Simultaneous steady-state and dynamic13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells

Journal of Biological Chemistry

Volumn 289, Issue 9, 2014, Pages 6212-6224

  Yang, Chendong ^a   Harrison, Crystal ^b   Jin, Eunsook S ^b   Chuang, David T ^c   Sherry, A Dean ^b   Malloy, Craig R ^b,f   Merritt, Matthew E ^b,c,e,g   DeBerardinis, Ralph J ^a,d,g  

^a Children's Medical Center   (United States)

^b Advanced Imaging Research Center   (United States)

^c Department of Biochemistry ^*  (United States)

^d McDermott Center for Human Growth and Development   (United States)

^e The University of Texas Southwestern Medical Center   (United States)

^f Veterans Affairs North Texas Healthcare System   (United States)

^g UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLATION; CELL CULTURE; CELL PROLIFERATION; CELLS; DISEASES; ISOMERS; ISOTOPES; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY;

ALTERNATIVE ROUTES; CANCER CELL GROWTH; DECARBOXYLATION REACTIONS; HYPERPOLARIZATION; ISOTOPOMER ANALYSIS; PYRUVATE METABOLISM; RELATIVE ACTIVITIES; SELECTIVE EXCITATIONS;

METABOLISM;

LACTATE DEHYDROGENASE; LACTIC ACID; PROTEIN KINASE B; PYRUVATE DEHYDROGENASE; PYRUVIC ACID;

ARTICLE; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CARBOXYLATION; CELL METABOLISM; CELL TRANSPORT; CITRIC ACID CYCLE; CONTROLLED STUDY; DECARBOXYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; GLYCOLYSIS; METABOLIC RATE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; STEADY STATE; TRANSPORT KINETICS;

ANAPLEROSIS; CANCER; HYPERPOLARIZATION; IMAGING; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PYRUVATE;

CARBON ISOTOPES; CELL LINE, TUMOR; GLUCOSE; GLYCOLYSIS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; PYRUVIC ACID;

EID: 84896880417     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.543637     Document Type: Article

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