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Volumn 47, Issue 1, 2014, Pages 53-59

Hippo pathway in mammary gland development and breast cancer

Author keywords

breast cancer; Hippo pathway; mammary gland development; TAZ; YAP

Indexed keywords

HIPPO PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

EID: 84922434091     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmu114     Document Type: Review
Times cited : (56)

References (108)
  • 1
    • 0028902594 scopus 로고
    • The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for th e control of cell shape and proliferation
    • Justice RW, Zilian O, Woods DF, Noll M, Bryant PJ. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for th e control of cell shape and proliferation. Genes Dev 1995, 9: 534-546.
    • (1995) Genes Dev , vol.9 , pp. 534-546
    • Justice, R.W.1    Zilian, O.2    Woods, D.F.3    Noll, M.4    Bryant, P.J.5
  • 2
    • 0028929414 scopus 로고
    • Identifying tumor suppressors in genetic mosaics: The drosophila lats gene e ncodes a putative protein kinase
    • Xu T, Wang W, Zhang S, Stewart RA, Yu W. Identifying tumor suppressors in genetic mosaics: The Drosophila lats gene e ncodes a putative protein kinase. Development 1995, 121: 1053-1063.
    • (1995) Development , vol.121 , pp. 1053-1063
    • Xu, T.1    Wang, W.2    Zhang, S.3    Stewart, R.A.4    Yu, W.5
  • 3
    • 77957883342 scopus 로고    scopus 로고
    • The Hippo signaling pathway in development and cancer
    • Pan D. The Hippo signaling pathway in development and cancer. Dev Cell 2010, 19: 491-505.
    • (2010) Dev Cell , vol.19 , pp. 491-505
    • Pan, D.1
  • 4
    • 33748308721 scopus 로고    scopus 로고
    • Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
    • Callus BA Verhagen AM Vaux DL. Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation FEBS J 2006 273 4264-4276.
    • (2006) FEBS J , vol.273 , pp. 4264-4276
    • Callus, B.A.1    Verhagen, A.M.2    Vaux, D.L.3
  • 5
    • 40149111984 scopus 로고    scopus 로고
    • Mobkl1a/mobkl1b phosphorylation by mst1 and mst2 inhibits cell proliferation
    • Praskova M, Xia F, Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol 2008, 18: 311-321.
    • (2008) Curr Biol , vol.18 , pp. 311-321
    • Praskova, M.1    Xia, F.2    Avruch, J.3
  • 6
    • 0034702214 scopus 로고    scopus 로고
    • Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor
    • Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T. Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. Oncogene 2000, 19: 3101-3109.
    • (2000) Oncogene , vol.19 , pp. 3101-3109
    • Hori, T.1    Takaori-Kondo, A.2    Kamikubo, Y.3    Uchiyama, T.4
  • 8
    • 84894088287 scopus 로고    scopus 로고
    • The Hippo-YAP signaling pathway and contact inhibition of growth
    • Gumbiner BM, Kim NG. The Hippo-YAP signaling pathway and contact inhibition of growth. J Cell Sci 2014, 127: 709-717.
    • (2014) J Cell Sci , vol.127 , pp. 709-717
    • Gumbiner, B.M.1    Kim, N.G.2
  • 9
    • 35948961118 scopus 로고    scopus 로고
    • Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    • Zhao B,Wei X, LiW, Udan RS, Yang Q, Kim J, Xie J, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 2007, 21: 2747-2761.
    • (2007) Genes Dev , vol.21 , pp. 2747-2761
    • Zhao, B.1    Wei, X.2    Li, W.3    Udan, R.S.4    Yang, Q.5    Kim, J.6    Xie, J.7
  • 11
    • 84891345748 scopus 로고    scopus 로고
    • A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway
    • Mohseni M, Sun J, Lau A, Curtis S, Goldsmith J, Fox VL, Wei C, et al. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat Cell Biol 2014, 16: 108-117.
    • (2014) Nat Cell Biol , vol.16 , pp. 108-117
    • Mohseni, M.1    Sun, J.2    Lau, A.3    Curtis, S.4    Goldsmith, J.5    Fox, V.L.6    Wei, C.7
  • 12
    • 84865260845 scopus 로고    scopus 로고
    • Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
    • Yu FX, Zhao B, Panup inthu N, Jewell JL, Lian I, Wang LH, Zhao J, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 2012, 150: 780-791.
    • (2012) Cell , vol.150 , pp. 780-791
    • Yu, F.X.1    Zhao, B.2    Panupinthu, N.3    Jewell, J.L.4    Lian, I.5    Wang, L.H.6    Zhao, J.7
  • 13
    • 84873734231 scopus 로고    scopus 로고
    • Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositidedependent kinase-1
    • Fan R, Kim NG, Gumbi ner BM. Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositidedependent kinase-1. Proc Natl Acad Sci USA 2013, 110: 2569-2574.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 2569-2574
    • Fan, R.1    Kim, N.G.2    Gumbiner, B.M.3
  • 15
    • 34548636132 scopus 로고    scopus 로고
    • Elucidation of a universal size-control mechanism in Drosophila and mammals
    • Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford SA, Gayyed MF, et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 2007, 130: 1120-1133.
