RNase H2-Initiated Ribonucleotide Excision Repair

Molecular Cell

Volumn 47, Issue 6, 2012, Pages 980-986

  Sparks, Justin L ^a   Chon, Hyongi ^b   Cerritelli, Susana M ^b   Kunkel, Thomas A ^c   Johansson, Erik ^d   Crouch, Robert J ^b   Burgers, Peter M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DNA POLYMERASE; FLAP ENDONUCLEASE; OKAZAKI FRAGMENT; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RIBONUCLEASE H; RIBONUCLEASE H2; RIBONUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA NICK TRANSLATION; DNA REPLICATION; ENZYME ACTIVE SITE; EXCISION REPAIR; NONHUMAN; RADIOACTIVITY; RIBONUCLEOTIDE EXCISION REPAIR; SACCHAROMYCES CEREVISIAE;

ACETYLTRANSFERASES; DNA LIGASES; DNA POLYMERASE II; DNA POLYMERASE III; DNA REPAIR; DNA-BINDING PROTEINS; EXODEOXYRIBONUCLEASES; MEMBRANE PROTEINS; PROLIFERATING CELL NUCLEAR ANTIGEN; RIBONUCLEASE H; RIBONUCLEOTIDES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 84866851215     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.06.035     Document Type: Article

References (34)

