The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi- Goutières syndrome defects

Journal of Biological Chemistry

Volumn 286, Issue 12, 2011, Pages 10540-10550

  Figiel, Małgorzata ^a   Chon, Hyongi ^b   Cerritelli, Susana M ^b   Cybulska, Magdalena ^a   Crouch, Robert J ^b   Nowotny, Marcin ^a  

^a INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE DISORDER; BIOCHEMICAL CHARACTERIZATION; CATALYTIC SUBUNITS; GENOMIC INSTABILITY; MOLECULAR BASIS; MONOMERIC PROTEINS; MUTATIONAL ANALYSIS; PROTEIN STABILITY; RNA SEQUENCES; SUBSTRATE BINDING; SUBSTRATE COMPLEXES; SUBSTRATE RECOGNITION; SUBSTRATE SPECIFICITY; THERMOTOGA MARITIMA; TYROSINE RESIDUES;

AMINO ACIDS; BACTERIOLOGY; CRYSTAL STRUCTURE; DNA; DNA SEQUENCES; NUCLEIC ACIDS; PROTEINS; RNA;

SUBSTRATES;

DNA; MAGNESIUM ION; RIBONUCLEASE; RIBONUCLEASE H2; RNA; UNCLASSIFIED DRUG;

AICARDI GOUTIERES SYNDROME; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA RNA HYBRIDIZATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME STRUCTURE; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; THERMOTOGA MARITIMA;

ANIMALS; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; BACTERIAL PROTEINS; HUMANS; MAGNESIUM; MICE; MODELS, MOLECULAR; MUTATION; NERVOUS SYSTEM MALFORMATIONS; NUCLEIC ACID HETERODUPLEXES; PROTEIN STRUCTURE, QUATERNARY; RIBONUCLEASE H; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY; THERMOTOGA MARITIMA;

BACTERIA (MICROORGANISMS); EUKARYOTA; THERMOTOGA MARITIMA;

EID: 79953170528     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.181974     Document Type: Article

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