    • (2007) Cell , vol.130 , pp. 1120-1133
    • Dong, J.1    Feldmann, G.2    Huang, J.3    Wu, S.4    Zhang, N.5    Comerford, S.A.6    Gayyed, M.F.7
  • 16
    • 41949138130 scopus 로고    scopus 로고
    • Tumor suppressor lats1 is a negative regulator of oncogene yap
    • Hao Y, Chun A, Cheung K, Rashidi B, Yang X. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem 2008, 283: 5496-5509.
    • (2008) J Biol Chem , vol.283 , pp. 5496-5509
    • Hao, Y.1    Chun, A.2    Cheung, K.3    Rashidi, B.4    Yang, X.5
  • 17
    • 55549098921 scopus 로고    scopus 로고
    • Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP
    • Oka T , Mazack V, Sudol M. Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). J Biol Chem 2008, 283: 27534-27546.
    • (2008) J Biol Chem , vol.283 , pp. 27534-27546
    • Oka, T.1    Mazack, V.2    Sudol, M.3
  • 18
    • 41149098966 scopus 로고    scopus 로고
    • TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
    • Lei QY, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, et al. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol 2008, 28: 2426-2436.
    • (2008) Mol Cell Biol , vol.28 , pp. 2426-2436
    • Lei, Q.Y.1    Zhang, H.2    Zhao, B.3    Zha, Z.Y.4    Bai, F.5    Pei, X.H.6    Zhao, S.7
  • 19
    • 17744380191 scopus 로고    scopus 로고
    • TAZ: A novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins
    • Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, et al. TAZ: A novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. Embo J 2000, 19: 6778-6791.
    • (2000) Embo J , vol.19 , pp. 6778-6791
    • Kanai, F.1    Marignani, P.A.2    Sarbassova, D.3    Yagi, R.4    Hall, R.A.5    Donowitz, M.6    Hisaminato, A.7
  • 20
    • 60849138138 scopus 로고    scopus 로고
    • Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
    • Ota M, Sasaki H. Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development 2008, 135: 4059-4069.
    • (2008) Development , vol.135 , pp. 4059-4069
    • Ota, M.1    Sasaki, H.2
  • 21
    • 47549095853 scopus 로고    scopus 로고
    • Tead mediates yapdependent gene induction and growth control
    • Zhao B, Ye X, Yu J, Li L, Li W, Li S, Yu J, et al. TEAD mediates YAPdependent gene induction and growth control. Genes Dev 2008, 22: 1962-1971.
    • (2008) Genes Dev , vol.22 , pp. 1962-1971
    • Zhao, B.1    Ye, X.2    Yu, J.3    Li, L.4    Li, W.5    Li, S.6    Yu, J.7
  • 22
    • 67649412006 scopus 로고    scopus 로고
    • TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition
    • Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, et al. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem 2009, 284: 13355-13362.
    • (2009) J Biol Chem , vol.284 , pp. 13355-13362
    • Zhang, H.1    Liu, C.Y.2    Zha, Z.Y.3    Zhao, B.4    Yao, J.5    Zhao, S.6    Xiong, Y.7
  • 24
    • 0035805487 scopus 로고    scopus 로고
    • Physical interaction with Yes-associated protein en hances p73 transcriptional activity
    • Strano S, Munarriz E, Rossi M, Castagnoli L, Shaul Y, Sacchi A, Oren M, et al. Physical interaction with Yes-associated protein en hances p73 transcriptional activity. J Biol Chem 2001, 276: 15164-15173.
    • (2001) J Biol Chem , vol.276 , pp. 15164-15173
    • Strano, S.1    Munarriz, E.2    Rossi, M.3    Castagnoli, L.4    Shaul, Y.5    Sacchi, A.6    Oren, M.7
  • 25
    • 70350416086 scopus 로고    scopus 로고
    • Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray
    • Visser S, Yang X. Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray. Gene 2010, 449: 22-29.
    • (2010) Gene , vol.449 , pp. 22-29
    • Visser, S.1    Yang, X.2
  • 26
    • 84859583470 scopus 로고    scopus 로고
    • Integrating developmental signals: A Hippo in the (path)way
    • Mauviel A Nallet-Staub F Varelas X. Integrating developmental signals: A Hippo in the (path)way Oncogene 2012 31 1743-1756.
    • (2012) Oncogene , vol.31 , pp. 1743-1756
    • Mauviel, A.1    Nallet-Staub, F.2    Varelas, X.3
  • 27
    • 84899924908 scopus 로고    scopus 로고
    • The dual functions of YAP-1 to promote and inhibit cell growth in human malignancy
    • Wang H, Du YC, Zhou XJ, Liu H, Tang SC. The dual functions of YAP-1 to promote and inhibit cell growth in human malignancy. Cancer Metastasis Rev 2014, 33: 173-181.
