Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Ren, Jian Guo ^a   Seth, Pankaj ^a   Clish, Clary B ^b   Lorkiewicz, Pawel K ^c,d   Higashi, Richard M ^c,d   Lane, Andrew N ^c,d   Fan, Teresa W M ^c,d   Sukhatme, Vikas P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c Center for Regulatory and Environmental Analytical Metabolomics   (United States)

^d UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MALATE DEHYDROGENASE; MALIC ACID DERIVATIVE; MALIC ENZYME 2; HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ADOLESCENT; ADULT; AGED; ANIMAL; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMISTRY; CHILD; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; FEMALE; GENETICS; HUMAN; LUNG NEOPLASMS; MALE; METABOLISM; MIDDLE AGED; NUDE MOUSE; PRESCHOOL CHILD; PROCEDURES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR CELL LINE; VERY ELDERLY; WESTERN BLOTTING; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; LUNG NEOPLASMS; MALATE DEHYDROGENASE; MALATES; MALE; MICE, NUDE; MIDDLE AGED; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS; YOUNG ADULT;

EID: 84903123419     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05414     Document Type: Article

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