1. Bubeck D., Reijns M.A., Graham S.C., Astell K.R., Jones E.Y., Jackson A.P. PCNA directs type 2 RNase H activity on DNA replication and repair substrates. Nucleic Acids Res. 2011, 39:3652-3666.
2. Budd M.E., Tong A.H., Polaczek P., Peng X., Boone C., Campbell J.L. A network of multi-tasking proteins at the DNA replication fork preserves genome stability. PLoS Genet. 2005, 1:e61.
3. Burgers P.M. Polymerase dynamics at the eukaryotic DNA replication fork. J. Biol. Chem. 2009, 284:4041-4045.
4. Cerritelli S.M., Crouch R.J. Ribonuclease H: the enzymes in eukaryotes. FEBS J. 2009, 276:1494-1505.
5. Chon H., Vassilev A., DePamphilis M.L., Zhao Y., Zhang J., Burgers P.M., Crouch R.J., Cerritelli S.M. Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex. Nucleic Acids Res. 2009, 37:96-110.
6. Clark A.B., Lujan S.A., Kissling G.E., Kunkel T.A. Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ε. DNA Repair (Amst.) 2011, 10:476-482.
7. Crow Y.J., Leitch A., Hayward B.E., Garner A., Parmar R., Griffith E., Ali M., Semple C., Aicardi J., Babul-Hirji R., et al. Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection. Nat. Genet. 2006, 38:910-916.
8. Eder P.S., Walder J.A. Ribonuclease H from K562 human erythroleukemia cells. Purification, characterization, and substrate specificity. J. Biol. Chem. 1991, 266:6472-6479.
9. Fiorentini P., Huang K.N., Tishkoff D.X., Kolodner R.D., Symington L.S. Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitro. Mol. Cell. Biol. 1997, 17:2764-2773.
10. Garg P., Stith C.M., Sabouri N., Johansson E., Burgers P.M. Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication. Genes Dev. 2004, 18:2764-2773.
11. Ghaemmaghami S., Huh W.K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Global analysis of protein expression in yeast. Nature 2003, 425:737-741.
12. Huertas P., Aguilera A. Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination. Mol. Cell 2003, 12:711-721.
13. Joyce C.M. Choosing the right sugar: how polymerases select a nucleotide substrate. Proc. Natl. Acad. Sci. USA 1997, 94:1619-1622.
14. Kim N., Huang S.N., Williams J.S., Li Y.C., Clark A.B., Cho J.E., Kunkel T.A., Pommier Y., Jinks-Robertson S. Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I. Science 2011, 332:1561-1564.
15. Lazzaro F., Novarina D., Amara F., Watt D.L., Stone J.E., Costanzo V., Burgers P.M., Kunkel T.A., Plevani P., Muzi-Falconi M. RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA. Mol. Cell 2012, 45:99-110.
16. Lee Y.D., Elledge S.J. Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1. Genes Dev. 2006, 20:334-344.
17. Li X., Li J., Harrington J., Lieber M.R., Burgers P.M. Lagging Strand DNA Synthesis at the Eukaryotic Replication Fork Involves Binding and Stimulation of FEN-1 by proliferating cell nuclear antigen. J. Biol. Chem. 1995, 270:22109-22112.
18. Matsumoto Y. Molecular mechanism of PCNA-dependent base excision repair. Prog. Nucleic Acid Res. Mol. Biol. 2001, 68:129-138.
19. Montecucco A., Rossi R., Levin D.S., Gary R., Park M.S., Motycka T.A., Ciarrocchi G., Villa A., Biamonti G., Tomkinson A.E. DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories. EMBO J. 1998, 17:3786-3795.
20. Nick McElhinny S.A., Kumar D., Clark A.B., Watt D.L., Watts B.E., Lundström E.B., Johansson E., Chabes A., Kunkel T.A. Genome instability due to ribonucleotide incorporation into DNA. Nat. Chem. Biol. 2010, 6:774-781.
21. Nick McElhinny S.A., Watts B.E., Kumar D., Watt D.L., Lundström E.B., Burgers P.M., Johansson E., Chabes A., Kunkel T.A. Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases. Proc. Natl. Acad. Sci. USA 2010, 107:4949-4954.
22. Pontarin G., Fijolek A., Pizzo P., Ferraro P., Rampazzo C., Pozzan T., Thelander L., Reichard P.A., Bianchi V. Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage. Proc. Natl. Acad. Sci. USA 2008, 105:17801-17806.
23. Powell R.D., Holland P.J., Hollis T., Perrino F.W. Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase. J. Biol. Chem. 2011, 286:43596-43600.
24. Reijns M.A., Rabe B., Rigby R.E., Mill P., Astell K.R., Lettice L.A., Boyle S., Leitch A., Keighren M., Kilanowski F., et al. Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. Cell 2012, 149:1008-1022.
25. Rychlik M.P., Chon H., Cerritelli S.M., Klimek P., Crouch R.J., Nowotny M. Crystal structures of RNase H2 in complex with nucleic acid reveal the mechanism of RNA-DNA junction recognition and cleavage. Mol. Cell 2010, 40:658-670.
26. Rydberg B., Game J. Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts. Proc. Natl. Acad. Sci. USA 2002, 99:16654-16659.
27. Sekiguchi J., Shuman S. Site-specific ribonuclease activity of eukaryotic DNA topoisomerase I. Mol. Cell 1997, 1:89-97.
28. Stetson D.B., Ko J.S., Heidmann T., Medzhitov R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 2008, 134:587-598.
29. Stith C.M., Sterling J., Resnick M.A., Gordenin D.A., Burgers P.M. Flexibility of eukaryotic Okazaki fragment maturation through regulated strand displacement synthesis. J. Biol. Chem. 2008, 283:34129-34140.
30. Tadokoro T., Kanaya S. Ribonuclease H: molecular diversities, substrate binding domains, and catalytic mechanism of the prokaryotic enzymes. FEBS J. 2009, 276:1482-1493.
31. Tran P.T., Erdeniz N., Dudley S., Liskay R.M. Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae. DNA Repair (Amst.) 2002, 1:895-912.
32. Vijayakumar S., Chapados B.R., Schmidt K.H., Kolodner R.D., Tainer J.A., Tomkinson A.E. The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase. Nucleic Acids Res. 2007, 35:1624-1637.
33. Watt D.L., Johansson E., Burgers P.M., Kunkel T.A. Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases. DNA Repair (Amst.) 2011, 10:897-902.
34. Williams J.S., Clausen A.R., Nick McElhinny S.A., Watts B.E., Johansson E., Kunkel T.A. Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase ε. DNA Repair (Amst.) 2012, in press.