    • (2014) Cancer Metastasis Rev , vol.33 , pp. 173-181
    • Wang, H.1    Du, Y.C.2    Zhou, X.J.3    Liu, H.4    Tang, S.C.5
  • 28
    • 0042733354 scopus 로고    scopus 로고
    • The drosophila mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
    • Harvey K F, Pfleger CM, Hariharan IK. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 2003, 114: 457-467.
    • (2003) Cell , vol.114 , pp. 457-467
    • Harvey, K.F.1    Pfleger, C.M.2    Hariharan, I.K.3
  • 29
    • 79960997489 scopus 로고    scopus 로고
    • The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
    • Zhao B, Tumaneng K, Guan KL. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol 2011, 13: 877-883.
    • (2011) Nat Cell Biol , vol.13 , pp. 877-883
    • Zhao, B.1    Tumaneng, K.2    Guan, K.L.3
  • 30
    • 78650724753 scopus 로고    scopus 로고
    • Hippo signaling: Growth control and beyond
    • Halder G, Johnson RL. Hippo signaling: Growth control and beyond. Development 2011, 138: 9-22.
    • (2011) Development , vol.138 , pp. 9-22
    • Halder, G.1    Johnson, R.L.2
  • 31
    • 69249117040 scopus 로고    scopus 로고
    • Hippo signaling pathway and organ size control
    • Zhang L, Yue T, Jiang J. Hippo signaling pathway and organ size control. Fly 2009, 3: 68-73.
    • (2009) Fly , vol.3 , pp. 68-73
    • Zhang, L.1    Yue, T.2    Jiang, J.3
  • 32
    • 76549124517 scopus 로고    scopus 로고
    • Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
    • Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, Wang Y, et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci USA 2010, 107 : 1437-1442.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 1437-1442
    • Lu, L.1    Li, Y.2    Kim, S.M.3    Bossuyt, W.4    Liu, P.5    Qiu, Q.6    Wang, Y.7
  • 34
    • 34247191134 scopus 로고    scopus 로고
    • Hippo signaling in organ size control
    • Pan D. Hippo signaling in organ size control. Genes Dev 2007, 21: 886-897.
    • (2007) Genes Dev , vol.21 , pp. 886-897
    • Pan, D.1
  • 36
    • 0141616617 scopus 로고    scopus 로고
    • Hippo promotes proliferation arrest and apoptosis in the salvador/warts pathway
    • Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol 2003, 5: 914-920.
    • (2003) Nat Cell Biol , vol.5 , pp. 914-920
    • Udan, R.S.1    Kango-Singh, M.2    Nolo, R.3    Tao, C.4    Halder, G.5
  • 37
    • 14844297327 scopus 로고    scopus 로고
    • Control of cell proliferation and apoptosis by mob as tumor suppressor, mats
    • Lai ZC,Wei X, Shimizu T, Ramos E, Rohrbaugh M, Nikolaidis N, Ho LL, et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 2005, 120: 675-685. 38.
    • (2005) Cell , vol.120 , pp. 675-685
    • Lai, Z.C.1    Wei, X.2    Shimizu, T.3    Ramos, E.4    Rohrbaugh, M.5    Nikolaidis, N.6    Ho, L.L.7
  • 38
    • 0042232429 scopus 로고    scopus 로고
    • Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    • Wu S, Huang J, Dong J, Pan D. Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 2003, 114: 445-45 6.
    • (2003) Cell , vol.114 , pp. 445-456
    • Wu, S.1    Huang, J.2    Dong, J.3    Pan, D.4
  • 39
    • 0141505119 scopus 로고    scopus 로고
    • The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
    • Pantalacci S, Tapon N, Leopold P. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol 2003, 5: 921-927.
    • (2003) Nat Cell Biol , vol.5 , pp. 921-927
    • Pantalacci, S.1    Tapon, N.2    Leopold, P.3
  • 40
    • 0142123293 scopus 로고    scopus 로고
    • The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis
    • Jia J, Zhang W , Wang B, Trinko R, Jiang J. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev 2003, 17: 2514-2519.
    • (2003) Genes Dev , vol.17 , pp. 2514-2519
    • Jia, J.1    Zhang, W.2    Wang, B.3    Trinko, R.4    Jiang, J.5
  • 44
    • 84862764408 scopus 로고    scopus 로고
    • The hippo signaling pathway and stem cell biology
    • Ramos A, Camargo FD. The Hippo signaling pathway and stem cell biology. Trends Cell Biol 2012, 22: 339-346.
    • (2012) Trends Cell Biol , vol.22 , pp. 339-346
    • Ramos, A.1    Camargo, F.D.2
  • 45
    • 78650187792 scopus 로고    scopus 로고
    • The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration
    • Shaw RL, Kohlmaier A, Polesello C, Veelken C, Edg ar BA, Tapon N. The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development 2010, 137: 4147-4158.
