATION; DNA; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; GENE KNOCKDOWN TECHNIQUES; GENOMIC INSTABILITY; HELA CELLS; HUMANS; NERVOUS SYSTEM MALFORMATIONS; RIBONUCLEASE H; RIBONUCLEOTIDES;

EID: 84922470690     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu485     Document Type: Article

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