    • (2010) Development , vol.137 , pp. 4147-4158
    • Shaw, R.L.1    Kohlmaier, A.2    Polesello, C.3    Veelken, C.4    Edgar, B.A.5    Tapon, N.6
  • 46
    • 78650202455 scopus 로고    scopus 로고
    • TheHippo tumor suppressor pathway regulates intestinal stem cell regeneration
    • Karpowicz P, Perez J, PerrimonN . TheHippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development 2010, 137: 4135-4145.
    • (2010) Development , vol.137 , pp. 4135-4145
    • Karpowicz, P.1    Perez, J.2    Perrimon, N.3
  • 47
    • 77953040994 scopus 로고    scopus 로고
    • The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
    • Lian I Kim J Okazawa H Zhao J Zhao B Yu J Chinnaiyan A et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation Genes Dev 2010 24 1106-1118 .
    • (2010) Genes Dev , vol.24 , pp. 1106-1118
    • Lian, I.1    Kim, J.2    Okazawa, H.3    Zhao, J.4    Zhao, B.5    Yu, J.6    Chinnaiyan, A.7
  • 48
    • 79953149145 scopus 로고    scopus 로고
    • Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF
    • Tamm C, Bower N, Anneren C. Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF. J Cell Sci 2011, 124: 1136-1144.
    • (2011) J Cell Sci , vol.124 , pp. 1136-1144
    • Tamm, C.1    Bower, N.2    Anneren, C.3
  • 50
    • 84859235472 scopus 로고    scopus 로고
    • Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming
    • Qin H, Blaschke K, Wei G, Ohi Y, Blouin L, Qi Z, Yu J, et al. Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming. Hum Mol Genet 2012, 21: 2054-2067.
    • (2012) Hum Mol Genet , vol.21 , pp. 2054-2067
    • Qin, H.1    Blaschke, K.2    Wei, G.3    Ohi, Y.4    Blouin, L.5    Qi, Z.6    Yu, J.7
  • 51
    • 84862897996 scopus 로고    scopus 로고
    • The Hippo pathway regulates stem cell proliferation, self-renewal, and differentiation
    • Liu H, Jiang D, Chi F, Zhao B. The Hippo pathway regulates stem cell proliferation, self-renewal, and differentiation. Protein Cell 2012, 3: 291-304.
    • (2012) Protein Cell , vol.3 , pp. 291-304
    • Liu, H.1    Jiang, D.2    Chi, F.3    Zhao, B.4
  • 52
    • 81055140859 scopus 로고    scopus 로고
    • The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
    • Co rdenonsi M, Zanconato F, Azzolin L, ForcatoM, Rosato A, Frasson C, Inui M, et al. The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell 2011, 147: 759-772.
    • (2011) Cell , vol.147 , pp. 759-772
    • Cordenonsi, M.1    Zanconato, F.2    Azzolin, L.3    Forcato, M.4    Rosato, A.5    Frasson, C.6    Inui, M.7
  • 54
    • 84871425210 scopus 로고    scopus 로고
    • Bone metastatic process of breast cancer involves methylation state affecting E-cadherin expression through TAZ and WWOX nuclear effectors
    • Matteucci E, Maroni P, Luzzati A, Perrucchini G, Bendinelli P, Desiderio MA. Bone metastatic process of breast cancer involves methylation state affecting E-cadherin expression through TAZ and WWOX nuclear effectors. Eur J Cancer 2013, 49: 231-244.
    • (2013) Eur J Cancer , vol.49 , pp. 231-244
    • Matteucci, E.1    Maroni, P.2    Luzzati, A.3    Perrucchini, G.4    Bendinelli, P.5    Desiderio, M.A.6
  • 55
    • 84891748709 scopus 로고    scopus 로고
    • The two faces of Hippo: Targeting the Hippo pathway for regenerative medicine and cancer treatment
    • Johnson R, Halder G. The two faces of Hippo: Targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov 2014, 13: 63-79.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 63-79
    • Johnson, R.1    Halder, G.2
  • 56
    • 39849097306 scopus 로고    scopus 로고
    • The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals
    • Zeng Q, Hong W. The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals. Cancer Cell 2008, 13: 188-192.
    • (2008) Cancer Cell , vol.13 , pp. 188-192
    • Zeng, Q.1    Hong, W.2
  • 57
    • 84919930711 scopus 로고    scopus 로고
    • The role of the Hippo pathway in human disease and tumorigenesis
    • Barron DA, Kagey JD. The role of the Hippo pathway in human disease and tumorigenesis. Clin Transl Med 2014, 3: 25.
    • (2014) Clin Transl Med , vol.3 , pp. 25
    • Barron, D.A.1    Kagey, J.D.2
  • 58
    • 77951837150 scopus 로고    scopus 로고
    • The Hippo-YAP pathway in organ size control and tumorigenesis: An updated version
    • Zhao B, Li L, Lei Q, Guan KL. The Hippo-YAP pathway in organ size control and tumorigenesis: An updated version. Genes Dev 2010, 24: 862-874.
    • (2010) Genes Dev , vol.24 , pp. 862-874
    • Zhao, B.1    Li, L.2    Lei, Q.3    Guan, K.L.4
  • 60
    • 84901774050 scopus 로고    scopus 로고
    • The Hippo signaling pathway in stem cell biology and cancer
    • Mo JS, Park HW, Guan KL. The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep 2014, 15: 642-656.
    • (2014) EMBO Rep , vol.15 , pp. 642-656
    • Mo, J.S.1    Park, H.W.2    Guan, K.L.3
  • 62
    • 84922435279 scopus 로고    scopus 로고
    • An emerging role for Hip po-YAP signaling in cardiovascular development
    • Zhou J. An emerging role for Hip po-YAP signaling in cardiovascular development. J Biomed Res 2014, 28: 251-254.
    • (2014) J Biomed Res , vol.28 , pp. 251-254
    • Zhou, J.1
  • 63
    • 84906910084 scopus 로고    scopus 로고
    • BMP2-SMAD signaling represses the proliferat ion of embryonic neural stem cells through YAP
    • Yao M, Wang Y, Zhang P, Chen H, Xu Z, Jiao J, Yuan Z. BMP2-SMAD signaling represses the proliferat ion of embryonic neural stem cells through YAP. J Neurosci 2014, 34: 12039-12048.
    • (2014) J Neurosci , vol.34 , pp. 12039-12048
    • Yao, M.1    Wang, Y.2    Zhang, P.3    Chen, H.4    Xu, Z.5    Jiao, J.6    Yuan, Z.7
  • 64
    • 84896824055 scopus 로고    scopus 로고
    • A temporal requirement for Hippo sig naling in mammary gland differentiation, growth, and tumorigenesis
    • Chen Q, Zhang N, Gray RS, Li H, Ewald AJ, Zahnow CA, Pan D. A temporal requirement for Hippo sig naling in mammary gland differentiation, growth, and tumorigenesis. Genes Dev 2014, 28: 432-437.
    • (2014) Genes Dev , vol.28 , pp. 432-437
    • Chen, Q.1    Zhang, N.2    Gray, R.S.3    Li, H.4    Ewald, A.J.5    Zahnow, C.A.6    Pan, D.7
  • 66
    • 84897104535 scopus 로고    scopus 로고
    • The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment
    • Skibinski A, Breindel JL, Prat A, Galvan P, Smith E, Rolfs A, Gupta PB, et al. The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Cell Rep 2014, 6: 1059-1072.
    • (2014) Cell Rep , vol.6 , pp. 1059-1072
    • Skibinski, A.1    Breindel, J.L.2    Prat, A.3    Galvan, P.4    Smith, E.5    Rolfs, A.6    Gupta, P.B.7
  • 68
    • 84860485144 scopus 로고    scopus 로고
    • Yes-associated protein promotes tumour development in luminal epithelial derived breast cancer
    • Wang X Su L Ou Q. Yes-associated protein promotes tumour development in luminal epithelial derived breast cancer. Eur J Cancer 2012 48 1227-1234.
    • (2012) Eur J Cancer , vol.48 , pp. 1227-1234
    • Wang, X.1    Su, L.2    Ou, Q.3
  • 69
    • 84892702028 scopus 로고    scopus 로고
    • Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer
    • Vlug EJ, Van de Ven RA, Vermeulen JF, Bult P, Van Diest PJ, Derksen PW. Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer. Cell Oncol 2013, 36: 375-384.
    • (2013) Cell Oncol , vol.36 , pp. 375-384
    • Vlug, E.J.1    Van De Ven, R.A.2    Vermeulen, J.F.3    Bult, P.4    Van Diest, P.J.5    Derksen, P.W.6
  • 70
    • 84904356717 scopus 로고    scopus 로고
    • Yes-associated protein (YAP) is differentially expressed in tumor and stroma according to the molecular subtype of breast cancer
    • Kim SK, Ju ng WH, Koo JS. Yes-associated protein (YAP) is differentially expressed in tumor and stroma according to the molecular subtype of breast cancer. Int J Clin Exp Pathol 2014, 7: 3224-3234.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 3224-3234
    • Kim, S.K.1    Jung, W.H.2    Koo, J.S.3
  • 71
    • 84891940884 scopus 로고    scopus 로고
    • Interplay of mevalonate and Hippo pathways regulates RHAMMtranscription via YAP to modulate breast cancer cell motility
    • Wang Z, Wu Y, Wang H, Zhang Y, Mei L, Fang X, Zhang X, et al. Interplay of mevalonate and Hippo pathways regulates RHAMMtranscription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci USA 2014, 111: E89-E98.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 89-98
    • Wang, Z.1    Wu, Y.2    Wang, H.3    Zhang, Y.4    Mei, L.5    Fang, X.6    Zhang, X.7
  • 72
    • 84890916735 scopus 로고    scopus 로고
    • Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase
    • Serrano I, McDonald PC, Lock F, Muller WJ, Dedhar S. Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase. Nat Commun 2013, 4: 2976.
    • (2013) Nat Commun , vol.4 , pp. 2976
    • Serrano, I.1    McDonald, P.C.2    Lock, F.3    Muller, W.J.4    Dedhar, S.5
  • 74
    • 79959832245 scopus 로고    scopus 로고
    • The induction of KLF5 transcription factor by progesterone contributes to progesterone-induced breast cancer cell proliferation and dedifferentiation
    • Liu R, Zhou Z, Zhao D, Chen C. The induction of KLF5 transcription factor by progesterone contributes to progesterone-induced breast cancer cell proliferation and dedifferentiation. Mol Endocrinol 2011, 25: 1137-1144.
    • (2011) Mol Endocrinol , vol.25 , pp. 1137-1144
    • Liu, R.1    Zhou, Z.2    Zhao, D.3    Chen, C.4
  • 75
    • 84880311787 scopus 로고    scopus 로고
    • Role of KLF5 in hormonal signaling and breast cancer development
    • Liu R, Dong JT, Chen C. Role of KLF5 in hormonal signaling and breast cancer development. Vitam Horm 2013, 93: 213-225.
    • (2013) Vitam Horm , vol.93 , pp. 213-225
    • Liu, R.1    Dong, J.T.2    Chen, C.3
  • 76
    • 0037179848 scopus 로고    scopus 로고
    • A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer
    • Chen C, Bhalala HV, Qiao H, Dong JT. A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer. Oncogene 2002, 21: 6567-6572.
    • (2002) Oncogene , vol.21 , pp. 6567-6572
    • Chen, C.1    Bhalala, H.V.2    Qiao, H.3    Dong, J.T.4
  • 77
    • 84861650780 scopus 로고    scopus 로고
    • YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor
    • Zhi X, Zhao D, Zhou Z, Liu R, Chen C. YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor. Am J Pathol 2012, 180: 2452-2461.
    • (2012) Am J Pathol , vol.180 , pp. 2452-2461
    • Zhi, X.1    Zhao, D.2    Zhou, Z.3    Liu, R.4    Chen, C.5
  • 78
    • 84886409934 scopus 로고    scopus 로고
    • Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isofo rm of Angiomotin by the LATS1/2 protein kinases
    • Adler JJ, Johnson DE, Heller BL, Bringman LR, Ranahan WP, Conwell MD, Sun Y, et al. Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isofo rm of Angiomotin by the LATS1/2 protein kinases. Proc Natl Acad Sci USA 2013, 110: 17368-17373.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 17368-17373
    • Adler, J.J.1    De, J.2    Heller, B.L.3    Bringman, L.R.4    Ranahan, W.P.5    Conwell, M.D.6    Sun, Y.7
  • 79
    • 79952769108 scopus 로고    scopus 로고
    • The adaptor protein amot promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases
    • Ranahan WP, Han Z, Smith-Kinnaman W, Nabinger SC, Heller B, Herbert BS, Chan R, et al. The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases. Cancer Res 2011, 71: 2203-2211.
    • (2011) Cancer Res , vol.71 , pp. 2203-2211
    • Ranahan, W.P.1    Han, Z.2    Smith-Kinnaman, W.3    Nabinger, S.C.4    Heller, B.5    Herbert, B.S.6    Chan, R.7
  • 80
  • 81
    • 84870261155 scopus 로고    scopus 로고
    • LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker
    • Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta S, et al. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med 2012, 18: 1511-1517.
    • (2012) Nat Med , vol.18 , pp. 1511-1517
    • Chen, D.1    Sun, Y.2    Wei, Y.3    Zhang, P.4    Rezaeian, A.H.5    Teruya-Feldstein, J.6    Gupta, S.7
  • 82
    • 84870534509 scopus 로고    scopus 로고
    • YAP-Hippo signalling downstream of leukemia inhibitory factor receptor: Implications for breast cancer
    • Hergovich A. YAP-Hippo signalling downstream of leukemia inhibitory factor receptor: Implications for breast cancer. Breast Cancer Res 2012, 14: 326.
    • (2012) Breast Cancer Res , vol.14 , pp. 326
    • Hergovich, A.1
  • 83
    • 84900424727 scopus 로고    scopus 로고
    • The transcriptional regulators TAZ and YAP direct transforming growth factor beta-induced tumorigenic phenotypes in breast cancer cells
    • Hiemer SE, Szymaniak AD, Varelas X. The transcriptional regulators TAZ and YAP direct transforming growth factor beta-induced tumorigenic phenotypes in breast cancer cells. J Biol Chem 2014, 289: 1346 1-13474.
    • (2014) J Biol Chem , vol.289 , pp. 13461-13474
    • Hiemer, S.E.1    Szymaniak, A.D.2    Varelas, X.3
  • 85
    • 84856212176 scopus 로고    scopus 로고
    • Loss of Yes-associated protein (YAP) expression is associated with estrogen and progesterone receptors negativity in invasive b reast carcinomas
    • Tufail R, Jorda M, Zhao W, Reis I, Nawaz Z. Loss of Yes-associated protein (YAP) expression is associated with estrogen and progesterone receptors negativity in invasive b reast carcinomas. Breast Cancer Res Treat 2012, 131: 743-750.
    • (2012) Breast Cancer Res Treat , vol.131 , pp. 743-750
    • Tufail, R.1    Jorda, M.2    Zhao, W.3    Reis, I.4    Nawaz, Z.5
  • 87
    • 34748812613 scopus 로고    scopus 로고
    • RASSF1 A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein
    • Matallanas D, Romano D, Yee K, Meissl K, Kucerova L, Piazzolla D, Baccarini M, et al. RASSF1 A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol Cell 2007, 27: 962-975.
    • (2007) Mol Cell , vol.27 , pp. 962-975
    • Matallanas, D.1    Romano, D.2    Yee, K.3    Meissl, K.4    Kucerova, L.5    Piazzolla, D.6    Baccarini, M.7
  • 88
    • 84879298347 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomaincontaining oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer
    • Bendinelli P, Maroni P, Matteucci E, Luzzati A, Perrucchini G, Desiderio MA. Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomaincontaining oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer. Eur J Cancer 2013, 49: 2608-2618.
    • (2013) Eur J Cancer , vol.49 , pp. 2608-2618
    • Bendinelli, P.1    Maroni, P.2    Matteucci, E.3    Luzzati, A.4    Perrucchini, G.5    Desiderio, M.A.6
  • 89
    • 67649770134 scopus 로고    scopus 로고
    • TEADs mediate nuclear retention of TAZ to promote oncogenic transformation
    • Chan SW, Lim CJ, Loo LS, Chong YF, Huang C, HongW. TEADs mediate nuclear retention of TAZ to promote oncogenic transformation. J Biol Chem 2009, 284: 14347-14358.
    • (2009) J Biol Chem , vol.284 , pp. 14347-14358
    • Chan, S.W.1    Lim, C.J.2    Loo, L.S.3    Chong, Y.F.4    Huang, C.5    Hong, W.6
  • 90
    • 84855404337 scopus 로고    scopus 로고
    • TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis
    • Zhao D Zhi X Zhou Z Chen C. TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis Carcinogenesis 2012 33 59-67.
    • (2012) Carcinogenesis , vol.33 , pp. 59-67
    • Zhao, D.1    Zhi, X.2    Zhou, Z.3    Chen, C.4
  • 91
    • 42349088170 scopus 로고    scopus 로고
    • A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells
    • Chan SW, Lim CJ, Guo K, Ng CP, Lee I, HunzikerW, Zeng Q, et al. A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. Cancer Res 2008, 68: 2592-2598.
    • (2008) Cancer Res , vol.68 , pp. 2592-2598
    • Chan, S.W.1    Lim, C.J.2    Guo, K.3    Ng, C.P.4    Lee, I.5    Hunziker, W.6    Zeng, Q.7
  • 92
    • 84930925114 scopus 로고    scopus 로고
    • Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration
    • Mi W, Lin Q, Chi ldress C, Sudol M, Robishaw J, Berlot CH, Shabahang M, et al. Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration. Oncogene 2014, doi: 10.1038/onc.2014.251.
    • (2014) Oncogene
    • Mi, W.1    Lin, Q.2    Childress, C.3    Sudol, M.4    Robishaw, J.5    Berlot, C.H.6    Shabahang, M.7
  • 93
    • 84864541239 scopus 로고    scopus 로고
    • Taz induces growth factor-independent proliferation through activation of egfr ligand amphiregulin
    • Yang N, Morrison CD, Liu P, Miecznikowski J, BsharaW, Han S, Zhu Q, et al. TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin. Cell Cycle 2012, 11: 2922-2930.
    • (2012) Cell Cycle , vol.11 , pp. 2922-2930
    • Yang, N.1    Morrison, C.D.2    Liu, P.3    Miecznikowski, J.4    Bshara, W.5    Han, S.6    Zhu, Q.7
  • 94
    • 84863692961 scopus 로고    scopus 로고
    • Tumour suppressor genes in chemotherapeutic drug response
    • Lai D, Visser-Grieve S, Yang X. Tumour suppressor genes in chemotherapeutic drug response. Biosci Rep 2012, 32: 361-374.
    • (2012) Biosci Rep , vol.32 , pp. 361-374
    • Lai, D.1    Visser-Grieve, S.2    Yang, X.3
  • 95
    • 84879492700 scopus 로고    scopus 로고
    • Micrornas and drug resistance of breast cancer: Basic evidence and clinical applications
    • TianW, Chen J, He H, Deng Y. MicroRNAs and drug resistance of breast cancer: Basic evidence and clinical applications. Clin Transl Oncol 2013, 15: 335-342.
    • (2013) Clin Transl Oncol , vol.15 , pp. 335-342
    • Tian, W.1    Chen, J.2    He, H.3    Deng, Y.4
  • 96
    • 79953310106 scopus 로고    scopus 로고
    • Taxol resistance in breas t cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF
    • Lai D, Ho KC, Hao Y, Yang X. Taxol resistance in breas t cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res 2011, 71: 2728-2738.
    • (2011) Cancer Res , vol.71 , pp. 2728-2738
    • Lai, D.1    Ho, K.C.2    Hao, Y.3    Yang, X.4
  • 97
    • 84905987393 scopus 로고    scopus 로고
    • Yap-induced resistance of cancer cells to antitubulin drugs is modulated by a hippo-independent pathway
    • Zhao YL, Khanal P, Savage P, She YM, C yr TD, Yang XL. YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway. Cancer Res 2014, 74: 4493-4503.
    • (2014) Cancer Res , vol.74 , pp. 4493-4503
    • Zhao, Y.L.1    Khanal, P.2    Savage, P.3    She, Y.M.4    Cyr, T.D.5    Yang, X.L.6
  • 99
    • 84870831806 scopus 로고    scopus 로고
    • The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ
    • Habbig S, Bartram M P, Sagmuller JG, Griessmann A, Franke M, Muller RU, Schwarz R, et al. The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ. Hum Mol Genet 2012, 21: 5528-5538.
    • (2012) Hum Mol Genet , vol.21 , pp. 5528-5538
    • Habbig, S.1    Bartram, M.P.2    Sagmuller, J.G.3    Griessmann, A.4    Franke, M.5    Muller, R.U.6    Schwarz, R.7
  • 100
    • 84864387121 scopus 로고    scopus 로고
    • The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFbeta-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition
    • Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, et al. The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFbeta-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem 2012, 287: 26245-26253.
    • (2012) J Biol Chem , vol.287 , pp. 26245-26253
    • Huang, W.1    Lv, X.2    Liu, C.3    Zha, Z.4    Zhang, H.5    Jiang, Y.6    Xiong, Y.7
  • 101
    • 84893830229 scopus 로고    scopus 로고
    • EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration
    • Marastoni S, Andreuzzi E, Paulitti A, Colladel R, Pellicani R, Todaro F, Schiavinato A, et al. EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration. J Pathol 2014, 232: 391-404.
    • (2014) J Pathol , vol.232 , pp. 391-404
    • Marastoni, S.1    Andreuzzi, E.2    Paulitti, A.3    Colladel, R.4    Pellicani, R.5    Todaro, F.6    Schiavinato, A.7
  • 102
    • 70350780570 scopus 로고    scopus 로고
    • Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
    • Alarcon C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fu jisawa S, Barlas A, et al. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 2009, 139: 757-769.
    • (2009) Cell , vol.139 , pp. 757-769
    • Alarcon, C.1    Zaromytidou, A.I.2    Xi, Q.3    Gao, S.4    Yu, J.5    Fujisawa, S.6    Barlas, A.7
  • 103
    • 79952297528 scopus 로고    scopus 로고
    • Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin
    • Zhang H, Pasolli HA, Fuchs E. Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci USA 2011, 108: 2270-2275.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 2270-2275
    • Zhang, H.1    Pasolli, H.A.2    Fuchs, E.3
  • 104
    • 84862951862 scopus 로고    scopus 로고
    • Regulation and function of the TAZ transcription co-activator
    • Liu C, HuangW, Lei Q. Regulation and function of the TAZ transcription co-activator. Int J Biochem Mol Biol 2011, 2: 247-256.
    • (2011) Int J Biochem Mol Biol , vol.2 , pp. 247-256
    • Liu, C.1    Huang, W.2    Lei, Q.3
  • 106
    • 84897584171 scopus 로고    scopus 로고
    • VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex
    • Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, et al. VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell Res 2014, 24: 331-343.
    • (2014) Cell Res , vol.24 , pp. 331-343
    • Zhang, W.1    Gao, Y.2    Li, P.3    Shi, Z.4    Guo, T.5    Li, F.6    Han, X.7
  • 107
    • 84896092147 scopus 로고    scopus 로고
    • A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer
    • Jiao S, Wang H , Shi Z, Dong A, Zhang W, Song X, He F, et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell 2014, 25: 166-180.
    • (2014) Cancer Cell , vol.25 , pp. 166-180
    • Jiao, S.1    Wang, H.2    Shi, Z.3    Dong, A.4    Zhang, W.5    Song, X.6    He, F.7
  • 108
    • 84881271660 scopus 로고    scopus 로고
    • Emerging paradigms in GPCR allostery: Implications for drug discovery
    • Wootten D, Christopoulos A, Sexton PM. Emerging paradigms in GPCR allostery: Implications for drug discovery. Nat Rev Drug Discov 2013, 12: 630-644.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 630-644
    • Wootten, D.1    Christopoulos, A.2    Sexton, P.M.3


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